Medicine and Health Sciences Commons^™

Rational Design Of 2,4-Disubstituted Quinazoline Small Molecules To Inhibit The Inflammatory Cytokine Oncostatin M, Riley Olsen

Boise State University Theses and Dissertations

Inflammation is one of the body's most important natural defense mechanisms involved in wound healing. It is usually triggered by a harmful event, such as physical trauma or exposure to external stimuli including bacteria, fungi, viruses, harmful chemicals, or environmental particulates. The inflammatory process brings blood containing inflammatory mediators consisting of leukocytes, hormones, and cytokines to the site of trauma to begin healing. However, the lack of a proper inflammatory response or an overactive response can lead to further progressive tissue damage resulting in chronic inflammatory conditions or death. The cytokine oncostatin M (OSM) is of particular interest due to …

Documenting Social Media Engagement As Scholarship: A New Model For Assessing Academic Accomplishment For The Health Professions, Kimberly D. Acquaviva, Josh Mugele, Natasha Abadilla, Tyler Adamson, Samantha L. Bernstein, Rakhee K. Bhayani, Annina Elisabeth Büchi, Darcy Burbage, Christopher L. Carroll, Samantha P. Davis, Natasha Dhawan, Alice Eaton, Kim English, Jennifer T. Grier, Mary K. Gurney, Emily S. Hahn, Heather Haq, Brendan Huang, Shikha Jain, Jin Jun, Wesley T. Kerr, Timothy Keyes, Amelia R. Kirby, Marion Leary, Mollie Marr, Ajay Major, Jason V. Meisel, Erika A. Petersen, Barak Raguan, Allison Rhodes, Deborah D. Rupert, Nadia A. Sam-Agudu, Naledi Saul, Jarna R. Shah, Lisa Kennedy Sheldon, Christian T. Sinclair, Kerry Spencer, Natalie H. Strand, Carl G. Streed Jr., Avery M. Trudell

Respiratory Therapy Faculty Publications and Presentations

Background: The traditional model of promotion and tenure in the health professions relies heavily on formal scholarship through teaching, research, and service. Institutions consider how much weight to give activities in each of these areas and determine a threshold for advancement. With the emergence of social media, scholars can engage wider audiences in creative ways and have a broader impact. Conventional metrics like the h-index do not account for social media impact. Social media engagement is poorly represented in most curricula vitae (CV) and therefore is undervalued in promotion and tenure reviews.

Objective: The objective was to develop crowdsourced guidelines …

Reaching Out Handbook, Boise State University

Rebuilding the Launchpad: Serving Students During Covid Resource Library

The Reaching Out Handbook has been created for the purpose of providing you with information about Counseling Services, about other campus resources, and how to most effectively assist individuals in distress.

Our goal is to help you recognize some of the symptoms of individual distress, as well as provide some specific options for intervention and for referral to campus resources. We are available to assist you with problem situations and to consult with you on whether to intervene with a particular individual and when to refer.

Guidelines are offered but each individual will need to consider what is appropriate in …

Influence Of Woodsmoke Exposure On Molecular Mechanisms Underlying Alzheimer’S Disease: Existing Literature And Gaps In Our Understanding, Adam Schuller, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

Woodsmoke poses a significant health risk as a growing component of ambient air pollution in the United States. While there is a long history of association between woodsmoke exposure and diseases of the respiratory, circulatory, and cardiovascular systems, recent evidence has linked woodsmoke exposure to cognitive dysfunction, including Alzheimer’s disease dementia. Alzheimer’s disease is a progressive neurodegenerative disorder with largely idiopathic origins and no known cure. Here, we explore the growing body of literature which relates woodsmoke-generated and ambient air pollution particulate matter exposure to Alzheimer’s disease (AD) onset or exacerbation, in the context of an inflammation-centric view of AD. …

Smoke From Wildfires Can Worsen Covid-19 Risk, Putting Firefighters In Even More Danger, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

Two forces of nature are colliding in the western United States, and wildland firefighters are caught in the middle.

Emerging research suggests that the smoke firefighters breathe on the front lines of wildfires is putting them at greater risk from the new coronavirus, with potentially lethal effects.

At the same time, firefighting conditions make precautions such as social distancing and hand-washing difficult, increasing the chance that, once the virus enters a fire camp, it could quickly spread.

