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Articles 1 - 22 of 22
Full-Text Articles in Medicine and Health Sciences
Oral Lesions As Clinical Markers For Antiretroviral Therapy Failure In Hiv Patients, Irene M. Tamí-Maury
Oral Lesions As Clinical Markers For Antiretroviral Therapy Failure In Hiv Patients, Irene M. