Medicine and Health Sciences Commons^™

Adenosquamous Carcinoma Of The Tongue, Yeshwant B. Rawal, Kenneth M. Anderson

School of Dentistry Faculty Research and Publications

A 51-year-old white female presented with a painful ulcer of the left ventrolateral tongue. An incisional biopsy confirmed a diagnosis of adenosquamous carcinoma. The adenosquamous carcinoma is an uncommon malignant tumor with histopathological features of a squamous carcinoma and an adenocarcinoma. A definitive diagnosis requires histopathological examination of a deep biopsy involving the submucosal tissue. This malignant tumor shows aggressive behavior with early invasive growth and a poor prognosis. The histopathological findings and differential diagnosis of a case of adenosquamous carcinoma of the tongue are discussed.

Impending Total Airway Collapse Involving A Maxillary Removable Partial Denture: A Clinical Report, Georgios Maroulakos, Stylianos Voulgarelis

School of Dentistry Faculty Research and Publications

This article presents a rare incident of a bilateral maxillary removable partial denture as an airway foreign body. The removable partial denture and the surrounding soft tissue irritation caused partial obstruction of the airway. Impending airway collapse was avoided after successful removal of the foreign body. Removing a removable dental prostheses at night, not only to prevent soft tissue pathology but also to avoid ingestion or aspiration of the prosthesis, must be emphasized.

Using Enamel Matrix Derivative To Improve Treatment Efficacy In Periodontal Furcation Defects, Reza Masaeli, Kavosh Zandsalimi, Zahra Lotfi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Furcations are complicated periodontal defects. Untreated furcations lead to loss of the involved teeth and supporting tissues. It has been demonstrated that regenerative biomaterials are beneficial in reconstruction of the bone surrounding furcation‐affected teeth. These biomaterials range from bone grafts and nonresorbable/resorbable barrier membranes to biologics that are able to trigger inactive regenerative processes in periodontal tissues. Selection of appropriate material(s) to treat furcations is challenging. The aim of this article is to provide a comparative outlook on different biomaterials applicable in regeneration of furcations with a focus on enamel matrix derivative (EMD).

Methods

Scientific databases including PubMed/MEDLINE, ScienceDirect, …

Management Of Cervical Root Fracture Injury In A Patient With Epilepsy: Case Report With 5-Year Follow-Up, Elif Ataol, Gizem Erbaş Ünverdi, H. Cem Güngör

School of Dentistry Faculty Research and Publications

The difficulty in providing stability to the coronal segment makes cervical root fracture one of the most challenging dental traumatic injury. This type of injury is less frequent in children. However, due to their serious consequences and poor prognosis, tooth loss may occur. This report presents the management of a case of cervical root fracture in an 11-year-old patient with epilepsy. The stabilization of the root-fractured tooth with a splint failed due to the recurrent seizures the patient had. Coronal fragment was removed and vital root submergence was performed in order to support the alveolar growth. The natural tooth crown …

In Reply, Yeshwant B. Rawal, Joshua S. Brandner, Louis J. Kim, Jasjit K. Dillon

School of Dentistry Faculty Research and Publications

No abstract provided.

In Vitro Effect Of Graphene Structures As An Osteoinductive Factor In Bone Tissue Engineering: A Systematic Review, Dorsa Mohammadrezaei, Hossein Golzar, Maryam Rezai Rad, Meisam Omidi, Hamid Rashedi, Fatemeh Yazdian, Arash Khojasteh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Graphene and its derivatives have been well‐known as influential factors in differentiating stem/progenitor cells toward the osteoblastic lineage. However, there have been many controversies in the literature regarding the parameters effect on bone regeneration, including graphene concentration, size, type, dimension, hydrophilicity, functionalization, and composition. This study attempts to produce a comprehensive review regarding the given parameters and their effects on stimulating cell behaviors such as proliferation, viability, attachment and osteogenic differentiation. In this study, a systematic search of MEDLINE database was conducted for in vitro studies on the use of graphene and its derivatives for bone tissue engineering from January …

