Medicine and Health Sciences Commons^™

The Role Of Micrornas In The Pathophysiology Of Neonatal Hypoxic-Ischemic Brain Injury, Eric S. Peeples

Theses & Dissertations

Neonatal hypoxic-ischemic brain injury (HIBI) is a devastating injury resulting from impaired blood flow and oxygen delivery to the brain at or around the time of birth. The subsequent metabolic failure and cellular injury in the brain can be partially attenuated by rapid initiation of therapeutic hypothermia, but even with prompt induction of hypothermia, more than one in four survivors suffer from major developmental disabilities – an indication of the critical need for more effective therapies. MicroRNAs (miRNA) may be able to act as therapeutic targets in neonatal HIBI; however, very little is known about the endogenous expression of miRNAs …

Minimally Invasive Postmortem Intestinal Tissue Sampling In Malnourished And Acutely Ill Children Is Feasible And Informative, Erika Feutz, Wieger Voskuijl, Peter J Finch, Ta-Chiang Liu, Robert H J Bandsma, Phillip I Tarr, Christopher Alan Moxon, Kelley Vanbuskirk, Sarah Lawrence, Grace Umutesi, Kirkby D Tickell, James A Berkley, Judd L Walson, Steve Kamiza, Donna M Denno

2020-Current year OA Pubs

BACKGROUND: Intestinal disorders such as environmental enteric dysfunction (EED) are prevalent in low- and middle-income countries (LMICs) and important contributors to childhood undernutrition and mortality. Autopsies are rarely performed in LMICs but minimally invasive tissue sampling is increasingly deployed as a more feasible and acceptable procedure, although protocols have been devoid of intestinal sampling to date. We sought to determine (1) the feasibility of postmortem intestinal sampling, (2) whether autolysis precludes enteric biopsies' utility, and (3) histopathologic features among children who died during hospitalization with acute illness or undernutrition.

METHODS: Transabdominal needle and endoscopic forceps upper and lower intestinal sampling …

Developing Deep-Learning Methods For Diagnosis And Prognosis Of Pediatric Progressive Diseases Using Modern Imaging Techniques, Mahdieh Shabanian

Theses and Dissertations (ETD)

Purpose and Rationale. Central nervous system manifestations form a significant burden of disease in young children. There have been efforts to correlate the neurological disease state in tuberous sclerosis complex (TSC) neurological disease state with imaging findings is a standard part of patient care. However, such analysis of neuroimaging is time- and labor-intensive. Automated approaches to these tasks are needed to improve speed, accuracy, and availability. Automated medical image analysis tools based on 3D/2D deep learning algorithms can help improve the quality and consistency of image diagnosis and interpretation for cognitive disorders in infants. We propose to automate neuroimaging analysis …

Nicu Experiences Of Adoptive Parents & Desired Preparation, Catherine J. Howe

MSU Graduate Theses

Parents who have newborns admitted into the Neonatal Intensive Care Unit (NICU) have multiple experiences and emotions. Additional social and emotional layers are experienced by adoptive couples when the infant they wish to adopt needs specialized care. This research study was completed to find out what adoptive parents experience in the NICU and what preparation would have been helpful. The method included semi-structured, open-ended interviews with seven couples who adopted a newborn at a Midwestern adoption agency within the past three years and had a NICU experience. The results described adoptive couples’ experiences on the unit, bonding and attachment, fears …

Case Study--Jimmy (Zero Balancing And Cst), Judith Sullivan

Journal of Transformative Touch

Jimmy started receiving Zero Balancing and CranioSacral Therapy when he was 11 months old for significant torticollis and scoliosis. In 7 sessions between the beginning of November and the beginning of February. His x-rays show changes within normal ranges.

