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Full-Text Articles in Medicine and Health Sciences
Evaluation Of Cyp2b6 G15631t Polymorphism As A Risk Factor For Development Of Chronic Myeloid Leukemia, Enas S. Essa, Mayada G. Hagag, Suzan A. Alhassanin, Wafaa M. Radwan
Evaluation Of Cyp2b6 G15631t Polymorphism As A Risk Factor For Development Of Chronic Myeloid Leukemia, Enas S. Essa, Mayada G. Hagag, Suzan A. Alhassanin, Wafaa M. Radwan
Menoufia Medical Journal
Objectives The objective of this study was to investigate the possible relationship between CYP2B6 G15631T gene polymorphism and chronic myeloid leukemia (CML) risk. Background The cytochrome P450 (CYP) enzymes constitute one of the biggest gene families and play a vital role in the metabolism of endogenous biomolecules, drugs, and xenobiotics. One of the members of this family, CYP2B6, plays a very important role in metabolizing carcinogens and medications. CYP2B6 G15631T gene polymorphism reduces CYP2B6 enzyme activity. Patients and methods Fifty CML patients and 32 matched healthy controls were enrolled in this study. CYP2B6 G15631T polymorphic variant was detected by PCR-restriction …
Association Between Survivin Gene Polymorphism And Colorectal Cancer, Belal Montaser, Mohamed S. Amar, Mona Maamoun Ahmed, Waleed M. Fathy
Association Between Survivin Gene Polymorphism And Colorectal Cancer, Belal Montaser, Mohamed S. Amar, Mona Maamoun Ahmed, Waleed M. Fathy
Menoufia Medical Journal
Objective To study the possible association of genetic polymorphism of survivin gene (rs9904341) with the risk of developing colorectal cancer (CRC) in Egyptian patients and explore the mechanisms of survivin polymorphism in the development of CRC. Background Survivin gene is an inhibitor of apoptosis, plays an important role in cell cycle regulation, and may be involved in the development and progression of cancer. Structurally, the human survivin gene comprises four exons and three introns spanning 14.7 kb, which encodes a 16.5 kDa protein. Survivin gene is expressed mostly at the G2/M phase and declines rapidly in the G1 phase of …
Scope Of Genetic Counseling In Reducing The Magnitude Of Hereditary Disorders: Developing Nations' Perspective, Ramasamy Jegadeesh, Shrivastava Saurabh Rambiharilal, Shrivastava Prateek Saurabh
Scope Of Genetic Counseling In Reducing The Magnitude Of Hereditary Disorders: Developing Nations' Perspective, Ramasamy Jegadeesh, Shrivastava Saurabh Rambiharilal, Shrivastava Prateek Saurabh
Menoufia Medical Journal
Genetic counseling is defined as a process of communication and education, which addresses concerns relating to the development and/or transmission of a hereditary disorder. Despite the proven utility of genetic counseling in improving the clinical outcome and quality-of-life of people, its overall contribution in the health sector has remained far from expected. Recognizing the scope of genetic counseling, the need of the hour is to deliver easily accessible and quality-assured genetic counseling services to the entire population. In conclusion, global expansion of genetic counseling services is the need of the hour, to have a significant impact on the patient-related clinical …