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Faculty of Dental Medicine (Girls' branch)
Head and Neck Squamous Cell; carcinoma; Vitamin D; apoptosis
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Full-Text Articles in Medicine and Health Sciences
Effects Of Vitamin D On Growth Inhibition Of Head And Neck Squamous Cell Carcinoma. (In Vitro Study), Heba Hussein
Effects Of Vitamin D On Growth Inhibition Of Head And Neck Squamous Cell Carcinoma. (In Vitro Study), Heba Hussein
Al-Azhar Journal of Dentistry
Objective: To assess the anti-cancer capacity of vitamin D in head and neck squamous cell carcinoma cell line. Materials and Methods: vitamin D cytotoxic effect and cell apoptosis effect were evaluated using Prestoblue cell viability assay and Flow Cytometry. Results: Vitamin D was found to inhibit the cell growth in a dose-dependent manner in head and neck squamous cell carcinoma JHU-29 cell line at three days’ treatment. However, it was not found to cause significant apoptosis at one day treatment. Conclusion: vitamin D inhibits the growth of head and neck squamous cell carcinoma in a dose-dependent manner.