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Aga Khan University

Obstetrics and Gynecology

2019

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Articles 1 - 30 of 49

Full-Text Articles in Medicine and Health Sciences

Postpartum Endometritis And Infection Following Incomplete Or Complete Abortion: Case Definition & Guidelines For Data Collection, Analysis, And Presentation Of Maternal Immunization Safety Data, C E. Rouse, L O. Eckert, F M. Muñoz, J S A. Stringer, S Kochhar, L Bartlett, M Sanicas, D J. Dudley, D M. Harper, Fyezah Jehan Dec 2019

Postpartum Endometritis And Infection Following Incomplete Or Complete Abortion: Case Definition & Guidelines For Data Collection, Analysis, And Presentation Of Maternal Immunization Safety Data, C E. Rouse, L O. Eckert, F M. Muñoz, J S A. Stringer, S Kochhar, L Bartlett, M Sanicas, D J. Dudley, D M. Harper, Fyezah Jehan

Department of Paediatrics and Child Health

Abstract are not provided by the author/publisher


Maternal Characteristics And Outcomes Affected By Hypothyroidism During Pregnancy (Maternal Hypothyroidism On Pregnancy Outcomes, Mhpo-1), Zareen Kiran, Aisha Sheikh, Sarwar Malik, Areeba Meraj, Maha Masood, Safana Ismail, Owais Rashid, Quratulain Shaikh, Numan Majeed, Lumaan Sheikh, Najmul Islam Dec 2019

Maternal Characteristics And Outcomes Affected By Hypothyroidism During Pregnancy (Maternal Hypothyroidism On Pregnancy Outcomes, Mhpo-1), Zareen Kiran, Aisha Sheikh, Sarwar Malik, Areeba Meraj, Maha Masood, Safana Ismail, Owais Rashid, Quratulain Shaikh, Numan Majeed, Lumaan Sheikh, Najmul Islam

Section of Diabetes, Endocrinology and Metabolism

Background: Hypothyroidism in pregnancy is an arena of ongoing research, with international conflicts regarding screening, management, and outcomes. Various studies have described the outcomes depending on geographical and international diagnostic criteria. No study has been conducted in this regard from the region of Pakistan. Therefore, we aim to report the clinical features and maternal outcomes of hypothyroid pregnancies and compare the maternal outcomes between uncontrolled and controlled TSH levels in the preconception as well as the gestational period.
Methods: We conducted a cross-sectional retrospective study on 718 cases in the Aga Khan University Hospital after ethical approval. We collected information …


A Cross-Sectional Analysis Of Factors Associated With Detection Of Oncogenic Human Papillomavirus In Human Immunodeficiency Virus-Infected And Uninfected Kenyan Women, Aaron Ermel, P. Tonui, M. Titus, Y. Tong, N. Wong, J. Ong’Echa, Kapten Muthoka, Stephen Kiptoo, A. Moormann, Elkanah Omenge Dec 2019

A Cross-Sectional Analysis Of Factors Associated With Detection Of Oncogenic Human Papillomavirus In Human Immunodeficiency Virus-Infected And Uninfected Kenyan Women, Aaron Ermel, P. Tonui, M. Titus, Y. Tong, N. Wong, J. Ong’Echa, Kapten Muthoka, Stephen Kiptoo, A. Moormann, Elkanah Omenge

Obstetrics and Gynaecology, East Africa

Background: Cervical cancer is caused by oncogenic human papillomaviruses (HPV) and is one of the most common malignancies in women living in sub-Saharan Africa. Women infected with the human immunodeficiency virus (HIV) have a higher incidence of cervical cancer, but the full impact on HPV detection is not well understood, and associations of biological and behavioral factors with oncogenic HPV detection have not been fully examined. Therefore, a study was initiated to investigate factors that are associated with oncogenic HPV detection in Kenyan women.

