Medicine and Health Sciences Commons^™

Increasing Organizational Chemotherapy Competencies, Ruth Manuel Monsalud

Master's Projects and Capstones

Problem: Despite its 21 facilities in Northern California, the organization has limited capability to administer chemotherapy infusion, resulting in both provider and patient inconveniences due to lack of qualified chemotherapy-certified nurses.

Context: The cost of interfacility transfers for 1 year were over $1.7 million, not including decreased provider and patient satisfaction.

Interventions: 12 staff nurses on 6S unit will complete a two-phase individualized training program and earn an Oncology Nursing Society Fundamentals of Chemotherapy Immunotherapy Administration provider card to ensure adequate coverage for patients requiring chemotherapy administration during their hospital stay.

Measures: Training existing nurses in chemotherapy was encouraged. Another …

Immunotherapy In Childhood Acute Lymphoblastic Leukemia, Gazmend Temaj

UBT International Conference

Acute lymphoblastic leukemia (ALL) is known as a heterogeneous disease. The progress is possible to make in understanding of biological mechanism who play pivotal role in the development of therapies. Here I will try to summarize the current and future possibilities of management of adult and children ALL. Many inhibitors are used to inhibit tyrosine kinase, chimeric antigen receptor and gene therapy for cure of ALL. The FDA has approved a number of drugs for treatment of children who are sick from ALL. Currently, is known that long term of survival is achieved in more than 50% of patients with …

Atypical Involvement Of Central Nervous System In Classic Hodgkin Lymphoma: A Case Report, Shanila Ahmed, Babar Irfan, Muhammad Raza, Ghulam Haider

Section of Haematology/Oncology

Background: Hodgkin lymphoma is a systemic disease that commonly involves the cervical, supraclavicular, and mediastinal lymph nodes. The involvement of central nervous system in Hodgkin lymphoma is extremely rare, and diagnosis is usually established using distinct morphological and immunohistochemical staining on the tissue biopsied. Extranodal presentation of HL is a rare occurrence. It has been evident that prognosis is encouraging in patients with disease that is limited to just central nervous system initially or as relapse, compared with involvement of multiple sites of relapse.
Case presentation: We herein report a case of a 35-year-old South-East Asian male with relapsed Hodgkin …

Bioactive Nanotherapeutic Trends To Combat Triple Negative Breast Cancer, Pallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications and Presentations

The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeutic outcome of FDA-approved treatment regimen. This review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s) for breast cancer treatment. This article also documents novel strategies to employ cellular and cell membrane cloaked (biomimetic) nanoparticles for effective clinical …

Targeting The Cdk6 Dependence Of Ph+ Acute Lymphoblastic Leukemia, Patrizia Porazzi, Marco De Dominici, Joseph Salvino, Bruno Calabretta

Department of Cancer Biology Faculty Papers

Ph+ ALL is a poor-prognosis leukemia subtype driven by the BCR-ABL1 oncogene, either the p190-or the p210-BCR/ABL isoform in a 70:30 ratio. Tyrosine Kinase inhibitors (TKIs) are the drugs of choice in the therapy of Ph+ ALL. In combination with standard chemotherapy, TKIs have markedly improved the outcome of Ph+ ALL, in particular if this treatment is followed by bone marrow transplantation. However, resistance to TKIs develops with high frequency, causing leukemia relapse that results in

Generating Cisplatin Resistant Hpv-Positive Hnscc Cell Lines, Temitope Akintola

Undergraduate Student Research Internships Conference

Acquired or innate resistance to chemotherapy poses a significant challenge in the treatment of head and neck squamous cell carcinomas (HNSCC). HNSCCs are often treated with a combination of surgery, radiation and chemotherapy, with cisplatin being a standard-of-care chemotherapy drug. Human Papillomavirus (HPV) associated HNSCCs have better treatment outcomes and prognosis when compared to HPV- HNSCCs. However, a subset (15-20%) of HPV+ patients develop treatment resistant diseases. The purpose of this study is to generate in-vitro models of cisplatin resistance in five HNSCC cell lines. We aim to characterize the generated cells in order to identify target genes that may …

Impact Of Clinical And Pharmacogenetic Variables On The Risk Of Fluoropyrimidine-Related Adverse Events Within Ontario, Theodore J. Wigle

