Medicine and Health Sciences Commons^™

The Longitudinal Relationship Between Depression Symptoms And Disability For Older Adults: A Population-Based Study, Chun-Min Chen, Judy Mullan, Yung-Yu Su, David Atherton Griffiths, Irene Kreis, Herng-Chia Chiu

Professor David Griffiths

Background. Although depressive symptoms in older adults are common, their relationship with disability and the influence of disability on the development of depressive symptoms over time is not well understood. This longitudinal study investigates the change trajectories of both depressive symptoms and disability, as well as their associations over time. Methods. Participants included 442 community-dwelling older adults living in Taiwan, aged 65 years or older, who completed six waves of survey interviews. Depression was scored with the Short Psychiatric Evaluation Schedule and disability with the instrumental and physical activities of daily living measure during each consecutive data collection wave. The …

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Trevor Crowe

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …

"It Could Probably Help Someone Else But Not Me": A Feasibility Study Of A Snack Programme Offered To Meals On Wheels Clients, K E. Charlton, K Walton, L Moon, K Smith, A T. Mcmahon, F Ralph, M Stuckey, F Manning, J Krassie

Faculty of Science, Medicine and Health - Papers: part A

Objectives Community-based services, such as Meals on Wheels (MOW), allow older adults to remain in their homes for as long as possible. Many MOW recipients experience decreased appetite that limits intake at mealtimes. This pilot study aimed to determine the feasibility of providing high protein high energy snacks to improve nutrient intakes of MOW clients in a regional centre of New South Wales, Australia.

Participants A convenience sample of 12 MOW clients.

Intervention Participants received snacks five times a week, in addition to their usual MOW order, for four weeks.

Measurements Nutritional status was assessed using the Mini Nutritional Assessment …

Study Protocol: A Randomized Controlled Trial Of A Computer-Based Depression And Substance Abuse Intervention For People Attending Residential Substance Abuse Treatment, Peter J. Kelly, Frances Kay-Lambkin, Amanda Baker, Frank P. Deane, Adam C. Brooks, Alexandra Mitchell, Sarah Marshall, Meredith Whittington, Genevieve A. Dingle

Frank Deane

"Background: A large proportion of people attending residential alcohol and other substance abuse treatment have a co-occurring mental illness. Empirical evidence suggests that it is important to treat both the substance abuse problem and co-occurring mental illness concurrently and in an integrated fashion. However, the majority of residential alcohol and other substance abuse services do not address mental illness in a systematic way. It is likely that computer delivered interventions could improve the ability of substance abuse services to address co-occurring mental illness. This protocol describes a study in which we will assess the effectiveness of adding a computer delivered …

Does Psychological Status Influence Clinical Outcomes In Patients With Inflammatory Bowel Disease (Ibd) And Other Chronic Gastroenterological Diseases: An Observational Cohort Prospective Study, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Gerald J. Holtmann, Jane M. Andrews

Ian G Wilson

Background: Whether there is a temporal relationship between psychological problems and clinical outcomes in patients with diseases of the digestive tract has not been widely researched. Thus, our aims were 1) To observe and compare prospectively clinical outcomes in relation to psychological co-morbidity in patients with inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and chronic hepatitis C (HCV) and, 2) To test the hypothesis that patients with psychological co-morbidities are less likely to have a satisfactory response to standard treatment at 12 months. Methods: Overall, 139 patients were enrolled in this observational cohort prospective study. Over the ensuing year, …

Big Fish In A Big Pond: A Study Of Academic Self Concept In First Year Medical Students, Kirsty Jackman, Ian G. Wilson, Marjorie Seaton, Rhonda G. Craven

Ian G Wilson

Background: Big-fish-little-pond effect (BFLPE) research has demonstrated that students in high-ability environments have lower academic self-concepts than equally able students in low-ability settings. Research has shown low academic self-concepts to be associated with negative educational outcomes. Social comparison processes have been implicated as fundamental to the BFLPE. Methods: Twenty first-year students in an Australian medical school completed a survey that included academic self-concept and social comparison measures, before and after their first written assessments. Focus groups were also conducted with a separate group of students to explore students’ perceptions of competence, the medical school environment, and social comparison processes. Results: …

Decreased Density Of Serotonin 2a Receptors In The Superior Temporal Gyrus In Schizophrenia - A Postmortem Study, Xu-Feng Huang, Chao Deng, Qing Wang, Kai Kang

