Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- CVT (2)
- Cerebral Venous (2)
- MRI (2)
- Thrombosis (2)
- Amnesia (1)
-
- Angiography (1)
- Antituberculous therapy (1)
- Asian (1)
- Botulinum (1)
- Brain tumor (1)
- Cancer stem cell (1)
- Cerebral Venous Thrombosis (1)
- Cerebral palsy (1)
- Cholesterol (1)
- Countries (1)
- Dengue (1)
- Dopamine (1)
- Emergency room (1)
- Encephalitis (1)
- Epidemiology (1)
- Guidelines (1)
- Haemodynamic (1)
- Haemoglobin (1)
- Haemorrhage (1)
- Hemi-necklace bruise (1)
- Heparin; cerebral venous thrombosis. (1)
- Incidence; epidemiology; cerebral venous thrombosis. (1)
- Infectious disease (1)
- Isolated Deep Venous Thrombosis; (1)
- Local thrombolytic (1)
- Publication
- Publication Type
Articles 1 - 30 of 42
Full-Text Articles in Medicine and Health Sciences
Narcotic Analgesics For Acute Migraine In The Emergency Room: Are We Meeting Headache Societies' Guidelines?, Mohammad Wasay, Khawaja Slaman Zaki, Saqib Uddin Khan, Rifat Rehmani
Narcotic Analgesics For Acute Migraine In The Emergency Room: Are We Meeting Headache Societies' Guidelines?, Mohammad Wasay, Khawaja Slaman Zaki, Saqib Uddin Khan, Rifat Rehmani
Department of Emergency Medicine
We analysed 161 patients with acute migraine in our emergency room (ER) to identify the use of narcotic analgesics as first-line treatment. Twenty-four percent of patients were treated with opioid analgesics and 76% patients were treated with non-opioid analgesics. Pain was completely relieved in 100 (62%) patients, partially relieved in 50 (31%) patients and was not relieved in 11 (7%) patients at the time of discharge. Pain relief was not related to the use of opioids vs. non-opioids. The treatment of acute migraine in our ER is in line with the guidelines of the Headache Societies and needs further improvement.
Towards A Cure For Traumatic Paraplegia - Is There Cause For Hope?, Rashid Jooma
Towards A Cure For Traumatic Paraplegia - Is There Cause For Hope?, Rashid Jooma
Section of Neurosurgery
In the past decade, great strides have been made in the field of CNS tissue repair and expectations have been raised that a cure of spinal paralysis is at hand. The two broad categories of investigational approaches to spinal regeneration are: (1) Enhancing the Regenerative Milieu of the Cord and (2) Cellular and Tissue Transplantation. Amongst the latter approaches, the early use of foetal cord tissue has given way to the more sophisticated studies on stem cell therapy and the implants of olfactory ensheating cells. These have engendered considerable public interest and are being offered as commercially available therapies in …
The Future Of National Medical Journals, Kamran Abbasi
The Future Of National Medical Journals, Kamran Abbasi
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Presentation And Features Of Conversion Disorder At A Tertiary Care Hospital In Karachi, Sameer Khan, Abdullah Ladha, Sarah Khalid Khan, Sana Farooq Khan, Awais Amjad Malik, Zehra Memon, Samiullah Ghulam Nabi, Hafiz Yasir Adnan, Haider Ali Naqvi
Presentation And Features Of Conversion Disorder At A Tertiary Care Hospital In Karachi, Sameer Khan, Abdullah Ladha, Sarah Khalid Khan, Sana Farooq Khan, Awais Amjad Malik, Zehra Memon, Samiullah Ghulam Nabi, Hafiz Yasir Adnan, Haider Ali Naqvi
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Epilepsy And Crohn's Disease, Muhammad Shazam Hussain, S. Nizam Ahmed
Epilepsy And Crohn's Disease, Muhammad Shazam Hussain, S. Nizam Ahmed
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Hyperhomocysteinemia And Cerebralvenoussinus Thrombosis, Mughis Sheerani, Bhojo A. Khealani
Hyperhomocysteinemia And Cerebralvenoussinus Thrombosis, Mughis Sheerani, Bhojo A. Khealani
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Current Approach To Primary Central Nervous System Lymphoma, Amar Lal, Nehal Masood
Current Approach To Primary Central Nervous System Lymphoma, Amar Lal, Nehal Masood
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Treatment Of Spinal Tuberculosis: Role Of Surgical Intervention, Syed Ather Enam, Ahmed Ali Shah