As an environmental toxicologist, I have spent the last decade expanding our understanding of how wood smoke exposure impacts human health. Much of …

Caring For Vulnerable Populations During A Pandemic: Literature Review, Jennifer L. Marsh, Marilyn O'Mallon, Steven Stockdale, Danita R. Potter

Nursing Faculty Publications and Presentations

Vulnerable populations account for a substantial proportion of the United States population. The current COVID-19 pandemic has highlighted the elderly and those with underlying health issues as having the highest risk of mortality. This literature review utilizes a matrix approach to explore the challenges to providing care for the vulnerable elderly, those with underlying health issues, with disabilities, with low income or homelessness, and those with mental health concerns in these extreme times. Appropriate care for vulnerable populations in times of crisis requires focus and planning in critical areas. This article discusses the critical areas of communications and trust, policies …

Neonatal Lead (Pb) Exposure And Dna Methylation Profiles In Dried Bloodspots, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

Lead (Pb) exposure remains a major concern in the United States (US) and around the world, even following the removal of Pb from gasoline and other products. Environmental Pb exposures from aging infrastructure and housing stock are of particular concern to pregnant women, children, and other vulnerable populations. Exposures during sensitive periods of development are known to influence epigenetic modifications which are thought to be one mechanism of the Developmental Origins of Health and Disease (DOHaD) paradigm. To gain insights into early life Pb exposure-induced health risks, we leveraged neonatal dried bloodspots in a cohort of children from Michigan, US …

What’S In Wildfire Smoke, And Why Is It So Bad For Your Lungs?, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

If I dare to give the coronavirus credit for anything, I would say it has made people more conscious of the air they breathe.

A friend texted me recently after going for a jog in the foothills near Boise, Idaho, writing: “My lungs are burning … explain what’s happening!!!”

A wildfire was burning to the east of town – one of hundreds of fires that were sending smoke and ash through communities in hot, dry western states. As an environmental toxicologist, I research how air pollution, particularly wood smoke, impacts human health and disease.

Decellularization Of Porcine Cartilage Promotes Chondrogenic Differentiation Of Human Chondrocytes, Roxanne Nicole Stone

Boise State University Theses and Dissertations

Knee osteoarthritis (knee OA) is the most common type of osteoarthritis (OA) and accounts for 70% of arthritis-related hospital admissions and 23% of clinical visits. Major limitations in both the current non-surgical and surgical methods are that they only relieve pain and show no evidence for restoring natural tissue anatomy. Leaders in the field propose that a stem cell treatment approach holds promise for the regeneration of a greater proportion of hyaline-like tissue at the repair site. (Cross et al., 2014; Escobar Ivirico, Bhattacharjee, Kuyinu, Nair, & Laurencin, 2017; Helmick et al., 2008; Toh, Foldager, Pei, & Hui, 2014).

It …

Countermovement Jump Assessment For Monitoring Prolonged Fatigue In Collegiate Female Soccer Players, Jeffrey A. Wilkins

Boise State University Theses and Dissertations

Introduction: Females are 4 to 6 times more likely to sustain an anterior cruciate ligament (ACL) injury than their male counterparts during running and cutting sports, such as soccer. This sex disparity is thought to result from altered lower limb neuromuscular control that females present when fatigued at the end of practice or games. Yet, current fatigue monitoring techniques typically vary in their reliability, applicability and efficiency. Purpose: The purpose of this study is to test the feasibility of the countermovement jump (CMJ) to quickly and reliably monitor fatigue in female soccer athletes. Methods: Twenty-two (age: 19.3 ± 1.1 yrs, …

Agricultural Workplace Compliance With The Environmental Protection Agency's Worker Protection Standard: An Idaho Analysis, Rachel Phinney

Boise State University Theses and Dissertations

Agricultural workers are at high risk for occupational pesticide exposure and pesticide-related illness. The Worker Protection Standard (WPS) is the primary federal regulation aimed at reducing pesticide exposure among agricultural workers. Agricultural employers are responsible for complying with the nearly 100 WPS requirements, including the provision of pesticide safety training, personal-protective equipment, and decontamination supplies to employees.

