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Full-Text Articles in Medicine and Health Sciences

Acceleration Of Wound Healing With High Voltage, Monophasic, Pulsed Current, Luther C. Kloth, Jeffery A. Feedar Apr 1988

Acceleration Of Wound Healing With High Voltage, Monophasic, Pulsed Current, Luther C. Kloth, Jeffery A. Feedar

Physical Therapy Faculty Research and Publications

The purpose of this study was to determine whether high voltage electrical stimulation accelerates the rate of healing of dermal ulcers. Sixteen patients with stage IV decubitus ulcers, ranging in age from 20 to 89 years, participated in the study. The patients were assigned randomly to either a Treatment Group (n = 9) or a Control Group (n = 7). Patients in the Treatment Group received daily electrical stimulation from a commercial high voltage generator. Patients in the Control Group had the electrodes applied daily but received no stimulation. The ulcers of patients in the Treatment Group healed at a …


Fibrinogen Birmingham: A Heterozygous Dysfibrinogenemia (Aα 16 Arg → His) Containing Heterodimeric Molecules, Kevin R. Siebenlist, J. T. Prchal, Michael W. Mosesson Mar 1988

Fibrinogen Birmingham: A Heterozygous Dysfibrinogenemia (Aα 16 Arg → His) Containing Heterodimeric Molecules, Kevin R. Siebenlist, J. T. Prchal, Michael W. Mosesson

Biomedical Sciences Faculty Research and Publications

Fibrinogen was isolated from the plasma of a 25-year-old female with a history of mild bleeding and several recent moderate to severe hemorrhagic episodes. Coagulability with thrombin approached 100% and varied directly with the time of incubation with the enzyme. High- performance liquid chromatography analysis of thrombin-induced fibrinopeptide release demonstrated retarded fibrinopeptide A (FPA) and fibrinopeptide B (FPB) release and the presence of an abnormal A peptide (FPA) amounting to 50% of the total. The same biochemical abnormalities were found in her asymptomatic father. Amino acid analysis and carboxypeptidase digestion of FPA demonstrated the substitution of His for Arg at …