Medicine and Health Sciences Commons^™

Protective Factors Of Low Bone Mineral Density: An Examination Between Two Samples Of Premenopausal Women, Charlene Norgan Radler, Christine M. Florez, Colin Wilborn, Lem Taylor, Ariane Hollub Secrest

International Journal of Exercise Science: Conference Proceedings

While minimal longitudinal data exists to support osteoporosis screening among premenopausal women, an increasingly modernized society may contribute to modifiable osteoporosis risk factors including poor nutrition and low physical activity. Evaluation of bone mineral density (BMD) and body composition differences in populations with varied levels of physical activity is of importance. PURPOSE: The purpose of the current research was to determine if there is a difference across body composition measurements including total lean mass, body mass index (BMI), and BMD among a subset of physically active premenopausal women (ACTIVE) at a small, southern Christian university compared to premenopausal women …

Nonpharmacologic Measures To Maintain Or Increase Bone Density In Patients At Risk For Osteoporosis: An Integrative Review, Katie Saporsky

Doctoral Dissertations and Projects

Osteoporosis is a major phenomenon, impacting a large proportion of the population of the United States. Effective prevention and mitigation strategies for this condition and its related complications are necessary to promote health and well-being for the aging population. Current pharmacologic agents used to combat osteoporosis bring the risk of adverse effects, resulting in poor patient adherence. Nonpharmacologic methodologies, specifically weight-bearing exercise, targeted nutrition, and whole-body vibration, have proven to be successful in increasing bone mineral density and mitigating the risk of osteoporosis and its related complications. Implementing these methodologies results in increasing bone mineral density, strength, and well-being.

Osteoporosis In The Setting Of Shoulder Arthroplasty: A Narrative Review, Mohammad Daher, Mohamad Fares, Peter Boufadel, Akshay Khanna, Ziad Zalaquett, Joseph A. Abboud

Rothman Institute Faculty Papers

Patients who undergo shoulder surgery are frequently affected by osteoporosis and osteopenia, and the prevalence of this association is expected to increase due to the growing number of elderly individuals undergoing these procedures. It may be advisable to conduct a preoperative DXA scan for orthopedic surgical candidates at high risk, to detect those who could benefit from early intervention and avoid any related adverse events. Some of these complications include periprosthetic fractures, infection, subsequent fragility fractures, and have an all-cause revision arthroplasty at 2 years post-op. Some studies analyzed the beneficence of antiresorptive medications pre-operatively but the latter did not …

Assessment Of Short Physical Performance Battery In Postmenopausal Women In Relation To Bone Mineral Density, Islam Fawzy Zaky, Mamdouh Khairy, Hassan Mohamad Awwad

Al-Azhar International Medical Journal

Background: Postmenopausal osteoporosis is one of the extreme combined musculoskeletal conditions. It may result from physical inactivity, so encouragement of physical activity is very important to avert osteoporosis.

Aim of the work: Assessment of short physical performance battery (SPPB) in postmenopausal women in relation to bone mineral density (BMD) by applying Dual Energy X-ray Absorptiometry.

Patients & methods: This research contained 90 postmenopausal females between 45 – 70 years (3 groups) 30 osteoporotic, 30 osteopenic and 30 control. The short physical performance battery (SPPB) test was applied to define lower limp performance. Through chair stand test (CST), gait speed test …

Bone Mineral Density In Weight-Bearing And Aquatic Athletes, Elizabeth Krauss, Kayla Stuckenberg, Hawley C. Almstedt

International Journal of Exercise Science: Conference Proceedings

Bone mineral density (BMD) is a measure of mineral deposit within the bone that can be used as an early-adulthood predictor for onset of osteoporosis. Type of exercise induces a stress-response which builds BMD. PURPOSE: Non-weight-bearing-athletes were compared to weight-bearing-athletes and controls to identify differences in bone health among groups. The participants were compared longitudinally to measure change in BMD overtime. This study was modeled after work by Taaffe et al. (1995) which concluded that female athletes who do not engage in weight-bearing-activities had lower BMD. METHODS: Height, weight, and calcium intake was collected for female students (20.0±1.3 years); 23 …

Bone Mineral Density, Serum Calcium, And Vitamin D Levels In Adult Thalassemia Major Patients: Experience From A Single Center In Eastern India, Soumya Santra, Kunal Sharma, Ipsita Dash, Shaikat Mondal, Himel Mondal

