Open Access. Powered by Scholars. Published by Universities.®
Himmelfarb Health Sciences Library, The George Washington University
Anesthesiology and Critical Care Medicine Faculty Publications
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Neurodevelopmental Consequences Of Sub-Clinical Carbon Monoxide Exposure In Newborn Mice, Ying Cheng, Adia Thomas, Feras Mardini, Shannon L. Bianchi, Junxia X. Tang, Jun Peng, Huafeng Wei, Maryellen F. Eckenhoff, Roderic G. Eckenhoff, Richard J. Levy
Neurodevelopmental Consequences Of Sub-Clinical Carbon Monoxide Exposure In Newborn Mice, Ying Cheng, Adia Thomas, Feras Mardini, Shannon L. Bianchi, Junxia X. Tang, Jun Peng, Huafeng Wei, Maryellen F. Eckenhoff, Roderic G. Eckenhoff, Richard J. Levy
Anesthesiology and Critical Care Medicine Faculty Publications
Carbon monoxide (CO) exposure at high concentrations results in overt neurotoxicity. Exposure to low CO concentrations occurs commonly yet is usually sub-clinical. Infants are uniquely vulnerable to a variety of toxins, however, the effects of postnatal sub-clinical CO exposure on the developing brain are unknown. Apoptosis occurs normally within the brain during development and is critical for synaptogenesis. Here we demonstrate that brief, postnatal sub-clinical CO exposure inhibits developmental neuroapoptosis resulting in impaired learning, memory, and social behavior. Three hour exposure to 5 ppm or 100 ppm CO impaired cytochrome c release, caspase-3 activation, and apoptosis in neocortex and hippocampus …