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Full-Text Articles in Medicine and Health Sciences

Reinforcement Learning, Error-Related Negativity, And Genetic Risk For Alzheimer's Disease, Christina Marie Figueroa Apr 2016

Reinforcement Learning, Error-Related Negativity, And Genetic Risk For Alzheimer's Disease, Christina Marie Figueroa

Dissertations (1934 -)

Reinforcement learning (RL) has been widely used as a model of animal and human learning and decision-making. The neural networks underlying RL involve many of the same structures primarily affected by Alzheimer’s disease (AD) such as the hippocampus. Yet, RL and non-invasive evaluation of its neural underpinnings have been underutilized as a framework for understanding disease pathology and its pre-clinical states. This study aimed to provide a novel approach for assessing subtle changes in asymptomatic apolipoprotein-E (APOE) carriers and non-carriers. Electroencephalography was collected from forty APOE genotyped older adults (Male n = 11; Mage = 79.30; Meducation = 14.88 years) …


Video Game Interventions To Improve Cognition In Older Adults, David E. C. Marra Apr 2016

Video Game Interventions To Improve Cognition In Older Adults, David E. C. Marra

Master's Theses (2009 -)

Cognitive abilities decline as part of the normal aging process. Various non-pharmacological interventions are being studied in an effort to ameliorate this cognitive decline. Some of these interventions include computerized cognitive training, such as neuropsychological software (i.e., brain training games) and video games. A previous study in our lab found that older adults who played a brain training game or a video poker game showed similar cognitive gains. The purpose of the present study was to follow the methodological procedures of our previous study to try and determine if the positive effects seen for the brain training program and video …