Medicine and Health Sciences Commons^™

Obesity Reduces Left Ventricular Strains, Torsion, And Synchrony In Mouse Models: A Cine Displacement Encoding With Stimulated Echoes (Dense) Cardiovascular Magnetic Resonance Study, Sage P. Kramer, David K. Powell, Christopher M. Haggerty, Cassi M. Binkley, Andrea C. Mattingly, Lisa A. Cassis, Frederick H. Epstein, Brandon K. Fornwalt

Pediatrics Faculty Publications

BACKGROUND: Obesity affects a third of adults in the US and results in an increased risk of cardiovascular mortality. While the mechanisms underlying this increased risk are not well understood, animal models of obesity have shown direct effects on the heart such as steatosis and fibrosis, which may affect cardiac function. However, the effect of obesity on cardiac function in animal models is not well-defined. We hypothesized that diet-induced obesity in mice reduces strain, torsion, and synchrony in the left ventricle (LV).

METHODS: Ten 12-week-old C57BL/6 J mice were randomized to a high-fat or low-fat diet. After 5 months on …

The Relationships Between Using The Rating Of Perceived Exertion, Metabolic Equivalent And Maximum Heart Rate At Ventilatory Threshold Into Determine Appropriate Exercise Prescription For Intensity In Obese Diabetic Patients: A Preliminary Study, Yan-Wen Chen, Francois Liang, Sen-Wei Tsai, Shih-Yi Lin, I. T. Lee, Sheu-Chen Liu, Shin-Shan Lu

Rehabilitation Practice and Science

Background: The rating of perceived exertion (RPE), metabolic equivalent (MET) and maximum heart rate (HRmax) at ventilatory threshold (VT) are commonly used methods as physiological parameters for monitoring exercise intensity. However, the appropriate levels of training intensity for obese type 2 diabetic diabetes mellitus (type 2 DM) patients have not been established.Purpose: To examine the parameters in obese Type 2 DM patients at ventilatory threshold, the exercise capacity of obese Type 2 DM patients, and to determine the appropriate levels of exercise intensity for exercise prescription in obese type 2 DM patients was investigated.Methods: Twenty obese type 2 DM patients …

Food Advertisements In Two Popular U.S. Parenting Magazines: Results Of A Five-Year Analysis, Corey H. Basch, Rodney N. Hammond, Danna Ethan, Lalitha Samuel

Publications and Research

Obesity rates among American youth have prompted an examination of food advertisements geared towards children. Research indicates children’s high exposure to these advertisements and their influence on food preferences. Less is known about the presence of these advertisements in parenting magazines. This study’s objective was to examine prevalence of food advertisements in popular parenting magazines and identify products by USDA food category. We analyzed 116 issues of two popular U.S. parenting magazines across five years. All food and beverage advertisements for USDA Food Category were coded. Breakfast cereals were coded for nutritional quality. The coding took place at varied libraries …

The Concomitant Relationship Shared By Sleep Disturbances And Type 2 Diabetes: Developing Telemedicine As A Viable Treatment Option, Pennie S. Seibert, Jennifer Valerio, Codieann Dehaas

Pennie S. Seibert

Individually, sleep disturbances and type 2 diabetes pose pervasive challenges to health. In addition, the negative symptomology associated with each condition is exacerbated further when presenting concomitantly. This relationship formulates a destructive loop wherein those with diabetes experience decreased sleep quality, which, in turn, worsens a wide range of health threats experienced by those with diabetes, including obesity and glucose intolerance. Because major lifestyle changes and daily care are needed to effectively manage both diabetes and sleep disturbances, an efficient and timely modality of treatment is essential. Advanced technology incorporating telemedicine and telehealth has the potential to enhance treatment by …

Reimagining My Body, Center For Public Service

SURGE

I stood there, shoulders slouched, elbows locked, hands glued to the side of the toilet. My body convulsing, I told myself, “this is the last time, just one more time and you’ll get back on track tomorrow.” It wasn’t the last time. I had been forcing myself to purge for months at this point, and each time I hated myself for it.

