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The Level Of Transforming Growth Factor Beta As A Possible Predictor Of Cyclophosphamide Response In Children With Steroid-Resistant Nephrotic Syndrome, Ahmedz Widiasta, Kurnia Wahyudi, Yunia Sribudiani, Dedi Rachmadi
The Level Of Transforming Growth Factor Beta As A Possible Predictor Of Cyclophosphamide Response In Children With Steroid-Resistant Nephrotic Syndrome, Ahmedz Widiasta, Kurnia Wahyudi, Yunia Sribudiani, Dedi Rachmadi
BioMedicine
Background:Steroid-resistant nephrotic syndrome (SRNS) is a burden in the country due to the progressive severity of chronic kidney disease (CKD). Calcineurin inhibitors (CNIs) or monoclonal antibodies are currently recommended for the treatment of this disease. In developing countries, steroid and cyclophosphamide (CPA) are available drugs used during the treatment. This study aims to provide a non-invasive modality that can be used to predict the response of SRNS children to CPA therapy. Subsequently, the proteinuria duration was shortened to reduce the risk of glomerular damage.
Method:A prospective-cohort-study was conducted at Hasan Sadikin General Hospital Bandung, Indonesia. A total of …