Medicine and Health Sciences Commons^™

Rational Use Of Blood And Blood Components In A Tertiary Care Hospital: A Crossectional Study., Rupali Chordia Dr, Dr Himani Shemar Dr

Digital Journal of Clinical Medicine

Abstract:

Introduction: Blood transfusion is a life saving process and a complex phenomenon. Judicial use of blood and its components is the need of the hour. Objectives: The present study was planned with the objective to assess the appropriateness of blood transfusions in patients admitted in the hospital as per WHO guidelines. Materials and Methods: A crossectional study was conducted at tertiary care hospital for a period of one and a half years. Records of patients from blood bank were evaluated to collect data. MS Excel was used to enter the data and IBM SPSS Statistics for Windows …

Improving The Blood Product Administration Process At Hca Florida Osceola Hospital, Kar Shun Constant Mak, Neha Meda, Natalia Tejada, Parasto Asnaashari, Joshua Sutarwan, Joshua Shultz, Maria Wallis-Crespo, Sarah Tinsley

North Florida Division GME Research Day 2023

No abstract provided.

Expression Of Cd55 And Cd35 On Red Blood Cells Of Children With Beta-Thalassemia Major, Amira M. F. Shehata, Esraa G. R. Awad, Mahmoud A. El-Hawy, Rawhia H. El-Edel

Menoufia Medical Journal

Background Beta-thalassemia is a hereditary disease that is characterized by ineffective erythropoiesis and shortened red blood cell survival. In severe cases, blood transfusion is a mainstay therapy; however, regular blood transfusions result in iron overload with serious complications. Complement-mediated erythrocyte destruction is one of the pathological causes of hemolysis in beta-thalassemia. Membrane-bound complement regulatory proteins such as CD55 and CD35 ensure that the complement system does not become overactivated, thus causing harm to self-tissues. Objectives To assess the expression of CD55 and CD35 on erythrocytes of β-thalassemia patients and its correlation with hemoglobin (Hb) levels and other markers of hemolysis. …

Evaluation Of Blood Transfusion Practice At University Of Science & Technology Hospital, Yemen, Noor Abdull-Aziz Bin Kroom

Hadhramout University Journal of Natural & Applied Sciences

Blood transfusion is a vital part of the health care system. The accrediting and regulatory agencies make essential policies and guidelines for its transfusion process. The study aimed to evaluate blood transfusion practice specifically its indications at the University of Science and Technology (UST) Hospital in Sana‟a, Yemen to improve this service. This was a retrospective descriptive study. A total of 200 files (100 donors, 100 recipients) were reviewed during the study period from January to December 2013. The sample was selected using simple random technique and the size was determined as a rule of thumb. Data was collected in …

Restrictive Versus Liberal Transfusion Thresholds In Very Low Birth Weight Infants: A Systematic Review With Meta-Analysis, Peng Wang, Xing Wang, Haidong Deng, Linjie Li, Weelic Chong, Yang Hai, Yu Zhang

Department of Medicine Faculty Papers

BACKGROUND: To assess the efficacy and safety of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants.

METHODS: We searched MEDLINE, EMBASE, and Cochrane database without any language restrictions. The last search was conducted in August 15, 2020. All randomized controlled trials comparing the use of restrictive versus liberal red blood cell transfusion thresholds in very low birth weight (VLBW) infants were selected. Pooled risk ratio (RR) for dichotomous variable with 95% confidence intervals were assessed by a random-effects model. The primary outcome was all-cause mortality.

RESULTS: Overall, this meta-analysis included 6 randomized controlled trials …

Supply, Demand, And Quality: A Three-Pronged Approach To Blood Product Management In Developing Countries, Kyle L. Gress, Karina Charipova, Ivan Urits, Omar Viswanath, Alan D. Kaye

Journal of Patient-Centered Research and Reviews

While transfusion of blood and blood products is instinctively linked to the provision of emergent care, blood and blood products are also routinely used for the treatment of subacute and chronic conditions. Despite the efforts of the World Health Organization and others, developing countries are faced with a three-part problem when it comes to access to and delivery of transfusions: insufficient supply, excessive demand, and inadequate quality of available supply. Developing countries rely heavily on replacement and remunerated donors rather than voluntary nonremunerated donors due to concerns regarding donation- and transfusion-transmitted infection as well as local and cultural beliefs. While …

Comorbidities And Complications In Adults With Pyruvate Kinase Deficiency., Audra N. Boscoe, Yan Yan, Elizabeth Hedgeman, Eduard J. Van Beers, Hanny Al-Samkari, Wilma Barcellini, Stefan W. Eber, Bertil Glader, Hassan M. Yaish, Satheesh Chonat, Mukta Sharma, Kevin H M Kuo, Ellis J. Neufeld, Heng Wang, Madeleine Verhovsek, Sujit Sheth, Rachael F. Grace

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Pyruvate kinase (PK) deficiency is caused by PKLR gene mutations, leading to defective red blood cell glycolysis and hemolytic anemia. Rates of comorbidities and complications by transfusion history and relative to the general population remain poorly quantified.