It was something I couldn’t control. It wasn’t out of a need for attention as so commonly thought, but a pure need to be the unreachable level of thin that I thought would make me beautiful. I was …

Obesity And Physical Function In Rural Women Who Enroll In A Lifestyle Modification Intervention For Reducing Blood Pressure, Patricia A. Hageman, Carol H. Pullen, Paul J. Dizona, Kristin Schmidt, Linda S. Boeckner

Journal Articles: Physical Therapy

Purpose: Rural women have high prevalence of obesity and prehypertension. Obesity, if associated with poor physical function, may have implications for applying activity guidelines for women volunteering for lifestyle modification. This study examined associations of body mass index (BMI) and percent body fat with measures of 1-mile walk time, post-walk perceived exertion, and 10-repetition chair stands in rural women ages 40-69.

Methods: Cross-sectional baseline data were collected using standardized methods from 289 rural women with prehypertension who volunteered for a lifestyle clinical trial for reducing blood pressure. ANOVAs and linear regression were used for analysis.

Results: With exception of the …

3-D Oropharyngeal Airway Analysis Of Different Antero-Posterior And Vertical Craniofacial Skeletal Patterns In Children And Adolescents, Chi Kim Huynh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Sleep apnea disorder has recently emerged as a significant public health issue. While the prevalence of obesity is on the rise among children, it is one of the main risk factors associated with apnea. Upper airway dimensions and morphology seem to be major components of obstructive sleep apnea (OSA) and can be affected by different craniofacial patterns. The purpose of this retrospective, cross-sectional pilot study is to correlate gender, Body Mass Index, risk for OSA, neck circumference, and 3-D oropharyngeal airway dimensions in children and adolescents with different antero-posterior (AP) and vertical craniofacial skeletal patterns. A total of 86 pre-orthodontic …

Lactose Intolerance: Lack Of Evidence For Short Stature Or Vitamin D Deficiency In Prepubertal Children, Nithya Setty-Shah, Louise S. Maranda, Ninfa Candela, Jay G. Fong, Idris Dahod, Alan D. Rogol, Benjamin U. Nwosu

Benjamin U. Nwosu

Background: The health consequences of lactose intolerance (LI) are unclear. Aims: To investigate the effects of LI on stature and vitamin D status. Hypotheses: LI subjects will have similar heights and vitamin D status as controls. Subjects and Methods: Prepubertal children of ages 3-12 years with LI (n=38, age 8.61 ± 3.08y, male/female 19/19) were compared to healthy, age- and gender-matched controls (n=49, age 7.95±2.64, male/female 28/21). Inclusion criteria: prepubertal status (boys: testicular volume Results: There was no significant difference in 25(OH)D between the LI and non-LI subjects (60.1±21.1, vs. 65.4 ± 26.1 nmol/L, p = 0.29). Upon stratification into …

Microrna Function In Human Diseases, Sathish Kumar Natarajan, Mary A. Smith, Cody J. Wehrkamp, Ashley M. Mohr, Justin L. Mott

Journal Articles: Biochemistry & Molecular Biology

MicroRNAs are emerging as a hot topic in research, and rightfully so. They show great promise as targets of treatment and as markers for common human diseases, such as cancer and metabolic diseases. In this review, we address some of the basic questions regarding micro- RNA function in human disease and the clinical significance of microRNAs. Specifically, micro- RNAs in epigenetics, cancer, and metabolic diseases are discussed, with examples taken from cholangiocarcinoma and nonalcoholic fatty liver disease.

Are Im Injections Im In Obese And Overweight Females?: A Study In Injection Technique, Sara Palma, Pamela Strohfus

Nursing Faculty Publications and Presentations

If given incorrectly, intramuscular injections may result in poor absorption of drug, reduced drug effectiveness, or irritation to surrounding tissues. In this study, IM injection techniques were observed and documented for needle length, injection site, needle insertion, and stretching or bunching of the skin during injection in a population of adult females. The patients' weights and BMIs were recorded to determine the amount of subcutaneous fat at the injection site. In 22 patients of varied weights, 90% of injections were given within current Advisory Committee on Immunization Practice (ACIP) guidelines in normal and underweight patients, and 17% were given within …

The Concomitant Relationship Shared By Sleep Disturbances And Type 2 Diabetes: Developing Telemedicine As A Viable Treatment Option, Pennie S. Seibert, Jennifer Valerio, Codieann Dehaas

Psychological Sciences Faculty Publications and Presentations

Individually, sleep disturbances and type 2 diabetes pose pervasive challenges to health. In addition, the negative symptomology associated with each condition is exacerbated further when presenting concomitantly. This relationship formulates a destructive loop wherein those with diabetes experience decreased sleep quality, which, in turn, worsens a wide range of health threats experienced by those with diabetes, including obesity and glucose intolerance. Because major lifestyle changes and daily care are needed to effectively manage both diabetes and sleep disturbances, an efficient and timely modality of treatment is essential. Advanced technology incorporating telemedicine and telehealth has the potential to enhance treatment by …

