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Investigation Of The Relationship Between Endometrial Mmp Activities And Sex Hormones In Mature Bitches, Wei-Yau Shia, Po-Chen Chu, Chih-Chung Chou, Wei-Ming Lee
Investigation Of The Relationship Between Endometrial Mmp Activities And Sex Hormones In Mature Bitches, Wei-Yau Shia, Po-Chen Chu, Chih-Chung Chou, Wei-Ming Lee
The Thai Journal of Veterinary Medicine
Endometrial matrix metalloproteinases (MMPs) are extensively studied in humans. However, owing to thedistinct differences of the estrous cycle of bitches, the expression and activities of endometrial MMPs regulated by sexhormones should be significantly different. To understand the effect of sex hormones on the activity of MMPs, thisstudy investigates the activities of endometrial MMP-2 and MMP-9 during different phases of the estrous cycle inbitches through the use of gelatine zymography. Estradiol and progesterone concentrations were also determinedusing enzyme-linked fluorescent assay. The activities of the latent forms of both MMP-2 and -9 were significantlyhigher in metestrus (MP) and late diestrus phases (L-DP) …
The Activity Of Plasma Matrix Metalloproteinase-9 As A Marker To Reflect The Tissue Level Of Mammary Glands Tumor In Dogs, Wei-Yau Shia, Shih-Ming Liu, Chun-Sheng Lee, Jian-Liang Lin, Chih-Chung Chou, Yumi Yuasa, Shih-Chieh Chang, Wei-Ming Lee
The Activity Of Plasma Matrix Metalloproteinase-9 As A Marker To Reflect The Tissue Level Of Mammary Glands Tumor In Dogs, Wei-Yau Shia, Shih-Ming Liu, Chun-Sheng Lee, Jian-Liang Lin, Chih-Chung Chou, Yumi Yuasa, Shih-Chieh Chang, Wei-Ming Lee
The Thai Journal of Veterinary Medicine
In order to understand the change of MMP-2 and MMP-9 in dogs with mammary gland tumor (MGT), theactivity of MMP-2 and MMP-9 in plasma samples, MGT tissues and near by normal mammary gland tissues wereevaluated by gelatin zymography. The levels of MMP-2 and MMP-9 were significantly higher in tumor tissues thanthose in normal gland tissues (p<0.05). Plasma MMP-9 levels in malignant cases were higher than those in benign(p=0.15) and non-tumor cases (p<0.05). Likewise, plasma MMP-2 levels in malignant MGT cases were higher thannon-tumor (p<0.01) and benign cases (p=0.54). Furthermore, plasma MMP-9 levels were reflected and positivelycorrelated with MMP-9 in tumor tissues (r=0.78, p=0.02), but not MMP-2. Our results indicated that the MMP-2 andMMP-9 levels are associated with tumor malignancy, and plasma MMP-9 activity can become a potential marker bothin follow-up and prognosis of canine MGT patients.