Electronic Thesis and Dissertation Repository

Severe life-threatening adverse events are a major limitation of fluoropyrimidine chemotherapy, these events are disastrous for patients and costly to the healthcare system. Identifying patients at high risk for developing adverse events would allow for preventive dose reduction, improving patient outcomes and reducing healthcare cost. This thesis uses data pulled from provincial databases to quantify the adverse event burden of fluoropyrimidines in Ontario. We found that 31% of Ontario patients treated with fluoropyrimidine systemic chemotherapy developed a severe adverse event that requires acute medical care. Patients that required acute medical therapy were significantly costlier to the public system averaging an …

Lapatinib And Poziotinib Overcome Abcb1-Mediated Paclitaxel Resistance In Ovarian Cancer, J. Robert Mccorkle, Justin W. Gorski, Jinpeng Liu, Mckayla J. Riggs, Anthony B. Mcdowell Jr., Nan Lin, Chi Wang, Frederick R. Ueland, Jill M. Kolesar

Markey Cancer Center Faculty Publications

Conventional frontline treatment for ovarian cancer consists of successive chemotherapy cycles of paclitaxel and platinum. Despite the initial favorable responses for most patients, chemotherapy resistance frequently leads to recurrent or refractory disease. New treatment strategies that circumvent or prevent mechanisms of resistance are needed to improve ovarian cancer therapy. We established in vitro paclitaxel-resistant ovarian cancer cell line and organoid models. Gene expression differences in resistant and sensitive lines were analyzed by RNA sequencing. We manipulated candidate genes associated with paclitaxel resistance using siRNA or small molecule inhibitors, and then screened the cells for paclitaxel sensitivity using cell viability assays. …

Assessment And Oral Care: An Essential Nursing Activity For Patients Receiving Cancer Treatment, Radhika R. Pai, Ravikiran Ongole, Sourjya Banerjee

Manipal Journal of Nursing and Health Sciences

Head and neck radiation therapy and chemoradiation are inherently associated with severe oral complications such as oral mucositis, infection, and functional issues of the oral cavity, significantly affecting the quality of oral cavity health in cancer patients. Oral care in cancer patients is a vital part of nursing care but can be seen as a most neglected job, along with other duties or a tedious task to undertake. Recognizing the effect of cancer treatment and delivery of oral care as per the specific guidelines to cancer patients is not well known, and it is not clear. Literature review reports that …

Here Comes The Sun … For Retinoblastoma, Carol L Shields, Jerry A Shields

Wills Eye Hospital Papers

No abstract provided.

The Success Of Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy In Breast Cancer Patients, Ahmad S. El-Gammal, Ahmad M. Elbeih, Alaa A. El-Sisi, Suzy F. Gohar

Menoufia Medical Journal

Aim and objectives To assess the effectiveness of sentinel lymph node biopsy in evaluation of the axillary status after neoadjuvant chemotherapy in breast cancer cases in comparison with standard axillary dissection. Background Breast carcinoma is the commonest malignant tumor in women. In Egypt, it accounts for ~25.5% of all women cases. In Egyptian women, the average age incidence is ~44.1 years, being more common in nullipara. The standard axillary lymph node dissection done in patients with breast cancer has many comorbidities that affect the patients' quality of life. Patients and methods The present cross-sectional study was conducted at Menoufia University …

Association Of Cumulative Social Risk And Social Support With Receipt Of Chemotherapy Among Patients With Advanced Colorectal Cancer, Rachel E. Davis, Amber W. Trickey, Paul Abrahamse, Ikuko Kato, Kevin Ward, Arden M. Morris

Faculty Publications

Importance: Approximately 38% of patients with advanced colorectal cancer do not receive chemotherapy. Objective: To determine whether cumulative social risk (ie, multiple co-occurring sociodemographic risk factors) is associated with lower receipt of chemotherapy among patients with advanced colorectal cancer and whether social support would moderate this association. Design, Setting, and Participants: This cross-sectional, population-based, mailed survey study was conducted from 2012 to 2014. Participants were recruited between 2011 and 2014 from all adults within 1 year after diagnosis of stage III colorectal cancer in the Detroit, Michigan, and State of Georgia Surveillance, Epidemiology, End-Results cancer registries. Patients were eligible if …

