Medicine and Health Sciences Commons^™

Endogenous Renal Adiponectin Drives Gluconeogenesis Through Enhancing Pyruvate And Fatty Acid Utilization, Toshiharu Onodera, May-Yun Wang, Joseph M Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S Balzer, Dae-Seok Kim, Xuenan Sun, Yu A An, Bianca C Field, Charlotte Lee, Ei-Ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M Kusminski, Ruth Gordillo, Laurent Gautron, Denise K Marciano, Ming Chang Hu, Shawn C Burgess, Katalin Susztak, Orson W Moe, Philipp E Scherer

Student and Faculty Publications

Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is unknown. We assessed the impact of renal adiponectin by utilizing male inducible kidney tubular cell-specific adiponectin overexpression or knockout mice. Kidney-specific adiponectin overexpression induces a doubling of phosphoenolpyruvate carboxylase expression and enhanced pyruvate-mediated glucose production, tricarboxylic acid cycle intermediates and an upregulation of fatty acid oxidation (FAO). Inhibition of FAO reduces the adiponectin-induced enhancement of glucose production, highlighting the role of FAO in the induction …

Study Of Serum Adiponectin And Chemerin In Patients With Non-Alcoholic Fatty Liver Disease, Hosam El-Din Mustafa Seleem, Ayman M. El- Lehleh, Mohsen Mohamed Elkhayat, Osama L. El Abd, Eman A. Badr, Enas F. Elmezein, Ahmed .A Ahmed Teima

Menoufia Medical Journal

Objective: To study the levels of serum adiponectin and chemerin in patients with nonalcoholic fatty liver disease(NAFLD) and their diagnostic role.

Background: NAFLD is the most common cause of chronic liver disease, which is a major cause of morbidity and mortality. Liver biopsy remains the gold standard for its diagnosis, but it is an invasive procedure. chemerin and adiponectin can be possible noninvasive diagnostic markers.

Patients and methods: This prospective study was conducted from March 2020 to October 2021 on 90 subjects including 60 patients with NAFLD and 30 age and gender-matched healthy individuals as control group. All were subjected …

The Possible Relationship Of Adiponectin And Gestational Weight Gain During Different Stages Of Pregnancy Amongst Different Ethnic Groups, Jayshree Chauhan, Xinhua Chen

Rowan-Virtua Research Day

Introduction: Gestational Weight Gain (GWG) is defined as weight gain between conception and birth. Adiponectin, a fat derived hormone, has an inverse relationship with weight gain. We investigated the relationship of maternal adiponectin concentration and GWG during different pregnancy stages among ethnic groups. Method: Serum adiponectin levels were measured at entry (week 16) and trimester three (week 28) in pregnant women (n = 1634, age 22.0±5.3, pre-pregnancy BMI 25.7±6.3) which included Hispanic (47%), African American (37%) and Caucasian (16%) women. GWG was measured at week 24, 28, 32, and delivery and was divided into inadequate, adequate, and excessive according to …

Adipose Tissue Metabolic Changes In Chronic Kidney Disease, Eurico Serrano, Prashamsa Shenoy, Maria Paula Martinez Cantarin

Division of Nephrology Faculty Papers

Adipose tissue is a complex organ whose functions go beyond being an energy reservoir to sustain proper body energy homeostasis. Functioning as an endocrine organ, the adipose tissue has an active role in the body's metabolic balance regulation through several secreted factors generally termed as adipokines. Thus, adipose tissue dysregulation in chronic kidney disease (CKD) can have a deep impact in the pathophysiology of diseases associated with metabolic dysregulation including metabolic syndrome, insulin resistance (IR), atherosclerosis, and even cachexia. CKD is a progressive disorder linked to increased morbidity and mortality. Despite being characterized by renal function loss, CKD is accompanied …

Evaluation Of Leptin And Adiponectin Levels In Obese Patients With Acne Vulgaris, Magda M. Haggag, Manal A. Safan, Nafisa Z. I Abd Algalil

Menoufia Medical Journal

Objective This study aimed to evaluate adipokines such as leptin and adiponectin in obese patients with acne vulgaris. Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit characterized by increased sebum production in response to androgens. The adipokines secreted from the sebaceous glands are considered novel factors affecting acne inflammation. Patients and methods This study was carried out at the Dermatology and Medical Biochemistry and Molecular Biology Departments of Faculty of Medicine, Menoufia University. Patients were grouped as follows: group I (patient group) included 60 obese patients with acne vulgaris, and group II (control group) included 30 …