METHODS: Data for patients aged ≥ 18 years with two confirmed PKLR mutations were obtained from the PK deficiency Natural History Study (NCT02053480). Frequencies of select conditions were compared with an age- and sex-matched cohort from a general insured US population without PK deficiency.

RESULTS: Compared with the matched population (n = 1220), patients with PK deficiency (n = 122) had significantly …

Complications In Cardiac Surgery, Christine Williamitis

Theses and Dissertations--Nursing

Quality of care and outcomes from cardiac surgery have always been of primary importance to providers and the entire health care team when caring for cardiac surgical patients. Providers in cardiac surgery have had a long history of tracking procedural morbidity and mortality rates in programs nationally and internationally. Morbidity and mortality rates vary widely among hospitals. In most studies in which procedural outcomes from cardiac surgery are evaluated, the focus has been on operative morbidity and mortality and the probability of death after a cardiac surgical procedure. Less attention has been paid to predictors of perioperative complications, and sample …

Blood Transfusion: Knowledge, Perspectives, And Experiences Of Individuals With Sickle Cell Disease, Raymona H. Lawrence, Ashley Singleton, Jane Branscomb

Department of Health Policy and Community Health Faculty Publications

Patient voice and perspective were needed to inform effective, comprehensive strategies for reducing preventable transfusion-associated complications. This report presents the results of interviews with sickle cell disease (SCD) patients and implications for strategies to reduce transfusion complications in this population. Twenty-two participants were recruited from 2 comprehensive SCD treatment centers in Georgia and interviewed regarding knowledge about transfusions and potential complications, attitudes about data storage and sharing, and the transfusion experience. Participants had general knowledge of physiology, blood products, and blood transfusions, including knowing the risk of complications, but varied in comprehension of complex health information and level of misinformation. …

The Proportion Of Acute Transfusion Reaction At Outpatient Blood Transfusion Unit In Tertiary Hospital In Indonesia, Ahmad Fariz Malvi Zamzam Zein, Lugyanti Sukrisman

Jurnal Penyakit Dalam Indonesia

Introduction. Acute transfusion reaction (ATR) is an important issue related to patient safety. The prevalence of ATR at tertiary hospital in Indonesia is 0.5%. This study was aimed to determine the proportion of ATR in outpatient blood transfusion unit at tertiary hospital. Method. This retrospective study implemented data from medical records of adult patients who underwent blood transfusion in outpatient blood transfusion unit, Cipto Mangunkusumo Hospital between August – October 2014. The blood components included packed red cells (PRC), thrombocyte concentrate (TC), fresh frozen plasma (FFP), and cryoprecipitate. We recorded the administration of premedication and ATR-related symptoms/signs. The ATR report …

Establishment Of Laboratory Methods To Assess The Application Of Blood Transfusions In Reptiles, Anke Cordula Stoehr

LSU Master's Theses

A broad knowledge base on veterinary transfusion medicine has been developed in common mammalian species, but little is known in reptiles. The goals of this thesis were to establish laboratory methods to assess the application of blood transfusions in reptiles. Morphological and physiological differences in reptiles, including their erythrocytes, hamper direct adaption of mammalian laboratory methods.

Quantification of percentage hemolysis is a crucial tool for quality assessment of stored red blood cell products. We evaluated measurement of the required analytes for this calculation (supernatant and total hemoglobin) with different methods in blood from American alligators and found that the use …

The Impact Of Delayed Treatment Of Uncomplicated P. Falciparum Malaria On Progression To Severe Malaria: A Systematic Review And A Pooled Multicentre Individual-Patient Meta-Analysis, Andria Mousa, Abdullah Al-Taiar, Nicholas M. Anstey, Cyril Badaut, Bridget E. Barber, Quique Bassat, Joseph D. Challenger, Aubrey J. Cunnington, Dibyadyuti Datta, Chris Drakeley, Azra C. Ghani, Victor R. Gordeuk, Matthew J. Grigg, Pierre Hugo, Chandy C. John, Alfredo Mayor, Florence Migot-Nabias, Robert O. Opoka, Geoffrey Pasvoi, Claire Rees, Hugh Reyburn, Eleanor M. Riley, Binal N. Shah, Antonio Sitoe, Colin J. Sutherland, Philip E. Thuma, Stefan A. Unger, Firmine Viwami, Michael Walther, Christopher J.M. Whitty, Timothy William, Lucy C. Okell

