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Full-Text Articles in Medicine and Health Sciences
Acute And Chronic Toxicity Of Moringa Oleifera Linn Leaves Extracts, Songpol Chivapat, Pornchai Sincharoenpokai, Nalinphat Saktiyasuthorn, Aussavachai Shuaprom, Pratom Thongsrirak, Apirak Sakpetch, Anudep Rungsipipat
Acute And Chronic Toxicity Of Moringa Oleifera Linn Leaves Extracts, Songpol Chivapat, Pornchai Sincharoenpokai, Nalinphat Saktiyasuthorn, Aussavachai Shuaprom, Pratom Thongsrirak, Apirak Sakpetch, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
Moringa oleifera leaves have been reported to possess potential hypotensive and hypocholesterolemic andhypoglycemic activities; nevertheless toxicological data of this herb in animal models have still been scanty. Theobjective of this study was to evaluate both acute and chronic toxicity of the water extract of M. oleifera leaves by oraladministration. Acute toxicity test in mice by gavage with the extract twice, each at the dose of 10 g/kg, revealed thatthe extract produced no acute toxic symptoms and gross lesions of vital organs. Chronic toxicity study wasinvestigated in eighty Wistar rats allocated into four groups, each of ten per sex. Group 1 …
Chronic Toxicity Study Of Garcinia Mangostana Linn. Pericarp Extract, Songpol Chivapat, Pranee Chavalittumrong, Prapai Wongsinkongman, Chada Phisalpong, Anudep Rungsipipat
Chronic Toxicity Study Of Garcinia Mangostana Linn. Pericarp Extract, Songpol Chivapat, Pranee Chavalittumrong, Prapai Wongsinkongman, Chada Phisalpong, Anudep Rungsipipat
The Thai Journal of Veterinary Medicine
Ethanolic extracts from fruit pericarp of mangosteen (Garcinia mangostana L.) possess many biological andpharmacological activities. However, chronic toxicity study of ethanolic extract has never been investigated. Theobjective of this study was to evaluate the safety of 95% ethanolic extract from mangosteen pericarp in animal model.The oral administration of the extract was performed in 180 Wistar rats randomly allocated to six groups, each of15/sex. Group 1 was control group receiving distilled water. Group 2 to 6 were treatment groups receiving the extractat the doses of 10, 100, 500, 1000 and 1000 mg/kg/day for six months respectively. The last group was assigned …