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Full-Text Articles in Medicine and Health Sciences

Macomb Care Experience Patient And Family Advisory Council - A Year Of Change, Maureen G. Bennett, Brooke Shankin, Kristi Theol, Austin Lasota Oct 2023

Macomb Care Experience Patient And Family Advisory Council - A Year Of Change, Maureen G. Bennett, Brooke Shankin, Kristi Theol, Austin Lasota

2023 Patient Advisor Retreat

Vision of the Committee: To create partnerships among health care practitioners, patients and families that will lead to the best outcomes and enhance the quality and safety of our health care. Objective/Purpose: Provide advice, consultation, evaluation and recommendations regarding programs, educational efforts, selected research activities and operational initiatives that affect patients and families. Provide feedback and suggestions to enhance the patient/family experience at Henry Ford Macomb Hospital. Promote respectful, effective partnerships between patients, families, healthcare providers and administration. Provide a vital link between Henry Ford Macomb Hospital and the community. Participate in educating hospital personnel about various issues from a …


Patient Involvement And Communication Council, Angela Murphy, Laura Gooseberry, Becca Austin, Rob Behrendt, Lara Miskevich Oct 2023

Patient Involvement And Communication Council, Angela Murphy, Laura Gooseberry, Becca Austin, Rob Behrendt, Lara Miskevich

2023 Patient Advisor Retreat

Patient-Centered Care (nothing about me without me) is the best approach to improve outcomes and provide value to each patient. The Council is involved in the following: Act as champions of patient experience andbring ideas, thoughts, and opinions on various topics and processes. Review patient and family communications to ensure engagement in health care services. Provide feedback regarding communication gaps between patients and providers. Revise and improve materials to be understood by patients and their caregivers.


Steps Pfac: Seniors Using Technology To Engage In Pain Self-Management, Lisa D. Landvogt, Leslie Grijalva, Tracie Mason, Jessica Judson, Courtney Latimer, Jaye Clement, Kimberlydawn Widsom, Tashfia Jilu, Sara Nguyen, Rebecca Lindsay, Mary Javenic Oct 2023

Steps Pfac: Seniors Using Technology To Engage In Pain Self-Management, Lisa D. Landvogt, Leslie Grijalva, Tracie Mason, Jessica Judson, Courtney Latimer, Jaye Clement, Kimberlydawn Widsom, Tashfia Jilu, Sara Nguyen, Rebecca Lindsay, Mary Javenic

2023 Patient Advisor Retreat

STEPS stands for Seniors using Technology to Engage in Pain Self-management. We are testing to see if a pain self-management program can help people live better with chronic pain and reduce pain’s impact on their lives. Participants will: Complete three 60-minute telephone surveys Baseline, 2-month follow-up, and 12-month follow-up. Be randomly placed into one of two groups (50/50 chance): Intervention Group: A 7-week program with web-based videos and weekly telephone sessions led by a Community Health Worker. Control Group: A control group that receives program materials & a half-day workshop after the final survey.


All Of Us Research Program Pfac, Janine Hussein, Tiffany S. Lee, Cathy Peltz, Christine C. Johnson, Brian Ahmedani Oct 2023

All Of Us Research Program Pfac, Janine Hussein, Tiffany S. Lee, Cathy Peltz, Christine C. Johnson, Brian Ahmedani

2023 Patient Advisor Retreat

The goal of the All of Us Research Program (AoURP) is to help improve the future of health by accelerating health research and medical breakthroughs. The AoURPis part of the National Institutes of Health (NIH) Precision Medicine Initiative and seeks to help researchers understand more about why people get sick or stay healthy. The All of Us Research Program has established nationwide partnerships to build a research cohort to advance precision medicine. One million or more people living in the U.S. are being asked to share various types of health data over 10 years or more to build the largest …


Shift Worker Patient & Family Advisor Council (Pfac), Grace Paniccia, Jonny Russell, Salma Habash, Philip Cheng Oct 2023

Shift Worker Patient & Family Advisor Council (Pfac), Grace Paniccia, Jonny Russell, Salma Habash, Philip Cheng