Community & Environmental Health Faculty Publications

BACKGROUND: Delay in receiving treatment for uncomplicated malaria (UM) is often reported to increase the risk of developing severe malaria (SM), but access to treatment remains low in most high-burden areas. Understanding the contribution of treatment delay on progression to severe disease is critical to determine how quickly patients need to receive treatment and to quantify the impact of widely implemented treatment interventions, such as 'test-and-treat' policies administered by community health workers (CHWs). We conducted a pooled individual-participant meta-analysis to estimate the association between treatment delay and presenting with SM.

METHODS AND FINDINGS: A search using Ovid MEDLINE and Embase …

Understanding The Nursing Practices And Perspectives Of Premedication And Transfusion Reaction Reporting: A Qualitative Description Study, Wenxin Miao

Electronic Thesis and Dissertation Repository

This qualitative description study is a sub-study of a knowledge translation (KT) project to implement evidence-based blood transfusion practices at an urban tertiary hospital. The goals of the KT project are to reduce the use of pre-transfusion medications (premedication) and to improve transfusion reaction (TR) reporting practices at this institution. This study explored the nursing practices and perspectives of premedication and TR reporting by conducting interviews with 25 nurses. The findings showed a lack of standardized premedication and TR reporting practices at this institution. A practice change is needed to achieve the goals of the KT project. The study also …

N653_Prospectus_Final_V2_Alternatives To Transfusions .Docx, Donita Rose

Donita Rose

Update Of Blood Transfusion Protocols At A Regional Hospital In Rural Illinois, Kendra Tracy

Doctor of Nursing Practice Projects

The chief nursing officer (CNO) at a small regional hospital in rural Illinois requested an update to their blood transfusion policy and protocol based on current evidence-based information. These documents were updated with current information on safe assembly and delivery, identification of transfusion reactions, and appropriate responses to these reactions. In collaboration with the CNO and Quality Improvement Committee (QIC), drafts of a new policy and protocol and a Blood Transfusion Skills Checklist were developed. These documents were presented at a hospital-wide Skills Lab Day to registered nurses employed at the facility. A Likert Scale evaluation survey was presented to …

Increased Risk Of Blood Transfusion In Patients With Diabetes Mellitus Sustaining Non-Major Burn Injury, Linda Mai, Katrina Spilsbury, Dale W. Edgar, Aaron Berghuber, Fiona M. Wood

Health Sciences Papers and Journal Articles

Background: Due to the increased mortality and morbidity associated with blood transfusion, identifying modifiable predictors of transfusion are vital to prevent or minimise blood use. We hypothesised that burn patients with diabetes mellitus were more likely to be prescribed a transfusion. These patients tend to have increased age, number of comorbidities, infection risk and need for surgery which are all factors reported previously to be associated with blood use.

Objective: To determine whether patients with diabetes mellitus who have sustained a burn ≤20% total body surface area (TBSA) are at higher risk of receiving red blood cell transfusion compared to …

Effect Of Dilutional Anemia That Can Be Treated With Only One Unit Of Red Blood Cell Transfusion On Tissue Oxygenation In Cardiac Surgery Patients, Büşra Tezcan, Demet Bölükbaşi, Alev Şaylan, Sema Turan, Sultan Sevi̇m Yakin, Di̇lek Kazanci, Ayşegül Özgök, Hi̇ja Yazicioğlu

Turkish Journal of Medical Sciences

Background/aim: Cardiac surgery, especially in the presence of cardiopulmonary bypass (CPB), is associated with an inflammatory reaction that may promote microcirculatory alterations, in addition to the general impact on system hemodynamics. Anemia and transfusion make patients more susceptible to the deleterious effects of CPB. In this study, it was aimed to evaluate the effect of dilutional anemia, which is caused by CPB and can be treated with 1?2 units of red blood cell (RBC) transfusion, on global tissue oxygenation parameters in cardiac surgery patients.Materials and methods: This prospective observational study comprised 127 patients who had a relatively stable operation period …

