Medicine and Health Sciences Commons^™

Beyond Low-Earth Orbit: Characterizing Immune And Microrna Differentials Following Simulated Deep Spaceflight Conditions In Mice, Amber M. Paul, Margareth Cheng-Campbell, Elizabeth A. Blaber, Sulekha Anand, Sharmila Bhattacharya

Publications

Spaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune responses in mice following ground-based, simulated deep spaceflight conditions, compared with data from astronauts on International Space Station missions. For ground studies, we simulated microgravity using the hindlimb unloaded mouse model alone or in combination with acute simulated galactic cosmic rays or solar particle events irradiation. Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight. Circulating plasma microRNA sequence analysis revealed …

Let-Dependent Low Dose And Synergistic Inhibition Of Human Angiogenesis By Charged Particles: Validation Of Mirnas That Drive Inhibition, Amber M. Paul, Yen-Ruh Wuu, Burong Hu, Hazeem Okunola, Elizabeth A. Blaber, Margareth Cheng-Campbell, Afshin Beheshti, Peter Grabham

Publications

Space radiation inhibits angiogenesis by two mechanisms depending on the linear energy transfer (LET). Using human 3D micro-vessel models, blockage of the early motile stage of angiogenesis was determined to occur after exposure to low LET ions (/AMU), whereas inhibition of the later stages occurs after exposure to high LET ions (>8 KeV/AMU). Strikingly, the combined effect is synergistic, detectible as low as 0.06 Gy making mixed ion space radiation more potent. Candidates for bystander transmission are microRNAs (miRNAs), and analysis on miRNA-seq data from irradiated mice shows that angiogenesis would in theory be downregulated. Further analysis of three …

Are Countries With Higher Levels Of Mental Health Cases Experience Higher Divorce Rates?, Liu Ying Wong, Yi Pei Goh

Introduction to Research Methods RSCH 202

This paper aims to determine if spouses’ mental health can be a factor affecting the divorce rate of marriage. A regression analysis is carried out to determine how the percentage of mental health cases in a country’s population affects the divorce rates of a country, while controlling the effects of labour force participation and income. The data from the selected 20 countries are collected from reputable world organizations selected. The results obtained from the regression analysis show that mental health has a marginally significant association with divorce rate and the association between income index and divorce rate is statistically significant.

Relationship Between Abortion Rates And Ethnicity, Ronald Foon, Nur Diyanah Ayub Mansul

Introduction to Research Methods RSCH 202

This research paper will serve as the first study in analysing discrepancies in birth rates among women of different ethnic groups in Singapore. The objective of this study is to root out any inequalities and effectively promote access to better healthcare for all women in Singapore. Additionally, a quantitative study in the form of a survey is proposed in this paper to collect original data. This survey will be disseminated in abortion clinics following the principles of cluster sampling. A regression analysis will be conducted to identify the statistical significance and correlation of each independent variables including age, income level, …

Novel Computational Infant Musculoskeletal Model For Biomechanical Analysis Of Infant Movement, Yeram Lim

Doctoral Dissertations and Master's Theses

Computational musculoskeletal models are increasing in commonality and popularity in the study of biomechanics. These models, however, are mainly used to represent fully developed adults, while infant musculoskeletal models are nonexistent. This study aims to develop a novel computational infant musculoskeletal model for biomechanical analysis of infant movement. For this study, 31 reflective markers were placed on an infant, and marker-based motion capture data was collected. The computational study used a generic GAIT2392 OpenSim musculoskeletal model that was scaled to create a customized subject-specific infant model. By using the motion capture data recorded of the infant during a kicking motion, …

Neutrophil-To-Lymphocyte Ratio: A Biomarker To Monitor The Immune Status Of Astronauts, Amber M. Paul, Siddhita D. Mhatre, Egle Cekanaviciute, Ann-Sofie Schreurs, Candice G.T. Tahimic, Ruth K. Globus, Sulekha Anand, Brian E. Crucian, Sharmila Bhattacharya

Publications

A comprehensive understanding of spaceflight factors involved in immune dysfunction and the evaluation of biomarkers to assess in-flight astronaut health are essential goals for NASA. An elevated neutrophil-to-lymphocyte ratio (NLR) is a potential biomarker candidate, as leukocyte differentials are altered during spaceflight. In the reduced gravity environment of space, rodents and astronauts displayed elevated NLR and granulocyte-to-lymphocyte ratios (GLR), respectively. To simulate microgravity using two well-established ground-based models, we cultured human whole blood-leukocytes in high-aspect rotating wall vessels (HARV-RWV) and used hindlimb unloaded (HU) mice. Both HARV-RWV simulation of leukocytes and HU-exposed mice showed elevated NLR profiles comparable to spaceflight …

A Statistical Learning Regression Model Utilized To Determine Predictive Factors Of Social Distancing During Covid-19 Pandemic, Timothy A. Smith, Albert J. Boquet, Matthew V. Chin