Enterovirus D68-Associated Acute Respiratory Illness ─ New Vaccine Surveillance Network, United States, July-November 2018-2020., Melisa M. Shah, Ariana Perez, Joana Y. Lively, Vasanthi Avadhanula, Julie A. Boom, James Chappell, Janet A. Englund, Wende Fregoe, Natasha B. Halasa, Christopher J. Harrison, Robert W. Hickey, Eileen J. Klein, Monica M. Mcneal, Marian G. Michaels, Mary Moffatt, Catherine Otten, Leila C. Sahni, Elizabeth Schlaudecker, Jennifer E. Schuster, Rangaraj Selvarangan, Mary A. Staat, Laura S. Stewart, Geoffrey A. Weinberg, John V. Williams, Terry Fan Fei Ng, Janell A. Routh, Susan I. Gerber, Meredith L. Mcmorrow, Brian Rha, Claire M. Midgley

Manuscripts, Articles, Book Chapters and Other Papers

Enterovirus D68 (EV-D68) is associated with a broad spectrum of illnesses, including mild to severe acute respiratory illness (ARI) and acute flaccid myelitis (AFM). Enteroviruses, including EV-D68, are typically detected in the United States during late summer through fall, with year-to-year fluctuations. Before 2014, EV-D68 was infrequently reported to CDC (1). However, numbers of EV-D68 detection have increased in recent years, with a biennial pattern observed during 2014-2018 in the United States, after the expansion of surveillance and wider availability of molecular testing. In 2014, a national outbreak of EV-D68 was detected (2). EV-D68 was also reported in 2016 via …

Micronutrient Supplements Can Promote Disruptive Protozoan And Fungal Communities In The Developing Infant Gut, Ana Popovic, Celine Bourdon, Pauline W. Wang, David S. Guttman, Sajid Bashir Soofi, Zulfiqar Ahmed Bhutta, Robert H J. Bandsma, John Parkinson, Lisa G. Pell

Centre of Excellence in Women and Child Health

Supplementation with micronutrients, including vitamins, iron and zinc, is a key strategy to alleviate child malnutrition. However, association of gastrointestinal disorders with iron has led to ongoing debate over their administration. To better understand their impact on gut microbiota, we analyse the bacterial, protozoal, fungal and helminth communities of stool samples collected from a subset of 80 children at 12 and 24 months of age, previously enrolled into a large cluster randomized controlled trial of micronutrient supplementation in Pakistan (ClinicalTrials.gov identifier NCT00705445). We show that while bacterial diversity is reduced in supplemented children, vitamins and iron (as well as …

Infant Outcomes Following Maternal Infection With Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2): First Report From The Pregnancy Coronavirus Outcomes Registry (Priority) Study., Valerie J. Flaherman, Yalda Afshar, W. John Boscardin, Roberta L. Keller, Anne H. Mardy, Mary K. Prahl, Carolyn T. Phillips, Ifeyinwa V. Asiodu, Vincenzo Berghella, Brittany D. Chambers, Joia Crear-Perry, Denise J. Jamieson, Vanessa L. Jacoby, Stephanie L. Gaw

Department of Obstetrics and Gynecology Faculty Papers

Infant outcomes after maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are not well described. In a prospective US registry of 263 infants, maternal SARS-CoV-2 status was not associated with birth weight, difficulty breathing, apnea, or upper or lower respiratory infection through 8 weeks of age.

The Effect Of Specific Locomotor Experiences On Infants’ Avoidance Behaviour On Real And Water Cliffs, Carolina Burnay, Rita Cordovil, Chris Button, James L. Croft, Matthew Schofield, Joana Pereira, David I. Anderson

Research outputs 2014 to 2021

© 2020 John Wiley & Sons Ltd Infants’ avoidance of drop-offs has been described as an affordance learning that is not transferable between different locomotor postures. In addition, there is evidence that infants perceive and act similarly around real and water cliffs. This cross-sectional study investigated the effects of specific locomotor experiences on infants’ avoidance behaviour using the Real Cliff/Water Cliff paradigm. The experiments included 102 infants, 58 crawling, but pre-walking, infants (Mage = 11.57 months, SD = 1.65) with crawling experience ranging between 0.03 and 7.4 months (M = 2.16, SD = 1.71) and 44 walking infants (Mage = …

Treadmill Training For Infants With Down Syndrome: A Case Study, Mary Ngo Spt, Anna Paradee Spt, Julia Looper Pt, Phd

Physical Therapy Research Symposium

Background: Children with Down syndrome (DS) experience motor delays particularly with ambulation. Previous research has suggested that a 5 time per week, 8 minute per session protocol for treadmill training (TT) was effective in earlier acquisition of walking.