Stress And Eating: A Dual Role For Bombesin-Like Peptides, Zul Merali, S. Graitson, J. C. Mackay, P. Kent

Brain and Mind Institute

The current obesity "epidemic" in the developed world is a major health concern; over half of adult Canadians are now classified as overweight or obese. Although the reasons for high obesity rates remain unknown, an important factor appears to be the role stressors play in overconsumption of food and weight gain. In this context, increased stressor exposure and/or perceived stress may influence eating behavior and food choices. Stress-induced anorexia is often noted in rats exposed to chronic stress (e.g., repeated restraint) and access to standard Chow diet; associated reduced consumption and weight loss. However, if a similar stressor exposure takes …

Riptek: Best Thermogenic Fat Loss Accelerator, Lissa Coffey

LissaCoffey

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Aspirin And Low-Molecular Weight Heparin Combination Therapy Effectively Prevents Recurrent Miscarriage In Hyperhomocysteinemic Women., Pratip Chakraborty, Sayani Banerjee, Piyali Saha, Shyam Sundar Nandi, Sunita Sharma, Sourendra K. Goswami, Baidyanath Chakravarty, Syed N. Kabir

Journal Articles: Cellular & Integrative Physiology

The management of recurrent pregnancy loss (RPL) still remains a great challenge, and women with polycystic ovarian syndrome (PCOS) are at a greater risk for spontaneous abortion. Treatment with low-molecular-weight heparin (LMWH) has become an accepted treatment option for women with RPL; however, the subgroup of women, who are likely to respond to LMWH, has not been precisely identified. The present study evaluated the efficacy of LMWH with reference to PCOS and associated metabolic phenotypes including hyperhomocysteinemia (HHcy), insulin resistance (IR) and obesity. This prospective observational study was conducted at Institute of Reproductive Medicine, Kolkata, India. A total of 967 …

The Effect Of Malnutrition On Patients Undergoing Elective Joint Arthroplasty., Ronald Huang, Md, Max Greenky, Bs, Glenn J. Kerr, Md, Mathew S. Austin, Md, Javad Parvizi, Md, Frcs

Rothman Institute Faculty Papers

Malnutrition has been linked to serious complications in patients undergoing elective total joint arthroplasty (TJA). This study prospectively evaluated 2,161 patients undergoing elective TJA for malnutrition as defined by either an abnormal serum albumin or transferrin. The overall incidence of malnutrition was 8.5% (184 of 2,161) and the rate of overall complications in the malnourished group was 12% as compared to 2.9% in patients with normal parameters (P55years-old undergoing TJA and is associated with a significant increase in post-operative complications.

Risk Of Early & Late Obstetric Complications In Women With Ivf- Conceived Pregnancies And Polycystic Ovary Syndrome (Pcos), N. A. Bagegni, J. Blaine, Bradley J. Van Voorhis, Anuja Dokras

Bradley J Van Voorhis

There is conflicting evidence on the association between PCOS and early and late obstetric complications. It is unclear if the reported risks are independent of BMI, preexisting hypertension and diabetes. We performed a retrospective chart review to examine the risk of early and late obstetrical complications after IVF in women with PCOS (n=130) compared to controls (n=130). The miscarriage rate was 17.7% in PCOS women and 15.4% in controls. PCOS was not associated with miscarriage independent of age and BMI. The prevalence of gestational DM (GDM) was similar in both groups (12% PCOS versus 11% controls). BMI was independently associated …

Co-Morbidities Associated With Adult Obesity In Mississippi, Richmond Lachney

MSN Research Projects

Obesity rates are rapidly increasing in Mississippi and the entire United States. It is estimated that 34.9% of Mississippi residents and 75 million Americans over the age of 20 are considered obese. Numerous studies have shown the high risk of developing co­ morbidities once a person develops obesity. The number of adult Americans living with obesity and its associated co-morbidities is alarming. The purpose of this study was to determine which co-morbidities are most prevalent among obese residents of rural Mississippi and whether they can be reduced or reversed with significant weight reduction. Nola Pender’s Health Promotion Model was utilized …

Systemic Leptin Modulates The Expression Of E-Cadherin, Β-Catenin In The Ovary Of Dietary-Induced Obese Infertile Rats, Olufunke A. Sokan