Xu-Feng Huang

The superior temporal gyrus (STG) is strongly implicated in the pathophysiology of schizophrenia,particularly with regards to auditory hallucinations. In this study, using in situ quantitative autoradiography in postmortem tissue, we investigated the binding of the [3H]ketanserin to 5-HT2A receptors and [3H] mesulergine to 5-HT2C receptors in the left STG of 8 male schizophrenic patients compared to 8 control subjects. A strong [3H]ketanserin binding was observed in the STG, however there was a very weak [3H] mesulergine binding in the STG. A significant decrease in binding of [3H]ketanserin was clearly observed in schizophrenia patients in comparison with control subjects. There were …

Risk Of Road Traffic Accidents In Patients Discharged Following Treatment For Psychotropic Drug Overdose: A Self-Controlled Case Series Study In Australia, Tharaka L. Dassanayake, Alison L. Jones, Patricia Michie, Gregory Carter, Patrick Mcelduff, Barrie J. Stokes, Ian Whyte

Alison L Jones

Background: Use of psychotropic drugs is known to impair driving and increase the risk of road traffic accidents. They are also the most common drugs taken in overdose in hospital-treated episodes of self-poisoning. Most patients who take psychotropic drug overdoses are discharged within 48 hours, while they still have possible subclinical drug effects. Objective: Using a self-controlled case series design, we aimed to determine whether patients with psychotropic drug overdose are at a higher risk of a traffic accident in the period following discharge compared with a control period not associated with hospital-treated drug overdose. Methodology: Using the New South …

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Frank Deane

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …

Effectiveness Of A Cognitive Behavioral Weight Management Intervention In Obese Patients With Psychotic Disorders Compared To Patients With Non-Psychotic Disorders Or No Psychiatric Disorders: Results From A 12-Month, Real-World Study, Jian-Ping Zhang Md, Phd, Jeffrey J. Weiss Phd, Melissa Mccardle Ph.D., Hope Klopchin Phd, Eileen Rosendahl Phd, Lawrence Maayan Md, Antonio Convit, John M. Kane Md, Peter Manu Md, Christoph U. Correll Md

Faculty Works: SW (2011-2020)

Objective—Studies of behavioral weight loss intervention in psychotic patients are sparse and its efficacy compared to other obese patients is unknown. Therefore, we compared the effect of a cognitive-behavioral weight loss intervention in obese subjects with psychotic disorders, other psychiatric diagnoses and without psychiatric disorders. Methods—12-month, naturalistic study of weekly group or individual cognitive-behavioral weight management in 222 consecutively enrolled obese patients (body mass index (BMI): 43.7±9.6) with psychotic-spectrum disorders (PSD, n=47), other psychiatric disorders (OPD, n=49) and no psychiatric disorder (NPD, n=126).

Results—PSD patients had greater treatment persistence (48.9%) and longer treatment duration (8.7±4.4 months) than OPD (22.4%, 5.4±4.3 …

Using The Theory Of Planned Behavior And Barriers To Treatment To Predict Intention To Enter Further Treatment Following Residential Drug And Alcohol Detoxification: A Pilot Study, Peter J. Kelly, Frank P. Deane, Zoe Mccarthy, Trevor P. Crowe

Peter Kelly

There has been limited research examining the impact of clients’ behavioural beliefs on whether they intend to access further treatment following residential drug and alcohol detoxification. Treatment post-detoxification is generally recommended to reduce relapse and for more sustained positive outcomes. The present pilot study examined the extent to which (1) primary components of the Theory of Planned Behaviour (TPB), (2) perceived barriers to accessing treatment and (3) the participants’ previous involvement in substance abuse treatment predicted intentions to enter further treatment following residential detoxification. One hundred and sixty eight participants accessing Salvation Army detoxification units in Australia completed a survey …

Consumers' Salient Beliefs Regarding Dairy Products In The Functional Food Era: A Qualitative Study Using Concepts From The Theory Of Planned Behaviour, Deborah Nolan, Elizabeth Neale, Yasmine Probst, Karen E. Charlton, Linda C. Tapsell

L. C. Tapsell

Background Inadequate consumption of dairy products without appropriate dietary substitution may have deleterious health consequences. Social research reveals the factors that may impede compliance with dietary recommendations. This is particularly important given the recent introduction of functional dairy products. One of the challenges for public health professionals is to demonstrate the efficacy of nutrition education in improving attitudes toward nutrient rich foods. The aim of this study was to explore the salient beliefs of adult weight loss trial participants regarding both traditional and functional dairy products and to compare these with a control group not exposed to nutrition education Methods …

