Medicine and Health Sciences Commons^™

Behavioral Assessment Of Acute Inhibition Of System XC - In Rats, Victoria Lutgen, Jon M. Resch, Krista Qualmann, Nicholas J. Raddatz, Cristina Panhans, Ellen M. Olander, Linghai Kong, Sujean Choi, John R. Mantsch, David A. Baker

Biomedical Sciences Faculty Research and Publications

Rationale

Gaps in our understanding of glutamatergic signaling may be key obstacles in accurately modeling complex CNS diseases. System x_c ^- is an example of a poorly understood component of glutamate homeostasis that has the potential to contribute to CNS diseases.

Objectives

This study aims to determine whether system x_c ^- contributes to behaviors used to model features of CNS disease states.

Methods

In situ hybridization was used to map mRNA expression of xCT throughout the brain. Microdialysis in the prefrontal cortex was used to sample extracellular glutamate levels; HPLC was used to measure extracellular glutamate and tissue …

Augmented Cystine–Glutamate Exchange By Pituitary Adenylate Cyclase-Activating Polypeptide Signaling Via The Vpac1 Receptor, Jon M. Resch, Rebecca Albano, Xiaoqian Liu, Julie Hjelmhaug, Doug Lobner, David A. Baker, Sujean Choi

Biomedical Sciences Faculty Research and Publications

In the central nervous system, cystine import in exchange for glutamate through system x_c^- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system x_c^- activity affects multiple aspects of cellular physiology and may contribute to disease states. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuronally derived peptide that has already been demonstrated to modulate multiple aspects of glutamate signaling suggesting PACAP may also target activity of cystine–glutamate exchange via system x_c^-. In this study, 24-h treatment of primary cortical …

Nurse Value-Added And Patient Outcomes In Acute Care, Olga Yakusheva, Richard C. Lindrooth, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Objective

The aims of the study were to (1) estimate the relative nurse effectiveness, or individual nurse value-added (NVA), to patients’ clinical condition change during hospitalization; (2) examine nurse characteristics contributing to NVA; and (3) estimate the contribution of value-added nursing care to patient outcomes.

Data Sources/Study Setting

Electronic data on 1,203 staff nurses matched with 7,318 adult medical–surgical patients discharged between July 1, 2011 and December 31, 2011 from an urban Magnet-designated, 854-bed teaching hospital.

Study Design

Retrospective observational longitudinal analysis using a covariate-adjustment value-added model with nurse fixed effects.

Data Collection/Extraction Methods

Data were extracted from the study …

Chronic Conditions In Elders In Assisted Living Facilities: Associations With Daily Functioning, Self-Assessed Health, And Depressive Symptoms, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Background

The increasing life expectancy of older adults has prompted an increase in chronic conditions that may interfere with their daily living and impact physical and mental health.

Objectives

This study examined associations between commonly reported chronic conditions, daily functioning, self-assessed health, and depressive symptoms of elders.

Methods/Design

A secondary analysis of existing data from 314 elderly residents of 29 facilities was conducted.

Results

The most frequently reported conditions were arthritis (64%), hypertension (47%), and heart problems (35%). Elders who reported having all three of these most frequently reported conditions differed significantly from those who reported none or one of …

Gender Differences In Neighborhood Walking In Older Adults, N. A. Gallagher, P. J. Clarke, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Objective: This study examined mobility, self-efficacy, outcome expectations, neighborhood (density, destinations, and design), and neighborhood walking in older men (n = 106, 60-99 years, M = 76.78, SD = 8.12) and women (n = 216, 60-99 years, M = 75.81, SD = 8.46).

Method/Results: In hierarchical regression, the variables explained 32% of the variance in neighborhood walking in men (p < .001) and 27% of the variance in women (p < .01). Self-efficacy (β = .49, p < .01), density (β= .22, p < .05), and design (β= .21, p = .05) were associated with walking in men. Significant design characteristics included sidewalks (β= .25, p < .05) and crime (β= .36, p < .01). In women, self-efficacy (β= .48, p < .001) and destinations (β= .15, p < .05) were associated with walking. Walking was associated with self-efficacy for walking despite individual barriers in women (β= .38, p < .001) and neighborhood barriers in men (β= .30, p < .05).

