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Full-Text Articles in Medicine and Health Sciences
Co-Existent Klinefelter's Syndrome, Acquired Cutaneous Hepatic Porphyria And Systemic Lupus Erythematosus, M. Saeed-Uz-Zafar, W. R. Gronewald, G. B. Bluhm
Co-Existent Klinefelter's Syndrome, Acquired Cutaneous Hepatic Porphyria And Systemic Lupus Erythematosus, M. Saeed-Uz-Zafar, W. R. Gronewald, G. B. Bluhm
Henry Ford Hospital Medical Journal
A patient is reported with Klinefelter's syndrome, systemic lupus erythematosus (SLE) and acquired cutaneous hepatic porphyria. Although patients with chromatin positive Klinefelter's syndrome may have elevated auto-antibodies, this patient had definite diagnostic criteria for SLE. Furthermore, evidence of disturbed porphyrin metabolism compatible with acquired cutaneous hepatic porphyria was found. It is speculated that the major disturbance in our patient's porphyrin biosynthesis may be distal to ^-ALA synthetase. Any association between the three diseases is conjectural: however, it is noteworthy that both SLE and porphyria are more common in the female and that our patient had two X chromosomes in addition …
Mycosis Fungoides With Thrombotic Microangiopathy And Major Central Nervous System Manifestations, T. A. Chapel, S. M. Saeed, B. W. Steinhauer
Mycosis Fungoides With Thrombotic Microangiopathy And Major Central Nervous System Manifestations, T. A. Chapel, S. M. Saeed, B. W. Steinhauer
Henry Ford Hospital Medical Journal
A case of mycosis fungoides is presented which terminated in death by an acute central nervous system illness. Autopsy revealed thrombotic microangiopathy. This is felt to be the first report of thrombotic thrombocytopenic purpura occurring in a patient with mycosis fungoides. Since thrombotic thrombocytopenic purpura has been reported in association with other malignancies, the association of these relatively rare disorders may represent more than a coincidence.
The Prevention Of Recurrent Peritoneal Adhesions: A Clinical And Laboratory Investigation, T. A. Cromwell, Joseph L. Ponka
The Prevention Of Recurrent Peritoneal Adhesions: A Clinical And Laboratory Investigation, T. A. Cromwell, Joseph L. Ponka
Henry Ford Hospital Medical Journal
This study documented the fact that recurrent episodes of small bowel obstruction were not uncommon (38%) in a review of 120 patients who underwent lysis of adhesions or lysis of adhesions and Noble Plication. A laboratory experiment using dogs was constructed to compare dextran to a combined promethazine-dexamethasone regimen for the prevention of adhesion formation in the immediate post-operative period. Dextran was completely ineffective in preventing adhesion reformation. Meticulous surgical technique remains the single most important factor in adhesion prevention.
Renal Cell Carcinoma Masquerading As A Pancreatic Pseudocyst: A Case Report, Stuart J. Kingma, Hubert M. Allen
Renal Cell Carcinoma Masquerading As A Pancreatic Pseudocyst: A Case Report, Stuart J. Kingma, Hubert M. Allen
Henry Ford Hospital Medical Journal
A case is reported in which an abdominal mass was treated initially as a traumatic pseudocyst of the pancreas. Subsequent studies elucidated the true nature of the lesion, a renal cell carcinoma. The use of visceral arteriography as a definitive diagnostic tool is illustrated by this case.
Dose-Response Relationship Of Bile Flow To Cholecystokinin Stimulation As Measured By Duodenal Drainage, Robert J. Priest, Roberto F. Gluckmann, J. Edward Berk, Joseph A. Rinaldo
Dose-Response Relationship Of Bile Flow To Cholecystokinin Stimulation As Measured By Duodenal Drainage, Robert J. Priest, Roberto F. Gluckmann, J. Edward Berk, Joseph A. Rinaldo
Henry Ford Hospital Medical Journal
A study was done to evaluate the dose-response of cholecystokinin administered intravenously to normal patients and to patients with diseased gallbladders. The volumes of bile and bilirubin units were measured in duodenal aspirates. A dosage of cholecystokinin between 12.5 and 25 Ivy dog units differentiated the several categories studied. Lower doses of cholecystokinin resulted in no change in the volume of bile, but significantly reduced the output of bilirubin units.
