Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (2)
- Biochemistry (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
- Cardiovascular Diseases (1)
-
- Chemicals and Drugs (1)
- Chemistry (1)
- Diseases (1)
- Medical Sciences (1)
- Medicinal and Pharmaceutical Chemistry (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Natural Products Chemistry and Pharmacognosy (1)
- Nucleic Acids, Nucleotides, and Nucleosides (1)
- Organic Chemistry (1)
- Pharmaceutics and Drug Design (1)
- Pharmacy and Pharmaceutical Sciences (1)
- Physical Sciences and Mathematics (1)
- Institution
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Synthesis Of 2,4,6-Substituted Pyrrolo[2,3-D]Pyrimidines As Potential Anticancer Agents, Si Yang
Synthesis Of 2,4,6-Substituted Pyrrolo[2,3-D]Pyrimidines As Potential Anticancer Agents, Si Yang
Electronic Theses and Dissertations
This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, et. al. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-d]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-d]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.
A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun
A Novel Method For Synthesis Of Hydroxytyrosol, Emmanuel Onobun
Electronic Theses and Dissertations
Hydroxytyrosol, 3,4-dihydroxyphenolethanol, a naturally occurring polyphenol most common in olive tree (Olea europaea), is one of the most effective member of the polyphenols family, because of its remarkable antioxidant activity, its ability to inhibit oxidation of low density lipids (LDL), and its protection against DNA oxidative damage. Hydroxytyrosol, which is widely used in cosmetics and food supplements industries, can be purchased as an olive oil extract that contains low concentration of hydroxytyrosol besides other polyphenols. The price and low natural abundance of hydroxytyrosol make alternative synthetic sources very attractive. In this research, a novel method for the synthesis of pure …
Synthesis Of A-Cyanostilbenes And Testing Of Their Anticancer Properties, Gabrielle Cook
Synthesis Of A-Cyanostilbenes And Testing Of Their Anticancer Properties, Gabrielle Cook
Honors Theses
This research project involves synthesizing cyanostilbenes and testing their anticancer properties in breast cancer cells. Breast cancer is a global issue, one that great improvement has been found in the last few decades, but also one that remains a large killer. The components of the cyanostilbene hybrids have all been shown to have anticancer properties on their own, and we would like to see if we can increase these properties by combining multiple into a single hybrid. Then these cyanostilbene compounds are tested on Her2+ human breast cancer cells. The goals is to assess whether or not the cyanostilbenes have …
Evaluation Of Cytotoxic, Membrane, And Dna Damaging Effects Of Thymus Revolutuscélak Essential Oil On Different Cancer Cells, Aysun Özkan, Ayşe Erdoğan
Evaluation Of Cytotoxic, Membrane, And Dna Damaging Effects Of Thymus Revolutuscélak Essential Oil On Different Cancer Cells, Aysun Özkan, Ayşe Erdoğan
Turkish Journal of Medical Sciences
Background/aim: In this study, we evaluated Thymus revolutus Célak essential oil and its two main constituents, γ-terpinene and p-cymene, as potential oxidative agents against lung cancer and epidermoid carcinoma cells. Materials and methods: Cell viability assessment was made by CellTiter-Blue® cell viability and 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide (MTT) assay after treatment with 5?600 ?g/mL concentrations of essential oil, γ-terpinene, and p-cymene. Malondialdehyde and 8-hydroxy-2'-deoxyguanosine levels in parental H1299, epirubicin-resistant (drug-resistant) H1299, A549, and A431 cells were also assayed after essential oil, γ-terpinene, and p-cymene had been administered for 24 h. Glutathione S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GRx), and glucose …