Electronic Theses and Dissertations

One of the numerous complications of obesity is infertility. Leptin has been shown to reverse infertility; however, exact mechanism is poorly understood. Recent evidence indicates Ecadherin/ β-catenin complex, which is a structural constituent of adherens junction, is expressed in the rat ovary during folliculogenesis. We hypothesized that systemic leptin modulates the expression of E-cadherin and β-catenin in dietary-induced obese infertile rats to reverse infertility. Female Sprague-Dawley rats were fed either regular chow diet (RCD) (n=6) or high fat diet (HFD) (n=14). Oestrus cycles were monitored daily until their cycles became irregular. 100 ug/ml of leptin was given intraperitoneally to HFD-fed …

Metformin-Induced Pedf Expression Regulates Cell Proliferation And Lipid Metabolism In Prostate Cancer Cells, Miguel Angel Tolentino

Theses and Dissertations

Prostate cancer (PCa) is one of the most common cancers in American males. A high fat diet and obesity accelerate PCa progression and increase the 1risk of death from disease. Epidemiological studies have indicated that PCa patients with type 2 diabetes have higher mortality rates than PCa patients without diabetes. Type 2 diabetics who are on metformin, a drug to control blood sugar levels, show a delay in PCa progression in comparison with PCa patients with type 2 diabetes who are not on metformin. It has been proposed that metformin inhibits proliferation via activation of AMP-activated protein kinase (AMPK) or …

Online Healthy Lifestyle Support In The Perinatal Period: What Do Women Want And Do They Use It?, Lydia A. Hearn, Margaret R. Miller, Anna Fletcher

Research outputs 2013

Unhealthy weight gain and retention during pregnancy and postpartum is detrimental to mother and child. Although various barriers limit the capacity for perinatal health care providers (PHCPs) to offer healthy lifestyle counselling, they could guide women to appropriate online resources. This paper presents a project designed to provide online information to promote healthy lifestyles in the perinatal period. Focus groups or interviews were held with 116 perinatal women and 76 PHCPs to determine what online information perinatal women and PHCPs want, in what form, and how best it should be presented. The results indicated that women wanted smartphone applications (apps) …

Effects Of Niacin In Human Vascular Endothelial Cells During Lipotoxicity, Jennifer M. Hughes-Large

Electronic Thesis and Dissertation Repository

Nicotinic acid (NA) can improve vascular function and regeneration independent of correcting dyslipidemia. NA, as a potential biosynthetic precursor for NAD⁺, may elicit these vascular benefits through SIRT-mediated NAD⁺-dependent responses. We hypothesized that NA improves endothelial cell function under lipotoxic conditions through NAD⁺-dependent pathways. Angiogenic function in excess palmitate was assessed by tube formation assay following treatment of human microvascular endothelial cells (HMVEC) with NA or nicotinamide mononucleotide (NMN; a direct NAD⁺ precursor). Both NA and NMN improved HMVEC angiogenic function during palmitate overload. Only NMN increased cellular NAD⁺ and SIRT1 activity, …

How To Get Rid Of Thunder Thighs, Helena E. Yang

SURGE

I appreciate the insightful and important things your muffin top has to say to me, but my thunder thighs still think they’re fat.

I’m overweight (sometimes).

On a BMI scale, I fluctuate in and out of the dreaded “overweight” category. While I acknowledge that the BMI scale has its flaws, it was designed to be a quick approximation of weight to height; it is not designed to be a scientific test. Sometimes I tell myself I am super muscular and the scale doesn’t apply to me, but it’s actually not true. [excerpt]

Crosstalk Between Adipocytes And Immune Cells In Adipose Tissue In An Obese Inflammatory State: Role Of Contact-Mediated Signaling, Carolina Franco Nitta

Biomedical Sciences ETDs

Obesity is defined as heightened fat accumulation leading to health impairments. It has been directly correlated to cardiovascular disease, type II diabetes mellitus, and cancer. Heightened cytokine levels are found in serum and adipose tissue of obese subjects, including TNFα (tumor necrosis factor alpha), IL-6 (interleukin-6), and MCP-1 (monocyte chemoattractant protein-1), being characterized as a chronic low-grade inflammatory disease. In this dissertation, I have generated a novel co-culture model between adipocytes and immune cells (derived from splenocytes) that mimics inflammation seen in obese adipose tissue. This co-culture model allows for distinct evaluation between secreted paracrine factors (indirect cultures) and these …

Parents’ Role In Prevention Of Childhood Obesity, Shireen Shehzad

School of Nursing & Midwifery

No abstract provided.