Dextran Hydrogels Incorporated With Bioactive Glass-Ceramic: Nanocomposite Scaffolds For Bone Tissue Engineering, Parisa Nikpour, Hamed Salimi-Kenari, Farahnaz Fahimipour, Sayed Mahmood Rabiee, Mohammad Imani, Erfan Dashtimoghadam, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A series of nanocomposite scaffolds comprised of dextran (Dex) and sol–gel derived bioactive glass ceramic nanoparticles (nBGC: 0–16 (wt%)) were fabricated as bioactive scaffolds for bone tissue engineering. Scanning electron microscopy showed Dex/nBGC scaffolds were consisting of a porous 3D microstructure with an average pore size of 240 μm. Energy-dispersive x-ray spectroscopy illustrated nBGC nanoparticles were homogenously distributed within the Dex matrix at low nBGC content (2 wt%), while agglomeration was observed at higher nBGC contents. It was found that the osmotic pressure and nBGC agglomeration at higher nBGC contents leads to increased water uptake, then reduction of the compressive …

Clinical Long-Term Success Of Contemporary Nano-Filled Resin Composites In Class I And Ii Restorations Cured By Led Or Halogen Light, Torsten Pflaum, Stefan Kranz, Regina Montag, Arndt Guentsch, Andrea Völpel, Robin Mills, Klaus Jandt, Bernd Sigusch

School of Dentistry Faculty Research and Publications

Objectives

The use of LED light-curing units (LED LCUs) for polymerising resin-based composite restorations has become widespread throughout dentistry. Unfortunately, there is a paucity of clinical longitudinal studies that evaluate the comparative efficacy of LED-based polymerisation in direct posterior composite restorations. The aim of the present study was to investigate the performance of class I and II resin composite restorations for two successful composite restorative materials cured with LED versus halogen LCUs.

Methods

One hundred restorations were placed using the nano-filled composites Grandio® or Filtek™ Supremé. The following test groups were established: LED-Grandio® n = 23 (LG), LED-Filtek™ Supremé n …

A Hemispherical Contact Model For Simplifying 3d Occlusal Surfaces, Miguel Castro-Garcia, Pedro Ángel Moreno-Cabello, Miguel Ángel Rubio-Paramio, Pilar Carranza-Cañadas, Geoffrey A. Thompson

School of Dentistry Faculty Research and Publications

Statement of problem

Currently, dental articulators can recreate mandibular movements and occlusal contacts. However, whether virtual articulators can also provide information about occluding dental surfaces, functional movements, and the mandibular condyles is unclear.

Purpose

The purpose of this in vitro study was to evaluate the occluding surfaces on dental casts obtained from a patient and approximate them to a hemispherical contact model. Both models were tested by digitizing the Dentatus ARL dental articulator.

Material and methods

A combination of photogrammetry and structure from motion methods were used to scan a Dentatus ARL articulator and representative dental casts. Using computer-aided engineering …

Quality Of Postoperative Pain Management After Maxillofacial Fracture Repair, Andre Peisker, Winfried Meissner, Gregor F. Raschke, Mina D. Fahmy, Arndt Guentsch, Juliane Schiller, Stefan Schultze-Mosgau

School of Dentistry Faculty Research and Publications

Background: Effective pain management is an essential component in the perioperative care of surgical patients. However, post-operative pain after maxillofacial fracture repair and its optimal therapy has not been described in detail.

Materials and Methods: In a prospective cohort study, 95 adults rated their pain on the first postoperative day after maxillofacial fracture repair using the questionnaire of the Quality Improvement in Postoperative Pain Management (QUIPS) project. Quality Improvement in Postoperative Pain Management allowed for a standardized assessment of patients’ characteristics and pain- related parameters.

