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Full-Text Articles in Medicine and Health Sciences
Preparation And In Vitro/In Vivo Evaluation Of Orally Disintegrating/Modified-Release Praziquantel Tablets, Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan
Preparation And In Vitro/In Vivo Evaluation Of Orally Disintegrating/Modified-Release Praziquantel Tablets, Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan
Faculty and Student Publications
This study was designed to develop orally disintegrating/sustained-release praziquantel (PZQ) tablets using the hot-melt extrusion (HME) technique and direct compression, and subse-quently evaluate their release in in vitro and in vivo pharmacokinetics. For the extrusion process, hypromellose acetate succinate (HPMCAS)-LG was the carrier of pure PZQ, with a standard screw configuration used at an extrusion temperature of 140◦ C and a screw rotation speed of 100 rpm. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR) were performed to characterize the extru-date. Orally disintegrating/sustained-release praziquantel tablets (PZQ ODSRTs) were prepared by direct compression …
Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka
Development And Characterization Of Sustained-Released Donepezil Hydrochloride Solid Dispersions Using Hot Melt Extrusion Technology, Abdullah Alshetaili, Bjad K. Almutairy, Sultan M. Alshehri, Michael A. Repka
Faculty and Student Publications
The aim of this work was to develop the sustained release formulation of donepezil hydrochloride (DH) using the hot-melt extruded solid dispersion technique via the rational screening of hydrophobic carriers. Hydrophobic carriers with different physicochemical properties such as pH-independent swellability, low-permeability (Eudragit® RS PO (E-RS)), pH-independent non-swellability (ethyl cellulose N7 (EC-N7)), and the presence of lipids (Compritol® 888 ATO (C-888)) with or without pore-forming agents were used to achieve the sustained release profile of DH. Mannitol (MNT) was chosen as the temporary pore-forming agent. The thermal analysis showed that both the drug and C-888 preserved their crystallinity within a solid …
Effect Of Lutrol® F Grades (Poloxamer) On Dissolution Of Hot-Melt Extruded Kollidon® Va64-Felodipine Matrices, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Michael A. Repka
Effect Of Lutrol® F Grades (Poloxamer) On Dissolution Of Hot-Melt Extruded Kollidon® Va64-Felodipine Matrices, Saad M. Alshahrani, Abdullah Alshetaili, Bjad K. Almutairy, Michael A. Repka
Faculty and Student Publications
The objective of this study was to assess the potential of Lutrol® F grades as polymeric surfactants for dissolution enhancement of Kollidon®VA64-drug matrices produced by hot-melt extrusion (HME). The poorly soluble model drug felodipine (FEL) with a medium melting point was selected for this study. Two different grades of Lutrol® F (also called Kolliphor® P grades) were added into the HME systems to investigate their influence on the drug-incorporated matrices. Two grades of Lutrols i.e., Lutrol® F 68 (Kolliphor®P 188) and Lutrol® F 127 (Kolliphor®P 407) were studied as polymeric solubilizers. FEL was mixed with Kollidon®VA64, with or without Lutrol®F …