Haemoglobin: An Amenable Outcome Factor Of Acute Ischemic Stroke After Thrombolysis, Saumya H. Mittal, Rakshith Kc, Misri Zk, Shivanand Pai

Manipal Journal of Medical Sciences

Objective: To study the role of haemoglobin in outcome of thrombolysis after stroke. Material and method: Our observational study was conducted over five years at KMC Hospital, Mangalore from July 2011 to July 2016. All patients above the age of 18 years presenting to the hospital within 4.5 hours of onset of stroke were included into the study. The patients’ stroke severity was calculated by National Institute of Health Stroke Scale (NIHSS) score, while the outcome was measured by Modified Rankin Scale (mRS) score. The patients were divided into good outcome, poor outcome and expired group of patients depending on …

"It's A Precious Gift, Not To Waste": Is Routine Cross Matching Necessary In Orthopedics Surgery?: Retrospective Study Of 699 Patients In 9 Different Procedures, Obada Hasan, Eraj Khurshid Khan, Moiz Ali, Sadaf Sheikh, Anum Fatima, Haroon Ur Rashid

Section of Orthopaedic Surgery

Background: Orthopedic surgeries are usually associated with excessive blood loss which leads surgeons to overestimate need for blood transfusions and over ordering of blood. The cross matched blood, when not used, leads to the wastage of blood bank resources in terms of time, money and manpower. The objective of this study was to investigate the compliance to previously proposed MSBOS and to provide updated recommendations for all orthopedic procedures.
Methods: A retrospective analysis was conducted between 1st June 2015 and 31st May 2016. Patients admitted to the orthopedic surgery service for whom blood products were requested were included. Cross Match/Transfusion …

Changing The Standard Of Blood Management In Australia: An Overview, Alana Delaforce, Jed Duff, Nicholas Ralph

Journal of Perioperative Nursing

No abstract provided.

Anemia Of Unknown Origin In An Otherwise Healthy Asa 1 18-Year-Old Male, Andrew Rook

Nursing Capstones

No abstract provided.

Anesthesia Considerations For Intraoperative Blood Transfusion, Ana I. Dahl

Nursing Capstones

No abstract provided.

Outcome Of Judet's Quadricepsplasty For Knee Contractures And The Effect Of Local Infiltration Of Epinephrine On Reducing Blood Loss, Akber Jalil Zuberi, Haroon Rashid, Rizwan Haroon Rashid, Moiz Ali, Pervaiz Hashmi

Section of Orthopaedic Surgery

Objective: To evaluate the effectiveness of Judet's quadricepsplasty for treatment of knee contractures and to identify the effect of local infiltration of epinephrine on blood loss associated with this procedure.
Methods: A retrospective cohort study was conducted in which all cases of knee contractures managed with Judet's quadricepsplasty from 1st January 2009 to 31st December 2013 were included and were divided into two groups. The epinephrine group included patients who were infiltrated with diluted epinephrine (1:400,000) along with xylocaine, around the operative field 15 min prior to the incision time, while the control group did not receive any infiltration. Judet's …

Tnf-Α And Tgf-Ss Level After Intraoperative Allogeneic Red Blood Cell Transfusion In Orthopedic Operation Patients, Hamed Hassani, Alireza Khoshdel, Seyed Reza Sharifzadeh, Mohammad Foad Heydari, Shaban Alizadeh, Ali Noroozi Aghideh

Turkish Journal of Medical Sciences

Background/aim: Blood transfusion is associated with immunosuppression, referred to as transfusion-related immunomodulation (TRIM). In this study, for the first time, changes in the concentration of TGF-ß and TNF-α were measured postoperatively in orthopedic patients with intraoperational allogeneic red blood cell transfusion. Considering the use of packed cell units with different ages, it is possible to suggest the more appropriate product for clinical applications.Materials and methods: Two groups of 35 orthopedic surgery patients (with or without transfusion as case and control groups, respectively) were involved. Serum levels of TNF-α and TGF-ß were measured by ELISA.Results: The data suggested significant differences in …

Strategies For The Management Of Postoperative Anemia In Elective Orthopedic Surgery, Taylor D. Steuber, Meredith L. Howard, Sarah A. Nisly

Scholarship and Professional Work – COPHS

Objective: To assess the use of oral iron, intravenous (IV) iron, and erythropoiesis-stimulating agents (ESAs) for the prevention and management of perioperative anemia in elective orthopedic surgery patients, and to provide a clinical algorithm for use. Data Sources: A PubMed and MEDLINE search was conducted from 1964 through March 2016 using the following search terms alone or in combination: orthopedic, surgery, elective, anemia, blood transfusion, iron, erythropoiesisstimulating agents, and erythropoietin. Study Selection and Data Extraction: All English-language prospective and retrospective human studies and meta-analyses evaluating oral iron, IV iron, or ESA alone or in combination in elective orthopedic surgery …