Conclusion: Walking interventions targeting older women should incorporate local destinations. In older …

Phosphate And Acidosis Act Synergistically To Depress Peak Power In Rat Muscle Fibers, Cassandra R. Nelson, Edward P. Debold, Robert H. Fitts

Biomedical Sciences Faculty Research and Publications

Skeletal muscle fatigue is characterized by the buildup of H⁺ and inorganic phosphate (P_i), metabolites that are thought to cause fatigue by inhibiting muscle force, velocity, and power. While the individual effects of elevated H⁺ or P_i have been well characterized, the effects of simultaneously elevating the ions, as occurs during fatigue in vivo, are still poorly understood. To address this, we exposed slow and fast rat skinned muscle fibers to fatiguing levels of H⁺ (pH 6.2) and P_i (30 mM) and determined the effects on contractile properties. At 30°C, elevated P_{i …}

The Economic Costs And Benefits Of Dental Education: An Empirical Analysis, Gary L. Stafford, Farrokh Nourzad, William K. Lobb, Jason R. Beall

School of Dentistry Faculty Research and Publications

The rising costs associated with obtaining a dental education have caused some to question the financial benefit of pursuing a dental degree. There is a concern that recent graduates may have difficulty finding professional opportunities that provide the income necessary to service their accumulated educational debt. The aim of this study was to evaluate the trends in educational costs to aid in making an accurate appraisal of the financial benefit of a dental education. Adjusted into constant dollar terms, data from a variety of sources were collected for economic variables such as tuition, fees, student indebtedness, and dentists’ earnings. These …

An Emerging Population: The Chronically Critically Ill, Philip Jurasinski, Christine A. Schindler

College of Nursing Faculty Research and Publications

No abstract provided.

Effect Of A Social Script Ipad Application For Children With Autism Going To Imaging, Norah L. Johnson, Octavia Bree, Erin E. Lalley, Kelly Rettler, Pam Grande, Md O. Gani, Sheikh Iqbal Ahamed

College of Nursing Faculty Research and Publications

This randomized controlled trial feasibility study tested the effectiveness of an iPad® application (app) social script intervention for children with autism spectrum disorder (ASD) going to imaging and their parent (n = 32 parent/child dyads). Parents of the children exposed to the app (n = 16) had lower state anxiety compared to the parents whose children were not exposed to the app (n = 16) (effect size 0.33). Children exposed to the app had fewer externalized challenging behaviors than the control group (effect size 0.56). The results demonstrate feasibility and efficacy of the intervention. Further study of …

Effects Of Sex And Gender On Adaptation To Space: Musculoskeletal Health, Lori Ploutz-Snyder, Susan Bloomfield, Scott M. Smith, Sandra K. Hunter, Kim Templeton, Debra Bemben

Exercise Science Faculty Research and Publications

There is considerable variability among individuals in musculoskeletal response to long-duration spaceflight. The specific origin of the individual variability is unknown but is almost certainly influenced by the details of other mission conditions such as individual differences in exercise countermeasures, particularly intensity of exercise, dietary intake, medication use, stress, sleep, psychological profiles, and actual mission task demands. In addition to variations in mission conditions, genetic differences may account for some aspect of individual variability. Generally, this individual variability exceeds the variability between sexes that adds to the complexity of understanding sex differences alone. Research specifically related to sex differences of …

Effect Of Different Enamel Conditionings On The Bond Strength Of Glass Ionomer Cement And Ceramic Brackets, Dauro Douglas Oliveira, T. Gerard Bradley, Matheus Melo Pithon, Mariele Cristina Garcia Pantuzo, Emilio Akaki, Virendra B. Dhuru

