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Full-Text Articles in Medicine and Health Sciences
Effect Of Target Controlled Propofol Infusion Versus Intermittent Boluses During Oesophagogastroduodenoscopy: A Randomized Controlled Trial, Catherine Ndosi, Vitalis Mung’Ayi, Ednah Gisore, Samina Mir
Effect Of Target Controlled Propofol Infusion Versus Intermittent Boluses During Oesophagogastroduodenoscopy: A Randomized Controlled Trial, Catherine Ndosi, Vitalis Mung’Ayi, Ednah Gisore, Samina Mir
Anaesthesiology, East Africa
Background: Propofol is administered as intermittent boluses to achieve deep sedation to facilitate oesophagogastroduodenoscopy. Target controlled infusion (TCI) can be employed for this purpose.
Methods: 176 adults were randomly allocated into two groups of 88 patients. Control group: Received an initial bolus of propofol 1mg/kg, with repeat boluses of 0.25mg/kg. Intervention group: Received an initial target effect-site concentration of 4mcg/ml, followed by maintenance target effect-site concentration of 2.5mcg/ml, titrated by 0.5mcg/ml from baseline infusion rate as needed. Oxygen saturation, blood pressure and heart rate were evaluated immediately before administering the sedative and at 2.50, 5.00, 7.50 and 10.00 minutes. Oxygen …
Effect Of Removal Of Auraonce™ Laryngeal Mask In Awake Or Deep Anaesthesia: A Randomized Controlled Trial, Ronald Ombaka, Vitalis Mung’Ayi, David Nekyon, Samina Mir
Effect Of Removal Of Auraonce™ Laryngeal Mask In Awake Or Deep Anaesthesia: A Randomized Controlled Trial, Ronald Ombaka, Vitalis Mung’Ayi, David Nekyon, Samina Mir
Anaesthesiology, East Africa
Background: The manufacturer Ambu® recommends that the AuraOnce™ laryngeal mask be removed once the patient is fully awake. Studies have shown benefit in removal of the laryngeal mask airway while a patient is deeply anaesthetized. Current evidence is inconclusive, as to which approach is preferable and safer in adults.
Methods: one hundred and sixteen adult patients were randomly assigned to two groups of 58. For the deep arm; The AuraOnceTM laryngeal mask was removed after attaining an end tidal minimum alveolar concentration of Isoflurane of 1.15%. Occurrence of airway complication(s) (One or more of the following; Airway obstruction requiring airway …
Effect Of Low-Dose Ketamine Versus Fentanyl On Attenuating The Haemodynamic Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing General Anaesthesia: A Prospective, Double-Blinded, Randomised Controlled Trial, Angela Ongewe, Vitalis Mung’Ayi, Rajpreet Bal
Effect Of Low-Dose Ketamine Versus Fentanyl On Attenuating The Haemodynamic Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing General Anaesthesia: A Prospective, Double-Blinded, Randomised Controlled Trial, Angela Ongewe, Vitalis Mung’Ayi, Rajpreet Bal
Anaesthesiology, East Africa
Background: The use of drugs to attenuate the haemodynamic response to laryngoscopy and endotracheal intubation is the standard of care during elective surgery. Current evidence is conflicting concerning the best agent and optimal dose for this purpose. In the majority of cases, fentanyl is widely utilized to attenuate haemodynamic responses. Ketamine, an established available drug, has been scarcely studied in this regard at low doses and against varying doses of other common agents.
Objective: To compare the overall occurrence of hypertension and tachycardia immediately pre-intubation (post-induction) until 10 minutes post intubation between the study group receiving fentanyl at 1.0 µg/kg …