Treatment Of Spinal Tuberculosis: Role Of Surgical Intervention, Syed Ather Enam, Ahmed Ali Shah
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Psychiatry, Syed Ahmer
Psychiatry, Syed Ahmer
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Neuroradiology, Zafar Sajjad
Neuroradiology, Zafar Sajjad
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Incidence And Epidemiology Of Cerebral Venous Thrombosis., Fazeel Mukhtar Siddiqui, Ayeesha Kamran Kamal
Incidence And Epidemiology Of Cerebral Venous Thrombosis., Fazeel Mukhtar Siddiqui, Ayeesha Kamran Kamal
Department of Medicine
Cerebral venous sinus thrombosis is a disorder whose epidemiology has changed over the past few decades. It is no longer regarded as a uniformly fatal disease. CVST is not a rare disorder. It may have a differential geographic distribution with a higher incidence in the Asian world. It is a disease of neonates, younger women and men, often a hypercoagulable state, either acquired (e.g., cancer) or a genetic prothrombotic condition may be present. Outcome is not uniformly dismal and prognostic criteria that detect patients with a poor outcome have become available from prospective studies. There is a paucity of well …
Cerebral Venous Thrombosis: Recent Advances And Need For An Asian Registry, Mohammad Wasay, Ayeesha K. Kamal
Cerebral Venous Thrombosis: Recent Advances And Need For An Asian Registry, Mohammad Wasay, Ayeesha K. Kamal
Department of Medicine
No abstract provided.
Isolated Deep Venous Thrombosis--Case Series, Literature Review And Long Term Follow Up., Ayeesha Kamran Kamal, Ahmed Itrat, Sana Shoukat, Asumal Khealani, Kamran Kamal
Isolated Deep Venous Thrombosis--Case Series, Literature Review And Long Term Follow Up., Ayeesha Kamran Kamal, Ahmed Itrat, Sana Shoukat, Asumal Khealani, Kamran Kamal
Department of Medicine
Cerebral Venous Sinus thrombosis may rarely be isolated to a cortical vein or to the deep venous system. When the deep venous system is involved, prognosis is generally poor. In addition, long term follow up is not reported. We conducted a retrospective review of all patients admitted to a major tertiary care center, with the diagnosis of isolated deep venous thrombosis. Two patients were identified with isolated involvement of the deep venous system, they are reviewed in detail with long term follow up. Two young South Asian women in their thirties with rapid onset of neurologic signs and symptoms are …
Thrombolytic Therapy In Cerebral Venous Sinus Thrombosis., Ayeesha Kamran Kamal
Thrombolytic Therapy In Cerebral Venous Sinus Thrombosis., Ayeesha Kamran Kamal
Department of Medicine
The use of thrombolytic agents to rapidly lyse the clot has emerged as a therapeutic modality, in concert with interventional neuroradiologic approaches to deliver the agent locally at the site of thrombosis. There are no randomized, double blind, placebo, controlled trials to support thrombolysis as a first line therapy in patients with cerebral venous sinus thrombosis compared to standard therapy using anticoagulation with weight based dose adjusted unfractionated Heparin. Numerous case reports and a single non randomized trial have shown that it is comparatively safe and may rescue patients who are deteriorating despite anticoagulation with unfractionated Heparin. Consideration must be …
Mechanism Of Neuronal Injury In Cerebral Venous Thrombosis, Uzma Usman, Mohammad Wasay
Mechanism Of Neuronal Injury In Cerebral Venous Thrombosis, Uzma Usman, Mohammad Wasay
Department of Medicine
The impact of CVT on the brain is wide spectrum, ranging from completely normal parenchyma to brain oedema and/or haemorrhage. Multiple factors relate to neuronal injury in CVT including; dural sinus pressure, increased venous flow velocities, collateralization of venous channels, rate of occlusion, development of cytotoxic and vasogenic oedema, recanalization and accelerated myelination. It is suggested that recanalization of occluded vein, as well as, the presence or absence and the efficiency of intracranial venous collaterals, may have an impact on the extent of brain tissue damage and hence the prognosis of acute CVT.