Results: Overall, the mean maximal pain and pain on activity (numeric rating scales) were significantly …

Oral Sciences Phd Program Enrollment, Graduates, And Placement: 1994 To 2016, C. R. Herzog, David W. Berzins, P. Denbesten, R. L. Gregory, K. M. Hargreaves, R. L.W. Messer, M. Mina, M. P. Mooney, M. L. Paine, C. Phillips, R. B. Presland, R. G. Quivey, F. A. Scannapieco, J F. Sheridan, K. K.H. Svoboda, P. C. Trackman, M. P. Walker, S. G. Walker, C. Y. Wang, J. C.C. Hu

School of Dentistry Faculty Research and Publications

For decades, dental schools in the United States have endured a significant faculty shortage. Studies have determined that the top 2 sources of dental faculty are advanced education programs and private practice. Those who have completed both DDS and PhD training are considered prime candidates for dental faculty positions. However, there is no national database to track those trainees and no evidence to indicate that they entered academia upon graduation. The objective of this study was to assess outcomes of dental school–affiliated oral sciences PhD program enrollment, graduates, and placement between 1994 and 2016. Using the American Dental Association annual …

Analysis Of Flexural Strength And Contact Pressure After Simulated Chairside Adjustment Of Pressed Lithium Disilicate Glass-Ceramic, Ali Ramadhan, Geoffrey A. Thompson, Georgios Maroulakos, David W. Berzins

School of Dentistry Faculty Research and Publications

Statement of problem

Research evaluating load-to-failure of pressed lithium disilicate glass-ceramic (LDGC) with a clinically validated test after adjustment and repair procedures is scarce.

Purpose

The purpose of this in vitro study was to investigate the effect of the simulated chairside adjustment of the intaglio surface of monolithic pressed LDGC and procedures intended to repair damage.

Material and methods

A total of 423 IPS e.max Press (Ivoclar Vivadent AG) disks (15 mm diameter, 1 mm height) were used in the study. The material was tested by using an equibiaxial loading arrangement (n≥30/group) and a contact pressure test (n≥20/group). Specimens were …

Nanomagnetic-Mediated Drug Delivery For The Treatment Of Dental Disease, Yadong Ji, Seung K. Choi, Ahmed S. Sultan, Kong Chuncai, Xiaoying Lin, Erfan Dashtimoghadam, Mary Anne Melo, Michael Weir, Huakun Xu, Lobat Tayebi, Ahihong Nie, Didier A. Depireux, Radi Masri

School of Dentistry Faculty Research and Publications

Maintaining the vitality of the dental pulp, the highly innervated and highly vascular, innermost layer of the tooth, is a critical goal of any dental procedure. Upon injury, targeting the pulp with specific therapies is challenging because it is encased in hard tissues. This project describes a method that can effectively deliver therapeutic agents to the pulp. This method relies on the use of nanoparticles that can be actively steered using magnetic forces to the pulp, traveling through naturally occurring channels in the dentin (the middle layer of the tooth). This method can reduce the inflammation of injured pulp and …

Trends And Racial/Ethnic Disparities In Antibiotic Prescribing Practices Of Dentists In The United States, Christopher Okunseri, C. Zheng, C. N. Steinmetz, Elaye Okunseri, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objective

The aim of this study was to examine trends and racial/ethnic disparities in antibiotic prescribing practices of dentists in the United States.

Methods

The US Medical Expenditure Panel Survey data for 1996‐2013 was analyzed. Information on patient sociodemographic characteristics, dental visits, receipt of dental procedures, and type of antibiotics prescribed following visits was obtained. Descriptive statistics were calculated separately for each year. Logistic regression analyses were conducted to identify associations during the period with and without adjustment for dental procedures and sociodemographic characteristics. Survey weights were incorporated to handle the sampling design.