X-Ray Diffraction Powder Data For Amino Acid Derivatives, Jonathan Parsons, Joseph A. Scilla, William T. Beher
X-Ray Diffraction Powder Data For Amino Acid Derivatives, Jonathan Parsons, Joseph A. Scilla, William T. Beher
Henry Ford Hospital Medical Journal
This paper follows a group of ten publications in this Journal reporting x-ray diffraction powder data for steroids. The data here reported is for a group of amino acid derivatives.
Immunologic Competence In Idiopathic Ulcerative Colitis (Humoral Aspects Of Immunity), Gerald A. Logrippo, Klaus Anselm, Hajime Hayashi, Robert J. Priest
Immunologic Competence In Idiopathic Ulcerative Colitis (Humoral Aspects Of Immunity), Gerald A. Logrippo, Klaus Anselm, Hajime Hayashi, Robert J. Priest
Henry Ford Hospital Medical Journal
Systemic immune status was studied in 86 idiopathic ulcerative colitis patients. Quantitation of the major serum immunoglobulins (IgG, IgA and IgM) and qualitation for specific enteropathogens (bacterial and viral) associated with the immunoglobulins are correlated with the severity and duration of the disease. The studies demonstrate the immunologic competence of these patients to respond to a variety of infections with normal activity and hyperactivity. In addition, systemic complications associated with ulcerative colitis, particularly liver involvement, are reflected in the immunologic studies.
The Effect Of Phenobarbital On Serum Bilirubin Of Full Term Infants: A Controlled Study, Mary J. Kokosky, Harold A. Falconer, Lester Weiss
The Effect Of Phenobarbital On Serum Bilirubin Of Full Term Infants: A Controlled Study, Mary J. Kokosky, Harold A. Falconer, Lester Weiss
Henry Ford Hospital Medical Journal
Three bundled twenty-eight infants weighing more than 2500 grams were studied for the effect of low dose phenobarbital (15 mg/day) upon third and fifth day serum bilirubin levels. The groups were divided according to sex, race and type of treatment. Controls were made for the possible effect of the 14% ethanol contained in phenobarbital elixir. It was found that males had higher mean serum bilirubin levels than females, Caucasians had higher mean serum bilirubin levels than Negroes, and control infants had higher serum bilirubin values than those infants treated with phenobarbital. However, in those patients who had lower serum bilirubin …
Immunoglobulin Levels In Spinal Fluid And Saliva By Direct Immunochemical Assay And Microscopic Measurements, Hajime Hayashi, Gerald A. Logrippo, Mary Perry
Immunoglobulin Levels In Spinal Fluid And Saliva By Direct Immunochemical Assay And Microscopic Measurements, Hajime Hayashi, Gerald A. Logrippo, Mary Perry
Henry Ford Hospital Medical Journal
The immunochemical procedure used in this hospital for serum immunoglobulins (Igs) has been modified to increase sensitivity (5-to-20-fold) so that minute quantities of immunoglobulins can now be measured directly in unconcentrated body fluids. Normal spinal fluid Ig levels (±2 S.D. from normal means) were found to be: 0.01-0.21 mg/100 ml for IgA; 0.5-2.50 mg/100 for IgG: and no detectable quantities for IgM. Normal (pooled) salivary Ig levels were found to be 0.01-2.25 mg/100 ml for IgA: trace quandties to 1.85 mg/100 ml for IgG: and no detectable quantities for IgM. Spinal fluid and salivary Igs were assayed in 227 adults …
Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research
Henry Ford Hospital Medical Journal
No abstract provided.