Role Of Surgery In Cerebral Venous Sinus Thrombosis, S. Ather Enam
Role Of Surgery In Cerebral Venous Sinus Thrombosis, S. Ather Enam
Department of Surgery
Cerebral venous sinus thrombosis (CVST) usually is taken care of by medical management or neuro-interventional vascular techniques. Some cases of CVST may take a malignant course if the intracranial pressure increases excessively. This increase in pressure is because of oedema in brain tissue due to impediment in venous return and/or intracerebral haemorrhage. Neurosurgical experience has shown remarkable recovery in these moribund patients if appropriate surgical intervention is done within reasonable time. Emergent decompressive craniotomy or other neurosurgical interventions are the only appropriate treatment in these malignant forms of CVST to prevent mortality and severe morbidity.
Oral Contraceptives And Cerebral Venous Thrombosis: Case Report And A Brief Review Of Literature, Mughis Sheerani, Mian Zainul Sajadeen Urfy
Oral Contraceptives And Cerebral Venous Thrombosis: Case Report And A Brief Review Of Literature, Mughis Sheerani, Mian Zainul Sajadeen Urfy
Section of Neurology
Cerebral venous thrombosis remains an important and sometimes an elusive cause of strokes. Oral contraceptives seem to have a strong causative association with this entity. We describe a case that highlights the importance of asking specific questions about oral contraceptive use in patients with strokes due to cerebral venous sinus thrombosis, especially, where the cause remains cryptic.
Prognostic Indicators In Cerebral Venous Sinus Thrombosis, Bilal Hameed, Nadir Ali Syed
Prognostic Indicators In Cerebral Venous Sinus Thrombosis, Bilal Hameed, Nadir Ali Syed
Section of Neurology
Cerebral venous sinus thrombosis (CVT) can affect all age groups, particularly women of childbearing age. Overall prognosis for survival and functional independence is better than it was believed. Mortality usually ranges from 6-15% and transtentorial herniation is the major cause of death. Approximately 80% of patients are functionally independent in the long term. Altered mental status and cerebral haemorrhage at presentation are the strongest predictors of death and disability. Patients with CVT related to pregnancy and puerperium generally do better than patients with other causes. Septic CVT carries a worse prognosis than aseptic CVT and of the latter, patients with …
Complications Associated With Cerebral Venous Thrombosis., Fazeel Mukhtar Siddiqui,, Ayeesha Kamran Kamal
Complications Associated With Cerebral Venous Thrombosis., Fazeel Mukhtar Siddiqui,, Ayeesha Kamran Kamal
Department of Medicine
Although CVT is associated with a good outcome in the majority of cases, it may be complicated by numerous unique and sometimes rare complications. The purpose of this review is to discuss the acute and chronic complications of CVT in greater detail. Awareness may lead to a more aggressive approach in those in which these complications are anticipated and perhaps avoided.
The complications of CVT may be temporally divided into those unique to the acute stage and those that are associated with the chronic stage of CVT. They are venous infarction and haemorrhage, subarachnoid haemorrhage, a rapid progression and pulmonary …
Heparin In The Treatment Of Cerebral Venous Thrombosis., Saad Shafqat, Ayeesha Kamran Kamal, Mohammad Wasay
Heparin In The Treatment Of Cerebral Venous Thrombosis., Saad Shafqat, Ayeesha Kamran Kamal, Mohammad Wasay
Department of Medicine
Cerebral venous thrombosis (CVT) is a potentially life-threatening condition requiring rapid diagnosis and urgent treatment. Heparin anticoagulation is the time-honoured treatment, and is advocated in all cases of CVT, irrespective of etiology or presence of haemorrhage. The supportive evidence is largely observational; data from randomized placebo-controlled trials shows a nonsignificant trend favouring heparin. Current practice is to begin heparin (unfractionated or low-molecular weight) immediately on confirmation of the diagnosis. Newer antithrombotic agents such as ximelagatran may offer advantages over heparin and need to be investigated in the treatment of CVT.
Pathophysiology Of Cerebral Venous Thrombosis--An Overview., Ahmed Itrat, Sana Shoukat, Ayeesha Kamran Kamal
Pathophysiology Of Cerebral Venous Thrombosis--An Overview., Ahmed Itrat, Sana Shoukat, Ayeesha Kamran Kamal
Department of Medicine
Cerebral venous sinus thrombosis is a disorder with a unique pathophysiology which needs to be described. A Medline search of all articles detailing pathophysiology of CVST was done, using keywords: cerebral venous thrombosis and pathophysiology. In addition, major texts were reviewed for additional references. The pathophysiology of CVST depends on two interconnected events, local signs due to venous infarct, e.g., hemiparesis and global signs due to raised ICP from an obstructed venous system--papilloedema and isolated intracranial hypertension being one of them. Pathophysiology of CVST is diverse and makes it easier to understand the diversity of clinical presentations.