Development Of Stress-Induced Cardiomyopathy After Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy, Saad Ahmed Naved, Sadiq Shoukat Parpia, Huma Shoukat Ali

Medical College Documents

Pseudomyxoma Peritonei, a massive mucinous peritoneal collection due to a rare epithelial neoplasm, can be effectively treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC). A 43-year-old female, previously treated for mucinous ovarian carcinoma with CRS-HIPEC, and total abdominal hysterectomy and bilateral salpingo-oophorectomy, presented with new-onset abdominal distension and early satiety. She was diagnosed with Pseudomyxoma Peritonei. After 48 hours of treatment with CRS-HIPEC, she presented haemodynamically unstable with acute chest pain. Electrocardiogram showed broad complex tachycardia with ST depression in leads V3-6. Severe systolic dysfunction with Ejection Fraction (EF) of 20% along with severe pulmonary hypertension, visualized on Echocardiography. …

Breast Cancer Treatment Causing Cardiovascular Complications: How Can We Prevent It?, Abigail L. Reese

Honors Theses

Breast cancer has the highest incidence rate of any cancer in the United States, and it is the second most deadly. It comprises 30% of all diagnosed cancers in women, and it is predicted that the incidence of breast cancer will continue to rise. Most common chemotherapeutic agents utilized in the treatment of breast cancer are known to be cardiotoxic, each with differing mechanisms and possible damage done to the patient. In turn, cardiovascular diseases are the number one killer of women in the United States, and their prevalence is continually growing. It is unknown exactly how many women who …

The Effects Of Chemotherapeutic Agents On Cognitive Function: A Literature Review, Corinne Menz

The Eleanor Mann School of Nursing Undergraduate Honors Theses

With increasing cancer diagnoses and an increase of chemotherapy treatment, many patients complain of cognitive decline during the duration of treatment as well as once treatment has been completed. The purpose of this review is to compile relevant research regarding chemotherapy-related cognitive impairment and its implications for the care of cancer patients. Peer-reviewed articles and studies focusing on the impact of chemotherapy on cognitive function were evaluated, resulting in a total of 12 studies utilized in this review. Overall, it has been found that a large percentage of patients undergoing chemotherapy treatment report a subjective decline in cognitive functioning, but …

Aromatherapy Essential Oil Usage In Managing Chemotherapy Side Effects: A Benchmark Study, Ariana C. Smith

MSN Capstone Projects

This capstone project details the usage of essential oil aromatherapy in managing the common side effects of chemotherapy in the outpatient setting. Patients often report that these side effects to to burdensome and place significant effects on one's quality of life. Through this project, viewers will learn about four common oils, including ginger oil, lavender oil, peppermint oil, and orange oil in managing the side effects of chemotherapy.

Concordance Between Clinical And Pathological Response Assessment After Neo-Adjuvant Chemotherapy In Patients With Invasive Lobular Carcinoma, Aisha Shaikh, Muhammad Usman Tariq, Shaista Khan, Romana Idress, Lubna Mushtaque Vohra, Saira Fatima Shaikh, Hira Waheed

Department of Surgery

Background: Neo-adjuvant chemotherapy (NAC) is frequently administered in breast carcinoma patients. The clinical response to NAC guides further treatment. The pathological response is not only an independent prognostic factor, but it also guides further treatment and prognosis.
Objectives: The aim of our study was to find the degree of concordance between clinical and pathological response assessments after NAC in Invasive lobular Carcinoma (ILC) cases by using World Health Organization (WHO) criteria and different pathological systems, respectively. We also tried to identify any useful parameter of clinical assessment that could better correlate with pathologic assessment and provide a better estimation of …

Autologous Bone Marrow Transplantation For Diffuse Large B-Cell Lymphoma In Egypt: A Two-Center Experience, Alaa E. Abdelhamid, Ali S. Ali, Essam A. Abdelmohsen, Ghada H. Akl, Mohamed A. Abdelhafez, Sabry A. Shoeib