Journal Articles

Background and objective Patients suffering from thalassemia major are at higher risk of osteoporosis. Due to their decreased life expectancy, the number of adult patients is low. However, their bone health is rarely checked in developing countries like India. There is no data available in the literature on the bone mineral density (BMD) of adult (aged ≥18 years) thalassemia major patients in eastern India. In this study, we aimed to measure the BMD and serum calcium and vitamin D levels in adult thalassemia major patients and to compare them with healthy controls. Materials and methods We conducted this cross-sectional observational …

Dickkopf-1 In Ankylosing Spondylitis Patients And Its Relation To Vertebral Fractures And Bone Mineral Density, Alaa A. Labeeb, Laila M. Zedan, Saga F. El Gazzar, Sally M. El-Hefnawy

Menoufia Medical Journal

Objective The aim was to measure serum levels of Dickkopf-1 (DKK1) in ankylosing spondylitis (AS) patients and to study its relation with vertebral fractures, bone mineral density (BMD), and disease activity. Background AS patients have an increased risk of bone loss and vertebral fractures, which might be related to the activity of the Wingless signaling pathway, and the serum levels of its circulating inhibitors, especially DKK1. Patients and methods This cross-sectional study included 80 participants, 40 patients diagnosed with AS and 40 healthy sex-matched and age-matched volunteers as controls, from 2018 to 2020. All patients and controls were evaluated for …

Physical Activity Estimated By Osteogenic Potential And Energy Expenditure Has Differing Associations With Bone Mass In Young Adults: The Raine Study, Carrie Anne Ng, David Scott, Marc Sim, Kun Zhu, Aris Siafarikas, Nicolas H. Hart, Jocelyn Tan, Paola Chivers

Research outputs 2022 to 2026

Summary: Ground impacts during physical activity may be important for peak bone mass. We found differences in how energy expenditure and impact scores estimated from a physical activity questionnaire related to bone health in young adults. Using both estimate types can improve our understanding of the skeletal benefits of physical activity. Purpose: It is unclear whether mechanical loading during physical activity, estimated from physical activity questionnaires which assess metabolic equivalents of task (METs), is associated with skeletal health. This longitudinal study investigated how physical activity loading scores, assessed at ages 17 and 20 years, (a) compares with physical activity measured …

Gender Difference In The Relationship Of Fatigue Index, Anaerobic Power And Capacity To Body Composition And Bone Mineral Status In Non-Athletes, Ali Mossayebi, Jehu N. Apaflo, Joshua Labadah, Victoria Rocha, Sudip Bajpeyi

International Journal of Exercise Science: Conference Proceedings

The fatigue index is considered an important indicator of anaerobic fitness. The lower the fatigue index, the greater the ability of the body to maintain its power output through an anaerobic performance. The Wingate test is widely used by coaches, athletes, and researchers to measure lower body power, anaerobic capacity, and fatigue index. Body composition is considered an important component of anaerobic fitness, it is not clear how gender may influence the relationship between body composition and anaerobic fitness. PURPOSE: The purpose of this study was to understand how gender may impact the relationship between body composition and anaerobic …

Alcohol Consumption, Bone Mineral Density, And Risk Of Osteoporotic Fractures: A Dose-Response Meta-Analysis, Justyna Godos, Francesca Giampieri, Emanuele Chisari, Agnieszka Micek, Nadia Paladino, Tamara Y Forbes-Hernández, José L Quiles, Maurizio Battino, Sandro La Vignera, Giuseppe Musumeci, Giuseppe Grosso

Rothman Institute Faculty Papers

Excess alcohol consumption is known to be detrimental to human health. However, the role of light-to-moderate alcohol intake is under investigation for potential certain health benefits— mostly related to the cardiovascular system. Nevertheless, there is no univocal agreement on this matter, and research is still ongoing to clarify whether there might be other potential outcomes affected by alcohol intake. In this regard, there is evidence that excess alcohol intake may negatively influence the risk of osteoporotic fractures. However, there is no comprehensive evidence of literature assessing the role of alcohol consumption in bone mineral density (BMD) and the risk of …

Comparing Efficacy Of Denosumab To Bisphosphonates In Fragility Fractures, Ronald Toledo Cardoso

Theses and Graduate Projects

Background: Osteoporosis is a disease of the bones with decreased bone mineral density and bone mass, leading to poor bone quality/structure, increasing the risk of fragility fractures. Pharmacological treatment is recommended to decrease risk of fractures. Current first line treatment is with bisphosphonates; however, alternative treatment includes denosumab. Both bisphosphonates and denosumab are antiresorptive drugs but differ in mechanism of action. Bisphosphonates remain as first line treatment.

