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Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
The Various Nervous System Drugs Commonly Used For Treatment And The Disparities In Availability Of These Drugs In Minority Groups, Iman Haurami
Honors Scholars Collaborative Projects
The nervous system is a complex network in our body that is responsible for actions, reflexes, and even sensations. With the brain being part of the CNS, many common nervous system disorders are due to a defect in the central nervous system and the functions of this organ. These disorders include mental health problems, degenerative diseases, seizures, infections, and other possible genetic diseases. Many of these diseases are common in society and constantly researched. Even though these diseases are common, treatment accessibility and effects on people of minority groups are overlooked compared to the focus on majority groups. For drug …
Awareness Of Racial Disparities In Healthcare: An Analysis Of Undergraduate Science Students’ Perceptions, Liz Bleyer
Awareness Of Racial Disparities In Healthcare: An Analysis Of Undergraduate Science Students’ Perceptions, Liz Bleyer
Honors Scholars Collaborative Projects
General and systemic racial inequalities, including slavery, mass incarceration, and health disparities, have existed throughout the history of the United States. Recent public health issues, specifically the COVID-19 pandemic, have shed light on enduring health disparities, including the disproportionate impact on black communities and other racial minorities. A crucial first step towards a more equitable healthcare system is increasing general awareness of the presence and effects of racial disparities. Previous research has quantified and described the awareness of racial disparities in healthcare practitioners, including medical students and practicing physicians, but little research has been dedicated to understanding the perspectives of …
Investigating The Efficacy Of Tazemetosttat For In Vitro Treatment Of Human Triple Negative Breast Cancer Cells, Harshita Indukuri
Investigating The Efficacy Of Tazemetosttat For In Vitro Treatment Of Human Triple Negative Breast Cancer Cells, Harshita Indukuri
Honors Scholars Collaborative Projects
Cancer is a formidable, genetic disease that affects many people, either directly or indirectly. Breast cancer is the most commonly diagnosed cancer worldwide (31). Triple-negative breast cancer (TNBC) is a type of breast cancer that has a higher lethality compared to other breast cancers and has a poor prognosis due to its highly invasive nature and limited treatment options. Finding safe, effective, and accessible treatment for TNBC is integral to treating TNBC patients. Tazemetostat is an EZH2-inhibitor that has recently been approved for use in epithelioid sarcoma (23). EZH2 is an overexpressed protein in many cancers, including TNBC (11). However, …
The Effect Of Twist1b And Twist2 Knockdown On Tgf-Beta Signaling Expression In Tendon Progenitors, Marinia N. Bishay
The Effect Of Twist1b And Twist2 Knockdown On Tgf-Beta Signaling Expression In Tendon Progenitors, Marinia N. Bishay
Honors Scholars Collaborative Projects
Somites are important mesoderm structures that form in regularly timed intervals from the anterior end of the paraxial mesoderm at the end of gastrulation during embryogenesis. Cells of the ventromedial portion of the somite, the sclerotome, undergo epithelial to mesenchymal transition, surround the notochord, and give rise to connective tissues of the axial skeleton including the vertebrae, tendons, and ligaments. We are interested in understanding how the sclerotome is compartmentalized into the region that makes tendons. Genes expressed in the sclerotome, twist1 and twist2, are likely involved in the downstream differentiation of sclerotome to tendon progenitors. Previous studies have shown …
The Interconnectivity Of Parkinson's Disease And Type Two Diabetes Mellitus, Erica Olfson
The Interconnectivity Of Parkinson's Disease And Type Two Diabetes Mellitus, Erica Olfson
Honors Scholars Collaborative Projects
This thesis is about the biochemical connection between Parkinson's disease and Type II Diabetes Mellitus.
A Literary Analysis Of The Origin Of Human Embryonic Stem Cells, Its Advancements, Philosophical, Ethical, Sociocultural, And Political Aspects; An Investigation Of The Underlying Attributes That Affect One’S Views On Hesc Research To Resolve Turkey And Brazil’S Hesc Policy, Religious, And Cultural Conflicts, Haleema Shamsuddin
Honors Scholars Collaborative Projects
Human embryonic stem cells (hESCs) are cells derived from 5-day human embryos and are self-renewing cell lines that change into any type of cell in the body, a trait called pluripotency. hESCs have almost unlimited clinical and medical research potential. Despite the great therapeutic promise of hESC research, it comes with a controversial ethical debate due to its involvement with the destruction of the human embryo. The central argument revolves around the question of whether or not these human embryos should be ascribed equal moral status to fully developed humans. This thesis aims to analyze the origin and advancements of …
Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence
Selinexor Hyperactivates Akt And Induces Its Nuclear Accumulation, Erin Lawrence
Honors Scholars Collaborative Projects
Selinexor is currently being used in several clinical trials for cancer and has shown anti-cancer effects in combination with other chemotherapies. Clinical trials evaluating the use of selinexor in the treatment of triple negative breast cancer are limited, but in vitro studies show promising results in its ability to kill triple negative breast cancer cells. The mechanism by which this occurs, however, is not understood. The goal of this research was to determine the mechanism by which selinexor kills BT- 549 triple negative breast cancer cells.
Unnatural Disasters: Environmental Trauma And Ecofeminist/Ecowomanist Resistance In Zora Neale Hurston’S Their Eyes Were Watching God And Jesmyn Ward’S Salvage The Bones, Sarah Anne Pfitzer
Unnatural Disasters: Environmental Trauma And Ecofeminist/Ecowomanist Resistance In Zora Neale Hurston’S Their Eyes Were Watching God And Jesmyn Ward’S Salvage The Bones, Sarah Anne Pfitzer
Honors Scholars Collaborative Projects
No abstract provided.
Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles
Effect Of Amodiaquine On Gene Expression And Apoptosis In Colorectal Cancer Cells, Holly Pyles
Honors Scholars Collaborative Projects
This study used gene expression analysis to explore the specific response to amodiaquine in HCT116 colorectal cancer cells. Real-time PCR revealed that 20 human stress and toxicity genes were upregulated by at least 3 fold in HCT116 colorectal cancer cells treated with AMQ. Of these 20 upregulated genes, 9 were found to be pro-apoptotic and 2 were DNA damage repair genes, which supports our original hypothesis that amodiaquine is inducing a stress response in these cells. These results are consistent with previous research done by Qiao et al. (2013), as DNA damage repair genes were among the genes upregulated in …
The Effects Of Language Barriers With Hispanic Patients In The Nashville, Rachel Poston
The Effects Of Language Barriers With Hispanic Patients In The Nashville, Rachel Poston
Honors Scholars Collaborative Projects
The existence of language barriers in the health care setting is a vital topic of study. This study assesses language barriers from the perspective of nurse-patient relationships, focusing on the Hispanic patient population in the Nashville, Tennessee area. A survey was designed using the Theory of Bureaucratic Caring by Marilyn Ray (2006) to investigate the current success, according to nursing perspectives, of healthcare facilities support of Hispanic patients to ensure quality outcomes and comprehension of care. The research design for this study was a non-experimental, descriptive study using a cross-sectional survey. The researcher used themes from the Theory of Bureaucratic …
Sleep Deprivation And High-Fat Diet During Adolescence Protect Stress Effects On Object Memory During Adulthood, Karina Glushchak
Sleep Deprivation And High-Fat Diet During Adolescence Protect Stress Effects On Object Memory During Adulthood, Karina Glushchak
Honors Scholars Collaborative Projects
No abstract provided.