Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Antipsychotic (1)
- Anxiety (1)
- Attention (1)
- Attention Bias (1)
- Behavioral pharmacology (1)
-
- Black Hole Illusion (1)
- Cerebellum (1)
- Chlorpromazine (1)
- Clinical Trial (1)
- Clozapine (1)
- Conditioned place preference (1)
- Drug discrimination (1)
- FMRI (1)
- Haptics (1)
- MAOI (1)
- Methylene blue (1)
- Mice (1)
- Monoamine oxidase inhibitor (1)
- Neuroimaging (1)
- Neuropharmacology (1)
- Neuropsychology (1)
- Neurorehabilitation (1)
- Nicotine (1)
- Norharmane (1)
- Psychopathology (1)
- Psychopharmacology (1)
- Quinacrine (1)
- Robotics (1)
- Stimulus generalization (1)
- Threat Processing (1)
- Publication
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
Cerebellum-Seeded Functional Connectivity Changes In Trait-Anxious Individuals Undergoing Attention Bias Modification Training, Katherine Elwell
All NMU Master's Theses
Anxiety and anxiety related disorders are increasing at a drastic rate in the past decade, with the NIMH reporting that 31.1% of U.S. adults will experience an anxiety disorder at some point in their lives. Anxiety is commonly characterized by increased attention bias to threat. Attention Bias Modification (ABM) is a new treatment used to reduce individual’s attention bias towards threat. The extent to which ABM leads to underlying neural changes is still unknown. The cerebellum is a neglected brain structure, with new research provides evidence that cerebellum’s functional connectivity and shared networks with threat processing regions has a direct …
Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander
Discriminative Stimulus Effects Of Putative Antipsychotic Drugs, Alex Lekander
All NMU Master's Theses
This study attempted to further explore the discriminative stimulus properties of antipsychotic drugs, by establishing the typical antipsychotic drug chlorpromazine, and the atypical antipsychotic drug clozapine as discriminative stimulus in two different groups of rats. The rats trained to discriminate chlorpromazine from vehicle failed to do so reliably, however nine of ten rats trained to discriminate 1.25 mg/kg clozapine from vehicle were able to acquire the discrimination in 19.1 sessions. The clozapine cue partially generalized (63.13% drug lever responding [SEM = ± 18.91]) to the antimalarial drug methylene blue at the 7.5 mg/kg dose, but not to the antimalarial quinacrine. …
Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo
Effects Of Norharmane And Nicotine On The Conditioned Place Preference Of Mice, Lindsey Galbo
All NMU Master's Theses
Tobacco smoking in the United States is used by approximately 25% of adults. Many studies using animal models have suggested that nicotine has rewarding properties. Contrastingly, several studies have also found it to be a weakly reinforcing substance at low and high dose levels. Due to this, other tobacco constituents, such as the monoamine oxidase inhibitor norharmane which is found in tobacco leaf and smoke, may be responsible for tobacco addiction by potentiating the rewarding properties of nicotine. Several studies have attempted to observe this phenomenon, however, monoamine oxidase inhibitors that are not found in tobacco leaf or smoke have …
Haptic And Exoskeleton Devices For Neurorehabilitation Of Upper Limb Paralysis: A State Of Art And A Night Landing Task, Samantha Renee Wagner
Haptic And Exoskeleton Devices For Neurorehabilitation Of Upper Limb Paralysis: A State Of Art And A Night Landing Task, Samantha Renee Wagner
All NMU Master's Theses
Rehabilitation is an important training phase for those suffering from upper limb paralysis as a result of brain injury. When successfully completed, the re-trained limb should be able to successfully complete daily life activities. An alternative to traditional therapy is the usage of effective rehabilitation by using haptic devices in a virtual environment. The type of haptic device and task are crucial for the success of the therapy training sessions. After presenting a state-of-art literature review of several haptic devices that has been used in research and clinical facilities, we thought to use the black hole illusion (BHI), a night …
An Introduction To Drugs And The Neuroscience Of Behavior, Adam J. Prus
An Introduction To Drugs And The Neuroscience Of Behavior, Adam J. Prus
Books
This up-to-date text provides an introductory overview of the nervous system actions and behavioral effects of the major classes of psychoactive drugs, using pedagogy unique among pharmacology texts to make the topic approachable.
The Quetiapine Active Metabolite N-Desalkylquetiapine And The Neurotensin Nts1 Receptor Agonist Pd149163 Exhibit Antidepressant-Like Effects On Operant Responding In Male Rats, Todd M. Hillhouse, Zachary Shankland, Katelin S. Matazel, Ashley Keiser, Adam J. Prus
The Quetiapine Active Metabolite N-Desalkylquetiapine And The Neurotensin Nts1 Receptor Agonist Pd149163 Exhibit Antidepressant-Like Effects On Operant Responding In Male Rats, Todd M. Hillhouse, Zachary Shankland, Katelin S. Matazel, Ashley Keiser, Adam J. Prus
Journal Articles
Major depressive disorder (MDD) is the most common mood disorder in the United States and European Union; however, the limitations of clinically available antidepressant drugs have led researchers to pursue novel pharmacological treatments. Clinical studies have reported that monotherapy with the atypical antipsychotic drug quetiapine produces a rapid reduction in depressive symptoms that are apparent following one week of quetiapine treatment, and it is possible that the active metabolite N-Desalkylquetiapine, which structurally resembles an antidepressant drug, produces antidepressant effects. Neuropharmacological evaluations of the neurotensin NTS1 receptor agonist PD149163 are suggestive of antidepressant efficacy, but the effects of a NTS …