Methods: Women without cervical dysplasia were enrolled in a longitudinal study. Data from enrollment are presented …


Is There Value To Sub-Specialty Training In Sub-Saharan Africa?, Elkanah Omenge, S. E. Sinasac, Peter Itsura, Philip Tonui, B. Rosen, A. Covens Nov 2019

Is There Value To Sub-Specialty Training In Sub-Saharan Africa?, Elkanah Omenge, S. E. Sinasac, Peter Itsura, Philip Tonui, B. Rosen, A. Covens

Obstetrics and Gynaecology, East Africa

Over the past three decades, Africa has focused on combatting infectious diseases, such as tuberculosis, malaria, and HIV/ AIDS. As treatment strategies for infectious diseases have improved over time, life expectancy has increased, shifting the burden to chronic diseases, such as cancer. The WHO has now identified non-communicable diseases, including cancer, as the new epidemic in sub-Saharan Africa1. Cancer incidence and mortality are increasing rapidly in low and middle-income countries (LMIC) as compared to high-income countries. By 2020, it is predicted that 70% of all new cancers worldwide will occur in LMIC2. In 2012 850 000 new cancers were diagnosed …


Association Of Female Sexual Dysfunction And Fertility: A Cross Sectional Study, Felix Oindi, Alfred Murage, Valentino Manase Lema, Abraham Mukaindo Nov 2019

Association Of Female Sexual Dysfunction And Fertility: A Cross Sectional Study, Felix Oindi, Alfred Murage, Valentino Manase Lema, Abraham Mukaindo

Obstetrics and Gynaecology, East Africa

Background: Sexual function plays an essential role in the bio-psychosocial wellbeing and quality of life of women and disturbances in sexual functioning often result in significant distress. Female sexual dysfunction (FSD) and subfertility are common problems affecting approximately 43 and 20% of women respectively. However, despite the high prevalence of both conditions, little has been studied on the effects of subfertility on sexual functioning especially in sub-Saharan Africa. We set out to compare the prevalence of female sexual dysfunction in patients on assessment for sub-fertility and those either seeking or already on fertility control services at a private tertiary teaching …


Time To Adopt Developmental Origins Of Health And Disease (Dohad) Science In Pakistan, Rozina Nuruddin, Akbar Shoukat Ali, Nuruddin Badruddin Mohammed Nov 2019

Time To Adopt Developmental Origins Of Health And Disease (Dohad) Science In Pakistan, Rozina Nuruddin, Akbar Shoukat Ali, Nuruddin Badruddin Mohammed

Community Health Sciences

No abstract provided.


Assessing The Adherence Of Obstetricians Towards Postpartum Diabetes Screening Guidelines: A Pre- And Post-Intervention Study At Secondary Care Hospital In Karachi, Pakistan, Sadiqa Munir Razzaqui, Neelofur Babar, Zaib Un Nisa Memon, Sarah Rafiq Nov 2019

Assessing The Adherence Of Obstetricians Towards Postpartum Diabetes Screening Guidelines: A Pre- And Post-Intervention Study At Secondary Care Hospital In Karachi, Pakistan, Sadiqa Munir Razzaqui, Neelofur Babar, Zaib Un Nisa Memon, Sarah Rafiq

Department of Obstetrics & Gynaecology

Objective: To assess the adherence level of obstetricians towards postpartum diabetes screening guidelines.
Methods: The quasi-experimental pre- and post-intervention study was conducted from May 2014 to April 2015 at Aga Khan Hospital for Women-Karimabad, Karachi, and comprised all obstetricians practicing at the time. All the booked women with gestational diabetes delivered in the 6 months before refresher lecture (group 1) and those delivering in the 6 months following the intervention (group 2) were included. Data was analysed using SPSS 19.
Results: Of the 550 cases, 275(50%) each were in groups 1 and 2. All pregnant women had live-birth. The intervention …


Factors Related To Congenital Heart Disease In Offspring From Women With Rheumatic Heart Disease: Case Reports From Moi Teaching And Referral Hospital, Eldoret, Kenya, Philippe P. A, Elkanah Omenge, Barasa F. A Nov 2019

Factors Related To Congenital Heart Disease In Offspring From Women With Rheumatic Heart Disease: Case Reports From Moi Teaching And Referral Hospital, Eldoret, Kenya, Philippe P. A, Elkanah Omenge, Barasa F. A

Obstetrics and Gynaecology, East Africa

Maternal exposure to environmental factors has been reported to be associated with birth defects. Congenital heart defects are the most common and are associated with high morbidity and mortality in offspring. However, the relation of maternal rheumatic heart disease to congenital heart defects in the offspring is a rare event not yet reported. The authors report 2 cases of infants with congenital heart defects born from mothers with rheumatic heart disease. This study highlights factors related to congenital heart defects in both newborns.