Purpose: The purpose of this literature review is aimed at the PICO question in adults with osteoporosis, what is the efficacy of denosumab compared to bisphosphonates in decreasing the risk of …

Association Between Colia1 Gene Polymorphism And Bone Marrow Density In Children With Beta-Thalassemia Major, Dalia S. Morgan, Karim I. Sobhy, Rehab M. Abd Elkareem, Waleed M. El Malah

Menoufia Medical Journal

Objectives To determine the incidence of SP1 polymorphism in the COLIA1 gene and its correlation to bone mineral density in patients with beta-thalassemia major (TM). Background B-thalassemia is an autosomal-recessive disorder and considered one of the most severe health problems worldwide. Osteoporosis is a devastating bone disease marked by loss of bone mass, microarchitecture, and increased fracture risk. Polymorphism at the Sp1-binding site of the collagen-type I A1 (COLIA1) gene is thought to be an essential factor in the development of osteoporosis. Methods Alleles S and s in the regulatory site of the COLIA1 gene were investigated in 72 children …

Examination Of Athlete Triad Symptoms Among Endurance-Trained Male Athletes: A Field Study, Erin M. Moore, Clemens Drenowatz, David F. Stodden, Kelly Pritchett, Thaddus C. Brodrick, Brittany T. Williams, Justin M. Goins, Toni M. Torres-Mcgehee

All Faculty Scholarship for the College of Education and Professional Studies

Background: Studies examining the physiological consequences associated with deficits in energy availability (EA) for male athletes are sparse.

Purpose: To examine male athlete triad components; low energy availability (LEA) with or without an eating disorder risk (ED), reproductive hormone [testosterone (T)], and bone mineral density (BMD) in endurance-trained male athletes during different training periods.

Methods: A cross-sectional design with 14 participants (age: 26.4 ± 4.2 years; weight: 70.6 ± 6.4 kg; height: 179.5 ± 4.3 cm; BMI: 21.9 ± 1.8 kg/m2) were recruited from the local community. Two separate training weeks [low (LV) and high (HV) training volumes] were used …

Biomarkers For Impending Risk Of Osteoporosis In Premenopausal Women, Rehana Rehman, Ali Usman, Aisha Sheikh, Rozeena Baig

Department of Biological & Biomedical Sciences

Objective: To compare 'cytokines' and 'bone turnover markers' in pre- and post-menopausal women and identify their relationship with bone mineral density (BMD) in both groups. Study Design: A cross-sectional study.
Place and duration of study: Department of Biological & Biomedical Sciences, The Aga Khan University, Karachi, Pakistan, from June 2017 to August 2019.
Methodology: Groups comprised of healthy premenopausal and postmenopausal women from the general population belonging to different ethnic groups and socio-economic status. Serum cytokines and bone turnover markers were assessed by solid-phase immunoassays, BMD (gm /cm2)] measurement was performed by dual-energy X-ray absorptiometry at the hip, lumbar spine, …

Bone Quality In Chronic Kidney Disease Patients: Current Concepts And Future Directions – Part Ii, Kamyar Asadipooya, Mohamed Abdalbary, Yahya Ahmad, Elijah Kakani, Marie-Claude Monier-Faugere, Amr El-Husseini

Internal Medicine Faculty Publications

Background: Patients with chronic kidney disease (CKD) have an increased risk of osteoporotic fractures, which is due not only to low bone volume and mass but also poor microarchitecture and tissue quality. The pharmacological and nonpharmacological interventions detailed, herein, are potential approaches to improve bone health in CKD patients. Various medications build up bone mass but also affect bone tissue quality. Antiresorptive therapies strikingly reduce bone turnover; however, they can impair bone mineralization and negatively affect the ability to repair bone microdamage and cause an increase in bone brittleness. On the other hand, some osteoporosis therapies may cause a redistribution …

The Utility Of Genetic Risk Score To Improve Performance Of Frax For Fracture Prediction In Us Postmenopausal Women, Xiangxue Xiao, Qing Wu