Publications

In an application of the mathematical theory of statistics, predictive regression modelling can be used to determine if there is a trend to predict the response variable of social distancing in terms of multiple predictor input “predictor” variables. In this study the social distancing is measured as the percentage reduction in average mobility by GPS records, and the mathematical results obtained are interpreted to determine what factors drive that response. This study was done on county level data from the state of Florida during the COVID-19 pandemic, and it is found that the most deterministic predictors are county population density …

Surveying The Safety Culture Of Academic Laboratories, Emily Faulconer, Zachary Dixon, John C. Griffith, Hayden Frank

Publications

The university traditionally has been the foundation for young adults’ professional development, yet the proclivity toward safety culture has garnered less focus in higher education than in the workforce. A survey of faculty at a medium-sized, research-active, private institution revealed specific areas of policy noncompliance as well as specific safety attitudes that can be targeted for interventions. Albeit a snapshot view, the survey implies that safety needs better representation in the classroom, teaching laboratories, and research facilities at universities. Safety is not abandoned by any means, and there is a strong presence of safety-oriented individuals, but the data show barriers …

Hello, I’M Fat: Finding Myself In A Hulu Original, Mac Clark

Student Works

My first relationship happened when I was 18. We matched on Tinder and spent the following month doing everything people in relationships do, just without the label. This casual mindset was not my choice, and neither was the constant feeling of disappointment. I yearned to be respected; I knew it wasn’t right for him to sleep through our dates nor return my texts for days at a time. I wanted a real relationship, one where I wouldn’t have to beg for clarity, but as a fat, young woman, I believed this lesser form of relationship was my only option, so …

Face Mask Effects Of Co2, Heart Rate, Respiration Rate, And Oxygen Saturation On Instructor Pilots, Andrew R. Dattel, Nicola M. O'Toole, Guillermina Lopez, Kenneth P. Byrnes

Publications

The COVID-19 pandemic has required people to take new measures to mitigate the spread of the communicable virus. Guidelines from health organizations, government offices, and universities have been disseminated. Adherence to these guidelines cannot be more critical for flight training. This study explored the effects face masks had on CO2, heart rate, respiration rate, and oxygen saturation while wearing a face mask at an oxygen level simulated to 5,000 feet. Thirty-two instructor pilots (IP) volunteered to participate in the study. IPs spent 90 minutes in a normobaric chamber while wearing a cloth face mask or a paper face mask. Participants …

Facts About Mold: A Consumer Focus, Cheri Marcham

Publications

The U.S. Centers for Disease Control and Prevention, the Institute of Medicine of the U.S. National Academy of Sciences, the American Academy of Allergy Asthma and Immunology, Health Canada, and the World Health Organization all agree that living or working in a building with mold-damaged building materials results in an increased risk of respiratory diseases such as asthma.

The American Industrial Hygiene Association (AIHA) has worked to translate the advice from these public health and medical authorities into state-of-the-art inspection and sampling protocols. These protocols are captured in AIHA’s second edition of the Recognition, Evaluation and Control of Indoor Mold …

Facts About Mold: An Aiha Perspective For Ieq Investigators, Physicians, And Engineers, Cheri Marcham

Publications

The U.S. Centers for Disease Control and Prevention (CDC), the Institute of Medicine of the U.S. National Academy of Sciences, the American Academy of Allergy, Asthma & Immunology (AAAAI), Health Canada, and the World Health Organization all agree that living or working in a building with mold-damaged building materials results in increased risk of respiratory diseases such as asthma.

The American Industrial Hygiene Association (AIHA) has worked to translate the advice from these public health and medical authorities into state-of-the-art inspection and sampling protocols. These protocols are captured in AIHA’s Recognition, Evaluation and Control of Indoor Mold publication, also known …

The Value Of Iaq: A Review Of The Scientific Evidence Supporting The Benefits Of Investing In Better Indoor Air Quality, Vickie R. Hawkins,, Cheryl L. Marcham, John P. Springston, J. David Miller, Geoffrey Braybrooke, Craig Maunder, Lydia Feng, Ben Kollmeyer

Publications

Other studies have examined how ventilation rates, combined with the presence of pollutant sources, can affect productivity. These studies provide evidence that increased ventilation, including increases above common guidance levels such as ASHRAE’s ventilation standards, improve occupant productivity. Increased occupant control over ventilation has also been shown to improve productivity. Higher indoor carbon dioxide (CO2) levels have been directly associated with impaired work performance and increased health symptoms. Historically, it was believed that these associations exist only because higher indoor CO2 concentrations, resulting from lower outdoor air ventilation rates, are also correlated with higher levels of other indoor-generated pollutants that …

Abduction Contractures Within Infants With Developmental Dysplasia Of The Hip, Nathan Stanton

Doctoral Dissertations and Master's Theses

Developmental Dysplasia of the hip is a condition that affects 1 to 3 of every 1000 infants born globally. It is a pathology that involves the instability, subluxation, or dislocation of the femoral head from the acetabulum. Through a rating system by the International Hip Dysplasia Institute or Graf System, hips are rated based on their level of instability or dislocation and the infant is then prescribed a treatment. While Finite element models of dysplastic hips have been developed previously, a study that seeks to understand the contribution of an abduction contracture of the hip has yet to be performed. …

Integrating Aviation Technology, Emergency Services, And Human Resilience: Considerations From Social Scientists, Chelsea A. Lenoble Ph.D., Joel M. Billings Ph.D., Allison A. Kwesell Ph.D., Ray H. Chang Ph.D.