A Study Of Headache In North American Primary Care: Report For The Ambulatory Sentinel Practice Network, L A. Becker, Donald C. Iverson, F M. Read, N Calogne, R S. Miller, W L. Freeman

Don C. Iverson

Headache is a common symptom in primary care about which surprisingly little is known. Over a 14-month period 3847 patients making 4940 consecutive visits for headache to 38 primary care practices in the USA and Canada were studied. The clinical characteristics of patients, as well as the diagnostic and therapeutic strategies employed by their doctors, were examined. Visits for headache represented 1.5% of all visits during this period. Most patients (72.0%) made only one visit, and nearly half of the headaches reported were new. Only a small number of patients (3.0%) received a computerized tomographic scan; other investigations were used …

Circumventing The Who Code? An Observational Study, Nina J. Berry, Sandra C. Jones, Donald C. Iverson

Don C. Iverson

Background This study compares the formula milk advertisements that appeared in parenting magazines published in two countries that have enacted measures to restrict the advertising of infant formula products in response to the international code with two that have not. Methods Content analysis was used to compare the type and frequency of formula milk advertisements that appeared in parenting magazines collected from the USA, Canada, the UK and Australia during 2007, and to examine whether there was a relationship between these frequencies and advertising regulations. Findings Advertisements that promoted formula products or brands occurred in all of the magazines sampled …

Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell

Don C. Iverson

School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …

Case Study In Academic And Industry Collaboration: The Development Of An Adolescent Targeted Sun Protection Intervention In Nsw, Melinda Williams, Sandra Jones, Donald Iverson, Peter Caputi, Sofia Potente

Don C. Iverson

Academic and industry collaboration is increasingly identified as a critical element in the future health of Australians through linking theory and practice, with the major priority for academic institutions being the identification of new knowledge and the transfer of this knowledge into changes in policy and health services. Collaborations between academia and industry are increasingly encouraged in Australia by research funding schemes such as ARCLinkage and, more recently, NHMRC Partnerships. While a recent US study suggests that such schemes have a moderate effect on academics’ propensity to work with industry (Bozeman and Gaughan, 2007), industry groups have recognised the value …

Can The Survival Processing Effect Be Replicated In Non-Ancestral Survival Scenarios?, Ciro Griffiths

Honors Theses

When primed to think about one’s survival, participants experience an increase in recall for a set of words. This result called the ‘survival processing effect’ was initially found for participants primed to think about their survival in an ancestral environment. The present study was designed to access whether the effect could be replicated in non-ancestral scenarios. Analyses showed that the effect could be replicated and that non-ancestral scenarios even led to a slightly higher level of recall than the traditional ancestral scenario. Various characteristics of the modern scenarios are believed to have been responsible for this finding including an increase …

Cybercycling For Cognitive Health: Comparing Physical Mental And Combined Exercise, Anna Scribner

Honors Theses

Several meta-analyses of randomized controlled trials (RCT) have shown exercise to improve cognitive function in normal aging, mild cognitive impairment (MCI) and dementia (Colcombe & Kramer, 2003, O’ Leary et al., 2011). Cognitive benefit from mental exercise alone is less definitive. A recent RCT (Anderson-Hanley et al., 2012) found greater benefit from three months of virtual-reality enhanced exercise than physical exercise alone among 79 independent living older adults. The current study aimed to replicate this work. In this study, six seniors that either lived or worked at Schaffer Heights were enrolled in the study. Participants were randomized into one of …

Simulation Study Of Ion Pairing In Concentrated Aqueous Salt Solutions With A Polarizable Force Field, Yun Luo, Wei Jiang, Haibo Yu, Alexander D. Mackerrell, Benoit Roux

Faculty of Science, Medicine and Health - Papers: part A

The accuracy of empirical force fields is critical for meaningful molecular dynamics simulations of concentrated ionic solutions. Current models are typically developed on the basis of single ion properties such as the monohydrate energy in the gas phase, or the absolute hydration free energy at infinite dilution. However, the failure of these models to represent accurately the properties of concentrated solutions cannot be excluded. Here, these issues are illustrated for a polarizable potential based on classical Drude oscillators. To model accurately concentrated ionic solutions, the parameters of the potential functions are optimized to reproduce osmotic pressure data. The sodium-chloride potential …