Menoufia Medical Journal

Objective The aim of this work was to study the outcome of autologous bone marrow transplantation in diffuse large B-cell lymphoma (DLBCL) according to the experience of two centers, Naser Institute and Sheikh Zayed centers. Background Treatment for patients with DLBCL is based on the international prognostic index score and age. Autologous stem-cell transplantation (ASCT) is actually recommended in young patients who did not achieve complete remission after first-line chemotherapy. Patients and methods This retrospective case series study included the files of 191 patients who were diagnosed as having DLBCL according to the 2008 WHO classification of lymphoma in Naser …

Bioactive Nanotherapeutic Trends To Combat Triple Negative Breast Cancer, Pallabita Chowdhury, Upasana Ghosh, Kamalika Samanta, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications and Presentations

The management of aggressive breast cancer, particularly, triple negative breast cancer (TNBC) remains a formidable challenge, despite treatment advancement. Although newer therapies such as atezolizumab, olaparib, and sacituzumab can tackle the breast cancer prognosis and/or progression, but achieved limited survival benefit(s). The current research efforts are aimed to develop and implement strategies for improved bioavailability, targetability, reduce systemic toxicity, and enhance therapeutic outcome of FDA-approved treatment regimen. This review presents various nanoparticle technology mediated delivery of chemotherapeutic agent(s) for breast cancer treatment. This article also documents novel strategies to employ cellular and cell membrane cloaked (biomimetic) nanoparticles for effective clinical …

Polθ Promotes The Repair Of 5'-Dna-Protein Crosslinks By Microhomology-Mediated End-Joining, Gurushankar Chandramouly, Shuren Liao, Timur Rusanov, Nikita Borisonnik, Marissa L Calbert, Tatiana Kent, Katherine Sullivan-Reed, Umeshkumar Vekariya, Ekaterina Kashkina, Tomasz Skorski, Hong Yan, Richard T Pomerantz

Department of Biochemistry and Molecular Biology Faculty Papers

DNA polymerase θ (Polθ) confers resistance to chemotherapy agents that cause DNA-protein crosslinks (DPCs) at double-strand breaks (DSBs), such as topoisomerase inhibitors. This suggests Polθ might facilitate DPC repair by microhomology-mediated end-joining (MMEJ). Here, we investigate Polθ repair of DSBs carrying DPCs by monitoring MMEJ in Xenopus egg extracts. MMEJ in extracts is dependent on Polθ, exhibits the MMEJ repair signature, and efficiently repairs 5' terminal DPCs independently of non-homologous end-joining and the replisome. We demonstrate that Polθ promotes the repair of 5' terminal DPCs in mammalian cells by using an MMEJ reporter and find that Polθ confers resistance to …

Fludarabine-Based Salvage Therapy For Refractory/Relapsed Acute Leukemias: A Single Center Experience, Abdul Muqtadir Abbasi, Mohammad Usman Shaikh, Natasha Bahadur Ali, Mohammad Nadir Haider

Section of Haematology/Oncology

No abstract provided.

Mithramycin And Analogs For Overcoming Cisplatin Resistance In Ovarian Cancer, David Schweer, J. Robert Mccorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick R. Ueland, Jill M. Kolesar

Obstetrics and Gynecology Faculty Publications

Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance. This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, …

Evaluation Of Benefits Associated With Chemotherapy Dose-Banding Practices, Alexis Mann Pharmd, Mba, Kyle Becker Pharmd, Mba, Bcop, Jesse Christman Pharmd, Bcop

Parkview Pharmacy Department

2021 ASHP Midyear Clinical Meeting / Virtual Meeting / Poster # 1130014

The objective of this study was to evaluate the benefit of applying a 10% rounding strategy with predetermined dose-bands to the current chemotherapy dosing policy at Parkview Health.

