Medicine and Health Sciences Commons^™

Rare Presentation Of A Rare Disease: Signet-Ring Cell Gastric Adenocarcinoma In Rothmund-Thomson Syndrome., Zeeshan Ali Md, Pritika S Manaktala, Saro Sarkisian Md, Muhammad A. Rizvi Md

Hematology-Medical Oncology Division

Rothmund-Thomson syndrome (RTS) is an exceedingly infrequent genetic disorder characterized by a multitude of skin findings collectively known as poikiloderma. In normal cells, the RECQL4 gene is involved in DNA replication and repair. RTS is caused by a mutation in the RECQL4 gene, which results in increased predilection to develop various malignancies. Osteosarcomas and skin cancers are typically associated with this syndrome. We present a rare case of signet-ring cell gastric adenocarcinoma in a patient with RTS.

Fibroblast Growth Factor Receptor 3 Amplified Metastatic Melanoma Treated With Erdafitinib., Saro Sarkisian, Alyson Mcintosh Md, Suresh G. Nair Md, Alexander N Shoushtari, Margaret Callahan

Hematology-Medical Oncology Division

The treatment of metastatic melanoma has changed dramatically in the last decade with the introduction of immunotherapy and targeted therapy. A futile disease in the past is now treated with various options, resulting in improvement in progression-free and overall survivals, along with improvement in the quality of life. Having said that, the majority of patients with metastatic melanoma eventually succumb to the disease. Molecular profiling of each tumor in the advanced stage is standard of care now, as this would lead to individualized treatment options for each patient. Here, we present a rare case of fibroblast growth factor receptor 3 …

Thrombotic Thrombocytopenic Purpura Induced By Immune Checkpoint Inhibitiors: A Case Report And Review Of The Literature., Zeeshan Ali Md, Muhammad Usman Zafar, Zachary Wolfe, Faisal Akbar, Bradley Lash

Hematology-Medical Oncology Division

In recent years, the role of immune checkpoint inhibitors (ICI) in cancer treatment has rapidly expanded. In randomized clinical trials, these agents have demonstrated clinical efficacy in extending survival and increasing response rates. Immune-related adverse effects (irAEs) involving various organs have been frequently narrated. Herein, we present a case report of thrombotic thrombocytopenic purpura (TTP) as a rare side effect of nivolumab, plus ipilimumab, in the treatment of metastatic renal cell carcinoma (RCC). A review of the literature for other case reports of TTP during treatment with ICIs was also performed. Our aim is to elucidate the significance of early …

Bad Blood: A Case Of Warm Autoimmune Hemolytic Anemia, Amogh M. Joshi Do, Kevin J. Hess Do, Zeeshan Ali Md, Nicholas Lamparella Do

Department of Medicine

No abstract provided.

A Retrospective Review Of Outcomes Associated With Treatment Modalities Utilized In The Management Of Diffuse Large B Cell Non-Hodgkin's Lymphoma, Benjamin Fry, Donna Colabroy Rn, Msn, Ocn, Ccm, Melissa Kratz Rn, Msn, Aocn, Dennis Sopka Md, Savitri Skandan Md

Research Scholars Poster Presentation

No abstract provided.

Identifying Baseline Characteristics For Consideration Of Prophylactic Feeding Tube Placement In Persons Undergoing Chemoradiotherapy For Head And Neck Cancer: A Retrospective Chart Review, Kenna Kita, Janine Gilboy Rd, Cso, Ldn, Erin Levine Rd, Cso, Ldn, Brian J. Patson Md, Jennifer Brennan Ms, Rd, Cso

Research Scholars Poster Presentation

No abstract provided.

Palbociclib-Induced Pneumonitis: A Case Report And Review Of The Literature., Saro Sarkisian Md, Christopher Markosian, Zeeshan Ali Md, Muhammad A. Rizvi Md

Department of Medicine

The treatment of metastatic breast cancer has undergone significant changes in recent years. New classes of medications have been approved by the Food and Drug Administration (FDA) for use in clinical practice to extend progression-free survival and overall survival along with increasing response rate. Here, we present a case report of pneumonitis as a rare side effect of palbociclib in the treatment of metastatic hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (ERBB2-) breast cancer in addition to endocrine therapy. We also review the literature for other reports of pneumonitis during treatment with palbociclib. Through this case report and review …

Pembrolizumab: An Immunotherapeutic Agent Causing Endocrinopathies., Abdul Chaudry, Misbat Chaudry Md, Jonaid Aslam Md

Department of Medicine

Pembrolizumab is an immune checkpoint inhibitor (programmed cell death 1) approved for use in non-small cell lung carcinoma (NSCLC). Pembrolizumab has shown remarkable results in regression of the size of tumors in NSCLC and has shown survival advantage. However, immune-related adverse effects are a serious negative outcome of therapy. The number of immune-related adverse effects with pembrolizumab has increased significantly over the recent past. We present a case of type 1 diabetes mellitus and autoimmune thyroiditis with pembrolizumab treatment for NSCLC.

Global Longitudinal Strain And Cardiac Events In Patients With Immune Checkpoint Inhibitor-Related Myocarditis., Magid Awadalla, Syed S Mahmood, John D Groarke, Malek Z O Hassan, Anju Nohria, Adam Rokicki, Sean P Murphy, Nathaniel D Mercaldo, Lili Zhang, Daniel A Zlotoff, Kerry L Reynolds, Raza M Alvi, Dahlia Banerji, Shiying Liu, Lucie M Heinzerling, Maeve Jones-O'Connor, Rula B Bakar, Justine V Cohen, Michael C Kirchberger, Ryan J Sullivan, Dipti Gupta, Connor P Mulligan, Sachin P Shah, Sarju Ganatra, Muhammad A. Rizvi Md, Gagan Sahni, Carlo G Tocchetti, Donald P Lawrence, Michael Mahmoudi, Richard B Devereux, Brian J Forrestal, Anant Mandawat, Alexander R Lyon, Carol L Chen, Ana Barac, Judy Hung, Paaladinesh Thavendiranathan, Michael H Picard, Franck Thuny, Stephane Ederhy, Michael G Fradley, Tomas G Neilan

Department of Medicine

BACKGROUND: There is a need for improved methods for detection and risk stratification of myocarditis associated with immune checkpoint inhibitors (ICIs). Global longitudinal strain (GLS) is a sensitive marker of cardiac toxicity among patients receiving standard chemotherapy. There are no data on the use of GLS in ICI myocarditis.

OBJECTIVES: This study sought to evaluate the role of GLS and assess its association with cardiac events among patients with ICI myocarditis.

METHODS: This study retrospectively compared echocardiographic GLS by speckle tracking at presentation with ICI myocarditis (cases, n = 101) to that from patients receiving an ICI who did not …

Implementation Of A Clinical Pathway For Pancreaticoduodenectomy Patients, Zach Whitham, Aaron U. Blackham Md

USF-LVHN SELECT

No abstract provided.