2023 Patient Advisor Retreat

The Shift Worker Patient and Family Advisory Council (SHIFT PFAC) is an active patient engagement program aimed at improving the lives of night shift workers through their involvement and influence in our studies. We are proud to work with night shift workers as they are a group often overlooked in healthcare initiatives. We aim to work with the SHIFT PFAC to improve not only the physical health, but also the job satisfaction and overall well-being of night shift workers. The purpose of the SHIFT PFAC meetings is to foster an open dialogue where study participants can share their valuable insights, …


Experienced Transformation Patient & Family Advisory Council, John Bollinger, Thomas Eisenmann, Missy Ewald, Julie Goldstein-Dunn, Ally Hunter, Jennifer Kindseth, Shivani Mehta, Vanessa Mona, Stephanie Ryan, Courtney Stevens, Rajitha Viswaraju Oct 2023

Experienced Transformation Patient & Family Advisory Council, John Bollinger, Thomas Eisenmann, Missy Ewald, Julie Goldstein-Dunn, Ally Hunter, Jennifer Kindseth, Shivani Mehta, Vanessa Mona, Stephanie Ryan, Courtney Stevens, Rajitha Viswaraju

2023 Patient Advisor Retreat

Providing Patient-Centered Care (Nothing about me without me) is the best approach to improving outcomes and providing value to each patient. This council works on initiatives and process improvement around pre-visit, onsite visit, and post-visit communication and delivery. Additional Henry Ford Health priorities are to leverage existing or new digital solutions that facilitate patient access, strengthen existing referral channels and growing new ones with potential future partners, assist patients with understanding and paying their health expenses, and better manage total per member per month cost through patient/member engagement in their wellness and care.


Hfwh Pfac Of Influence, Julie Johns, John Chandler Ii Oct 2023

Hfwh Pfac Of Influence, Julie Johns, John Chandler Ii

2023 Patient Advisor Retreat

Our team is engaged with leaders from multidisciplinary departments that are working on improvement projects, ranging from marketing and messaging materials, physical plant changes, hardwiring best practices in communication and patient engagement. Our goal is to assist department leaders by improving and enhancing communication between patients, families and staff and always keeping the patient voice present on behalf of our community.


Using Storytelling To Share Lived Experiences With Maternal Mental Health (Mama), Sara Santarossa, Amy Loree, Courtney Latimer, Wendy Corriveau, Sara Mertz, Hailey Maddox, Leah M. Copeland, Dana Murphy, Ashley B. Redding Oct 2023

Using Storytelling To Share Lived Experiences With Maternal Mental Health (Mama), Sara Santarossa, Amy Loree, Courtney Latimer, Wendy Corriveau, Sara Mertz, Hailey Maddox, Leah M. Copeland, Dana Murphy, Ashley B. Redding

2023 Patient Advisor Retreat

Mental health conditions are a top medical complication of pregnancy and childbirth and are associated with a range of adverse maternal and child outcomes. Approximately 1 in 7 to 1 in 4 birthing people experience symptoms of a mental health condition during pregnancy or postpartum, yet few are diagnosed or treated. There remain critical knowledge gaps and significant challenges to adequately addressing maternal mental health. Project aims to use storytelling to share diverse perspectives on MAternal MentAl health (MAMA), build capacity and engagement for patient centered research by sharing these stories in a Storytelling Symposium, and with the aid of …


West Bloomfield Care Experience Patient And Family Advisory Council: A Year Of Change, Maureen G. Bennett, Luke Sparkman, Ioana Harland, Colleen Berson Oct 2023

West Bloomfield Care Experience Patient And Family Advisory Council: A Year Of Change, Maureen G. Bennett, Luke Sparkman, Ioana Harland, Colleen Berson

2023 Patient Advisor Retreat

Purpose: To enable Henry Ford Health System to provide the highest standard of safe, comprehensive and compassionate healthcare while integrating the voice of the patients and families in policy and program decision making. Scope: Providing Patient-Centered Care (Nothing about me, without me) is the best approach to improving outcomes and providing value to each patient. The Patient Advisory Council members are involved in some or all ofthe following functions as part of their advisory role: Acting as Champions of the ideal patient experience by bringing their ideas, thoughts and opinions about various topics and processes. Reviewing communications to patients and …