Local Thrombolytic Treatment Of Cerebral Venous Thrombosis In Three Paediatric Patients, Mohammad Wasay, Rohit Bakshi, Alper Dai, Steve Roach
Local Thrombolytic Treatment Of Cerebral Venous Thrombosis In Three Paediatric Patients, Mohammad Wasay, Rohit Bakshi, Alper Dai, Steve Roach
Section of Neurology
There is increasing evidence that local thrombolysis can be used with relative safety and efficacy in adults with superior sagittal sinus thrombosis (SSST). However, little data is available on the use of local thrombolysis in children with SSST. We report three patients who received local thrombolysis for dural sinus thrombosis. Two patients received urokinase and one patient received urokinase followed by local TPA infusion. Recanalization was achieved in two patients.
Treatment Of Spinal Tuberculosis: Role Of Surgical Intervention, Ather Enam, Ahmed Ali Shah
Treatment Of Spinal Tuberculosis: Role Of Surgical Intervention, Ather Enam, Ahmed Ali Shah
Section of Neurosurgery
The treatment of tuberculosis of the spine (Pott's disease) is essentially conservative and a vast majority of patients can be successfully managed on antituberculo us therapy (ATT) alone.1 Surgery is indicated in a few specific cases where deformity of spine, pain, or neurological compromise is becoming a serious issue. In cases where surgery is indicated the benefits are almost immediate and excellent. Tuberculosis (TB) is one of the leading causes of infectious disease-related deaths in under-developed countries and it has had a resurgence in developed countries as well. The most common site of bony dissemination of this disease is in …
Botulinum Toxin Type-A In The Management Of Cerebral Palsy: Low Or High Dose?, Alper I. Dai, Mohammad Wasay
Botulinum Toxin Type-A In The Management Of Cerebral Palsy: Low Or High Dose?, Alper I. Dai, Mohammad Wasay
Department of Medicine
Cerebral palsy is the most common cause of severe physical disability in childhood. Spasticity is a common and disabling symptom for many patients with cerebral palsy. Therapy for spasticity is symptomatic with the aim of increasing functional capacity and relieving discomfort. Spasticity treatment by orally administered drugs and intramuscular chemodenervation agents has become more frequent. Most oral medications to treat spasticity have been inadequately studied in children, especially those with cerebral palsy. Since its first use in pediatric patients, reported in 1993, botulinum toxin (BTX-A), a relatively recent addition to the available medical interventions for children with cerebral palsy, has …
Operating On The Master Gland: 100consecutive Hypophysectomies At Aga Khan University Hospital, Karachi, Muhammad Shahzad Shamim, Faraz Khursheed, Muhammad Ehsan Bari
Operating On The Master Gland: 100consecutive Hypophysectomies At Aga Khan University Hospital, Karachi, Muhammad Shahzad Shamim, Faraz Khursheed, Muhammad Ehsan Bari
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Mult-Slice Ct Scanning, Zafar Sajjad
Mult-Slice Ct Scanning, Zafar Sajjad
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Stroke-Related Complications Due To Delay In Seeking Medical Care: A Review Of 100 Cases, Asad Ali
Stroke-Related Complications Due To Delay In Seeking Medical Care: A Review Of 100 Cases, Asad Ali
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Sporadic Hemiplegic Migraine: A Challenging Diagnosis, Azra Zafar, Shahid Mustafa, Kaneez Aelia
Sporadic Hemiplegic Migraine: A Challenging Diagnosis, Azra Zafar, Shahid Mustafa, Kaneez Aelia
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Clinical Applications Of Polysomnography, Imran I. Ali
Clinical Applications Of Polysomnography, Imran I. Ali
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.
Central Nervous System Involvement Indengue Viral Infection, Romasa Channa, Mohammad Wasay
Central Nervous System Involvement Indengue Viral Infection, Romasa Channa, Mohammad Wasay
Pakistan Journal of Neurological Sciences (PJNS)
No abstract provided.