Systematic Review Of Doppler For Detecting Intrapartum Fetal Heart Abnormalities And Measuring Perinatal Mortality In Low‐ And Middle‐Income Countries, Marya Plotkin, Benjamin Kamala, Jim Ricca, Linda Fogarty, Sheena Currie, Hussein Kidanto, Stephanie B. Wheeler Oct 2019

Systematic Review Of Doppler For Detecting Intrapartum Fetal Heart Abnormalities And Measuring Perinatal Mortality In Low‐ And Middle‐Income Countries, Marya Plotkin, Benjamin Kamala, Jim Ricca, Linda Fogarty, Sheena Currie, Hussein Kidanto, Stephanie B. Wheeler

Obstetrics and Gynaecology, East Africa

Background: Using Doppler to improve detection of intrapartum fetal heart rate (FHR) abnormalities coupled with appropriate, timely intrapartum care in low-and middle-income countries (LMIC) can save lives.

Objective: To review studies using Doppler to improve detection of intrapartum FHR abnormalities and intrapartum care quality in LMIC health facilities.

Search strategy: PubMed, Web of Science, Embase, Global Health, and Scopus were searched from inception to October 2018 by combining terms for Doppler, perinatal outcomes, and FHR monitoring.

Selection criteria: Selected studies compared Doppler and Pinard stethoscope for detecting/monitoring intrapartum FHR, or described provider and maternal preferences for FHR monitoring in LMIC …


Prevalence Of And Factors Associated With Female Sexual Dysfunction Among Women Using Hormonal And Non-Hormonal Contraception At The Aga Khan University Hospital Nairobi, Momin Butt, Valentino Lema, Abraham Mukaindo, Gulnaz Mohamoud, Jacob Shabani Oct 2019

Prevalence Of And Factors Associated With Female Sexual Dysfunction Among Women Using Hormonal And Non-Hormonal Contraception At The Aga Khan University Hospital Nairobi, Momin Butt, Valentino Lema, Abraham Mukaindo, Gulnaz Mohamoud, Jacob Shabani

Family Medicine, East Africa

Background: Female sexual function (FSD) is a complex phenomenon. It integrates all body systems and is influenced by a variety of factors. Contraceptives have shown to have variable effects on FSD. In Kenya, the majority of women use hormonal contraception with high rates of discontinuation of use, attributed to related side effects such as weight loss and loss of libido.

Aim: To determine the prevalence of and the factors affecting FSD among women using contraception in our setting.

Setting: The study was carried out at the Aga Khan University Hospital, Nairobi, at various clinical sites.

Methods: A cross-sectional study was …


Methicillin Resistant Staphylococcus Aureus Outbreak In A Neonatal Intensive Care Unit, Seema Irfan, Imran Ahmed, Farida Lalani, Naureen Anjum, Nadia Mohammad, Maria Owais, Afia Zafar Oct 2019

Methicillin Resistant Staphylococcus Aureus Outbreak In A Neonatal Intensive Care Unit, Seema Irfan, Imran Ahmed, Farida Lalani, Naureen Anjum, Nadia Mohammad, Maria Owais, Afia Zafar

Department of Pathology and Laboratory Medicine

The global and national burden of communicable and noncommunicable diseases continues to rise, thus making access to Healthcare workers (HCWs) colonized with methicillin-resistant Staphylococcus aureus (MRSA) may pose transmission risk to vulnerable patients including neonates. This study reports an MRSA outbreak in a level-II neonatal intensive care unit (NICU) of a secondary care hospital in Pakistan. Once identified, an infection control team from the parent hospital visited the facility, risk factors were listed and infection control measures taken to control the outbreak. Screening cultures of NICU staff and environmental cultures from NICU were obtained for the presence of MRSA. Five …


Potential Causes Of Early Death Among Admitted Newborns In A Rural Tanzanian Hospital, Robert Moshiro, Jeffrey M. Perlman, Paschal Mdoe, Hussein Kidanto, Jan Terje Kvaløy, Hege L. Ersdal Oct 2019

Potential Causes Of Early Death Among Admitted Newborns In A Rural Tanzanian Hospital, Robert Moshiro, Jeffrey M. Perlman, Paschal Mdoe, Hussein Kidanto, Jan Terje Kvaløy, Hege L. Ersdal

Obstetrics and Gynaecology, East Africa

Background: Approximately 40,000 newborns die each year in Tanzania. Regional differences in outcome are common. Reviewing current local data, as well as defining potential causal pathways leading to death are urgently needed, before targeted interventions can be implemented

Objective: To describe the clinical characteristics and potential causal pathways contributing to newborn death and determine the presumed causes of newborn mortality within seven days, in a rural hospital setting.