Bump: Burnout Mitigation In Physician Trainees, Jacqueline Pflaum-Carlson, Sara Santarossa, Lisa Mclean, Julie A. Hamilton, Dana Murphy, Ashley B. Redding Oct 2023

Bump: Burnout Mitigation In Physician Trainees, Jacqueline Pflaum-Carlson, Sara Santarossa, Lisa Mclean, Julie A. Hamilton, Dana Murphy, Ashley B. Redding

2023 Patient Advisor Retreat

Physician burnout affects healthcare organizations at every level and has been associated with higher self-reported errors, increased turnover, and has a negative impact on patient care; it is estimated that tens of thousands of Americans die each year as a result ofpreventable medical errors. This project seeks to reduce the symptoms of physician burnout by exploring Acceptance Commitment Therapy (ACT) compared to Body Mapping as effective interventions in preventing and mitigating burnout in physician trainees at Henry Ford Health (HFH) in Detroit, Michigan.


Improving Research Is A Multipronged Collaborative Approach Reliant On "Expert" Humility And Respect, Philip Cheng, Andrew Bossick, Ashley B. Redding Oct 2023

Improving Research Is A Multipronged Collaborative Approach Reliant On "Expert" Humility And Respect, Philip Cheng, Andrew Bossick, Ashley B. Redding

2023 Patient Advisor Retreat

Our project goal is to bring together Henry Ford health sciences researchers and community members to promote the engagement of diverse patient perspectives. This poster highlights current initiatives pertaining to the integration of diverse perspectives into the research process to enhance our science at the group, system, and NIH level.


Our Contributions To The Hermelin Brain Tumor Center (Hbtc), Megan Sauer, Marc Betman, Ron Leach, Mike Coughlin, Jeni Barry, Dominik Mackowski, Lisa Scarpace, Nestelynn Gay Oct 2023

Our Contributions To The Hermelin Brain Tumor Center (Hbtc), Megan Sauer, Marc Betman, Ron Leach, Mike Coughlin, Jeni Barry, Dominik Mackowski, Lisa Scarpace, Nestelynn Gay

2023 Patient Advisor Retreat

The Hermelin Brain Tumor Center Patient and Family Advisory Council is comprised of patients and care partners who have generously agreed to come together to share their experiences and ideas. Mission Statement: Our goal is to drive patient and caregiver education, innovation, research, and success to continue to be a center of excellence. We aim to amplify the strengths of the Hermelin Brain Tumor Center by sharing our combined experience as patients, caregivers, and clinicians to its continual improvement and development.


Peir Ideas (Patients Engaged In Research - Inclusion, Diversity, Equity, Acceptance, And Safety), Sara Santarossa, Andrew Bossick, Karen Kippen, Christine L. M Joseph, Leah M. Copeland, Dana Murphy, Ashley Redding, Angela Murphy, Maureen G. Bennett Oct 2023

Peir Ideas (Patients Engaged In Research - Inclusion, Diversity, Equity, Acceptance, And Safety), Sara Santarossa, Andrew Bossick, Karen Kippen, Christine L. M Joseph, Leah M. Copeland, Dana Murphy, Ashley Redding, Angela Murphy, Maureen G. Bennett

2023 Patient Advisor Retreat

This project involves long-, mid-, and short-term objectives to address gaps in the science of engagement in research focused on development and/or assessment of instruments that measure meaningful patient engagement in research (PEIR). PEIR involves patients undertaking roles beyond those of traditional study participants by including them throughout the entire research process. Long-term objective is to develop a national model for measuring meaningful PEIR that is adaptable for all settings and catchment areas. Mid-term objective is to create the sustained engagement of a diverse group of stakeholders in the design, implementation, evaluation, and dissemination of Science of Engagement research. How …


Pursuing Equity In Patient Care (Pepc), Linda Stechison, Jaquetta Hinton, Marla R. Gorosh, Kimberleydawn Wisdom Oct 2023

Pursuing Equity In Patient Care (Pepc), Linda Stechison, Jaquetta Hinton, Marla R. Gorosh, Kimberleydawn Wisdom

2023 Patient Advisor Retreat

Participating on the PEPC Committee is an opportunity to observe the exchange of information with leaders who are in positions to act on Quality Improvement (QI) projects/clinical research(CR) results to expand scope, encourage spread, and share resources. As Patient Advisors we use the lenses of our personal identities, work history, and life experiences to provide perspective for the patients’ voices. We see the barriers of the patient-clinician relationship that don’t address the power differential and make assumptions (unconscious bias) that affect adherence and outcomes of care.


