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Full-Text Articles in Medicine and Health Sciences
Prenatal Cocaine Exposure Increases Synaptic Localization Of A Neuronal Rasgef, Grasp-1 Via Hyperphosphorylation Of Ampar Anchoring Protein, Grip, Kalindi Bakshi, Mary Kosciuk, Robert G. Nagele, Eitan Friedman, Hoau-Yan Wang
Prenatal Cocaine Exposure Increases Synaptic Localization Of A Neuronal Rasgef, Grasp-1 Via Hyperphosphorylation Of Ampar Anchoring Protein, Grip, Kalindi Bakshi, Mary Kosciuk, Robert G. Nagele, Eitan Friedman, Hoau-Yan Wang
Publications and Research
Prenatal cocaine exposure causes sustained phosphorylation of the synaptic anchoring protein, glutamate receptor interacting protein (GRIP1/2), preventing synaptic targeting of the GluR2/3-containing alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid-type glutamate receptors (AMPARs; J. Neurosci. 29: 6308–6319, 2009). Because overexpression of GRIP-associated neuronal rasGEF protein (GRASP-1) specifically reduces the synaptic targeting of AMPARs, we hypothesized that prenatal cocaine exposure enhances GRASP-1 synaptic membrane localization leading to hyper-activation of ras family proteins and heightened actin polymerization. Our results show a markedly increased GRIP1-associated GRASP-1 content with approximately 40% reduction in its rasGEF activity in frontal cortices (FCX) of 21-day-old (P21) prenatal cocaineexposed rats. This cocaine effect …
“What” And “Where” In Auditory Sensory Processing: A High-Density Electrical Mapping Study Of Distinct Neural Processes Underlying Sound Object Recognition And Sound Localization, Victoria M. Leavitt, Sophie Molholm, Manuel Gomez-Ramirez, John J. Foxe
“What” And “Where” In Auditory Sensory Processing: A High-Density Electrical Mapping Study Of Distinct Neural Processes Underlying Sound Object Recognition And Sound Localization, Victoria M. Leavitt, Sophie Molholm, Manuel Gomez-Ramirez, John J. Foxe
Publications and Research
Functionally distinct dorsal and ventral auditory pathways for sound localization (WHERE) and sound object recognition (WHAT) have been described in non-human primates. A handful of studies have explored differential processing within these streams in humans, with highly inconsistent findings. Stimuli employed have included simple tones, noise bursts, and speech sounds, with simulated left–right spatial manipulations, and in some cases participants were not required to actively discriminate the stimuli. Our contention is that these paradigms were not well suited to dissociating processing within the two streams. Our aim here was to determine how early in processing we …
Pulsed Out Of Awareness: Eeg Alpha Oscillations Represent A Pulsed-Inhibition Of Ongoing Cortical Processing, Kyle E. Mathewson, Alejandro Lleras, Diane M. Beck, Monica Fabiani, Tony Ro, Gabriele Gratton
Pulsed Out Of Awareness: Eeg Alpha Oscillations Represent A Pulsed-Inhibition Of Ongoing Cortical Processing, Kyle E. Mathewson, Alejandro Lleras, Diane M. Beck, Monica Fabiani, Tony Ro, Gabriele Gratton
Publications and Research
Alpha oscillations are ubiquitous in the brain, but their role in cortical processing remains a matter of debate. Recently, evidence has begun to accumulate in support of a role for alpha oscillations in attention selection and control. Here we first review evidence that 8–12 Hz oscillations in the brain have a general inhibitory role in cognitive processing, with an emphasis on their role in visual processing. Then, we summarize the evidence in support of our recent proposal that alpha represents a pulsed-inhibition of ongoing neural activity. The phase of the ongoing electroencephalography can influence evoked activity and subsequent processing, and …