Methods: Prospective observational study of admitted newborns born October 2014–July 2017. Information about labour/delivery and newborn management/care were recorded on data collection forms. Causes of deaths were predominantly based on clinical diagnosis. …


Radical Hysterectomy For Operable Early Cervical Cancer In Hiv-Positive And Hiv-Negative Women In Western Kenya, Peter M. Itsura, Rachel N. Deraney, Elkanah Omenge, Philip Tonui, Barry Rosen, Susan Cu-Uvin Oct 2019

Radical Hysterectomy For Operable Early Cervical Cancer In Hiv-Positive And Hiv-Negative Women In Western Kenya, Peter M. Itsura, Rachel N. Deraney, Elkanah Omenge, Philip Tonui, Barry Rosen, Susan Cu-Uvin

Obstetrics and Gynaecology, East Africa

Radical hysterectomy is well tolerated with no increase in complications in HIV-infected women and is an appropriate form of treatment for early-stage cervical cancer in HIV-infected women.


Routine Late Trimester Ultrasound For The Detection Ofsmall-For-Gestational-Age And Growth-Restricted Fetus Inlow-Risk Pregnancy: A Randomised Controlled Trial, Sikolia Wanyonyi, Doreen Osoro, Marleen Temmerman Oct 2019

Routine Late Trimester Ultrasound For The Detection Ofsmall-For-Gestational-Age And Growth-Restricted Fetus Inlow-Risk Pregnancy: A Randomised Controlled Trial, Sikolia Wanyonyi, Doreen Osoro, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Objectives: To compare the proportion of small-for-gestational-age and fetal growth-restricted fetuses detected in women offered a routine growth ultrasound to those either offered selective or no ultrasound in the third trimester.

Methods: An open-label randomised control trial was conducted at the Aga Khan University Hospital, Nairobi. Eligible women were randomised into either the intervention or control group. Women in the intervention arm had a mandatory third trimester ultrasound for fetal growth performed between 36 weeks 0 days to 37 weeks 6 days. Those in the control group had a selective growth scan done if the clinician suspected abnormal fetal growth. …


Predictors For Expired Co2 In Neonatal Bag-Mask Ventilation At Birth: Observational Study, Kari Holte, Hege Langli Ersdal, Joar Eilevstjønn, Monica Thallinger, Jørgen Linde, Claus Klingenberg, Rene Holst, Samwel Jatosh, Hussein Kidanto, Ketil Stordal Oct 2019

Predictors For Expired Co2 In Neonatal Bag-Mask Ventilation At Birth: Observational Study, Kari Holte, Hege Langli Ersdal, Joar Eilevstjønn, Monica Thallinger, Jørgen Linde, Claus Klingenberg, Rene Holst, Samwel Jatosh, Hussein Kidanto, Ketil Stordal

Obstetrics and Gynaecology, East Africa

Background: Expired carbon dioxide (ECO2) indicates degree of lung aeration immediately after birth. Favourable ventilation techniques may be associated with higher ECO2 and a faster increase. Clinical condition will however also affect measured values. The aim of this study was to explore the relative impact of ventilation factors and clinical factors on ECO2 during bag-mask ventilation of near-term newborns.

Methods: Observational study performed in a Tanzanian rural hospital. Side-stream measures of ECO2, ventilation data, heart rate and clinical information were recorded in 434 bag-mask ventilated newborns with initial heart rate <120 beats per minute. We studied ECO2 by clinical factors (birth weight, Apgar scores and initial heart rate) and ventilation factors (expired tidal volume, ventilation frequency, mask leak and inflation pressure) in random intercept models and Cox regression for time to ECO2 >2%.

