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A Phase I Trial Of Aminolevulinic Acid-Photodynamic Therapy For Treatment Of Oral Leukoplakia, Stuart J. Wong, Bruce Campbell, Becky Massey, Denis P. Lynch, Ezra E.W. Cohen, Elizabeth M. Blair, Rebecca Selle, Julia Shklovskaya, Borko D. Jovanovic, Silvia Skripkauskas, Alexander Dew, Peter Kulesza, Vamsi Parimi, Raymond C. Bergan, Eva Szabo
A Phase I Trial Of Aminolevulinic Acid-Photodynamic Therapy For Treatment Of Oral Leukoplakia, Stuart J. Wong, Bruce Campbell, Becky Massey, Denis P. Lynch, Ezra E.W. Cohen, Elizabeth M. Blair, Rebecca Selle, Julia Shklovskaya, Borko D. Jovanovic, Silvia Skripkauskas, Alexander Dew, Peter Kulesza, Vamsi Parimi, Raymond C. Bergan, Eva Szabo
School of Dentistry Faculty Research and Publications
Background
Photodynamic therapy with aminolevulinic acid (ALA PDT) for oral leukoplakia has shown promising effects in regression of oral leukoplakia. Although ALA has been extensively studied and is an ideal photosensitizer, the optimal light dose for treatment of oral leukoplakia has not been determined. We conducted a phase I study to determine MTD and DLT of PDT in patients treated with ALA for leukoplakia.
Methods
Patients with histologically confirmed oral leukoplakia received a single treatment of ALA PDT in cohorts with escalating doses of light (585 nm). Clinical, histologic, and biologic markers were assessed.
Results
Analysis of 11 participants is …