Bypassing The Blood-Brain Barrier: A Physical And Pharmacological Approach For The Treatment Of Metastatic Brain Tumors, Samuel A. Sprowls

Graduate Theses, Dissertations, and Problem Reports

This dissertation (a) provided an in depth literature review of methods to disrupt the BBB/BTB and improve therapeutic distribution to brain tumors, (b) evaluated the use of azacitidine as a single agent therapy for the treatment of brain metastasis of breast cancer and a potential molecular mechanism by which brain tropic cells are sensitized to hypomethylating agents, (c) determined the impact cannabidiol has on P-glycoprotein mediated efflux at the blood-brain barrier and its potential for use as a single agent treatment for metastatic brain tumors, (d) developed a preclinical radiation therapy protocol for use in small animals and in vitro …

Feasibility And Efficacy Of A Multicomponent Exercise Medicine Programme In Patients With Pancreatic Cancer Undergoing Neoadjuvant Therapy (The Expan Trial): Study Protocol Of A Dual-Centre, Two-Armed Phase I Randomised Controlled Trial, Hao Luo, Daniel A. Galvao, Robert U. Newton, Colin Tang, Andrew Dean, Kevin Jasas, Mikael Johansson, Ian Yusoff, Nigel Spry, Dennis R. Taaffe

Research outputs 2014 to 2021

Introduction Exercise is emerging as a therapy in oncology for its physical and psychosocial benefits and potential effects on chemotherapy tolerability and efficacy. However, evidence from randomised controlled trials (RCTs) supporting exercise in patients with borderline resectable or locally advanced pancreatic cancer (PanCa) undergoing neoadjuvant therapy (NAT) are lacking. Methods and analysis The EXPAN trial is a dual-centre, two-armed, phase I RCT. Forty patients with borderline resectable or locally advanced PanCa undergoing NAT will be randomised equally to an exercise intervention group (individualised exercise+standard NAT) or a usual care control group (standard NAT). The exercise intervention will be supervised and …

The Role Of Psychological Distress In Maintaining Exercise After Cancer Diagnosis, Patrick Tertulien

Walden Dissertations and Doctoral Studies

AbstractCancer affects the lives of thousands of people every day and is a leading cause of death. Exercise has been shown to yield mental and physical benefits for patients and survivors, but the experiences of cancer patients who face a multiplicity of psychological stressors have not been clearly described. The purpose of this qualitative study was to understand the psychological factors that are associated with continuing to exercise after cancer diagnosis, during and/or following their treatment. The focus was on how cancer survivors maintained a regular routine of exercise while experiencing psychological distress associated with cancer diagnosis, treatment, and concerns …

The Prognostic Value Of Serum Levels Of A Proliferation-Inducing Ligand (April) Intreatment-Naïve Patients With Chronic Lymphocytic Leukemia, Si̇nem Ni̇hal Esatoğlu, Di̇lek Keski̇n, Ahmet Emre Eşkazan, Tuğrul Elverdi̇, Ayşe Sali̇hoğlu, Muhli̇s Cem Ar, Şeni̇z Öngören, Zafer Başlar, Yildiz Aydin, Hafi̇ze Uzun, Teoman Soysal

Turkish Journal of Medical Sciences

Background/aim: A proliferation-inducing ligand (APRIL) has been investigated as a prognostic marker in chronic lymphocytic leukemia (CLL) patients. However, there is no cut-off level for serum APRIL (sAPRIL) levels that predict time to treatment in CLL patients. Materials and methods: Between May and December 2012, 94 consecutive CLL patients and 25 healthy controls were assessed. sAPRIL levels were measured by ELISA. Demographic data and prognostic markers were obtained from the patients' files. Treatment-naïve patients were followed up for 6.5 years for any treatment need. Results: Patients were divided into 3 groups: Treatment-naïve (n = 47), chemotherapy receiving (n = 25), …

Lycopene Sensitizes The Cervical Cancer Cells To Cisplatin Via Targeting Nuclear Factorkappab (Nf-��B) Pathway, Oktay Hali̇t Aktepe, Taha Koray Şahi̇n, Gürkan Güner, Zafer Arik, Şuayi̇b Yalçin

Turkish Journal of Medical Sciences

Background/aim: Lycopene is associated with anticancer effects in various tumor types. However, the exact underlying mechanisms of action of lycopene in human cervical cancer remain to be determined. This study aimed to determine anticancer efficacy and mechanism of lycopene in human cervical carcinoma (HeLa) cells. Materials and methods: HeLa cells were treated with cisplatin (1 μM) alone, lycopene (10 μM) alone, and in combination for 72 h. The cell viability of HeLa cells was assessed via MTS assay. Western blot was used to analyze the expression levels of the nuclear factor-kappa B (NF-ΚB), B-cell-associated X protein (Bax), nuclear factor erythroid …