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Full-Text Articles in Medicine and Health Sciences
Caffeine With Links To Nafld And Accelerated Brain Aging, Ian James Martins
Caffeine With Links To Nafld And Accelerated Brain Aging, Ian James Martins
Research outputs 2014 to 2021
Nutritional diets are essential to prevent nonalcoholic fatty liver disease (NAFLD) in the global obesity and diabetes epidemic. The ingestion of palmitic acid-rich diets induces NAFLD in animal and human studies. The beneficial properties of olive oil (oleic acid) may be superseded by ingestion of palmitic acid-rich diets. Hepatic caffeine metabolism is regulated by palmitic and oleic acid with effects of these fats on amyloid beta metabolism. Healthy fats such as olive oil may facilitate rapid amyloid beta clearance in the periphery to maintain drug therapy in diabetes and various neurological diseases. Repression of the anti-aging gene sirtuin 1 (Sirt …
Neuromuscular Factors Contributing To Reductions In Muscle Force After Repeated, High-Intensity Muscular Efforts, Benjamin J. C. Kirk
Neuromuscular Factors Contributing To Reductions In Muscle Force After Repeated, High-Intensity Muscular Efforts, Benjamin J. C. Kirk
Theses: Doctorates and Masters
Fatigue can accumulate sufficiently to limit muscular force production during repeated, forceful muscle contractions, including those that occur in the occupational, clinical and athletic settings. Fatigue during such efforts is likely to result from disturbances to multiple processes in the nervous system and muscle. However, previous research examining the mechanisms underpinning fatigue have typically required subjects to perform low-level constant-force contractions or to repeat maximal efforts in a single set format. Such tasks do not translate well to occupational, daily living or athletic situations where high-intensity, yet submaximal, repeated efforts may be performed in work bouts (or sets) with brief …