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High Mobility Group Box-1 (Hmgb1) Participates In The Pathogenesis Of Alcoholic Liver Disease (Ald), Xiaodong Ge, Daniel J. Antoine, Yongke Lu, Elena Arriazu, Tung-Ming Leung, Arielle L. Klepper, Andrea D. Branch, Maria Isabel Fiel, Natalia Nieto

Pharmacology, Physiology and Toxicology

Growing clinical and experimental evidence suggests that sterile inflammation contributes to alcoholic liver disease (ALD). High mobility group box-1 (HMGB1) is highly induced during liver injury; however, a link between this alarmin and ALD has not been established. Thus, the aim of this work was to determine whether HMGB1 contributes to the pathogenesis of ALD. Liver biopsies from patients with ALD showed a robust increase in HMGB1 expression and translocation, which correlated with disease stage, compared with healthy explants. Similar findings were observed in chronic ethanol-fed wild-type (WT) mice. Using primary cell culture, we validated the ability of hepatocytes from …