Results: ECO2 rose non-linearly with increasing expired tidal volume …


Frequent Refresher Training On Newborn Resuscitation And Potential Impact On Perinatal Outcome Over Time In A Rural Tanzanian Hospital: An Observational Study, Estomih Mduma, Jan Terje Kvaløy, Eldar Soreide, Erling Svensen, Paschal Mdoe, Jeffrey Perlman, Caroline Johnson, Hussein Kidanto, Hege Langli Ersdal Sep 2019

Frequent Refresher Training On Newborn Resuscitation And Potential Impact On Perinatal Outcome Over Time In A Rural Tanzanian Hospital: An Observational Study, Estomih Mduma, Jan Terje Kvaløy, Eldar Soreide, Erling Svensen, Paschal Mdoe, Jeffrey Perlman, Caroline Johnson, Hussein Kidanto, Hege Langli Ersdal

Obstetrics and Gynaecology, East Africa

Objectives: Globally, perinatal mortality remains high, especially in sub-Saharan countries, mainly because of inadequate obstetric and newborn care. Helping Babies Breathe (HBB) resuscitation training as part of a continuous quality improvement (CQI) programme may improve outcomes. The aim of this study was to describe observed changes in perinatal survival during a 6-year period, while adjusting for relevant perinatal risk factors.

Setting: Delivery rooms and operating theatre in a rural referral hospital in northern-central Tanzania providing comprehensive obstetric and basic newborn care 24 hours a day. The hospital serves approximately 2 million people comprising low social-economic status.

Participants: …


Health Professionals' Experiences And Views On Obstetric Ultrasound In Vietnam: A Regional, Cross-Sectional Study, Sophia Holmlund, Pham Thi Lan, Kristina Edvardsson, Ho Dang Phuc, Joseph Ntaganira, Rhonda Small, Hussein Kidanto, Matilda Ngarina, Ingrid Mogren Sep 2019

Health Professionals' Experiences And Views On Obstetric Ultrasound In Vietnam: A Regional, Cross-Sectional Study, Sophia Holmlund, Pham Thi Lan, Kristina Edvardsson, Ho Dang Phuc, Joseph Ntaganira, Rhonda Small, Hussein Kidanto, Matilda Ngarina, Ingrid Mogren

Obstetrics and Gynaecology, East Africa

Objectives: Obstetric ultrasound is an important part of antenatal care in Vietnam, although there are great differences in access to antenatal care and ultrasound services across the country. The aim of this study was to explore Vietnamese health professionals' experiences and views of obstetric ultrasound in relation to clinical management, resources and skills.

Design: A cross-sectional questionnaire study was performed as part of the CROss Country UltraSound study.

Setting: Health facilities (n=29) in urban, semiurban and rural areas of Hanoi region in Vietnam.

Participants: Participants were 289 obstetricians/gynaecologists and 535 midwives.

Results: A majority (88%) …


Effects Of Implementing Free Maternity Service Policy In Kenya: An Interrupted Time Series Analysis, Evaline Lang’At, Lillian Mwanri, Marleen Temmerman Sep 2019

Effects Of Implementing Free Maternity Service Policy In Kenya: An Interrupted Time Series Analysis, Evaline Lang’At, Lillian Mwanri, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

Background: Maternal and perinatal mortality is a major public health concern across the globe and more so in low and middle-income countries. In Kenya, more than 6000 maternal deaths, and 35,000 stillbirths occur each year. The Government of Kenya abolished user fee for maternity care under the Free Maternity Service policy, in June of 2013 in all public health facilities, a move to make maternity services accessible and affordable, and to reduce maternal and perinatal mortality.

Method: An observational retrospective study was carried out in 3 counties in Kenya. Six maternal health output indicators were observed monthly, 2 years pre …


Detection And Concentration Of Plasma Aflatoxin Is Associated With Detection Of Oncogenic Human Papillomavirus In Kenyan Women, Jianjun Zhang, Elkanah Omenge, Philip Tonui, Yan Tong, Titus Manai, Stephen Kiptoo, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen Sep 2019

Detection And Concentration Of Plasma Aflatoxin Is Associated With Detection Of Oncogenic Human Papillomavirus In Kenyan Women, Jianjun Zhang, Elkanah Omenge, Philip Tonui, Yan Tong, Titus Manai, Stephen Kiptoo, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen

Obstetrics and Gynaecology, East Africa

Background: Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor.

Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus-uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration.

