Medicine and Health Sciences Commons^™

Benzyl Isothiocyanate As An Adjuvant Chemotherapy Option For Head And Neck Squamous Cell Carcinoma, Mary Allison Wolf

Theses, Dissertations and Capstones

Isothiocyanates (ITCs) are natural phytochemicals produced by cruciferous vegetables. Recent evidence supports that, in addition to cancer prevention, ITCs can use various mechanisms to target malignant cells. Current therapies for cancer often provoke detrimental side effects, however clinical evidence supports that ITCs have little to no side effects in patients. Consequently, ITCs may be a promising treatment option for cancer patients, especially patients suffering from head and neck squamous cell carcinoma (HNSCC).

Despite recent improvements in cancer treatment, overall survival of advanced HNSCC has not improved in the past three decades. Metastasis and chemoresistance represent two detrimental events that greatly …

Skin Condition Secondary To Elbow Dislocation In A Collegiate Diver, Brandi Leigh Anders

Theses, Dissertations and Capstones

Objective: The purpose of the case study is to inform athletic trainers about complications with post-surgical athletes caused from the materials used during or after the surgery.

Background: A nineteen year old female collegiate cheerleader with previous left elbow injuries developed a rash post-surgery to repair the elbow’s instability.

Differential Diagnosis: The differential diagnosis for this athlete included a medial collateral ligament tear, ulnar neuritis, elbow subluxation and cubital tunnel narrowing.

Treatment: The athlete had been placed in a posterior splint for two weeks. The athlete noticed a red, itchy patch around each of the stiches which began to itch …

Systematic Condition In A Ncaa-I Collegiate Soccer Player, Ashley D. Smith

Theses, Dissertations and Capstones

Objective: The purpose of this case study is to inform athletic trainers of a systematic disease not common in our patient population.

Background: The athlete, a twenty-one YO, 160 lb, 69 inch female NCAA-I collegiate soccer goalie presented with complaint of bilateral elbow and knee joint pain and stiffness along with tender red itchy bumps on the anterior aspect of her shins. The athlete had flu-like symptoms and a URI prior to this complaint. The athlete has a history of anemia, mononucleosis, and streptococcal.

Differential Diagnosis: Rheumatoid arthritis, lymphoma, HIV/aids, erythema nodosum, lupus, Lyme disease.

Treatment: The athlete sought out …

Chmp1 Negatively Regulates Epidermal Growth Factor Signaling In The Drosophila Wing, Meagan Elisabeth Valentine

Theses, Dissertations and Capstones

A critical step in cellular signaling through transmembrane receptors is the down-regulation of activated receptors through the multivesicular body (MVB) pathway to the lysosome. MVB generation is mediated by the highly conserved ESCRT (0, I, II, and III) protein complexes. Though the ESCRT-III complex provides the core function of the ESCRT machinery, it is the least characterized of the ESCRT complexes. The Chmp1 protein is an ESCRT-III component and a putative tumor suppressor that has been linked to pancreatic and renal cancers in humans. However, published data on Chmp1 activity are conflicting and its role during tissue development is not …

Examination Of Two Hydration Protocols During Simulated Forced Marching Under Acute Heat Stress, David Alan Cottrill

Theses, Dissertations and Capstones

The purpose of this study was to identify and compare the effects of ingesting either water or 6% solution of carbohydrates, electrolytes, and water on hydration status during simulated military road marching in hot environmental conditions. Five volunteer male subjects completed two 60 minute experimental trials exercising at a high intensity (RER .90-.95) in an improvised environmental chamber (29.7 ^{_{+ or -}} .18^oC, 11.3 + or - 2.13% relative humidity) in full army combat uniform carrying 18.18kg of equipment. Random assignment of either water or solution was completed prior to trial 1, and consumption of the unselected protocol …