Results

Nationally, the number of antibiotic prescribed …

Immunohistochemical Expression Of Tlr-4 In Temporomandibular Joint Dysfunction, Luis Eduardo Almeida, Kyle Hresko, Adam Sorenson, Seth Butcher, Lobat Tayebi, Rosalia Leonardi, Carla Loreto, Jose A. Bosio, Flavio Camejo, Andrea Doetzer

School of Dentistry Faculty Research and Publications

Objective

Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD). The purpose of this study was to histologically examine the level of expression of TLR-4 relative to severity of TMD.

Methods

Thirty-one human TMJ disc samples were immunostained for TLR-4 and evaluated for intensity of stain. Among the samples, 8 were control samples, 16 were from patients with anterior disc displacement with reduction (ADDwR), and 7 were from patients with anterior disc displacement without reduction (ADDwoR).

Results

There was no statistically significant difference …

Role Of Dentists In Prescribing Opioid Analgesics And Antibiotics: An Overview, Ralph Dana, Amir Azarpazhooh, Nima Laghapour, Katie J. Suda, Christopher Okunseri

School of Dentistry Faculty Research and Publications

No abstract provided.

Trends In Self‐Reported Oral Health Of Us Adults: National Health And Nutrition Examination Survey 1999‐2014, Kar Yan Li, Christopher Okunseri, Colman Mcgrath, May C.M. Wong

School of Dentistry Faculty Research and Publications

Objective

Single‐item self‐reported oral health (SROH) is a convenient and reliable measure for the assessment of population‐based oral health. However, little is known about trends and its associations among US adults. This study investigated trends in SROH (aged 20+ years) and the associated factors among adults living in the United States.

Methods

Self‐reported oral health data for 41 621 adults aged 20+ years from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2014 were analysed. Survey‐weighted descriptive statistics were computed to provide nationally representative estimates. Multivariable logistic regression was performed separately for each survey period with SROH as …

Intraosseous Hemangioma Of The Frontal Bone. Report Of A Case And Review Of The Literature, Joshua S. Brandner, Yeshwant B. Rawal, Louis J. Kim, Jasjit K. Dillon

School of Dentistry Faculty Research and Publications

Intraosseous hemangiomas of the maxillofacial region are rare lesions that constitute less than 1% of all osseous tumors. A review of the literature on intraosseous hemangiomas of the skull and facial bones showed a limited number of publications, much of which were largely limited to case reports. This case report summarizes the workup and surgical treatment of a 39-year-old woman with an intraosseous hemangioma of the left frontal bone. The histology, treatment, and literature are reviewed.

Oral Health Practices, Beliefs And Dental Service Utilization Of Albanian Immigrants In Milwaukee, Wisconsin: A Pilot Study, K. Rota, C. Spanbauer, Aniko Szabo, Christopher Okunseri

School of Dentistry Faculty Research and Publications

There is limited information on the oral health of Albanian immigrant population residing in the U.S. This creates a hinderance to developing and implementing appropriate dental care programs for the population. This study investigated oral health practices, beliefs, dental visits and associated factors of Albanian adults living in Milwaukee, Wisconsin. Purposive and snowball sampling methods were employed. Self-administered questionnaires were used to collect data on oral health practices, beliefs, dental visits and socio-demographic information. Descriptive and multivariable logistics regression were conducted. Overall, 266 adults were recruited, 54% male, 56% have lived 10 or more years in the U.S., 95% rated …

The Effect Of Partially Exposed Connective Tissue Graft On Root‐Coverage Outcomes: A Systematic Review And Meta‐Analysis, Austin Dodge, Jeffrey Garcia, Paul Luepke, Yu-Lin Lai, Moawia M. Kassab, Guo-Hao Lin

School of Dentistry Faculty Research and Publications

The aim of this systematic review was to compare the root‐coverage outcomes of using a partially exposed connective tissue graft (CTG) technique with a fully covered CTG technique for root coverage. An electronic search up to February 28^th, 2017, was performed to identify human clinical studies with data comparing outcomes of root coverage using CTG, with and without a partially exposed graft. Five clinical studies were selected for inclusion in this review. For each study, the gain of keratinized gingiva, reduction of recession depth, number of surgical sites achieving complete root coverage, percentage of root coverage, gain of …