Despite the potential health implications of WPS violations, information is limited regarding compliance levels in Idaho. We aim to fill this gap by describing compliance trends according to WPS inspection results archived by the Idaho State Department of Agriculture (ISDA). We analyzed 557 …

Communication In Healthcare Settings: Access And Barriers To Care Experienced By Deaf Patients, Elizabeth Schniedewind

Boise State University Theses and Dissertations

Deaf persons who use American Sign Language (ASL) as their primary form of communication are members of a cultural and linguistic minority that experiences significant health disparities yet are not recognized as a health disparity population by the National Institutes of Health. Studies have reported ineffective communication in healthcare interactions and reduced access to care experienced by Deaf patients. Requests for sign language interpreters in healthcare encounters are frequently denied, despite federal mandates to provide effective communication. Comprised of three articles, this dissertation investigates the diminished access to communication in healthcare settings experienced by Deaf patients and qualitative research methods …

No Longer Expert: A Meta-Synthesis Describing The Transition From Clinician To Academic, Jane S. Grassley, Pamela K. Strohfus, Andrea C. Lambe

Nursing Faculty Publications and Presentations

Background: Recruitment of nurse clinicians into academic nursing has been important in addressing the faculty shortage. A description of their experiences as novice faculty could provide insights into easing their transition and improving faculty retention. Method: A systematic review of existing qualitative evidence was conducted to describe how nurses experience the transition from clinical practice to nursing academic. Criteria established by the Joanna Briggs Institute guided the review. Results: The meta-synthesis of the 12 selected qualitative studies yielded 11 themes and four meta-themes, which included: Unprepared, No Longer an Expert, In Search of Mentoring, and Beginning to Thrive. Conclusion: The …

Boise State University Reintegration Guide, Boise State University

Rebuilding the Launchpad: Serving Students During Covid Resource Library

The Boise State University Reintegration Committee (“Committee”) is charged by President Marlene Tromp with recommending and advising when and under what conditions the university can reintegrate, or resume, in whole or part, in-person operations.

The Committee is chaired by Chief of Staff & Vice President for Compliance, Legal and Audit, Alicia Estey, JD, MPH, and has eleven additional members. The group meets regularly to review relevant research, modeling, clinical data and other inputs from respected sources that can help inform integrated and aligned recommendations, including recommendations from various work groups and subcommittees supporting reintegration. Through Chief of Staff and VP …

Cancer Rates Not Explained By Smoking: A County-Level Analysis, Douglas J. Myers, Polly Hoppin, Molly Jacobs, Richard Clapp, David Kriebel

Public Health and Population Science Faculty Publications and Presentations

Background: Debates over the importance of “lifestyle” versus “environment” contributions to cancer have been going on for over 40 years. While it is clear that cigarette smoking is the most significant cancer risk factor, the contributions of occupational and environmental carcinogens in air, water and food remain controversial. In practice, most cancer prevention messaging focuses on reducing cigarette smoking and changing other personal behaviors with little mention of environmental chemicals, despite widespread exposure to many known carcinogens. To inform decision-making on cancer prevention priorities, we evaluated the potential impact of smoking cessation on cancer rates.

Methods: Using cancer …

Self-Reported Eating Disorder Risk In Lean And Non-Lean Ncaa Collegiate Athletes, Anna Holdiman Mcdonald, Mary Pritchard, Mary Kate Mcguire

Psychological Sciences Faculty Publications and Presentations

Purpose The purpose of this present study was to examine gender differences in overall scores on the Eating Attitudes Test (EAT-26) in National Collegiate Athletic Association (NCAA) college athletes in “lean” sports versus “non-lean” sports.

Methods Using a self-report survey design, this study examined eating disorder risk in 121 NCAA college athletes, using the EAT-26. We expected that female athletes and athletes in “lean” sports would report higher scores on the EAT-26.

Results There was a significant effect of sport type (lean vs. non-lean) on eating attitudes and behaviors, with those in non-lean sports reporting higher scores, on average, on …

A Perspective On The Development Of Hemispheric Specialization, Infant Handedness, And Cerebral Palsy, Claudio L. Ferre, Iryna Babik, George F. Michel

Psychological Sciences Faculty Publications and Presentations

Cerebral Palsy (CP), a common form of neurological pediatric disability, results from pre- or perinatal brain injury. Although there is growing evidence of the efficacy of motor learning-based therapies, several factors interact to produce variability in impairment and limit the effectiveness of these therapies. The variability of hand function present in children with CP indicates that a range of developmental pathways must contribute to the manifestation of individually unique characteristics of impairment. Despite two decades of progress using therapies derived from understanding the mechanisms controlling hand function, very little is known about the sensorimotor experiences occurring during development that likely …

A Quality Improvement Pilot To Reduce Caregiver Burden In Caregivers Of Hematopoietic Stem Cell Transplant (Hsct) Patients In A Hsct Program In The Northwest, Jody Acheson

Doctor of Nursing Practice Projects

Background: Hematopoietic stem cell transplant (HSCT) is an intensive and complex treatment for certain blood cancers. Caregivers are required for patients receiving this treatment. Caregivers frequently experience caregiver burden. Providing an intervention to alleviate caregiver burden can positively impact patient and caregiver health outcomes.