Abstract 3144: A Role For Dok2 Methylation In Platinum Resistance And Tumor Suppression In Ovarian Cancer, Noelle L. Cutter Ph.D., Elena Lum, Michelle Vigliotti, Sohail Khan, Douglas Levine, Nevenka Dimitrova, Robert Lucito

Faculty Works: Biology, Chemistry, and Environmental Studies

Ovarian cancer is the 5th leading cause of cancer in women, affecting close to 22,000 women in the year 2011, of which nearly 15,500 will die. It is difficult to detect until it reaches advanced stages and becomes malignant. Currently, the standard treatment for ovarian cancer is platinum-based therapeutics, such as Carboplatin or Cisplatin, combined with Taxol. Unfortunately, approximately 25% of patients are inherently platinum-resistant and all patients who suffer from recurrence will have developed acquired platinum resistance. The genetic/epigenetic causes of this resistance are poorly understood. Epigenetic events are reversible and the identification of genes altered by this mechanism …

Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell

Faculty of Health and Behavioural Sciences - Papers (Archive)

School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …

The Effect Of Dairy Consumption On Blood Pressure In Mid-Childhood: Caps Cohort Study, A M. Rangan, V L. Flood, G Denyer, J G. Ayer, K L. Webb, G B. Marks, D S. Celermajer, Tim Gill

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background/objectives: It has been postulated that higher dairy consumption may affect blood pressure regulation. The aim of this study was to examine the association between dairy consumption and blood pressure in mid-childhood. Methods: Subjects (n=335) were participants of a birth cohort at high risk of asthma withinformation on diet at 18 months and blood pressure at 8 years. Multivariate analyses were used to assess the association of dairy consumption (serves) and micronutrient intakes (mg) at 18 m with blood pressure at 8 y. In a subgroup of children (n=201), dietary intake was measured at age 18 m and 9 y …

A Study Of Psychiatric And Physical Morbidity Among Residents Of Old Age Home, Vaishali Hedge, Srinivas Kosgi, Satheesh Rao, Nagesh Pai, Shankarappa Mudgal

Graduate School of Medicine - Papers (Archive)

Aims/objectives: To determine the frequency of psychiatric and physical morbidity and also to look into the association between psycho- social factors, morbidity and disability among residents of old age home. Materials and Methods: Study was conducted at an old age home where two hundred and forty five residents were screened using short psychiatric evaluation schedule (SPES).Hundred and ten residents scoring ≥ 4 on SPES suggestive of psychopathology were further evaluated. Information regarding socio-demography, past & present medical and psychiatric illness history was collected. Each individual’s detailed physical examination findings were recorded and Mini-International Neuropsychiatric Interview (MINI), social support scale, disability …

The Longitudinal Relationship Between Depression Symptoms And Disability For Older Adults: A Population-Based Study, Chun-Min Chen, Judy Mullan, Yung-Yu Su, David Atherton Griffiths, Irene Kreis, Herng-Chia Chiu

Graduate School of Medicine - Papers (Archive)

Background. Although depressive symptoms in older adults are common, their relationship with disability and the influence of disability on the development of depressive symptoms over time is not well understood. This longitudinal study investigates the change trajectories of both depressive symptoms and disability, as well as their associations over time. Methods. Participants included 442 community-dwelling older adults living in Taiwan, aged 65 years or older, who completed six waves of survey interviews. Depression was scored with the Short Psychiatric Evaluation Schedule and disability with the instrumental and physical activities of daily living measure during each consecutive data collection wave. The …

Patient Perceptions Of Anaesthesia Research Priorities - A Failed Study, Natalie A. Smith, D Martin

Graduate School of Medicine - Papers (Archive)

Professor Steven Shafer alerted conference delegates at a recent international meeting to the value of considering topics for future research in terms of what the most important questions are that remain to be solved1. He quoted from an issue of Science magazine, in which the editors reported questions they thought pointed to the greatest current scientific knowledge gaps2. Two of the top 25 related to anaesthesia in a broad sense: the biological basis of consciousness and how memories are stored and retrieved. Others have noted the relevance of asking patients what they considered research priorities to be3,4. We designed a …

Reducing Olanzapine-Induced Weight Gain Side-Effect By Using Betahistine: A Study In The Rat Model, Chao Deng, Jiamei Lian, Nagesh Brahmavar Pai, Xu-Feng Huang

Graduate School of Medicine - Papers (Archive)