Angioleiomyoma (Vascular Leiomyoma) Of The Oral Cavity, Swati Y. Rawal, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

A 70-year-old male presented with a slow growing, dome shaped and painless mass of the hard palate. The mass was excised. Histopathological examination confirmed the diagnosis of a angioleiomyoma (vascular leiomyoma). A leiomyoma is an uncommon benign tumor of smooth muscle differentiation. True leiomyomas of the oral cavity are rare and most oral tumors are derived from the smooth muscle of walls of blood vessels. Therefore, they are called vascular leiomyomas or angioleiomyomas. Clinically, they may resemble a myriad other conditions both benign and malignant. A definitive diagnosis depends upon histopathological examination of the biopsied tissue in correlation with the …

3d-Printed Membrane For Guided Tissue Regeneration, Lobat Tayebi, Morteza Rasoulianboroujeni, Keyvan Moharamzadeh, Thafar K.D. Almela, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

Three-dimensional (3D) printing is currently being intensely studied for a diverse set of applications, including the development of bioengineered tissues, as well as the production of functional biomedical materials and devices for dental and orthopedic applications. The aim of this study was to develop and characterize a 3D-printed hybrid construct that can be potentially suitable for guided tissue regeneration (GTR). For this purpose, the rheologyanalyses have been performed on different bioinks and a specific solution comprising 8% gelatin, 2% elastin and 0.5% sodium hyaluronate has been selected as the most suitable composition for printing a structured membrane for GTR …

The Post–Endodontic Adhesive Interface: Theoretical Perspectives And Potential Flaws, Georgios Maroulakos, Jianing He, William W. Nagy

School of Dentistry Faculty Research and Publications

Introduction

The aim of this review was to analyze the potential of successful bonds of endodontic posts to radicular dentin as well as the limitations of the post–endodontic adhesive interface.

Methods

The MEDLINE/PubMed and Web of Science electronic databases were searched. The search was augmented by a manual search of the pertinent bibliographies.

Results

The post–endodontic adhesive interface finds application in the endodontic cohesive units. Many techniques and materials exist to improve the bond between endodontic posts and resin-based materials as well as between resin-based materials and radicular dentin. Different techniques used for the adhesion of metallic and fiber-reinforced posts …

Immunological Compatibility Status Of Placenta-Derived Stem Cells Is Mediated By Scaffold 3d Structure, Sara Azizian, Fatemeh Katami, Khashayar Modaresifar, Nariman Mosaffa, Habibollah Peirovi, Lobat Tayebi, Soheyl Bahrami, Heinz Redl, Hassan Niknejad

School of Dentistry Faculty Research and Publications

Placenta-derived amniotic epithelial cells (AECs), a great cell source for tissue engineering and stem cell therapy, are immunologically inert in their native state; however, immunological changes in these cells after culture and differentiation have challenged their applications. The aim of this study was to investigate the effect of 2D and 3D scaffolds on human lymphocyte antigens (HLA) expression by AECs. The effect of different preparation parameters including pre-freezing time and temperature was evaluated on 3D chitosan–gelatine scaffolds properties. Evaluation of MHC class I, HLA-DR and HLA-G expression in AECs after 7 d culture on 2D bed and 3D scaffold of …

Collagenous Matrix Supported By A 3d-Printed Scaffold For Osteogenic Differentiation Of Dental Pulp Cells, Farahnaz Fahimipour, Erfan Dashtimoghadam, Morteza Rasoulianboroujeni, Mostafa Yazdimamaghani, Kimia Khoshroo, Mohammadreza Tahriri, Amir Yadegari, Jose Gonzalez, Daryoosh Vashaee, Douglas C. Lobner, Tahereh S. Jafarzadeh Kashi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objective

A systematic characterization of hybrid scaffolds, fabricated based on combinatorial additive manufacturing technique and freeze-drying method, is presented as a new platform for osteoblastic differentiation of dental pulp cells (DPCs).

