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Full-Text Articles in Medicine and Health Sciences
Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv
Antidepressant Effects Of The Nts1 Agonist Pd149163 In The Forced Swim Test, Lawrence Carey Iv
All NMU Master's Theses
Neurotensin is a neuropeptide that influences monoaminergic neurotransmission in areas of the brain involved in the pathophysiology of depression. The forced swim test is a commonly used screening model for putative antidepressant medications. Drugs that have antidepressant effects in humans reliably decrease the time animals spend in an immobile posture in the forced swim test without increasing general locomotor activity as measured in an open field test. The present study sought to examine the effects of the neurotensin NTS1 receptor agonist PD149163 and the tricyclic antidepressant drug imipramine on immobility in the forced swim test and on locomotor activity …
Characterization Of Hcmv-Encoded Chemokine Receptor Us28 Transduced Msu1.1 Human Fibroblast Cells, Danielle R. Vanbeckum
Characterization Of Hcmv-Encoded Chemokine Receptor Us28 Transduced Msu1.1 Human Fibroblast Cells, Danielle R. Vanbeckum
All NMU Master's Theses
Human Cytomegalovirus (HCMV) encodes the G-protein coupled receptor US28. Using a mouse model system, US28 was previously found to be oncomodulatory, increasing proliferation, inducing anchorage independent growth and loss of contact inhibition. Similarly, in the human glioblastoma cell line U373, US28 activated VEGF expression. To determine if US28 is oncomodulatory in normal human cells, we engineered the human fibroblast cell line MSU1.1 to express US28 via lentivirus infection. MSU1.1 cells were transduced with pHAGE-US28-ZsGreen. Fluorescent confocal microscopy was utilized to detect the ZsGreen tag and confirmed the successful transduction of MSU1.1 cells with the US28 vector or empty pHAGE vector. …
Acute Effects Of Long Distance Running On C-Reactive Protein And Arterial Stiffness, Bridget E. Durocher
Acute Effects Of Long Distance Running On C-Reactive Protein And Arterial Stiffness, Bridget E. Durocher
All NMU Master's Theses
Abstract
Central arterial stiffness, indicated by pulse wave velocity (PWV), is increased during the hour post ultramarathon (ULT), but it's currently unknown if PWV remains elevated 24 hours after ULT or marathon (MAR). PURPOSE: To determine the effects of ULT and MAR on C-reactive protein (CRP), aortic blood pressure (BP), aortic augmentation index (AIx), PWV, and LF:HF ratio. We hypothesized that CRP, AIx, PWV and LF:HF ratio would be elevated 24 hours post-race. Our secondary hypothesis was that changes in PWV would be inversely correlated to the percentage of moderate activity (3-6 METs) during competition. METHODS: Applanation tonometry was used …
The Effect Of Winter Versus Summer Running On Lower Extremity Musculoskeletal Injury Rate In Recreational Runners, Elizabeth Frieseke
The Effect Of Winter Versus Summer Running On Lower Extremity Musculoskeletal Injury Rate In Recreational Runners, Elizabeth Frieseke
All NMU Master's Theses
The effects of cryotherapy on body tissues suggest that cold exposure can decrease performance measures, including proprioception, strength, and agility. Since a decrease in proprioception and strength have been linked with an increase of injury rates, this suggests that exposure to cold conditions may increase injury rates. The main purpose of this study was to determine if there is a difference in musculoskeletal injury rates in the winter compared to the summer months in recreational runners. The participants were surveyed on their injury history for the past year. The results of this study showed that the injury rate for musculoskeletal …
Haptic And Exoskeleton Devices For Neurorehabilitation Of Upper Limb Paralysis: A State Of Art And A Night Landing Task, Samantha Renee Wagner
Haptic And Exoskeleton Devices For Neurorehabilitation Of Upper Limb Paralysis: A State Of Art And A Night Landing Task, Samantha Renee Wagner
All NMU Master's Theses
Rehabilitation is an important training phase for those suffering from upper limb paralysis as a result of brain injury. When successfully completed, the re-trained limb should be able to successfully complete daily life activities. An alternative to traditional therapy is the usage of effective rehabilitation by using haptic devices in a virtual environment. The type of haptic device and task are crucial for the success of the therapy training sessions. After presenting a state-of-art literature review of several haptic devices that has been used in research and clinical facilities, we thought to use the black hole illusion (BHI), a night …