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Onset Of Mild Cognitive Impairment In Parkinson Disease, David K. Johnson, Zachary Langford, Mauricio Garnier-Villarreal, John C. Morris, James E. Galvin

College of Nursing Faculty Research and Publications

Objective: Characterize the onset and timing of cognitive decline in Parkinson disease (PD) from the first recognizable stage of cognitively symptomatic PD-mild cognitive impairment (PD-MCI) to PD dementia (PDD). Thirty-nine participants progressed from PD to PDD and 25 remained cognitively normal.

Methods: Bayesian-estimated disease-state models described the onset of an individual’s cognitive decline across 12 subtests with a change point.

Results: Subtests measuring working memory, visuospatial processing ability, and crystalized memory changed significantly 3 to 5 years before their first nonzero Clinical Dementia Rating and progressively worsened from PD to PD-MCI to PDD. Crystalized memory deficits were …