Results: …


Colostrum And Mature Breast Milk Analysis Of Serum Irisin And Sterol Regulatory Element-Binding Proteins-1c In Gestational Diabetes Mellitus, Syeda Sadia Fatima, Erum Khalid, Asma Akbar Ladak, Syed Adnan Ali Sep 2019

Colostrum And Mature Breast Milk Analysis Of Serum Irisin And Sterol Regulatory Element-Binding Proteins-1c In Gestational Diabetes Mellitus, Syeda Sadia Fatima, Erum Khalid, Asma Akbar Ladak, Syed Adnan Ali

Department of Biological & Biomedical Sciences

Background: We aimed to evaluate irisin and SREBP-1c levels in serum, colostrum and mature breast milk in women with and without gestational diabetes (GDM); and to relate them with maternal glucose, lipid profile and weight status of babies.
Methods: GDM positive women (n = 33) and normal glucose tolerant women (NGT) (n = 33) were recruited. Maternal blood samples were collected at 28th week of gestation and later at 6-week post-partum while breast milk samples of the lactating mothers were collected within 72 hours of birth (colostrum) and at 6 weeks post-partum (mature milk). Irisin and SREBP-1c levels were analyzed …


Early Second Trimester Twin-To-Twin Transfusion Syndrome In Monoamniotic Twin Pregnancy: The Cause And Management–A Case Report From Resource Limited Settings, Philippe P. A., Andrew Cheruiyot, Sahara Shurie, M Pallavi, Elkanah Omenge Sep 2019

Early Second Trimester Twin-To-Twin Transfusion Syndrome In Monoamniotic Twin Pregnancy: The Cause And Management–A Case Report From Resource Limited Settings, Philippe P. A., Andrew Cheruiyot, Sahara Shurie, M Pallavi, Elkanah Omenge

Obstetrics and Gynaecology, East Africa

Monoamniotic twin pregnancies are the least common type of twin pregnancies, associated with high foetal death rates. In addition, twin-to-twin transfusion syndrome is a rare event in monoamniotic twins. The expectant management of early single-twin foetal demise is challenging due to risk to the surviving co-twin, and psychological impact on the mother. The authors report the case of early second trimester single-twin foetal demise, likely due to twin-to-twin transfusion syndrome in monochorionic twin pregnancy. The 22-year-old primigravida presented with vaginal bleeding in monoamniotic twin pregnancy. She then had sudden single-twin intrauterine demise at 16 weeks of gestation that ended with …


Antibiotic Prophylaxis In The Surgical Management Of Miscarriage In Low-Income Countries: A Cost-Effectiveness Analysis Of The Aims Trial, Ilias Goranitis, David M. Lissauer, Arri Coomarasamy, Amie Wilson, Jane Daniels, Lee Middleton, Jonathan Bishop, Catherine A. Hewitt, Andrew D. Week, Chisale Mhango, Ronald Mataya, Iffat Ahmed Sep 2019

Antibiotic Prophylaxis In The Surgical Management Of Miscarriage In Low-Income Countries: A Cost-Effectiveness Analysis Of The Aims Trial, Ilias Goranitis, David M. Lissauer, Arri Coomarasamy, Amie Wilson, Jane Daniels, Lee Middleton, Jonathan Bishop, Catherine A. Hewitt, Andrew D. Week, Chisale Mhango, Ronald Mataya, Iffat Ahmed

Department of Obstetrics & Gynaecology

Background: There is ongoing debate on the clinical benefits of antibiotic prophylaxis for reducing pelvic infection after miscarriage surgery. We aimed to study the cost-effectiveness of antibiotic prophylaxis in the surgical management of miscarriage in low-income countries.
Method: We did an incremental cost-effectiveness analysis using data from 3412 women recruited to the AIMS trial, a randomised, double-blind, placebo-controlled trial designed to evaluate the effectiveness of antibiotic prophylaxis in the surgical management of miscarriage in Malawi, Pakistan, Tanzania, and Uganda. Economic evaluation was done from a health-care-provider perspective on the basis of the outcome of cost per pelvic infection avoided within …


A Study Protocol For An Mhealth, Multi-Centre Randomized Control Trial To Promote Use Of Postpartum Contraception Amongst Rural Women In Punjab, Pakistan, Xaher Gul, Waqas Hameed, Sharmeen Hussain, Ishaque Sheikh, Junaid-Ur-Rehman Siddiqui Aug 2019

A Study Protocol For An Mhealth, Multi-Centre Randomized Control Trial To Promote Use Of Postpartum Contraception Amongst Rural Women In Punjab, Pakistan, Xaher Gul, Waqas Hameed, Sharmeen Hussain, Ishaque Sheikh, Junaid-Ur-Rehman Siddiqui