School of Dentistry Faculty Research and Publications

Aim: To evaluate the effect of different enamel conditionings on the shear bond strength (SBS) and bond failure patterns of a resin modified glass ionomer cement (RMGIC) used to bond ceramic brackets. Methods: 105 human premolars extracted for orthodontic reasons were divided into 7 groups according to the enamel surface treatments: conditioners (35% phosphoric acid and 10% polyacrylic acid), type of adhesive (Transbond® and Fuji Ortho LC Capsule®), washing time and drying of the surface. Results: A significant p0.05) to the group that had brackets bonded with composite resin. The two groups that had enamel prepared with polyacrylic acid and …

Factors Affecting Disruption In Families Of Adults With Mental Illness, M. Jane Suresky, Jaclene Zauszniewski, Abir K. Bekhet

College of Nursing Faculty Research and Publications

PURPOSE: This study examined relationships between vulnerability/risk and protective factors, and family functioning in women family members of adults with serious mental illness.

DESIGN AND METHODS: Using a descriptive, correlational design, this secondary analysis examined characteristics of the family member with mental illness (e.g., diagnosis, level of care) and measures of caregiver stigma and strain, client dependence, family disruption, sense of coherence, and resourcefulness.

FINDINGS: Family disruption was greatest inwomenwho provided direct care and whose family member had major depression, followed by bipolar disorder, schizophrenia, and panic disorder. Sense of coherence and resourcefulness were associated with lower family disruption, but …

Stress-Induced Cocaine Seeking Requires A Beta-2 Adrenergic Receptor-Regulated Pathway From The Ventral Bed Nucleus Of The Stria Terminalis That Regulates Crf Actions In The Ventral Tegmental Area, Oliver Vranjkovic, Paul J. Gasser, Clayton H. Gerndt, David A. Baker, John R. Mantsch

Biomedical Sciences Faculty Research and Publications

The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA), a site where the CRF receptor antagonist antalarmin prevents the reinstatement of cocaine seeking by a stressor, intermittent footshock, following intravenous self-administration in rats. The vBNST receives dense noradrenergic innervation and expresses β adrenergic receptors (ARs). Footshock-induced reinstatement was prevented by bilateral intra-vBNST injection of the β-2 AR antagonist, ICI-118,551, but not the β-1 AR antagonist, betaxolol. Moreover, bilateral intra-vBNST injection of …

Cyclic Ovarian Hormone Modulation Of Supraspinal Δ9-Tetrahydrocannabinol-Induced Antinociception And Cannabinoid Receptor Binding In The Female Rat, Alexa A. Wakley, Alisha A. Mcbride, Linda K. Vaughn, Rebecca M. Craft

Biomedical Sciences Faculty Research and Publications

Estrous cycle-related fluctuations in delta-9-tetrahydrocannabinol (THC)-induced antinociception have been observed in the rat. The aim of this study was to determine which major ovarian hormone modulates the antinociceptive effects of i.c.v. THC, and whether hormone modulation of THC's behavioral effects could be due to changes in brain cannabinoid receptors (CBr). Vehicle (oil) or hormones (estradiol or progesterone, or both) were administered to female rats on days 3 and 7 post-ovariectomy. On the morning or afternoon of day 8 or day 9, vehicle or THC (100 μg) was administered i.c.v. Paw pressure, tail withdrawal, locomotor activity and catalepsy tests were conducted …

Are Rural And Urban Newly Licensed Nurses Different? A Longitudinal Study Of A Nurse Residency Programme, Marilyn Meyer Bratt, Marianne Baernholdt, Jessica E. Pruszynski

College of Nursing Faculty Research and Publications

Aim

This study aimed to compare rural and urban nurse residency programme participants’ personal and job characteristics and perceptions of decision-making, job satisfaction, job stress, nursing performance and organisational commitment over time.

Background

Nurse residency programmes are an evolving strategy to foster transition to practice for new nurses. However, there are limited data available for programme outcomes particularly for rural nurses.

Method

A longitudinal design sampled 382 urban and 86 rural newly licensed hospital nurses during a 12-month nurse residency programme. Data were collected at the start of the programme, at 6 months and the end of the programme.