Project Design: The following was the project design: 1) review the literature to understand the best practices to prevent caregiver burden for caregivers of patients undergoing HSCT, 2) development a pilot quality improvement program based on the evidence, 3) implementation of the pilot, and 4) obtaining feedback from facilitators and participants to optimize intervention for ongoing …

Implementing A Health Promotion Physical Activity Program For Middle School Youth In A Rural, Faith-Based Organization, Karmin Maher-Hasse

Doctor of Nursing Practice Projects

Problem: Childhood obesity is more prevalent in rural areas, and these areas have fewer resources to address it. Geographic distance to available resources, health care provider shortages, parental obesity, and poverty contribute to higher prevalence of obesity in rural children compared to urban children.

Rationale: Obesity prevention and treatment often requires long-term healthy lifestyle behavior changes including nutrition counseling and physical activity (PA). It is likely an obese pre-adolescent will have obesity as an adult, and the likelihood increases if obesity continues into adolescence. Pre-adolescence provides a window of opportunity to influence healthier PA habits to prevent overweight (OW) and …

Analyzing Change-Of-Direction And The Laterally Resisted Split Squat: Incorporating A Lateral Vector Into The Single Leg Squat, Derek Maddy

Boise State University Theses and Dissertations

Improving change of direction (COD) with the use of strength training has led to mixed results. To date, the modified single leg squat (MSLS) and the bilateral squat (BS) have been successfully used to improve COD, with equal improvement. COD is primarily performed at a 45-75° frontal plane angle; however, the MSLS and BS are performed at a 90° frontal plane angle. Based on the force vector theory, it is proposed that a more mechanically similar strength training exercise, the Laterally Resisted Split Squat (LRSS), be used. The purpose of this study is to compare COD with the LRSS, MSLS, …

Influence Of Provider Characteristics On Opioid Prescribing Behavior Among Idaho Veterinarians, Tara A. Jones

Boise State University Theses and Dissertations

Opioid addiction and misuse have become widespread in the U.S. over the past decade, causing a rise in opioid related mortality. High opioid prescribing rates have led public health agencies to examine provider prescribing practices. Research has identified provider characteristics such as gender, age, and years of experience are predictive of opioid prescribing in human medical providers. Veterinarians are frequently licensed to prescribe opioids, yet less is known about the prescribing practices of veterinarians. From a public health perspective, it is important to explore the potential connection between veterinary medicine and the opioid epidemic. The current study assessed whether variations …

The Presence Of Legionellae In Respiratory Devices: Convenience Sampling Of Idaho Long Term Care Facilities, Andrew Nutting

Boise State University Theses and Dissertations

Legionella is a bacterium found naturally in moist environments. Persons can become infected when they inhale airborne droplets of water containing such bacteria. Legionellosis cases associated with the use of respiratory devices such as Continuous Positive Airway Pressure (CPAP) units, jet nebulizers, portable room humidifiers, and respiratory ventilation equipment have been identified in context of a Legionellosis outbreak. However, a systematic search for the presence of Legionella bacteria in respiratory devices outside of a Legionellosis outbreak has not been reported. The goal of this study was to carry out such a survey on different types of respiratory devices in long …

Change In Muscle Stiffness Using Shear Wave Elastography, Range Of Motion, And Perceived Pain Following A Cupping Therapy Treatment In Physically Active Adults, Molly Mccullough

Boise State University Theses and Dissertations

Introduction- Cupping therapy originated in Eastern medicine practices, became renowned in international sports, and is now utilized as a therapeutic device for treating musculoskeletal issues in a wide variety of physically active individuals. As with any modality, there is a question of efficacy. This study focused on the effect of cupping therapy on muscle stiffness (MS), active dorsiflexion (DF), and perceived pain. Purpose- The purpose of this study was to examine changes in MS, active DF, and perceived pain on the medial gastrocnemius following a cupping therapy treatment. Methods- Twenty physically active, healthy participants completed an exercise protocol to induce …

A Faith-Based Quality Improvement Project To Increase Awareness, Prevention, And Management Of Coronary Heart Disease In African Immigrants, Temitope S. Okpebho

Doctor of Nursing Practice Projects

Problem Description: Coronary heart disease (CHD) affects people globally, and it is the leading cause of death in the United States. Despite increased CHD awareness, evidence shows the increased prevalence and low CHD awareness among African Immigrants. According to Boateng et al. (2017), African immigrants are more likely to have CHD risk factors and be unaware. This may be due to changes in eating habits, lack of physical activity, increased stress level, and the adaptation of the Western diet.