The Patient Perspective On Covid-19 Restrictions Lifting: A Descriptive Study Of Resuming In-Person Meetings, Sara Santarossa, Ashley Rapp, Dana Murphy, Janine Hussein Oct 2023

The Patient Perspective On Covid-19 Restrictions Lifting: A Descriptive Study Of Resuming In-Person Meetings, Sara Santarossa, Ashley Rapp, Dana Murphy, Janine Hussein

2023 Patient Advisor Retreat

Henry Ford’s Patient Engaged Research Center (PERC): Our mission is to translate the patient voice into evidence-based care through community engagement and world-class research methods. PERC Patient Advisor Program: PERC relies on active participation of its Patient Advisors (PAs) in the Patient Advisor Program (the Program). PAs contribute their patient and/or caregiver experience and feedback to HFH projects and initiatives to ensure care is patient-centered. COVID-19: Due to the COVID-19 pandemic, the Program adapted virtual participation in order to continue to engage PAs. Purpose: When restrictions started lifting, PERC surveyed PAs to gather feedback on resuming in-person participation


Old Dog With New Tricks: 99mtc-Sestamibi Spect-Ct For Renal Mass Differentiation, Zachary Beswick, Ishani Dalal May 2019

Old Dog With New Tricks: 99mtc-Sestamibi Spect-Ct For Renal Mass Differentiation, Zachary Beswick, Ishani Dalal

Teaching and Education

Small renal masses have historically presented a diagnostic challenge for radiologists and urologists. MRI and CT have a limited capability to differentiate benign and malignant small solid renal masses. The relatively poor negative predictive value of renal biopsy limits the ability to avoid surgical resection in small renal masses with negative biopsy. 99mTc-sestamibi SPECT-CT can be an important tool in directing the management of patients with renal masses.We present the analysis of 99mTc-sestamibi uptake patterns in patients with small renal masses who underwent further characterization of these masses with 99mTc-sestamibi SPECT-CT. Pertinent interpretation points in differentiating renal cell carcinoma from …


Sublocalization Of The Multiple Endocrine Neoplasia Type 1 Gene, Catharina Larsson, Gunther Weber, Marie Janson Sep 1992

Sublocalization Of The Multiple Endocrine Neoplasia Type 1 Gene, Catharina Larsson, Gunther Weber, Marie Janson

Henry Ford Hospital Medical Journal

Tumorigenesis in multiple endocrine neoplasia type 1 (MEN 1) involves the unmasking of a recessive mutation at the MEN 1 locus which has been mapped to chromosomal region 11q11-13. By analyzing 58 DNA markers on a panel of radiation-reduced somatic cell hybrids, the region encompassing the MEN 1 gene was divided into nine subregions. Pulsed field gel electrophoresis analysis of markers within subgroups showed that the recombination rate around the MEN 1 locus is high. Combined linkage analysis in MEN 1 families and deletion mapping in MEN 1-related tumors suggest the MEN 1 gene is located centromeric to D11S807 and …


Proceedings Of The Fourth International Workshop On Multiple Endocrine Neoplasia: Introduction, Robert F. Gagel, Charles E. Jackson Sep 1992

Proceedings Of The Fourth International Workshop On Multiple Endocrine Neoplasia: Introduction, Robert F. Gagel, Charles E. Jackson

Henry Ford Hospital Medical Journal

No abstract provided.


The Importance Of Screening For The Men 1 Syndrome: Diagnostic Results And Clinical Management, C. J. M. Lips, H. P. F. Koppeschaar, M. J. H. Berends, J. M. Jansen-Schillhorn Van Veen, A. Struyvenberg, Th. J. M. V. Van Vroonhoven Sep 1992

The Importance Of Screening For The Men 1 Syndrome: Diagnostic Results And Clinical Management, C. J. M. Lips, H. P. F. Koppeschaar, M. J. H. Berends, J. M. Jansen-Schillhorn Van Veen, A. Struyvenberg, Th. J. M. V. Van Vroonhoven

Henry Ford Hospital Medical Journal

No abstract provided.


