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Interaction Of Hypothalamic GabaA And Excitatory Amino Acid Receptors Controlling Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco
Interaction Of Hypothalamic GabaA And Excitatory Amino Acid Receptors Controlling Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco
Scholarship and Professional Work – COPHS
We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to stress. The purpose of this study was to examine the role of excitatory amino acid (EAA) receptors in the DMH in generating the cardiovascular changes caused by withdrawal of local GABAergic inhibition in urethan-anesthetized rats. Local treatment of the DMH with the nonselective EAA antagonist kynurenic acid blocked or reversed the increases in heart rate and blood pressure caused by microinjection of the GABAA antagonists bicuculline methiodide (BMI) …
GabaA And Excitatory Amino Acid Receptors In Dorsomedial Hypothalamus And Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco
GabaA And Excitatory Amino Acid Receptors In Dorsomedial Hypothalamus And Heart Rate In Rats, Robert P. Soltis, Joseph A. Dimicco
Scholarship and Professional Work – COPHS
We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in emotional stress. The purpose of this study was to determine whether excitatory amino acids (EAAs) can produce a cardiovascular response similar to that caused by the GABAA receptor antagonist bicuculline methiodide (BMI) when microinjected at the same hypothalamic site in urethan-anesthetized rats and to clarify the precise locus of action of these agents. N-methyl-D-aspartic acid (NMDA, 0.68-6.8 pmol/50 nl) and kainic acid (KA, 0.47-4.7 pmol/50 nl) produced dose-related …