Rationale: This project included implementing a culture care theory in a faith-based organization to increase awareness, management, and prevention of CHD …

The Influence Of Undergraduate Research Assistant Experiences On Future Nursing Roles, Kelsy Mitchell, Julie Rekiere, Jane S. Grassley

Nursing Faculty Publications and Presentations

Undergraduate nursing students have difficulty comprehending the relevance of research to their future as nurses. Working as an undergraduate research assistant may provide opportunities to develop an appreciation of research. The purpose of this study was to explore former undergraduate research assistants' perceptions of their experience and its effects on their practice as professional nurses. This study used a qualitative descriptive design. Seven former undergraduate research assistants were interviewed. Interview transcripts were analyzed for themes using content analysis. Data analysis yielded three main themes: immersion in the research process, empowered to practice evidence-based nursing, and future …

Using The Fitness Challenge To Teach The Principles Of Conditioning And Improve Campus Physical Activity, Shawn R. Simonson

Kinesiology Faculty Publications and Presentations

The goal of KINES 432 Conditioning Procedures is for students to develop the skills to appropriately prescribe exercise and conditioning that will enhance the student’s ability as a practitioner to help others improve conditioning and achieve their health, fitness, and performance goals. The focus is on program objectives, planning, exercise analysis, and prescription as well as the supporting theories, rationale, and research. Application of concepts occurs via projects, service-learning and laboratory experiences. KINES 432 is also designated a university Finishing Foundations course. Boise State University’s Foundational Studies Program provides undergraduates with a broad-based education that spans the entire university experience. …

Coronavirus Closes In On Rohingya Refugees In Bangladesh’S Cramped, Unprepared Camps, Saleh Ahmed

University Author Recognition Bibliography: 2020

Coronavirus is spreading quickly in densely populated Bangladesh, despite a nationwide shutdown put in place a month ago.

This preventive measure has proven challenging to implement due to lack of awareness of the coronavirus and the absence of a social safety net. Extreme poverty also forces many Bangladeshis to keep working and looking for food despite the risks. Bangladesh had 2,948 confirmed COVID-19 cases as of April 20.

The disease has not yet spread into the refugee camps that house the Rohingya Muslims who fled ethnic violence in Myanmar in 2017, according to a recent update from the humanitarian organizations …

Wildfire Smoke Worsens Coronavirus Risk, Putting Firefighters In Extra Danger, Luke Montrose

Public Health and Population Science Faculty Publications and Presentations

As summer approaches, two forces of nature are on a collision course, and wildland firefighters will be caught in the middle.

New research suggests that the smoke firefighters breathe on the front lines of wildfires is putting them at greater risk from the new coronavirus, with potentially lethal effects.

At the same time, firefighting conditions make precautions such as social distancing and hand-washing difficult, increasing the chance that, once the virus enters a fire camp, it could quickly spread.

As an environmental toxicologist, I have spent the last decade expanding our understanding of how wood smoke exposure impacts human health. …

Implementation Of Peer Support And Shared Decision-Making Aids For The Transcatheter Aortic Valve Replacement Population, Kimberlee Einfeld

Doctor of Nursing Practice Projects

Background: Patients at a community hospital verbalized fear, stress and anxiety about transcatheter aortic valve replacement (TAVR). Patients with aortic stenosis eligible for TAVR may experience low self-efficacy and anxiety while considering valve replacement which may lead to poor quality of life, interfere with understanding information from medical providers, and other health complications.

Methods: All patients eligible for TAVR between June and August of 2019 were invited to participate in a pilot project using peer support and use of shared decision-making (SDM) aids. Former TAVR patients were trained to be Mended Hearts TAVR peer volunteers. Participants were connected by telephone …

Reducing Pressure Injuries In The Intensive Care Setting: Nursing Knowledge And Best Practices Approach, Michelle Harvey

Doctor of Nursing Practice Projects

Background: For many health care organizations, pressure injury (PI) prevention strategies have become a priority focus to improve patient outcomes and associated costs.

Problem: A rural community hospital located in the Eastern U.S. experienced an increase in hospital acquired pressure injuries (HAPIs), predominantly in the intensive care unit (ICU). In 2018, 17.4% of HAPIs occurred in the ICU.

Approach: Implementation of a Quality Improvement project in an adult ICU, providing education and on-going learning activities to nursing staff, and applying a standardized plan of care “bundle” for prevention interventions.

Outcomes: The approach resulted in improved documentation of flotation of heels, …