Public Health Faculty Publications

The ability of the fracture risk assessment tool (FRAX) in discriminating fracture and non-fracture in postmenopausal women remains suboptimal. Adding a genetic profile may improve the performance of FRAX. Three genetic risk scores (GRSs) (GRS_fracture, GRS_BMD, GRS_eBMD) were calculated for each participant in the Women’s Health Initiative Study (n = 23,981), based on the summary statistics of three comprehensive osteoporosis-related genome-wide association studies (GWAS). The primary outcomes were incident major osteoporotic fracture (MOF) and hip fracture (HF). The association between each GRS and fracture risk were evaluated in separate Cox Proportional Hazard models, with FRAX clinical risk factors adjusted for. …

Serum Adiponectin Level In Osteoporotic Postmenopausal Women With Type 2 Diabetes Mellitus, Mohammed A. Shaaban, Mohammed G. Habsh, Rasha G. Mostafa, Shimaa K. Zewain

Menoufia Medical Journal

Objective The aim was to evaluate the relationships between serum adiponectin level and lumbar bone mineral density (BMD) in osteoporotic postmenopausal women with or without type 2 diabetes mellitus. Background Adiponectin is a novel adipocytokine that could influence bone metabolism. Patients and methods This case–control study was conducted on 55 postmenopausal women selected from diabetic endocrinology inpatient and outpatient clinics. Patients were divided into three groups: osteoporotic group (group A), which included 20 nondiabetic osteoporotic postmenopausal women; diabetic osteoporotic group (group B), which included 20 type 2 diabetic osteoporotic postmenopausal women; and control group (group C), which included 15 nonosteoporotic, …

Beyond The Brain: A Study Of Α-Synuclein's Role In Bone And Adipose Tissue, Carolina A. Figueroa

Electronic Theses and Dissertations

α-Synuclein is a polypeptide encoded by the Snca gene, highly expressed in neurons, but it is also found in bones and adipose tissue. Co-expression analysis showed that Snca regulates skeletal homeostasis, and its deletion reduced estrogen deficiency-induced bone loss and weight gain. It is a major component of Lewy bodies (LB) in Parkinson’s disease (PD), leading to progressive immobilization and a range of nonmotor symptoms, including osteopenia, body composition alterations and insulin resistance. This thesis aimed to determine α-Synuclein’s intrinsic role in bone and adipose homeostasis. We discussed the PD pathophysiology emphasizing aspects of bone health and metabolism. By using …

Dual X-Ray Absorptiometry Has Limited Utility In Detecting Bone Pathology In Children With Hypophosphatasia: A Pooled Post Hoc Analysis Of Asfotase Alfa Clinical Trial Data., Jill H. Simmons, Eric T. Rush, Anna Petryk, Shanggen Zhou, Gabriel Á. Martos-Moreno

Manuscripts, Articles, Book Chapters and Other Papers

Asfotase alfa is an enzyme replacement therapy approved for treatment of patients with pediatric-onset hypophosphatasia (HPP), a rare, inherited, systemic disease causing impaired skeletal mineralization, short stature, and reduced physical function in children. The role of dual X-ray absorptiometry (DXA) in the assessment of children with HPP has been insufficiently explored. This post hoc analysis included pooled DXA data from 2 open-label, multicenter studies in 19 children with HPP. The study population was aged ≥5 to≤6.6 years at enrollment (male: 79%; median age at enrollment: 10.4 y [range: 5.9-16.7]; treatment duration: 6.3 y [range: 0.1-6.6]. Baseline height Z-scores indicated short …

Diagnostic Efficacy Of Routine Contrast-Enhanced Abdominal Ct For The Assessment Of Osteoporosis In The Turkish Population, Ayşegül Cansu, Di̇lara Atasoy, İlker Eyüboğlu, Murat Karkucak

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the diagnostic efficacy of vertebral Hounsfield unit (HU) values on routine contrast-enhanced abdominal computed tomography (CT) scans for the assessment of osteoporosis using dual-energy X-ray absorptiometry (DXA) T-scores as a reference standard.Materials and methods: A total of 111 consecutive patients who underwent contrast-enhanced abdominal CT examination for any indication and DXA within a 6-month period were retrospectively analyzed. The CT attenuation values of trabecular bone in HUs were measured in axial and sagittal planes from lumbar vertebrae 1-4 (L1-L4). The correlation between the DXA T-scores and HU values measured on the CT scans was …

Neuropeptide Y1 Receptor Antagonist But Not Neuropeptide Y Itself Increased Bone Mineral Density When Locally Injected With Hyaluronic Acid In Male Wistar Rats, Muhammer Özgür Çevi̇k, Petek Korkusuz, Feza Korkusuz

