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Full-Text Articles in Medicine and Health Sciences
Effect Of Age On Abrs In Mice With Epha4 Mutations, Melissa M. Teller
Effect Of Age On Abrs In Mice With Epha4 Mutations, Melissa M. Teller
Dissertations, 2014-2019
It is known that EphA4 can influence the establishment of tonotopic pathways in the auditory system. This can be measured by an increase in thresholds on the auditory brainstem response test (ABR) in mice. It is also known that the aging population in humans tends to have poorer thresholds in the high frequency sounds as they age, termed presbycusis or age-related hearing loss. The C57BL/6J background strain of mice that is known to experience a presbycusis-like process, although it is not specified when this process begins and how it progresses through their life span. The goal of this study was …
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Pre-Pulse Inhibition Assessment Of Sound Localization In Mice: Methodological, Functional, And Genetic Considerations, Megan Klingenberg
Dissertations, 2014-2019
Sound localization is an important aspect of normal hearing. The Eph/ephin family of signaling proteins, studied here, is known to guide the formation of central auditory connections in early development, particularly topographic inputs from the lateral superior olive (LSO) to the inferior colliculus (IC). Processing in the LSO and its influences on the IC are known to be heavily involved in sound localization tasks. One way to study sound localization in mice is through pre-pulse inhibition (PPI). PPI is the phenomenon by which a weak prestimulus inhibits the response to a subsequent startle stimulus. In studying sound localization, the prestimulus …
Effects Of Eph/Ephrin Mutations On Pre Pulse Inhibition In Mice, Andrea Marie Liuzzo
Effects Of Eph/Ephrin Mutations On Pre Pulse Inhibition In Mice, Andrea Marie Liuzzo
Dissertations, 2014-2019
The acoustic startle response (ASR) is a reliable reflexive behavioral response in mammals elicited by an unexpected intense acoustic startle eliciting stimulus (SES). It is mediated by a sub-cortical pathway that includes the inferior colliculus (IC). The ASR amplitude can be measured with an accelerometer beneath the subject attached to the cage, and can be decreased in amplitude by presenting a less intense, non-startling stimulus 20-300 ms before the SES. This reflexive decrement in ASR is called pre pulse inhibition (PPI) and indicates that the relatively soft pre pulse was heard. Murine species have been used to study this response …