Community Health Sciences

Background: Provision of family planning services during the immediate post-partum phase is considered effective and cost-efficient for promoting healthy timing and spacing of pregnancies. This research aims to test the effectiveness of mobile phone-based interventions in promoting use of postpartum contraception. Moreover, it will also test the non-inferiority of text and voice messages compared to interactive phone-based counselling.
Methods: A three-arm, 10-month, multicentre, randomized controlled trial will be conducted at 15 social franchise (SF) health facilities in Punjab province of Pakistan. Pregnant women aged 15-44 years who are in their first or second trimester and have a mobile phone for …


The Gender-Based Violence And Recovery Centre At Coast Provincial General Hospital, Mombasa, Kenya: An Integrated Care Model For Survivors Of Sexual Violence, Marleen Temmerman, Emilomo Ogbe, Griffins Manguro, Iqbal Khandwalla, Mary Thiongo, Kishor N. Mandaliya, Lou Dierick, Markus Macgill, Peter Gichangi Aug 2019

The Gender-Based Violence And Recovery Centre At Coast Provincial General Hospital, Mombasa, Kenya: An Integrated Care Model For Survivors Of Sexual Violence, Marleen Temmerman, Emilomo Ogbe, Griffins Manguro, Iqbal Khandwalla, Mary Thiongo, Kishor N. Mandaliya, Lou Dierick, Markus Macgill, Peter Gichangi

Obstetrics and Gynaecology, East Africa

  • Sexual violence (SV) is highly prevalent and a major public health problem globally. In Kenya, an estimated 32% of females and 18% of males were reported to have experienced SV before the age of 18 years.
  • This paper presents a data set collected between 2007 and 2018 and describes the gender-based violence and recovery centre (GBVRC) model under which survivors of SV were cared for at a 24-hour public hospital in Mombasa, Kenya—including its development, implementation, achievements, and challenges.
  • The GBVRC model is a partnership that provides (in addition to emergency healthcare) mental health support, paralegal services, and integrated cooperation …


Nasopharyngeal Carcinoma In Pregnancy: Management Approach Case Report At Moi Teaching And Referral Hospital, Eldoret-Kenya, Philip Tonui, Elly B. Odongo, Andrew Cheruiyot, Sahara Shurie, Elkanah Omenge Aug 2019

Nasopharyngeal Carcinoma In Pregnancy: Management Approach Case Report At Moi Teaching And Referral Hospital, Eldoret-Kenya, Philip Tonui, Elly B. Odongo, Andrew Cheruiyot, Sahara Shurie, Elkanah Omenge

Obstetrics and Gynaecology, East Africa

Nasopharyngeal carcinoma is an uncommon tumour, which raises management dilemma in pregnant women. The condition has a considerable effect on the pregnancy outcome, considering the risk of preterm delivery. This paper reports a case of 26 years old Gravida 7 Para 6 admitted at 28 weeks of gestation with epistaxis, hematemesis and a neck mass. The head CT scan showed a right paranasal space soft tissue mass with bony destruction and bilateral cervical adenopathy, consistent with neoplastic carcinoma. Histopathological examination confirmed the diagnosis of nasopharyngeal carcinoma. Deterioration of the patient’s condition, necessitated emergency caesarean delivery at 32 weeks to accommodate …


Use Of Long‐Acting Reversible Contraception In A Cluster‐Random Sample Of Female Sex Workers In Kenya, Frances H. Ampt, Megan . S.C Lim, Paul A. Agius, Matthew F. Chersich, Griffins Manguro, Caroline M. Gichuki, Mark Stoové, Marleen Temmerman, Walter Jaoko, Margaret Hellard, Peter Gichangi, Stanley Luchters Aug 2019

Use Of Long‐Acting Reversible Contraception In A Cluster‐Random Sample Of Female Sex Workers In Kenya, Frances H. Ampt, Megan . S.C Lim, Paul A. Agius, Matthew F. Chersich, Griffins Manguro, Caroline M. Gichuki, Mark Stoové, Marleen Temmerman, Walter Jaoko, Margaret Hellard, Peter Gichangi, Stanley Luchters

Obstetrics and Gynaecology, East Africa

Objective: To assess correlates of long-acting reversible contraceptive (LARC) use, and explore patterns of LARC use among female sex workers (FSWs) in Kenya.

Methods: Baseline cross-sectional data were collected between September 2016 and May 2017 in a cluster-randomized controlled trial in Mombasa. Eligibility criteria included current sex work, age 16–34 years, not pregnant, and not planning pregnancy. Peer educators recruited FSWs from randomly selected sex-work venues. Multiple logistic regression identified correlates of LARC use. Prevalence estimates were weighted to adjust for variation in FSW numbers recruited across venues.