Turkish Journal of Medical Sciences

Background/aim: The nervous system controls bone mass via both the central (CNS) and the peripheral (PNS) nervous systems. Intriguingly, neuropeptide Y (NPY) signaling occurs in both. Less is known on how the PNS stimulated NPY signaling controls bone metabolism. The objective of this study was to evaluate whether NPY or NPY1 receptor antagonist changes local bone mineral density (BMD) when injected into a Wistar rat tibia. Materials and methods: Tibial intramedullary area of 24 wild type male Wistar rats (average weight = 350 ± 50 g, average age = 4 ± 0.5 months) were injected with NPY (1 × 10-5 …

Evaluation Of The Effects Of Ss1-Selective Beta-Blockers On Bone Mineral Density And Fracture Risk In Postmenopausal Women, Betül Yavuz Keleş, Meltem Vural, Burcu Önder, Kadri̇ye Öneş

Turkish Journal of Medical Sciences

Background/aim: ß1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of ß1-selective BBs on bone mineral density (BMD) and fracture risk. Materials and methods: This study included postmenopausal women who used ß1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX). Results: A total of 60 participants were included in the study. L1-4 and L2-4 BMD values were …

Estimating Body Mass Through Bone Mineral Density Studies Using Dexa (Dual-Energy X-Ray Absorptiometry), Kaitlin Harstine

Master's Theses

Identification of a decedent is one of the primary goals of forensic anthropologists. In order to do this, one must build a biological profile based on the remains that are provided. Sex, age, ancestry, and stature are four of the most common, however a fifth addition piece of information that could be beneficial is body mass. The goal of this research is to explore the relationship between bone mineral density (BMD) and body mass, using data collected from dual x-ray absorptiometry (DEXA) scans of 107 collegiate football athletes. Athletes are a good fit for this study because they have achieved …

Association Between Abdominal Aortic Calcification, Bone Mineral Density And Fracture In Older Women, Joshua R. Lewis, Celeste J. Eggermont, John T. Schousboe, Wai H. Lim, Germaine Wong, Ben Khoo, Marc Sim, Mingxiang Yu, Thor Ueland, Jens Bollerslev, Jonathan M. Hodgson, Kun Zhu, Kevin E. Wilson, Douglas P. Kiel, Richard L. Prince

Research outputs 2014 to 2021

Although a relationship between vascular disease and osteoporosis has been recognized, its clinical importance for fracture risk evaluation remains uncertain. Abdominal aortic calcification (AAC), a recognized measure of vascular disease detected on single‐energy images performed for vertebral fracture assessment, may also identify increased osteoporosis risk. In a prospective 10‐year study of 1,024 older predominantly Caucasian women (mean age 75.0±2.6 years) from the Perth Longitudinal Study of Aging cohort we evaluated the association between AAC, skeletal structure and fractures. AAC and spine fracture were assessed at the time of hip densitometry and heel quantitative ultrasound. AAC was scored 0 to 24 …

Low Vitamin D Status Is Associated With Impaired Bone Quality And Increased Risk Of Fracture-Related Hospitalization In Older Australian Women, Kun Zhu, Joshua R. Lewis, Marc Sim, Richard L. Prince

Research outputs 2014 to 2021

The vitamin D debate relates in part to ideal public health population levels of circulating 25-hydroxyvitamin D (25OHD) to maintain bone structure and reduce fracture. In a secondary analysis of 1,348 women aged 70-85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women (PLSAW, a five-year calcium supplementation trial followed by two five-year extensions), we examined the dose-response relations of baseline plasma 25OHD with hip DXA BMD at year 1, lumbar spine BMD and trabecular bone score (TBS) at year 5, and fracture-related hospitalizations over 14.5 years obtained by health record linkage. Mean baseline plasma 25OHD …

Lipoprotein(A) Plasma Levels, Bone Mineral Density And Risk Of Hip Fracture: A Post Hoc Analysis Of The Women's Health Initiative, Usa, Bernhard Haring, Carolyn J. Crandall, Laura Carbone, Simin Liu, Wenjun Li, Karen C. Johnson, Jean Wactawski-Wende, Aladdin H. Shadyab, Margery L. Gass, Victor Kamensky, Jane A. Cauley, Sylvia Wassertheil-Smoller

Wenjun Li

OBJECTIVES: Elevated Lipoprotein(a) (Lp[a]) is a well-known risk factor for cardiovascular disease. However, its roles in bone metabolism and fracture risk are unclear. We therefore investigated whether plasma Lp(a) levels were associated with bone mineral density (BMD) and incident hip fractures in a large cohort of postmenopausal women.