Purpose: To examine the effectiveness of a home-based 2 time per week, 20 minute per session TT protocol on the development of independent step taking in an infant with DS.

Methods: A 20-month-old boy with DS, underwent a repair for esophageal atresia at 5 months, and currently uses a feeding tube. He was independently sitting and non-ambulatory. Weekly Zoom meetings were conducted …

Assessing Procedural Pain In Infants: A Feasibility Study Evaluating A Point-Of-Care Mobile Solution Based On Automated Facial Analysis, Kreshnik Hoti, Paola Teresa Chivers, Jeffery David Hughes

Research outputs 2014 to 2021

BACKGROUND: The management of procedural pain in infants is suboptimal, in part, compounded by the scarcity of a simple, accurate, and reliable method of assessing such pain. In this study, we aimed to evaluate the psychometric properties of the PainChek Infant, a point-of-care mobile application that uses automated facial evaluation and analysis in the assessment of procedural pain in infants. METHODS: Video recordings of 40 infants were randomly chosen from a purposely assembled digital library of 410 children undergoing immunisation as part of their standard care in Prishtina, Kosovo, between April 4, 2017, and July 11, 2018. For each infant …

Looking For Consistency In An Uncertain World: Test-Retest Reliability Of Neurophysiological And Behavioral Readouts In Autism., Shlomit Beker, John J Foxe, John Venticinque, Juliana Bates, Elizabeth M Ridgeway, Roseann C Schaaf, Sophie Molholm

Department of Occupational Therapy Faculty Papers

BACKGROUND: Autism spectrum disorders (ASD) are associated with altered sensory processing and perception. Scalp recordings of electrical brain activity time-locked to sensory events (event-related potentials; ERPs) provide precise information on the time-course of related altered neural activity, and can be used to model the cortical loci of the underlying neural networks. Establishing the test-retest reliability of these sensory brain responses in ASD is critical to their use as biomarkers of neural dysfunction in this population.

METHODS: EEG and behavioral data were acquired from 33 children diagnosed with ASD aged 6-9.4 years old, while they performed a child-friendly task at two …

Rapidiron: Reducing Anaemia In Pregnancy In India-A 3-Arm, Randomized-Controlled Trial Comparing The Effectiveness Of Oral Iron With Single-Dose Intravenous Iron In The Treatment Of Iron Deficiency Anaemia In Pregnant Women And Reducing Low Birth Weight Deliveries., Richard J. Derman, Shivaprasad S. Goudar, Simal Thind, Sudhir Bhandari, Zubair H. Aghai, Michael Auerbach, Rupsa Boelig, Umesh S. Charantimath, Rosemary Frasso, M. S. Ganachari, Kusum Lata Gaur, Michael K. Georgieff, Frances Jaeger, S. Yogeshkumar, Parth Lalakia, Benjamin Leiby, Mita Majumdar, Amarjeet Mehta, Seema Mehta, Sudhir Mehta, Stephen T. Mennemeyer, Amit P. Revankar, Dharmesh Kumar Sharma, Vanessa Short, Manjunath S Somannavar, Dennis Wallace, Hemang Shah, Manjula Singh, Sufia Askari, Mrutyunjaya B. Bellad, Rapidiron Trial Group

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Anaemia is a worldwide problem and iron deficiency is the most common cause. In pregnancy, anaemia increases the risk of adverse maternal, foetal and neonatal outcomes. India's anaemia rate is among the highest in the world with India's National Family Health Survey indicating over 50% of pregnant women were affected by anaemia. India's Anaemia Mukt Bharat-Intensified National Iron Plus Initiative aims to reduce the prevalence of anaemia among reproductive-age women, adolescents and children by 3% per year and facilitate the achievement of a Global World Health Assembly 2025 objective to achieve a 50% reduction of anaemia among women of …