Results …

Strength Properties Of Preceramic Brazed Joints Of A Gold-Palladium Alloy With A Microwave-Assisted Oven And Gas/Oxygen Torch Technique, Hyeongil Kim, Soni Prasad, Robert Dunford, Edward A. Monaco, Jr.

School of Dentistry Faculty Research and Publications

Statement of problem

The effect of microwave brazing on the strength properties of dental casting alloys is not yet known.

Purpose

The purpose of this study was to compare the strength properties of preceramic brazed joints obtained by using a microwave oven and a conventional torch flame for a high noble alloy (Au-Pd).

Material and methods

A total of 18 tensile bars made of an Au-Pd ceramic alloy were fabricated. Six specimens were cut and joined with a high-fusing preceramic solder in a specially designed microwave oven, and 6 specimens were joined with a conventional natural gas/oxygen torch. The remaining …

“Releasing A Lot Of Poisons From My Mind”: Patients' Delusional Memories Of Intensive Care, Jill L. Guttormson

College of Nursing Faculty Research and Publications

Objectives

To describe intensive care unit (ICU) patients' delusional memories and interpretations of those memories.

Background

Delusional memories of the ICU are distressing for patients and may impact psychological recovery.

Methods

This is a secondary analysis from a study of mechanically ventilated patients' recall in relation to sedation. Subjects, recruited from one medical-surgical ICU, participated in structured interviews after extubation.

Results

Subjects (n = 35) with a mean age of 66 (SD 12.9) and on the ventilator a median of 4.5 days provided detailed descriptions of delusional memories of being shackled, caged, strangled, or being in a foreign country. …

Social Script Ipad Application Versus Usual Care Before Undergoing Medical Imaging: Two Case Studies Of Children With Autism, Norah L. Johnson Phd, Rn, Cpnp, Octavia Alexis Bree

College of Nursing Faculty Research and Publications

Autism spectrum disorders (ASDs) are neurodevelopmental disorders of socialization, communication, and repetitive behaviors. Children with ASD have underlying anxiety leading to challenging behaviors in unfamiliar situations. The anxiety impacts timely completion of an imaging procedure. The purpose of the case study was to describe the process of the social script intervention delivered using the iPad application on parent and child anxiety, child behaviors, and imaging procedure length between two parent and child dyads. The case study of two parent-child dyads demonstrated the process for comparing the social script intervention iPad app for preparing for imaging versus usual care. Parent anxiety …

Pharyngeal And Cervical Cancer Incidences Significantly Correlate With Personal Uv Doses Among Whites In The United States, Dianne E. Godar, Rong Tang, Stephen Merrill

Mathematics, Statistics and Computer Science Faculty Research and Publications

Because we found UV-exposed oral tissue cells have reduced DNA repair and apoptotic cell death compared with skin tissue cells, we asked if a correlation existed between personal UV dose and the incidences of oral and pharyngeal cancer in the United States. We analyzed the International Agency for Research on Cancer's incidence data for oral and pharyngeal cancers by race (white and black) and sex using each state's average annual personal UV dose. We refer to our data as ‘white’ rather than ‘Caucasian,’ which is a specific subgroup of whites, and ‘black’ rather than African-American because blacks from other countries …

Comparison Of Abstinence And Coital Frequency Between 2 Natural Methods Of Family Planning, Richard J. Fehring, Mary Schneider

College of Nursing Faculty Research and Publications

Introduction

The length of periodic abstinence, due to overestimation of the fertile phase of the menstrual cycle, is often a cause for dissatisfaction, discontinuation, and user error with natural family planning (NFP) methods. The objective of this research was to compare the length of required abstinence (ie, estimated fertility) and coital frequency between 2 NFP methods.