Results: Among 879 participants, the prevalence of contraceptive use was 22.6% for …


A New Woman-Controlled Contraceptive Vaginal Ring: A Global Step Forward, Marleen Temmerman Aug 2019

A New Woman-Controlled Contraceptive Vaginal Ring: A Global Step Forward, Marleen Temmerman

Obstetrics and Gynaecology, East Africa

More than 40 years ago, the development of contraceptive vaginal rings began, based on the fact that the vaginal epithelium can absorb steroid hormones and the capacity of elastomers to release these hormones at almost constant rates. The growing interest in woman-controlled contraceptive methods has supported and accelerated the process.


‘I’M Here To Save My Life’: A Qualitative Study Of Experiences Navigating A Cryotherapy Referral System For Human Papillomavirus-Positive Women In Western Kenya, Megan Huchko, Konyin Adewumi, Sandra Oketch, Ibrahim Saduma, Elizabeth Bukusi Jul 2019

‘I’M Here To Save My Life’: A Qualitative Study Of Experiences Navigating A Cryotherapy Referral System For Human Papillomavirus-Positive Women In Western Kenya, Megan Huchko, Konyin Adewumi, Sandra Oketch, Ibrahim Saduma, Elizabeth Bukusi

Obstetrics and Gynaecology, East Africa

Background: We sought to understand the beliefs, social norms and logistical factors that affect human papillomavirus (HPV)-positive women’s uptake of cryotherapy treatment as part of a two-part cervical cancer screening strategy in rural Kenya.

Methods: In-depth interviews within a parent cluster-randomised trial.

Setting: Government-run county hospital in western Kenya.

Participants: 273 of 372 (73.4%) HPV-positive women who underwent cryotherapy

Results: Many women feared that an HPV infection meant they would develop cancer. Almost all women reported initial fear of the treatment procedure, followed by a more positive experience than anticipated. Lacking funds for transportation to the treatment site was the …


Ethical Considerations For Conducting Sexual And Reproductive Health Research With Female Adolescents Engaged In High-Risk Behaviours In China, Xu-Dong Zhang, Sabrina Ching Yuen Luk, Yue-Hong Han, Gui-Rong Chen, Bao-Sheng Zhu, Stanley Luchters Jun 2019

Ethical Considerations For Conducting Sexual And Reproductive Health Research With Female Adolescents Engaged In High-Risk Behaviours In China, Xu-Dong Zhang, Sabrina Ching Yuen Luk, Yue-Hong Han, Gui-Rong Chen, Bao-Sheng Zhu, Stanley Luchters

Population Health, East Africa

Background: Chinese female adolescents engaged in sex trade and substance use are often criminalized and stigmatized. As a result of these cultural, legal and political constraints, ethical concerns can discourage investigators from engaging these adolescents in research. This paper aims to address the ethical tensions between protection and inclusion in conducting sexual and reproductive health (SRH) research with adolescents engaged in high-risk behaviours. Processes of moral reasoning, and examples and practical mechanisms in managing such ethical challenges were presented in the hope of advancing the research ethics policies and practice with adolescents.

Methods: We extracted ethical issues from three previously …


How Providing Cervical Cancer Screening Results Via Cell Phone Affects Patient Follow-Up Rates In Western Kenya, Megan J. Huchko, Ibrahim Saduma, Cinthia Blat, Sandra Oketch, Elizabeth Bukusi Jun 2019

How Providing Cervical Cancer Screening Results Via Cell Phone Affects Patient Follow-Up Rates In Western Kenya, Megan J. Huchko, Ibrahim Saduma, Cinthia Blat, Sandra Oketch, Elizabeth Bukusi

Obstetrics and Gynaecology, East Africa

Purpose: Human papillomavirus (HPV) testing is being more widely used in simplified cervical cancer screening protocols in low-resource settings. One challenge to successful implementation is the multiple visits necessary to provide results and follow-up. mHealth strategies may reduce visit burden by providing information through text message.

Methods: As part of a cluster-randomized trial to compare HPV testing in clinics and community health campaigns in western Kenya, we carried out a mixed-methods study to assess women's preferences and experiences with different strategies to receive their results. Women could opt to receive their HPV results via text message, cell phone call, home …