Child Emotional Abuse And Its Relationship To Obesity, Kelly Anderson Driscoll

Sociology & Criminal Justice Theses & Dissertations

Over the past 30 years in the United States childhood obesity has more than tripled (Center for Disease Control and Prevention, 2010). In 2008, 18.5% of adolescents of the age 12-18 years old were obese in the United States (Center for Disease Control and Prevention, 2010). With the increase of obesity Americans have spent approximately 9% of their total medical costs on obesity-related illnesses (Finkelstein, Fiebelkorn, &Wang, 2003). Previous research documented the relationship between virtually every form of child abuse and subsequent obesity. Restricting focus to child emotional abuse, while studies have linked emotional abuse to the long-term consequence of …

Fetal And Neonatal Exposure To Nicotine Augments Hepatic Fatty Acid Synthesis In Rat Offspring Long-Term, Noelle L. Ma

Electronic Thesis and Dissertation Repository

While nicotine replacement therapy (NRT) is presumed to be a safer alternative to smoking in pregnancy, the long-term consequences in offspring are still largely unknown. Animal studies now suggest that maternal nicotine exposure during pregnancy and lactation (MNE-PL) leads to a wide variety of adverse outcomes for the offspring, including increased adiposity. The focus of this study was to investigate how MNE-PL in rats may lead to liver dysfunction long-term in offspring through alterations in gene expression and epigenetic modifications. Postnatal day 180 (PND180) offspring exposed to nicotine during pregnancy and lactation (1mg/kg/day) exhibited increased circulating and hepatic triglycerides concomitant …

Obesity As An Epidemic: Causes, Morbidities And Reproductive Performance, E. Hakan Duran

Eyup Hakan Duran

Obesity is an epidemic causing significant morbidity and mortality in United States. It is facilitated by many factors including sedentary life style, abundance of food, and unhealthy dietary habits. This review aims to briefly address causes and conditions associated with obesity, with a special emphasis on reproductive performance for Obstetricians and Gynecologists.

The Obesity Epidemic, Lenka Kollar, Evienne Epifano, Molly Mckneight, Jeff Miskovich, Heather Moore

Student Papers in Public Policy

The incidence of chronic, noncommunicable diseases, such as heart disease, is increasing at an alarming rate on the global scale. The growing prevalence of overweight and obesity have led to an upsurge in cases of diabetes and other obesity-related diseases. About 18 million people die every year from heart disease, of which diabetes and obesity are major predisposing factors. Worldwide, more than 1.1 billion adults are overweight, 312 million of which are obese. The number of children that are overweight or obese is also growing (Hossain, Parvez et al.). Obesity, and the associated diseases, has become a worldwide epidemic and …

The Relationship Between Adiposity And Stature In Prepubertal Children With Celiac Disease, Benjamin U. Nwosu, Rachel I. Snook, Louise S. Maranda

Benjamin U. Nwosu

Background and Aim: The pathogenesis of short stature in celiac disease (CD) is unknown. Obese children are generally taller than their non-obese peers; however, the role of adiposity on stature in CD is unclear. Our aim was to determine the association between adiposity and stature in CD.

Subjects and methods: We compared the anthropometric characteristics of prepubertal children of ages 3-12 years, with biopsy-proven CD (n=40) and who were not on gluten-free diet, to same aged, prepubertal non-CD children (n=50). Body mass index (BMI) was calculated using the formula weight/height2. Sex-adjusted midparental target height (MPTH) standard deviation score (SDS) was …

Risk Of Early & Late Obstetric Complications In Women With Ivf- Conceived Pregnancies And Polycystic Ovary Syndrome (Pcos), N. A. Bagegni, J. Blaine, Bradley J. Van Voorhis, Anuja Dokras

Bradley J Van Voorhis

There is conflicting evidence on the association between PCOS and early and late obstetric complications. It is unclear if the reported risks are independent of BMI, preexisting hypertension and diabetes. We performed a retrospective chart review to examine the risk of early and late obstetrical complications after IVF in women with PCOS (n=130) compared to controls (n=130). The miscarriage rate was 17.7% in PCOS women and 15.4% in controls. PCOS was not associated with miscarriage independent of age and BMI. The prevalence of gestational DM (GDM) was similar in both groups (12% PCOS versus 11% controls). BMI was independently associated …