Prospective Screening In Multiple Endocrine Neoplasia Type 1, Britt Skogseid, Kjell Oberg Sep 1992

Prospective Screening In Multiple Endocrine Neoplasia Type 1, Britt Skogseid, Kjell Oberg

Henry Ford Hospital Medical Journal

To assess the age of clinically detectable onset of multiple endocrine neoplasia type 1 (MEN 1), 88 members of four families were invited to participate in a ten-year biochemical screening program. Evidence for clinically detectable MEN 1 was found in adolescence. Pancreatic endocrine dysfunction constituted the presenting lesion in a majority of these individuals. The age at diagnosis of pancreatic endocrine tumors averaged 25 years and was lowered by almost two decades by prospective investigation. Furthermore, the penetrance of the pancreatic endocrine and parathyroid lesions equaled the penetrance found in autopsy studies. The use of a standardized meal stimulation test …


Practical Guidelines For Dna-Based Testing In Multiple Endocrine Neoplasia Type 1, Catharina Larsson, Magnus Nordenskjold, Britt Skogseid, Kjell Oberg Sep 1992

Practical Guidelines For Dna-Based Testing In Multiple Endocrine Neoplasia Type 1, Catharina Larsson, Magnus Nordenskjold, Britt Skogseid, Kjell Oberg

Henry Ford Hospital Medical Journal

Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant predisposition to neoplastic lesions of the parathyroid glands, the neuroendocrine pancreas, and the anterior pituitary gland. The predisposing genetic defect was localized to the long arm of chromosome 11 by genetic linkage analysis in three affected families. By analyzing six MEN 1 families with 14 DNA marker systems located close to the MEN 1 gene, we have developed a method to identify carriers of the MEN 1 predisposition. We describe practical aspects of such DNA-based diagnostic procedures.


Hyperparathyroidism With Normal Albumin-Corrected Total Calcium In Patients With Multiple Endocrine Neoplasia Type 1, J. J. Shepherd, Bin Tean Teh, V. Parameswaran, R. David Sep 1992

Hyperparathyroidism With Normal Albumin-Corrected Total Calcium In Patients With Multiple Endocrine Neoplasia Type 1, J. J. Shepherd, Bin Tean Teh, V. Parameswaran, R. David

Henry Ford Hospital Medical Journal

In the largest reported family of patients with multiple endocrine neoplasia type 1 (MEN 1), hyperparathyroidism was expressed at first screening in 33 patients by elevation of ionized calcium (IC) (30 cases) or parathyroid hormone (three cases) without elevation of albumin-corrected total calcium (ACTC). Three of these 33 patients have shown a progressive rise in IC and later an elevation of ACTC. However, the age distribution suggests that in others the level of IC may remain stable at a minimally elevated level throughout life with ACTC remaining normal except for transient rises at the times of intercurrent illness or surgical …


Parathyroid Tumor Biology In Familial Multiple Endocrine Neoplasia Type 1: A Model For Cancer Development, Maria Luisa Brandi Sep 1992

Parathyroid Tumor Biology In Familial Multiple Endocrine Neoplasia Type 1: A Model For Cancer Development, Maria Luisa Brandi

Henry Ford Hospital Medical Journal

Familial multiple endocrine neoplasia type 1 (FMEN 1) is an autosomal dominant disorder characterized by tumors of the parathyroid glands, pancreatic islets, and anterior pituitary. Hyperplasia appears to be the typical histopathological lesion in FMEN 1 endocrine tumors. A circulating mitogen related to basic fibroblast growth factor was active on proliferation of clonal bovine and human parathyroid endothelial cells. Moreover, the FMEN 1 mitogen modulated differentiation of human parathyroid endothelial cell in vitro. All these facts suggested that an extrinsic factor was active on parathyroid endothelial cell growth and differentiation. The FMEN 1 gene maps to chromosome 11q13, and allelic …


Surgical Treatment Of The Endocrine Pancreas And Zollinger-Ellison Syndrome In The Men 1 Syndrome, Norman W. Thompson Sep 1992

