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Epistasis In Alzheimer’S Disease: Interactions Between Clu-Ms4a4e And Wwc1-Tln2, Omoremi Hamblin
Epistasis In Alzheimer’S Disease: Interactions Between Clu-Ms4a4e And Wwc1-Tln2, Omoremi Hamblin
Undergraduate Honors Theses
Alzheimer’s disease is the most common form of dementia among people age 65 and older. Because of the complexity of this disease, many studies have taken the epistatic approach to discover underlying genetic disorders. Epistasis is the study of gene-gene interaction in which the effects of one gene mask the effects of the other gene. In this study, we attempted to replicate two earlier studies that identified three gene-gene interactions. We used the 2019 Alzheimer’s Diseases Genetics Consortium (ADGC) dataset and we conducted a logistic regression with and without the interaction terms. The interactions we considered were between CLU rs11136000 …