Cardiovascular Aging In The Female F344xbn Rat Model, Jacqueline C. Fannin

Theses, Dissertations and Capstones

Despite continued advances in medical care, cardiovascular disease (CVD) remains the leading cause of death for American women [1]. Although humans and non-human primates are the only mammals to experience menses, rodent models are commonly used to study age-associated cardiovascular alterations due to similar ovarian aging, low expense, and short lifetime to investigate cardiovascular aging. Previous studies have found that aging in the female rodent is characterized by increased ventricular apoptosis, elevations in oxidative-nitrosative stress, ventricular remodeling, increased collagen content, mild systolic and diastolic dysfunction, and reduced occurrence of arrhythmias compared to males [2-7]. Similarly, age-associated alterations in the female …

An Analysis Of The Effects Of The 2003 And 2011 Acgme Work Hour Rules On Medical Resident Satisfaction At An Independent Academic Medical Center, Rachael E. Trout

Theses, Dissertations and Capstones

The purpose of this research was to determine what effects, if any, the 2003 and 2011 ACGME work hour rules had on medical resident satisfaction at an independent academic medical center in the United States. This research analyzed results of a survey administered by an independent academic medical center utilizing its own instrument of measure. Items reviewed to determine self-perceived satisfaction included questions related to program director effectiveness, resident input, quality of life, and satisfaction with program. Four comparisons were reviewed and analyzed for statistical significance utilizing the Mann-Whitney U non-parametric test for independent samples. The results indicated neither the …

Cultural Language Variations: An Examination Of Appalachian Discourse, Katherine Ward

Theses, Dissertations and Capstones

Examinations of discourse are essential for documenting the linguistic variations of a particular culture. In turn, linguistic variations across cultures may suggest similar variations in global discourse measures. It is imperative for clinicians to first understand the framework and cultural norms of a particular dialect or language to properly identify deficits in disordered language. By first looking closely at specific aspects of discourse such as story grammar within a normative or non-brain injured population, clinicians can improve treatment protocols for working with aphasic or brain-injured clients. With Appalachia being the heart of the “stroke belt,” research in intervention strategies for …

Therapeutic Efficacy Of Cerium Oxide Nanoparticles Against Sepsis Induced Multi-Organ Dysfunction Syndrome In Sprague Dawley Rats, Nandini Durga Prasanna Kumar Manne

Theses, Dissertations and Capstones

Sepsis is a generalized term that signifies the presence of a pathogen in the blood stream to which the body responds by eliciting a systemic inflammatory response. Although sepsis is the leading cause of death in non-coronary intensive care units in United States, there are currently no FDA approved therapeutic drugs to treat this disorder. Cerium oxide nanoparticles (CeO₂) have been shown to exhibit anti-oxidant, anti-inflammatory, and anti-bacterial properties both in vitro and in vivo. Whether CeO₂ nanoparticles can be used for the treatment of sepsis is currently unclear.

To investigate whether CeO₂ nanoparticles can …

Identification And Characterization Of Downstream Effector Protein(S) Regulated By P53 And Prb, Miranda B. Carper

Theses, Dissertations and Capstones

A commonality among cancer types is the high frequency of mutations that inhibit or alter signaling of the p53 and pRb (Retinoblastoma) tumor suppressors. These genes regulate processes vital for cancer suppression such as apoptosis, senescence, and cell cycle arrest among others. Loss of both p53 and pRb promotes processes that support cancer progression and is associated with decreased patient survival and increased rates of tumor reoccurrence. Although data points to the ability of p53 and pRb to collaborate and to inhibit tumorigenesis, it remains unclear how p53 and pRb cooperate toward this task. Using RNA expression profiling, 179 p53 …

Secondhand Smoke Exposure As A Risk Factor For Perioperative Airway Complications In Pediatric Outpatient Procedures, Ashlee Denise Loudin

Theses, Dissertations and Capstones

Abstract: The purpose of this study is to assess the risk of perioperative airway complications, analyze extubation times, and PACU Length Of Stay (LOS), and their association with secondhand smoke exposure in pediatric populations receiving outpatient procedures that require general anesthesia.

Introduction: Tobacco Smoke Exposure (TSE), is well documented to cause physiologic changes in lung tissue that are associated with decreased lung function, increased risk of lower and upper respiratory tract illness, exacerbation of asthma or increased risk of asthma, increased prevalence of non-allergic bronchial hyperresponsiveness, sudden infant death syndrome, and a host of other respiratory complications in adult and …