Surgical Treatment Of The Endocrine Pancreas And Zollinger-Ellison Syndrome In The Men 1 Syndrome, Norman W. Thompson

Henry Ford Hospital Medical Journal

Islet cell neoplasia is a frequent occurrence in multiple endocrine neoplasia type 1 (MEN 1). Sixteen of 27 patients with MEN 1 developed functioning endocrine pancreatic tumor syndromes. Eleven of the 16 developed Zollinger-Ellison syndrome and each was evaluated by a combination of computed tomography and hepatic angiography to exclude hepatic metastasis and percutaneous transhepatic catheterization to localize the tumor. Seven of the 11 patients were found to have duodenal gastrinomas with multiple duodenal tumors in three patients. Four of the 11 patients had only pancreatic gastrinomas. In addition to the gastrinomas, other types of islet tumors in the pancreatic …


Isolation Of Yac Clones From The Pericentromeric Region Of Chromosome 10 And Development Of New Genetic Markers Linked To The Multiple Endocrine Neoplasia Type 2a Gene, Terry C. Lairmore, James R. Howe, Shenshen Dou, Rosalie Veile, Jennifer A. Korte-Sarfaty, Samuel A. Wells Jr., Helen Donis-Keller Sep 1992

Isolation Of Yac Clones From The Pericentromeric Region Of Chromosome 10 And Development Of New Genetic Markers Linked To The Multiple Endocrine Neoplasia Type 2a Gene, Terry C. Lairmore, James R. Howe, Shenshen Dou, Rosalie Veile, Jennifer A. Korte-Sarfaty, Samuel A. Wells Jr., Helen Donis-Keller

Henry Ford Hospital Medical Journal

Genetic linkage mapping and contig assembly using yeast artificial chromosome (YAC) technology form the basis of our strategy to clone and define the genomic structure of the pericentromeric region of chromosome 10 containing the multiple endocrine neoplasia type 2A gene. Thus far YAC walks have been initiated from five chromosome 10 pericentromeric loci including RBP3, D10S94, RET, D10Z1, and FNRB. Long range pulsed-field gel electrophoresis maps are constructed from the YACs isolated to define clone overlaps and to identify putative CpG islands. Bidirectional YAC walks are continued by rescreening the YAC library with sequence-tagged site assays developed from endclones. Several …


A Preliminary Analysis Of Consortium Data For Markers Tightly Linked To Multiple Endocrine Neoplasia Type 2a, J. B. Lichter, S. M. Hackleman, B. A. J. Ponder, D. Easton, S. A. Narod, G. M. Lenoir, R. F. Gagel, N. E. Simpson, E. Gardner, P. J. Goodfellow, S. Takai, A. J. Pakstis, K. K. Kidd Sep 1992

A Preliminary Analysis Of Consortium Data For Markers Tightly Linked To Multiple Endocrine Neoplasia Type 2a, J. B. Lichter, S. M. Hackleman, B. A. J. Ponder, D. Easton, S. A. Narod, G. M. Lenoir, R. F. Gagel, N. E. Simpson, E. Gardner, P. J. Goodfellow, S. Takai, A. J. Pakstis, K. K. Kidd

Henry Ford Hospital Medical Journal

We have analyzed DNA marker typing data contributed by six independent groups to estimate the pairwise genetic distances between these markers and the locus for multiple endocrine neoplasia type 2A (MEN 2A). We used LIPED to calculate these distances for female, male, and sex-average linkage maps and to determine the corresponding LOD scores. The preliminary analyses of this large data set (89 MEN 2A families and five non-MEN 2A references families, with 1,934 total individuals) are reported here. These refined estimates of the genetic map in this region will aid in the assignment of presymptomatic diagnoses. This study clearly points …


Localization Of The Gene For Men 2a, Jay B. Lichter, Michael Difilippantonio, Jingshi Wu, Diane Miller, David C. Ward, Paul J. Goodfellow, Kenneth K. Kidd Sep 1992

Localization Of The Gene For Men 2a, Jay B. Lichter, Michael Difilippantonio, Jingshi Wu, Diane Miller, David C. Ward, Paul J. Goodfellow, Kenneth K. Kidd

