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Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Hearing Studies In Old Mice: The Effect Of Pre-Pulse Inhibition On The Acoustic Startle Response, Ashley B. Hillyard, Nicolette S. Chuss
Senior Honors Projects, 2010-2019
The purpose of this study pertains to hearing in the species Peromyscus maniculatus (deer mice) — specifically their responses to a startling sound. Approximately seven mice were tested between four and five years of age, approaching the lifespan of this species. By means of an accelerometer, which measures a reflexive, motor response, the mice were presented with an acoustic startle-eliciting stimulus (SES) — that is a loud, startling, unexpected sound. During the study, the mice were also presented with a softer, less-intense stimulus — known as a pre-pulse — slightly before the more intense sound. This pre-pulse stimulus was in …