Methods

This was an analysis of data from a 12-month prospective comparison study in which participants were randomized into either an electronic hormonal fertility monitor (EHFM) group or a cervical mucus monitoring (CMM) group—both of which included a fertility algorithm as a double check …

Transition From Hospital To Home Following Pediatric Solid Organ Transplant: Qualitative Findings Of Parent Experience, Stacee M. Lerret, Marianne E. Weiss, Gail Stendahl, Shelley Chapman, Katie Neighbors, Joan Lokar, Ashley Voit, Jerome Menendez, Estella M. Alonso

College of Nursing Faculty Research and Publications

Transplant providers are challenged to determine appropriate interventions for patients and families due to limited published research regarding the context of the post-discharge experience from the perspective of parents of transplanted children. The purpose of this study is to describe the parent perspective of the transition from hospital to home following their child's solid organ transplant. Within a mixed-methods design, 37 parents of pediatric heart, kidney, and liver transplant recipients from three pediatric hospitals responded to qualitative interview questions on the day of hospital discharge and three wk following hospital discharge. Insight to the discharge preparation process revealed necessary education …

Reducing The Burden Of Medication Costs To Improve Medication Adherence, Christine R. Shaw

College of Nursing Faculty Research and Publications

The high cost of medications is one reason that patients do not adhere to treatment plans. Providers can take actions to relieve the economic burden such as prescribing generic medications and offering patients information on various resources, including discount generic drug lists, discount cards, mail-order pharmacies, and prescription assistance programs.

Self-Assessed Health In Caregivers Of Persons With Autism: Associations With Depressive Symptoms, Positive Cognitions, Resourcefulness, And Well-Being, Abir K. Bekhet

College of Nursing Faculty Research and Publications

Purpose

Caregiving for children with autism spectrum disorder (ASD) can affect family caregivers' self-assessed health. The purpose of this study was to determine whether depressive symptoms, positive cognitions, resourcefulness, and well-being will differ significantly among those who rated their health as fair, good, or excellent.

Design and Methods

This study is a secondary analysis of 109 ASD caregivers who were recruited from the Interactive ASD Network.

Findings

Depression was significantly lower among those who rated their health as excellent than among those who rated their health as fair. Positive cognitions, resourcefulness, and well-being were significantly higher among those who rated …

Time Course Of Cocaine-Induced Behavioral And Neurochemical Plasticity, Victoria Lutgen, Linghai Kong, Kristen S. Kau, Aric Madayag, John Mantsch, David A. Baker

Biomedical Sciences Faculty Research and Publications

Factors that result in augmented reinstatement, including increased withdrawal period duration and high levels of cocaine consumption, may provide insight into relapse vulnerability. The neural basis of augmented reinstatement may arise from more pronounced changes in plasticity required for reinstatement and/or the emergence of plasticity expressed only during a specific withdrawal period or under specific intake conditions. In this study, we examined the impact of withdrawal period duration and cocaine intake on the magnitude of cocaine-primed reinstatement and extracellular glutamate in the nucleus accumbens, which has been shown to be required for cocaine-primed reinstatement. Rats were assigned to self-administer under …

A Comparison Of Two Formulas Of Topical Menthol On Vascular Responses And Perceived Intensity Prior To And Following A Bout Of Maximum Voluntary Muscular Contractions (Mvmcs), Robert V. Topp, Alex V. Ng, Alyson Cybulski, Katalin W. Skelton, Paula Papanek

College of Nursing Faculty Research and Publications

The purpose of this study was to compare the vascular responses in the brachial artery and perceived intensity of two different formulas of topical menthol gels prior to and following a bout of maximum voluntary muscular contractions (MVMCs).

18 adults completed the same protocol on different days using blinded topical menthol gels (Old Formula and New Formula). Heart rate, brachial artery blood flow (ml/min), vessel diameter and reported intensity of sensation were measured at baseline (T1), at 5 min after application of the gel to the upper arm (T2), and immediately following five MVMCs hand grips (T3).