National Training Aircraft Symposium (NTAS)

Unmanned aerial systems (UAS) have a range of applications within the field of disaster response. This presentation offers a novel framework of psychosocial considerations designed to advance UAS and disaster management integration. Social scientists highlight important challenges to the effective integration of three primary entities: UAS, the team of teams that responds to disasters, and populations affected by disasters.

The presentation adopts an emerging theoretical perspective on the intersection between UAS capabilities and disaster phases and extends it by bringing necessary attention to social science issues. Specifically, the framework outlines psychosocial considerations and areas of improvement for preparation (training), response …

Fatigue In Collegiate Aviation, Flavio A. Coimbra Mendonca Ph.D., Erik Levin, Julius Keller Ph.D., Aaron Teo

National Training Aircraft Symposium (NTAS)

Flight training has received little attention in fatigue research. Only transfers of knowledge gained in commercial and military aviation have been applied to general aviation without bridging the gap to the training environment. The purpose of this study was to assess collegiate aviation students’ perceptions of lifestyle and mitigation strategies related to fatigue. Participants were recruited from a Midwestern university’s accredited Part 141 flight school and a partner fixed base operator (FBO). The researchers of this study used a survey questionnaire to gather quantitative and qualitative responses. The majority of participants (68%) had logged less than 250 flight hours and …

Recovering From Covid-19 Building Closures: Guidance Document, David Krause, Cheri Marcham, John Springston, Alex Lebeau, Robert Rottersman, Timothy Froehlig, Bart Ashley

Publications

While the country comes to terms with the inevitable impact that SARS-CoV-2, the virus that causes COVID-19, will have on our lives and communities, public health authorities remain focused on breaking the chain of transmission. Managing the risk has resulted in widespread closures of businesses, schools, universities, resorts, and other facilities deemed “non-essential.” Practically speaking, this means closing buildings and ceasing operations. For building owners and operators, this poses a significant challenge to protect their assets and to ensure they are ready to reoccupy once the pandemic subsides.

Workplace Cleaning For Covid-19: Guidance Document, David Krause,, Cheri Marcham, John Springston, Alex Lebeau, Robert Rottersman, Timothy Froehlig, George (Jerry) Mccaslin

Publications

Critical and essential workplaces operating during this pandemic need to implement procedures to reduce the risk of workers, contractors, vendors, customers, and members of the community becoming infected on their premises. Outside of healthcare and paramedical facilities, the infrastructure and standard practices of infection prevention and control have not been commonplace. Establishing enhanced routine cleaning and disinfection procedures in offices, factories, warehouses, call centers, grocery stores, and other non-healthcare workplaces is a critical step in reducing exposures and infections.

Physiological Effects During Aerobatic Flights On Science Astronaut Candidates, Pedro Llanos, Diego M. Garcia

Publications

Spaceflight is considered the last frontier in terms of science, technology, and engineering. But it is also the next frontier in terms of human physiology and performance. After more than 200,000 years humans have evolved under earth’s gravity and atmospheric conditions, spaceflight poses environmental stresses for which human physiology is not adapted. Hypoxia, accelerations, and radiation are among such stressors, our research involves suborbital flights aiming to develop effective countermeasures in order to assure sustainable human space presence. The physiologic baseline of spaceflight participants is subject to great variability driven by age, gender, fitness, and metabolic reserve. The objective of …

Physiological Effects On Scientist Astronaut Candidates: Hypobaric Training Assessment, Pedro Llanos, Diego Garcia

Publications

This paper is addressed to expanding our understanding of the effects of hypoxia training on our bodies to better model its dynamics and leverage some of its implications and effects on human health. Hypoxia training is a recommended practice for military and civilian pilots that allow them to recognize their early hypoxia signs and symptoms, and Scientist Astronaut Candidates (SACs) who underwent hypobaric hypoxia (HH) exposure as part of a training activity for prospective suborbital flight applications. This observational-analytical study describes physiologic responses and symptoms experienced by a SAC group before, during and after HH exposure and proposes a model …

Pennsylvania’S Covid-19 Response Vs. Homeland Security Frameworks And Research: Masking The Whole Community, Alexander Siedschlag

Publications

This essay offers an intermediate discussion of select policy, strategic, operational, and tactical issues that demonstrate where and how the Commonwealth of Pennsylvania’s novel coronavirus response on the one hand, and homeland security frameworks and research on the other, converge or—more often so—diverge, and how to narrow this gap. Although typically framed as a pandemic owned by the public health sector, the COVID-19 response falls directly within the homeland security mission space, whose core missions include “Ensuring Resilience to Disasters.” In some respects, Pennsylvania’s response exemplifies best practices suggested by research. In other dimensions, it is neither in line with …