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Full-Text Articles in Medicine and Health Sciences
Expression Of Mhc Class I Polypeptide-Related Sequence A (Mica) In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Marcelo Sakiyama, Veena Shenoy
Expression Of Mhc Class I Polypeptide-Related Sequence A (Mica) In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Marcelo Sakiyama, Veena Shenoy
Faculty and Student Publications
Background: The major histocompatibility complex class I polypeptide-related sequence A (MICA) is one of the ligands of the natural killer group 2D (NKG2D) activating receptor. MICA stimulates NKG2D, which further triggers activation of natural killer cells and leads to killing of infected target cells. To subvert the biological function of NKG2D, tumor cells utilize an escape strategy by shedding overexpressed MICA. In this study, we determined the levels of MICA in colorectal cancers (CRCs). Additionally, we established correlations between MICA expression and clinical characteristics. Publicly available data and bioinformatics tools were used for validation purposes. Methods: We determined the MICA …
Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy
Expression Of Trefoil Factor 3 Is Decreased In Colorectal Cancer, Ingrid Espinoza, Sumit Agarwal, Amit Reddy, Veena Shenoy
Faculty and Student Publications
In colorectal cancer (CRC), high expression of trefoil factor 3 (TFF3) is associated with tumor progression and reduced patient survival; however, bioinformatics analyses of public 'omics' databases show low TFF3 expression in CRCs as compared to normal tissues. Thus, we examined TFF3 expression in CRCs and matching normal tissues to evaluate its role in CRC progression. TFF3 gene expression was char- acterized using the bioinformatics portal UALCAN (http:// ualcan.path.uab.edu). Tissue microarrays (TMAs) of archival CRC specimens (n=96) were immunostained with anti-human TFF3 antibodies. Immunohistochemical (IHC) staining intensity was semi-quantitatively scored. For this cohort, the median follow-up was 5.4 years. Associations …