DESIGN: Post hoc analysis of data from the Women's Health Initiative (WHI), USA.

SETTING: 40 clinical centres in the USA.

PARTICIPANTS: The current analytical cohort consisted of 9698 white, postmenopausal women enrolled in the WHI, a national prospective study investigating determinants of chronic diseases including heart disease, breast and colorectal cancers and …

Bone Mineral Density Among Men And Women Aged 35 To 50 Years, Martha A. Bass, Ankita Sharma, Vinayak K. Nahar, Stacy Chelf, Brittany Zeller, Linda Pham, M. Allison Ford

Faculty and Student Publications

© 2019 American Osteopathic Association. Context: Osteoporosis is characterized by low bone mineral density (BMD) and has been thought to only be a major health concern for postmenopausal women. However, osteoporosis and its risk factors have been greatly understudied in the middle-aged and male populations. Objective: To assess the likelihood of low BMD and its association with related risk factors in early–middle-aged (defined in this study as 35-50 years) men and women.Methods: Eligible men and women completed a questionnaire assessing calcium intake, hours per week of exercise, and other related risk factors associated with osteoporosis and osteopenia. The primary outcome …

Abdominal Aortic Calcification, Bone Mineral Density And Fractures: A Systematic Review And Meta-Analysis Protocol, Alexander J. Rodríguez, Kevin Leow, Pawel Szulc, David Scott, Peter Ebeling, Marc Sim, Germaine Wong, Wai H. Lim, John T. Schousboe, Douglas P. Kiel, Richard L. Prince, Joshua R. Lewis

Research outputs 2014 to 2021

INTRODUCTION: Abdominal aortic calcification (AAC) is associated with low bone mass and increased fracture risk. Two previous meta-analyses have investigated the association between AAC and fracture. However, these meta-analyses only identified articles until December 2016, undertook limited searches and did not explore potential sources of between-study heterogeneity. We aim to undertake a sensitive and comprehensive assessment of the relationship between AAC, bone mineral density (BMD) as well as prevalent and incident fractures.

METHODS: We will search MEDLINE, EMBASE, Web of Science core collection and Google Scholar (top 200 articles sorted by relevance) from their inception to 1 June 2018. Reference …

Comparison Of Serum Levels Of Vitamin D And Vitamin D-Binding Protein In Normal, Osteopenic And Osteoporotic Postmenopausal Women, Rafat Murad, Tabassum Mahboob, Rehana Rehman, Rozeena Baig

Department of Biological & Biomedical Sciences

Objective: To compare the serum levels of vitamin D, vitamin D binding protein (VDBP) calcium and phosphate in normal, osteopenic and osteoporotic postmenopausal women categorized on the basis of bone mineral density (BMD) scores.
Methods: A cross sectional study carried out from May 2017 to August 2018. BMD measured by Dual energy X-ray Absorptiometry categorized women (aged 20- 70 years) into normal (n=37) (T score ≥ -1.0) osteopenic (n=25) (-2.5< T score, < -1) and osteoporotic (n= 26) (T score < -2.5) according to WHO classification. Serum concentrations of vitamin D, VDBP, calcium, phosphate analyzed by enzyme linked immunosorbent assay were compared by Analysis of Variance.
Results: In normal females higher levels of vitamin D and VDBP were observed [15.82 (8 - 69.18), 469.9 (269.57 - 875.55)] vs. osteopenic [(7.45 (4.66 - 15.1), 296.05 (232.58 - …

The Effect Of Parathyroidectomy On Bone Mineral Density In Primary Hyperparathyroidism, Mustafa Çalişkan, Selvi̇han Beysel, Muhammed Kizilgül, Mustafa Özbek, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the change in bone mineral density (BMD) before and 1 year after parathyroidectomy in patients with primary hyperparathyroidism (PHPT). Materials and methods: The clinical and biochemical parameters and DEXA screening of patients with symptomatic PHPT (n = 28) and asymptomatic PHPT (n = 63) were investigated before and 1 year after parathyroidectomy. Results: Patients with symptomatic PHPT had a higher prevalence of nephrolithiasis (18.2% vs. 4.6%, P = 0.032) when compared to the prevalence in patients with asymptomatic PHPT. The prevalence of osteoporosis in the lumbar spine (63.0% vs. 37.5%, P = 0.026) and …