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Full-Text Articles in Medicine and Health Sciences
Intravenous Prenatal Nicotine Exposure Alters Meth-Induced Hyperactivity, Conditioned Hyperactivity, And Bdnf In Adult Rat Offspring, Ryan T. Lacy, Russell. W. Brown, Amanda J. Morgan, Charles F. Mactutus, Steven B. Harrod
Intravenous Prenatal Nicotine Exposure Alters Meth-Induced Hyperactivity, Conditioned Hyperactivity, And Bdnf In Adult Rat Offspring, Ryan T. Lacy, Russell. W. Brown, Amanda J. Morgan, Charles F. Mactutus, Steven B. Harrod
ETSU Faculty Works
In the USA, approximately 15% of women smoke tobacco cigarettes during pregnancy. In utero tobacco smoke exposure produces somatic growth deficits like intrauterine growth restriction and low birth we
Nicotine Sensitization In A Rodent Model Of Schizophrenia: A Comparison Of Adolescents, Adults, And Neurotrophic Factors., Marla Kay Perna
Nicotine Sensitization In A Rodent Model Of Schizophrenia: A Comparison Of Adolescents, Adults, And Neurotrophic Factors., Marla Kay Perna
Electronic Theses and Dissertations
The behavioral effects of nicotine on locomotor activity in a rodent model of psychosis were analyzed. This model is based on neonatal quinpriole treatment (a dopamine D2/D3 agonist) which causes increased D2 receptor sensitivity, a phenomenon known as D2 priming that is common in schizophrenia. D2-primed adolescent rats did not demonstrate nicotine-induced hypoactivity early in training, and males demonstrated more rapid sensitization to nicotine as compared to controls administered nicotine. D2-primed females administered nicotine demonstrated increased stereotypic behavior. D2-primed adult rats given nicotine demonstrated significantly more robust sensitization to nicotine than controls given nicotine. Brain-derived neurotrophic factor (BDNF) was analyzed …