Does Tranexamic Acid Reduce Blood Transfusion Following Surgery For Inter-Trochanteric Fracture? A Randomized Control Trial, Yasir Mohib, Rizwan Haroon Rashid, Moiz Ali, Akbar Jaleel Zubairi, Masood Umer

Department of Surgery

Abstract

OBJECTIVE:

To compare the frequency of blood transfusion after surgery for fixation of inter-trochanteric fractures in patients given tranexamic acid versus placebo.

METHODS:

The randomised control trial was conducted at the Aga khan university hospital from May 1 to October 31, 2014, and comprised patients diagnosed with Inter-trochanteric fracture based on X-ray imaging. The patients were randomised into two equal groups based on a computer-generated random number table. The Intervention group received two doses of 10mg/kg body weight of tranexamic acid just before surgery and three hours later intravenously. The Control group received two doses of 10mg/kg body weight …

Anticipated And Unanticipated Complications Of Severe Dengue In A Primigravida, Madiha Hashmi, Ghulam Zainab, Farah Khan

Department of Obstetrics & Gynaecology

As the incidence of dengue is rising among adults more cases of dengue fever are being reported during pregnancy. Physiological changes of pregnancy mask the pathognomonic features of severe dengue such as increased hematocrit, thrombocytopenia, and leukopenia and a high index of suspicion are required in endemic areas. Massive hemorrhage may complicate operative deliveries in unsuspected patients. World Health Organization recommends that all patients with severe dengue should be admitted to a hospital with access to intensive care facilities and blood transfusion. We present the successful management of hemorrhage and unanticipated complications of severe dengue in a young primigravida admitted …

Variability In Splanchnic Tissue Oxygenation During Preterm Red Blood Cell Transfusion Given For Symptomatic Anaemia May Reveal A Potential Mechanism Of Transfusion-Related Acute Gut Injury, Sean M. Bailey, Karen D. Hendricks-Muñoz, Pradeep V. Mally

Pediatrics Publications

Background

There is increasing evidence indicating an association between red blood cell (RBC) transfusions and necrotising enterocolitis (NEC) in preterm infants, especially late-onset NEC. This phenomenon is referred to as transfusion-related acute gut injury (TRAGI). One theory as to a pathophysiological mechanism is that transfusion may result in an ischemia-reperfusion injury to intestinal tissue. We tested the hypothesis that there is significantly greater variability during transfusion in splanchnic tissue oxygen saturation (SrSO2) than in cerebral tissue oxygen saturation (CrSO2).

Materials and methods

This was a prospective, observational study using near-infrared spectroscopy to monitor SrSO2 and CrSO2in preterm neonates undergoing RBC …

Hiv Prevalence In Blood Donors And Recipients In Pakistan: A Meta-Analysis And Analysis Of Blood-Bank Data, Bushra Moiz, Barkat Ali, Muhammad Hasnain Chatha, Ahmed Raheem, Hasan Abbas Zaheer

Department of Pathology and Laboratory Medicine

Background:
The first instances of HIV-antibody detection in donated blood in Pakistan were reported in 1988. Since then, documentation of HIV in blood donors and of rates of transmission via transfusion has been limited. Previously assumed to have a low prevalence, HIV is an increasing health concern in Pakistan. Since there is no national, centralized blood-banking system, there are no reliable data on which to base estimated risks of transfusion-associated HIV infection. This study was therefore conducted to estimate the prevalence of HIV in blood donors and recipients in Pakistan between 1988 and 2012.
Methods:
Meta-analyses were undertaken of reported …

In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün

Turkish Journal of Medical Sciences

Background/aim: Currently, the provision of blood products largely depends on walking blood banks and limited amounts of stored blood with short shelf lives. We aimed to compare the efficacy of erythrocyte concentrate (ECs) by pre- and postfreezing in vitro tests. Materials and methods: In our study, 10 ECs were glycerolized, frozen, thawed, and then deglycerolized using the Naval Blood Research Laboratory method. In addition to using the standard tests, ATP and 2,3-DPG levels and the viability of erythrocytes were also determined. Results: The prefreezing mean viability rates of erythrocytes changed from 89.7 ± 13.7% to 98.6 ± 1.8% after thawing …