The New Formula …

Inhibition Of Food Intake By Pacap In The Hypothalamic Ventromedial Nuclei Is Mediated By Nmda Receptors, Jon M. Resch, Brian Maunze, Kailynn A. Phillips, Sujean Choi

Biomedical Sciences Faculty Research and Publications

Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the VMN is unknown. Though PACAP signaling has many targets, this neuropeptide has been shown to influence glutamate signaling in several brain regions through mechanisms involving NMDA receptor potentiation via activation of the Src family of protein tyrosine kinases. With this in mind, we examined the Src-NMDA receptor signaling pathway as a target for PACAP signaling in the VMN that may mediate its effects on feeding behavior. …

An Investigation Into The Mechanical And Aesthetic Properties Of New Generation Coated Nickel-Titanium Wires In The As-Received State And After Clinical Use, T. Gerard Bradley, David W. Berzins, Nicholas Valeri, Jessica E. Pruszynski, Theodore Eliades, Christos Katsaros

School of Dentistry Faculty Research and Publications

The orthodontic profession is constantly seeking to improve and optimize the aesthetics of orthodontic wires since the introduction of aesthetic brackets. Nickel-titanium (NiTi) wires since their introduction to orthodontics (Andreasen and Hilleman, 1971) have been extensively researched in vitro and are used as an initial levelling and aligning archwire because of its properties of springback and superelasticity (Burstone et al., 1985; Miura et al., 1986; Leu et al., 1990; Bishara et al., 1995; Bradley et al., 1996; Biermann et al., 2007; Berzins and Roberts 2010). Aesthetic wires are usually either coated NiTi wires or composite wires of reinforced polymers. Shape …

Changes In Glutamate Receptor Subunits Within The Medulla In Goats After Section Of The Carotid Sinus Nerves, Justin Robert Miller, Suzanne Neumueller, Clarissa Muere, Samantha Olesiak, Lawrence Pan, John D. Bukowy, Asem O. Daghistany, Matthew Hodges, Hubert Forster

Physical Therapy Faculty Research and Publications

The mechanisms which contribute to the time-dependent recovery of resting ventilation and the ventilatory CO₂ chemoreflex after carotid body denervation (CBD) are poorly understood. Herein we tested the hypothesis that there are time-dependent changes in the expression of specific AMPA, NMDA, and/or neurokinin-1 (NK1R) receptors within respiratory-related brain stem nuclei acutely or chronically after CBD in adult goats. Brain stem tissues were collected acutely (5 days) or chronically (30 days) after sham or bilateral CBD, immunostained with antibodies targeting AMPA (GluA1 or GluA2), NMDA (GluN1), or NK-1 receptors, and optical density (OD) compared. Physiological measurement confirmed categorization of each …

Patient Perceptions Of Patient-Empowering Nurse Behaviours, Patient Activation And Functional Health Status In Postsurgical Patients With Life-Threatening Long-Term Illnesses, Teresa Jerofke-Owen, Marianne E. Weiss, Olga Yakusheva

College of Nursing Faculty Research and Publications

Aim

To explore the trajectory of associations between the nursing care process of patient empowerment during postsurgical hospitalization and postdischarge patient self-management outcomes, specifically patient activation and functional health status.

Background

Patient-centred care models advocate for patient empowerment in long-term illness care. Postsurgical patients with life-threatening long-term illnesses frequently feel powerless, have unmet needs, decreased functional health status and high readmission rates; however, previous studies of patient empowerment have conceptualized empowerment as an outcome primarily in outpatient settings, with little attention paid to provider processes used to empower patients during hospitalizations.

Design

A non-experimental, prospective, correlational study.

Methods

This sample …

Psychometric Properties Of The Index Of Relocation Adjustment, Abir K. Bekhet, Jaclene Zauszniewski

College of Nursing Faculty Research and Publications

More and more American older adults are relocating to retirement communities, and they experience challenges in adjusting to new surroundings that may increase their depression and mortality. An instrument not previously tested in the United States, the Index of Relocation Adjustment (IRA), may help in early identification of poor relocation adjustment. This study examined the psychometric properties of the IRA using secondary data from a convenience sample of 104 older adults who relocated to 6 retirement communities in Northeast Ohio. Cronbach’s alpha was .86. The IRA was correlated with measures of positive cognitions (r = .48, p < .01) and relocation controllability (r = …