Methods

The scaffolds were consisted of a collagenous matrix embedded in a 3D-printed beta-tricalcium phosphate (β-TCP) as the mineral phase. The developed construct design was intended to achieve mechanical robustness owing to 3D-printed β-TCP scaffold, and biologically active 3D cell culture matrix pertaining to the Collagen extracellular matrix. The β-TCP precursor formulations were investigated for their flow-ability at various temperatures, which optimized for fabrication of 3D printed scaffolds with …

Outreach: Change The World, Change Yourself, Geoffrey A. Thompson, Edward J. Plekavich, Izchak Barzilay

School of Dentistry Faculty Research and Publications

No abstract provided.

Giant Pilomatrix Carcinoma Of The Face, Sapna Lohiya, Yeshwant B. Rawal, Jasjit K. Dillon

School of Dentistry Faculty Research and Publications

This case report describes an unusually large facial pilomatrix carcinoma (PC) in a 60-year-old man. This PC had been growing slowly for 11 months and had recently ulcerated. It measured 9 cm × 7 cm × 5 cm. Initial punch biopsy findings were inconclusive. The tumor was excised in total with 5-mm margins in a supra-superficial musculoaponeurotic system plane. The defect was reconstructed with a cervicofacial bilobed rotational advancement flap. Histopathologic findings confirmed the diagnosis of PC. There was no lymph node spread or distant metastasis. The patient recovered with a good esthetic result. This case represents one of the …

Survival Rates Of Teeth With Primary Endodontic Treatment After Core/Post And Crown Placement, Kandace Yee, Bhagavatula Pradeep, Sheila E. Stover, Fredrick Eichmiller, Lance Hashimoto, Scott Macdonald, Gordon L. Barkley Iii

School of Dentistry Faculty Research and Publications

Introduction

The objective of this study was to determine the effect of delayed placement of the core/post and crown on the outcomes of nonsurgical root canal therapy (NSRCT).

Methods

According to the Delta Dental of Wisconsin claims database, 160,040 NSRCTs were completed with a core/post and a crown placed before the end of the continuous coverage period or occurrence of an untoward event. Untoward events were defined as a retreatment, apicoectomy, or extraction as defined by the Code on Dental Procedures and Nomenclature. Statistical analysis was performed by using a multivariable Cox proportional hazards model.

Results

The survival rate from …

Orthognathic Surgical Outcomes In Patients With And Without Craniofacial Anomalies, Zohra Metalwala, Christopher Okunseri, Steven Fletcher, Veerasathpurush Allareddy

School of Dentistry Faculty Research and Publications

Purpose

The objective of this study is to examine hospitalization outcomes after orthognathic surgery. This study tests the hypothesis that patients with craniofacial anomalies have higher billed hospital charges, longer lengths of stay, and increased odds of development of infectious complications when compared with patients without craniofacial anomalies.

Materials and Methods

The Nationwide Inpatient Sample for the years 2012 and 2013 was used. All patients who underwent an orthognathic surgical procedure were selected. The primary independent variable of interest was presence of a congenital cleft and/or craniofacial anomaly. The outcome variables were the occurrence of complications, billed hospital charges, and …

A Method Of Locating The Abutment Screw Access Channel With Cone-Beam Computed Tomography And A 3d-Printed Drilling Guide, Waleed Nasir Asiri, Agnieszka Domagala, Seok-Hwan Cho, Geoffrey A. Thompson

School of Dentistry Faculty Research and Publications

In managing loose abutment screws, locating precisely the position of the screw access channel is difficult. This technique describes the use of cone-beam computed tomography (CBCT) and surgical guide planning software to locate the screw access channel with the intention of retrieving a loosened cement-retained implant-supported prosthesis. The method minimizes damage to the abutment crown assembly.