Henry Ford Hospital Medical Journal

The search for the gene that causes the multiple endocrine neoplasia type 2A (MEN 2A) syndrome is entering a new phase. Genetic linkage studies have localized the gene to the pericentromeric region of chromosome 10. The statistical portion of mapping the gene for MEN 2A is nearly complete and now classical molecular biological/gene mapping techniques will be employed. We have used fluorescence in situ hybridization to estimate the size of the MEN2A region to be about 2 to 5 mb, using some liberal assumptions; at worst the region should contain no more than about 10 mb of non-alphoid DNA. Our …


Screening For Multiple Endocrine Neoplasia Type 2a With Dna-Polymorphism Analysis, Estelle M.-F. Lamothe, Steven A. Narod, Shari Miller, Paul J. Goodfellow, David E. C. Cole, Dawna Gilchrist, Zdenka Pausova, David Goltzman, Geoffrey N. Hendy Sep 1992

Screening For Multiple Endocrine Neoplasia Type 2a With Dna-Polymorphism Analysis, Estelle M.-F. Lamothe, Steven A. Narod, Shari Miller, Paul J. Goodfellow, David E. C. Cole, Dawna Gilchrist, Zdenka Pausova, David Goltzman, Geoffrey N. Hendy

Henry Ford Hospital Medical Journal

Nine chromosome 10 DNA markers (FNRB, D10S34, D10Z1, MEN203, D10S94, RBP3, D10S15, MBP [48.11], D10S22) were typed in two large Canadian pedigrees with multiple endocrine neoplasia type 2A (MEN 2A). These markers and the gene for MEN 2A (MEN2A) are believed to be in one linkage group spanning approximately 15 cM (male). MEN203 and D10S94 were informative and tightly linked to MEN2A with no recombinants observed in 26 meiotic events. D10S15 (MCK2), widely used in DNA genotyping predictions, demonstrated two recombinants in these two families. The use of multiple flanking markers increases both the likelihood of informativeness and the accuracy …


High-Sensitivity Serum Calcitonin Assays Applied To Screening For Thyroid C-Cell Disease In Multiple Endocrine Neoplasia Type 2a, Michael M. Kaplan, Glenn M. Stall, Timothy Cummings, Andrew Macaulay, Philippe Motté, Hubert J. Wolfe, Seymour Reichlin, Arman J. Tashjian Jr. Sep 1992

High-Sensitivity Serum Calcitonin Assays Applied To Screening For Thyroid C-Cell Disease In Multiple Endocrine Neoplasia Type 2a, Michael M. Kaplan, Glenn M. Stall, Timothy Cummings, Andrew Macaulay, Philippe Motté, Hubert J. Wolfe, Seymour Reichlin, Arman J. Tashjian Jr.

Henry Ford Hospital Medical Journal

Two serum calcitonin assays with sensitivities ≤ 10 pg/mL were compared to our standard radioimmunoassay (sensitivity 100 pg/mL) in multiple endocrine neoplasia type 2A (MEN 2A) screening. Values from the Nichols displacement radioimmunoassay averaged 38% higher than values from the CIS immunoradiometric assay; values from both were highly correlated, r = 0.845. In three individuals, both of the newer assays revealed abnormalities in pentagastrin tests three to four years before abnormalities were detected by the standard assay. Pentagastrin tests after total thyroidectomy were assayed by the newer methods in patients with medullary thyroid carcinoma (MTC) diagnosed at initial testing (group …


Genetics Of The Multiple Endocrine Neoplasia Type 2b Syndrome, Charles E. Jackson, Robert A. Norum Sep 1992

Genetics Of The Multiple Endocrine Neoplasia Type 2b Syndrome, Charles E. Jackson, Robert A. Norum

Henry Ford Hospital Medical Journal

Multiple endocrine neoplasia type 2B (MEN 2B) is similar to MEN 2A in that both autosomal dominant syndromes include medullary thyroid cancers and pheochromocytomas. It is distinct in that MEN 2B patients have much earlier age of onset with more aggressive tumors and mucosa/neuromas of the lips and tongue. The neuromas allow ascertainment generally before age 5. Studies of two and three generations of 14 MEN 2B families disclosed close linkage of the MEN 2B gene to DNA markers to which MEN2A had been linked. Multipoint analysis utilizing additional results in three generations of a 15th family have disclosed a …