Medicine and Health Sciences Commons^™

Stimulation Of Anterior Thalamic Nucleus Protects Hippocampus Neural Injury In Kainic Acid-Induced Epileptic Rats, Na Yan, Ning Chen, Wei Gao, Wei Wang

Research outputs 2014 to 2021

Anterior nucleus of thalamus (ANT) stimulation has been proved to be effective in the treatment of refractory epilepsy, but the underlying mechanisms remain to be elucidated. We examined the role of ANT stimulation on hippocampal neuron death after seizures induced by kainic acid (KA). Our data showed that ANT stimulation could significantly rescue neurons from death induced by seizures, by reducing the release of cytochrome c (cyto c) and also via apoptosis-inducing factor (AIF) induced by seizures through inhibiting the activated caspase-9 and caspase-3. Our data suggest that ANT stimulation may protect against neuronal loss and reduce neuronal injury in …

Sirt1 Activation Mediates Heat-Induced Survival Of Uvb Damaged Keratinocytes, Leslie Calapre, Elin S. Gray, Sandrine Kurdykowski, Anthony David, Pascal Descargues, Mel R. Ziman Dr

Research outputs 2014 to 2021

Background

Exposure to heat stress after UVB irradiation induces a reduction of apoptosis, resulting in survival of DNA damaged human keratinocytes. This heat-mediated evasion of apoptosis appears to be mediated by activation of SIRT1 and inactivation of p53 signalling. In this study, we assessed the role of SIRT1 in the inactivation of p53 signalling and impairment of DNA damage response in UVB plus heat exposed keratinocytes.

Results

Activation of SIRT1 after multiple UVB plus heat exposures resulted in increased p53 deacetylation at K382, which is known to affect its binding to specific target genes. Accordingly, we noted decreased apoptosis and …