Mid-Upper Arm Circumference Assessment And Comparison With Weight For Length Z-Score In Infants ≤6 Months As An Indicator Of Severe Acute Malnutrition, Mahjabeen Zehra, Ali Faisal Saleem, Zaubina Kazi, Sadia Parkar

Department of Paediatrics and Child Health

Objective: To assess the frequency of severe acute malnutrition (SAM) and to determine the validity of mid-upper arm circumference (MUAC) as compared to weight for length z-score (WLZ-score) as an indicator of the nutritional status in this age group.
Methods: A cross-sectional study, with a purposive sampling was conducted from March 2018 to November 2018 to enroll 540 infants ≤6 months of age from three different sites in Karachi, Pakistan. The anthropometric measurements (MUAC, length and weight) were taken by experienced community health workers. The data were analyzed using SPSS. MUAC was compared with WLZ-score for sensitivity and specificity to …

Maternal Resources For Care Are Associated With Child Growth And Early Childhood Development In Bangladesh And Vietnam, Sulochana Basnet, Edward A. Frongillo Jr., Phuong Hong Nguyen, Spencer Moore, Mandana Arabi

Faculty Publications

BACKGROUND:

Suboptimal child growth and development are significant problems in low- and middle-income countries. Maternal resources for care may help to improve growth and development. This study examined the association of maternal resources for care on child length, motor development and language development of children 12-23.9 months old.

METHODS:

We used baseline data from the Alive & Thrive household surveys collected in Bangladesh (n = 803) and Vietnam (n = 635). Resources for care were represented by maternal education, knowledge, height, well-nourishment, mental well-being, decision-making, employment, support in chores and perceived support. The regression analyses were adjusted for household wealth …

Classical Findings Of Infantile Hepatic Hemangiomas, Senayit Demie, Michael Bossak

HCA Healthcare Journal of Medicine

Introduction

Hemangiomas are benign vascular tumors that are common during infancy. They are most commonly noted as superficial bright red lesions on the skin but can also be found deeper as subcutaneous lesions. Patients with multifocal cutaneous hemangiomas are at risk of visceral involvement with the liver being most commonly affected. Most hemangiomas can be monitored clinically as they are self-limiting. Despite this, hepatic hemangiomas can have serious complications including large arteriovenous shunts leading to cardiac compromise as well as severe hepatomegaly which can cause abdominal compartment syndrome, impaired ventilation and renal vein compression.

Clinical Findings

A six-month-old female, born …

The Role Of The Pharmacist In The Treatment Of Infantile Botulism, Rachel E. Huntsman, Abigail Schauble

HCA Healthcare Journal of Medicine

Infantile botulism is a potentially devastating disease caused by ingestion of Clostridium botulinum spores through food products or dust particles. The toxin produced by the spores can lead to descending paralysis requiring hospitalization for supportive care which sometimes includes mechanical ventilation. Human Botulism Immune Globulin-Intravenous (BIG-IV or BabyBIG) from the Infant Botulism Treatment and Prevention Program (IBTPP) has been shown to greatly improve outcomes. A previously healthy 5-month-old infant was admitted to her regional hospital for poor feeding and lethargy. When the weakness progressed and she had trouble with protecting her airway, she was intubated and transferred to our institution. …

Cohort Profile: The Alliance For Maternal And Newborn Health Improvement (Amanhi) Biobanking Study, Fahad Aftab, Salahuddin Ahmed, Aneeta Hotwani, Muhammad Ilyas, Mohammad Javaid, Fyezah Jehan, Farah Khalid, Usma Mehmood, Muhammad Imran Nisar, Muhammad Sajid

Department of Paediatrics and Child Health

No abstract provided.