Olanzapine is effective at treating multiple domains of schizophrenia symptoms. However, it induces serious metabolic side effects. Antipsychotic drug’s antagonistic affinity to histamine H1 receptors has been identified as a main contributor for weight gain/obesity side effects. This study therefore investigated whether a combined treatment of betahistine (a H1 receptor agonist and H3 receptor antagonist) could reduce the body weight/obesity induced by olanzapine. Female Sprague Dawley rats were treated orally with olanzapine (1 mg/kg, t.i.d.) and/or betahistine (2.67 mg/kg, t.i.d.), or vehicle for two weeks. Rats treated with olanzapine exhibited significant body weight gain and increased food intake. Co-treatment of …

Translation Of Tobacco Policy Into Practice In Disadvantaged And Marginalized Subpopulations: A Study Of Challenges And Opportunities In Remote Australian Indigenous Communities, Jan A. Robertson, Katherine M. Conigrave, Rowena Ivers, Kim Usher, Alan R. Clough

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background: In Australia generally, smoking prevalence more than halved after 1980 and recently commenced to decline among Australia's disadvantaged Indigenous peoples. However, in some remote Indigenous Australian communities in the Northern Territory (NT), extremely high rates of up to 83% have not changed over the past 25 years. The World Health Organisation has called for public health and political leadership to address a global tobacco epidemic. For Indigenous Australians, unprecedented policies aim to overcome disadvantage and close the 'health gap' with reducing tobacco use the top priority. This study identifies challenges and opportunities to implementing these important new tobacco initiatives …

Study Of The Relationship Between Infrared Stimulated Luminescence And Blue Light Stimulated Luminescence For Potassium-Feldspar From Sediments, Zhijun Gong, Bo Li, Sheng-Hua Li

Faculty of Science, Medicine and Health - Papers: part A

In luminescence measurements of potassium-feldspar (K-feldspar), both infrared (IR) and blue light (BL) can be used as stimulation sources. Component analysis suggests that the blue light stimulated luminescence (BLSL) measured at 60 °C from K-feldspar can be fitted using three components, namely fast, medium and slow. In order to explore the relationship between the origin of the infrared stimulated luminescence (IRSL) signal and the different components of the BLSL, five sets of experiments were conducted, namely post-IR BLSL (pIR-BLSL), post-BL IRSL (pBL-IRSL), pulse annealing tests, dose response and laboratory fading rate tests. It is observed that most of the IRSL …

Bioregional Assessment Project: Sydney Metropolitan, Southern Rivers And Hawkesbury-Nepean Catchments: Data Collation Phase To Study The Impact Of Mining Activity And Coal Seam Gas On Environmental Assets, John Bradd, Tim Cohen, Sam Marx, Sol Buckman, Emma Burkhardt, A Clarke, Nicole Cook, Stephen Cullen, James Daley, Alexi Gavin, Ren Hu, Emma Kiekebosch-Fitt, Matt Lemcke, Andrew Lowe, Thomas Mcmahon, Luke Mcneilage, Kaitlyn O'Mara, Garth Nagle, Sam Robson, Carolyn Silveri, Joe Stammers

Faculty of Science, Medicine and Health - Papers: part A

This study was commissioned by the Hawkesbury-Nepean (HNCMA), Sydney Metropolitan (SMCMA) and Southern Rivers (SRCMA) Catchment Management Authorities and undertaken by the University of Wollongong to collate existing data and to provide a preliminary assessment of the potential impacts of coal seam gas (CSG) and coal mining activities on environmental assets within the three CMA regions, where environmental assets were defined under three broad themes; water, land and biodiversity. This study formed part of the Australian Federal Government’s Department of Sustainability, Environment, Water, Population and Communities (SEWPaC) Bioregional Assessment initiative within regions potentially affected by CSG and coal mining activities. …

Learning Analytics: A Case Study Of The Process Of Design Of Visualizations, Martin M. Olmos, Linda Corrin

Graduate School of Medicine - Papers (Archive)

The ability to visualize student engagement and experience data provides valuable opportunities for learning support and curriculum design. With the rise of the use of learning analytics to provide "actionable intelligence" [1]on students' learning, the challenge is to create visualizations of the data which are clear and useful to the intended audience. This process of finding the best way to visually represent data is often iterative, with many different designs being trialled before the final design is settled upon. This paper presents a case study of the process of refining a visualization of students' learning experience data. In this case …