Quantitative Determination Of C-Reactive Protein (Crp) By Micro-Double Diffusion Technic, Hajime Hayashi, Gerald A. Logrippo, Mary Perry
Quantitative Determination Of C-Reactive Protein (Crp) By Micro-Double Diffusion Technic, Hajime Hayashi, Gerald A. Logrippo, Mary Perry
Henry Ford Hospital Medical Journal
C-reactive protein (CRP) determinations in serum have been evaluated by two methods: the capillary tube method (presently in use) and the double diffusion technic (a newly developed procedure standardized in this laboratory). Advantages of the double diffusion technic are (1) quantitation of CRP in milligrams per 100 ml of serum, (2) differentiation of CRP from non-specific precipitates often found in patients' sera, and (3) increased sensitivity. A normal range of CRP levels has been established by analyzing serum from 750 supposedly healthy blood bank donors. Ninety-five percent of the donor population possess less than 1.0 mg of CRP per 100 …
Health Nurse Clinician: An Extended Role For The Professional Nurse, C. E. Rupe, Diana Downs, Diane L. Kerr, William W. Hardy
Health Nurse Clinician: An Extended Role For The Professional Nurse, C. E. Rupe, Diana Downs, Diane L. Kerr, William W. Hardy
Henry Ford Hospital Medical Journal
A program to upgrade the level of nursing involvement in patient care has been established in conjunction with Wayne Slate University. Offered as a possible solution to the shortage of health care personnel, the master's degree program would result in an upward movement of medical personnel and provide more continuity of care to the patient. More specifically, the trained Health Nurse Clinician would be able to provide better nursing care because of the nurse's greater awareness of the patient's health problem. She (or he) could also free the physician from some of the time-consuming aspects of routine physical examination without …
Percutaneous Absorption Of Betamethasone-17-Benzoate, George R. Mikhail
Percutaneous Absorption Of Betamethasone-17-Benzoate, George R. Mikhail
Henry Ford Hospital Medical Journal
Percutaneous absorption of betamethasone-17-benzoate, a new topical corticosteroid, was sufficient enough to result in adrenocortical suppression in patients with psoriasis or atopic dermatitis when 0.025% of the steroid cream was applied under occlusion to 30% or more of the body surface, using 9 gm or more of the preparation. The adrenal function returned to normal within a short time after the cream was discontinued.
Effect Of Normal Menstrual Cycle On Platelet Adhesiveness, Janet Mak Yeung
Effect Of Normal Menstrual Cycle On Platelet Adhesiveness, Janet Mak Yeung
Henry Ford Hospital Medical Journal
Platelet adhesiveness was measured at intervals during the menstrual cycle in six normal females. Three normal males were studied during the .tame period of time to serve as controls. There was a significant difference of the variation of platelet adhesiveness between the two groups during the period of 30 days. Five out of six females showed much greater fluctuation than the males. No definite trend was observed in the platelet adhesiveness of females in relation to the menstrual cycle in this preliminary study. A larger number of samples from the population will be necessary to obtain a more accurate result.
Mixed Gonadal Stroma Cell Tumor Of The Testicle: A Case Report, Gerald B. Farrow, Arthur J. Johnson
Mixed Gonadal Stroma Cell Tumor Of The Testicle: A Case Report, Gerald B. Farrow, Arthur J. Johnson
Henry Ford Hospital Medical Journal
A specialized gonadal stromal tumor of mixed nature found in a 20-year-old Negro male is reported. Although the tumor had been present for six to seven years, there was no evidence of metastases or of hormonal imbalance. Reference is made to the confusing nomenclature of these rare tumors.
Hypophyseal Growth Hormone Ii. Interaction With Other Hormones, M. Saeed-Uz-Zafar, Raymond C. Mellinger, Lewis B. Morrow
Hypophyseal Growth Hormone Ii. Interaction With Other Hormones, M. Saeed-Uz-Zafar, Raymond C. Mellinger, Lewis B. Morrow
Henry Ford Hospital Medical Journal
Growth hormone (GH) synthesis and release is controlled by hypothalamic GH releasing factor. Thyroid hormones, androgens and estrogens in physiologic concentrations enhance GH secretion but a controlling role for glucagon and vasopressin in GH release is not established. Under stress, ACTH directly facilitates GH release while the similar action of the catecholamines is mediated by the a-adrenergic receptors. Though physiologic doses of glucorticoids and progestins do not affect GH liberation, prolonged administration of medroxyprogesterone acetate or of glucocorticoids in high dosage will decrease blood levels or blunt Gti responsiveness. GH enhances the release of insulin. A shift in adrenal steroid …
Assessing Attempted Suicide, Walter J. Cassidy
Assessing Attempted Suicide, Walter J. Cassidy
Henry Ford Hospital Medical Journal
Fifty successive patients attempting suicide are assessed from the standpoint of communication (how, when and to whom), manipulativeness, impulsiveness and the dangerousness of the pattern of behavior involved in the attempted suicide. This assessment is meant to clarify the component motivations of suicidal behavior, appeal and self-destruction. The earlier, more obvious the communication, the more definite is the manipulation, the more readily apparent the appeal function. Conversely the later, the less obvious the communication or the absence of communication, the more subtle or absent manipulation the greater is the dominance of self-destructive motivation over the appeal function of the attempted …
A Decade Of Heart Surgery And A Look Into The Future, Conrad R. Lam
A Decade Of Heart Surgery And A Look Into The Future, Conrad R. Lam
Henry Ford Hospital Medical Journal
No abstract provided.
Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research
Henry Ford Hospital Medical Journal
No abstract provided.
Spectacular Elevations Of Serum Alkaline Phosphatase: Clinical And Pathological Correlation Roy B., Roy B. Patton
Spectacular Elevations Of Serum Alkaline Phosphatase: Clinical And Pathological Correlation Roy B., Roy B. Patton
Henry Ford Hospital Medical Journal
The diseases responsible for extremely high serum alkaline phosphatase aclivily in 45 patients were proliferative bone disease (10 patients) and hepato-biliary tract disease (35 patients). Conditions found in these patients that are not usually thought to cause such high phosphatase levels were: drug-induced cholestasis (6 patients), non-malignant extra-hepatic bile duct obstruction (3 patients), biliary or portal cirrhosis (5 patients), and primary hyperparathyroidism with generalized osteitis fibrosa (1 patient).
Immunologic Status Of Uremic Patients, Gerald A. Logrippo, C. E. Rupe, Hajime Hayashi, Dean Lesher
Immunologic Status Of Uremic Patients, Gerald A. Logrippo, C. E. Rupe, Hajime Hayashi, Dean Lesher
Henry Ford Hospital Medical Journal
The immunologic status of 25 uremic patients was studied with a battery of tests evaluating the humoral and cytological aspects of immunity. The individual's humoral immune status was evaluated as follows: quantitation of the three major serum immunoglobulins (IgG, IgA and IgM) expressed in mg/100 ml of serum and compared to established normal clinical standards (±2 SD/mean); qualitation of IgG and IgM evaluated by specific virus antibody titers and antitoxin values associated with IgG and by isoagglutinin tilers of the ABO blood groups associated with IgM. Immunoglobulin status is grouped into hyper- and hypo-immunoglobulin variations from normal and correlated with …
The Hypocalcemic Effects Of Actinomycin D And Mithramycin, Eduardo L. Reyes, Robert W. Talley
The Hypocalcemic Effects Of Actinomycin D And Mithramycin, Eduardo L. Reyes, Robert W. Talley
Henry Ford Hospital Medical Journal
Both actinomycin D and mithramycin are useful agents in the treatment of cancer. They can also produce hypocalcemia, a comparatively rare phenomenon in cancer. Two such cases are presented in detail. Neither patient had the classic symptoms of hypocalcemia. Instead, the clinical picture was more compatible with hypercalcemia. The mechanism of action of each drug is explained; therapeutic implications are made with regards to their synergistic effects when used in combination with the standard calcium-lowering agents. Attention is drawn to the inhibitory action of these two agents on the calcium-mobilizing effect of the parathyroid hormone. The hypocalcemic effects of these …
Double Contrast Arthrography Of The Knee, Peter C. Larowe, Robert S. Ormond, Edwin Guise
Double Contrast Arthrography Of The Knee, Peter C. Larowe, Robert S. Ormond, Edwin Guise
Henry Ford Hospital Medical Journal
Arthrography is a safe and relatively simple diagnostic procedure which provides an accurate and graphic preoperative means of defining pathology of the knee. In those cases where the expeditious evaluation and diagnosis of knee injury are of prime importance, ie, the athlete and industrial compensation case, arthrography provides a significant contribution. The clinical pathological features, salient anatomy and technic of study of internal derangements of the knee are discussed. Selected double contrast arthrograms illustrate normal and abnormal findings. Arthrotomies were performed in 20 of the 32 patients in this study with a positive arthrogram-arthrotomy correlation of 85%.
Cephalexin: In Vitro And In Vivo Studies, Frank Cox Jr., Edward L. Quinn, Bienvenido G. Gatmaitan, Nancy Peterson
Cephalexin: In Vitro And In Vivo Studies, Frank Cox Jr., Edward L. Quinn, Bienvenido G. Gatmaitan, Nancy Peterson
Henry Ford Hospital Medical Journal
Cephalexin, a derivative of cephalosporin C, produces high serum and urine concentrations after oral administration. In addition, it shows good activity in vitro against most gram-positive and some gram-negative organisms. This study reports the in vitro susceptibility to cephalexin of a series of clinical isolates, the serum levels and urine concentrations in human volunteers and the results of its use in infections due to susceptible organisms. Results of in vitro susceptibility testing reveal that cephalexin was effective against most strains of the gram-positive organisms tested — group A streptococci, pneumococci, and staphylococci — although the MIC's are higher than those …