Provider And Caregiver Perceptions Of Sids/Siuds Prevention In The Black Hills Of South Dakota, Levi Franz, Kenneth Snell

Aesculapius Journal (Health Sciences & Medicine)

Introduction: In spite of advances in medical technology, Sudden Infant Death Syndrome (SIDS) and Sudden Unexplained Infant Death Syndrome (SUIDS) remain common causes of death throughout the US, and especially in South Dakota. This study aims to elucidating the assumptions that physicians and patients have regarding SIDS.

Methods: 300 surveys were distributed to care givers of 0-9 months old children at a local pediatric office. An additional 5 surveys were distributed to physicians at this clinic who were asked to predict the overall outcomes of the caregiver surveys. Data were entered into excel and analyzed with ANOVA.

Results: Caregivers who …

Integrated Omics Endotyping Of Infants With Respiratory Syncytial Virus Bronchiolitis And Risk Of Childhood Asthma., Yoshihiko Raita, Marcos Pérez-Losada, Robert J. Freishtat, Brennan Harmon, Jonathan M Mansbach, Pedro A Piedra, Zhaozhong Zhu, Carlos A Camargo, Kohei Hasegawa

Pediatrics Faculty Publications

Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little is known about its biologically-distinct endotypes. Here, we integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study. We identified four biologically- and clinically-meaningful endotypes: A) clinical

Helping Babies: The Mental And Physical Effects Of Massage Therapy On Preterm Infants, Sadie Johnson

Intuition: The BYU Undergraduate Journal of Psychology

The purpose of this paper is to address and review the literature regarding the effects of massage therapy on preterm infants. Each of the studies done focused on infants aged 0–12 months. The literature specifically looks at irritability states, stress, analgesia, weight-gain, sleep-wake cycles, cognition, and gastrointestinal function. In accordance with the studies reviewed in this article, I deduce that massage therapy can be used with preterm infants to reduce irritability and stress, increase weight-gain, support greater rest, facilitate short-term cognitive improvement, and create a greater improvement in gastrointestinal function. Massage therapy can also reduce pain in infants who have …

Community Support Model On Breastfeeding And Complementary Feeding Practices In Remote Areas In Vietnam: Implementation, Cost, And Effectiveness, Tuan T. Nguyen, Nemat Hajeebhoy, Jia Li, Chung T. Do, Roger Mathisen, Edward A. Frongillo Jr.

Faculty Publications

Background

Poor access to healthcare facilities and consequently nutrition counseling services hinders the uptake of recommended infant and young child feeding (IYCF) practices. To address these barriers and improve IYCF practices, Alive & Thrive (A&T) initiated community support groups in remote villages across nine provinces in Vietnam.

Objective

This study examines the effectiveness of the support group model and related project costs for reaching underserved areas to improve IYCF practices.

Methods

To evaluate the model’s implementation and project costs, we reviewed implementation guidelines, expenditure and coverage reports, monitoring data, and budgets for the nine provinces. To evaluate the model’s effectiveness, …

The Influence Of Side-Lying Position On Oropharyngeal Swallow Function In At-Risk Infants: An Exploratory Study, Julian White

Dissertations, 2020-current

Speech-Language Pathologists (SLP) are the primary healthcare providers responsible for the evaluation and treatment of infant feeding and swallowing disorders. At-risk infants, such as those born prematurely or with certain medical conditions, are more prone to swallowing impairments (i.e., dysphagia). Dysphagia in at-risk infants can have severe consequences such as chronic respiratory symptoms, pneumonia, progressive lung disease, undernutrition, and death. Therefore, it is important to have methods of examining an infant’s swallow functioning that are both safe and accurate. A leading method of evaluating infant swallowing is the Modified Barium Swallow Study (MBS). The works contained within this dissertation document …

Assessing Word Recognition Through Head Turn Preference In Infants With Chronic Otitis Media, Allison E. Schmidt

