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Full-Text Articles in Medicine and Health Sciences
Expression Of Matrix Metalloproteinase-1 In Knee Osteoarthritis: Association With Disease Severity, S Honsawek, J Poonphakdi, B Deepaisarnsakul, A Tanavalee, P Yuktanandana, S Ngarmukos, S. Tantavisut
Expression Of Matrix Metalloproteinase-1 In Knee Osteoarthritis: Association With Disease Severity, S Honsawek, J Poonphakdi, B Deepaisarnsakul, A Tanavalee, P Yuktanandana, S Ngarmukos, S. Tantavisut
Chulalongkorn Medical Journal
Background : Osteoarthritis (OA) is characterized by the progressive loss of articular cartilage and osteophyte formation resulting in pain, stiffness, reduced motion, swelling, crepitus, and disability. The aim of this study is to investigate plasma and synovial fluid matrix metalloproteinase-1 (MMP-1) levels of patients with primary knee OA and to examine their relationship with disease severity. Methods : Thirty-two patients aged 53 - 83 years old with knee OA and 10 healthy individuals were recruited into this study. Disease severity was determined using weight-bearing anteroposterior radiographs of the affected knee. The radiological grading of knee OA was performed according to …
Efficacy And Safety Of Diacerein In The Treatment Of Patients With Painful Knee Osteoarthritis: A Modified Regimen, P Yuktanandana, W. Suravech
Efficacy And Safety Of Diacerein In The Treatment Of Patients With Painful Knee Osteoarthritis: A Modified Regimen, P Yuktanandana, W. Suravech
Chulalongkorn Medical Journal
Background : Recent systematic meta-analyses provide evidence for the efficacy of diacerein 100 mg/day in the treatment of knee and hip osteoarthritis (OA). However, as diacerein may cause acceleration in intestinal transit time during the first 2 weeks of treatment, it is recommended to start with 50 mg/day for 4 weeks then increase the dose to 100 mg/day. However, no study has been performed on the treatment regimen. This study was conducted in order to assess the efficacy of diacerein according to the recommended regimen. Objective : To assess the efficacy and safety of diacerein in reducing pain and functional …