Dissertations, 2020-current

Previous studies across a variety of different languages have shown that eleven-month-olds tested via the head-turn preference paradigm show a preference for familiar words over unfamiliar words, as demonstrated by longer look times. This study examined the effect of chronic otitis media on the preference for familiar over unfamiliar words. Nine eleven-month-old children (mean age 342 days, SD = 9.61) with chronic ear infections, defined as three or more diagnoses before the test date, were tested using wordlists adapted from a study performed by Vihman et al. (2004). Children with a history of chronic otitis media did not show a …

"Incidence, Prevalence And Risk Factors Of Retinopathy Of Prematurity In Indian Scenario-A Systematic Review And Meta- Analysis", Ashwitha H Gamsa

Manipal College of Health Professions, Manipal Theses and Dissertations

No abstract provided.

The Relationship Between Mothers’ Negative Emotional Symptoms And Mother-Infant Interactions During The Covid-19 Pandemic., Kolbie A Vincent

College of Arts & Sciences Senior Honors Theses

The aim of this study was to examine the relationship between mothers' negative emotional symptoms (depression, anxiety, and stress) and mother-infant interactions during the COVID-19 pandemic. Data were collected in the early months of the pandemic, when daycares were closed, through an online survey of parents and infants. Participants included 54 mothers of infants 3-34 months of age living in Kentucky. Well-being was measured with the Depression, Anxiety, and Stress Scale – 21 (DASS 21). Questions related to parent-infant interactions included time spent interacting with the infants by reading, singing, playing freely with no set goal, engaging in a meaningful …

Tiny Tusks Internship: Barriers To Breastfeeding, Cameron Watson

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Tiny Tusks Breastfeeding and Infant Support Internship allows students to gain insight on breastfeeding practices through volunteering at University of Arkansas sporting events. Therefore, I chose to review prevalent barriers to breastfeeding that mothers in the United States face. These mothers were at least one of these: Hispanic, Marshallese, African American, disabled, employed, a veteran, living in a rural area, or a woman of the general American population. This topic is relevant because of the many benefits that breastfeeding provides for both the baby and the mother.

Tiny Tusk Internship: The Relationship Between Duration Of Breastfeeding And The Development Of Attention-Deficit / Hyperactivity Disorder, Mckenna Gribble

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that remains highly prevalent in the youth community, yet its cause cannot be definitively placed. With the idea that this condition is primarily targeting children, the problem and possible solution may lie in infancy. The purpose of this literature review was to integrate evidence from studies published from 2015 to 2021 on the relationships between duration of breastfeeding during infancy and the development of ADHD. The results of this review supported the hypothesis that a longer duration of breastfeeding has a protective effect on childhood development and reduces the risk of developing ADHD …

Tiny Tusks Internship: Does Breastfeeding Education In An Undergraduate Nursing Program Affect Student Knowledge And Attitudes Concerning Breastfeeding?, Grace Murphy

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Tiny Tusks provides honors nursing students enrolled in the Eleanor Mann School of Nursing at the University of Arkansas an opportunity to support mothers in the community by providing breastfeeding services, education, and assistance at public Razorback sporting events. Interns provide this support by setting up designated lactation spaces at sporting events, such as gymnastics meets, football, and basketball games, for mothers to breastfeed or pump. In this thesis, I reflect on my internship experience and provide a review of literature. Since the aim of Tiny Tusks is to provide breastfeeding education and support to mothers in the community, the …

Tiny Tusks Breastfeeding And Infant Support Internship, Anna Elizabeth Ray

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Tiny Tusks Breastfeeding and Infant Support is a program at the University of Arkansas that provides a clean, private area for mother’s to nurse, pump, and change their infant’s diaper at Razorback home athletic events. The Tiny Tusks area is utilized at multiple athletic events including football games, men’s basketball games, and women’s gymnastics meets. Mothers are supplied comfortable rocking chairs, clean changing tables, heaters or fans depending on the weather, bottled water, and informational handouts about a wide array of breastfeeding topics. Along with supporting mothers, the mission of Tiny Tusks is to normalize breastfeeding in public areas and …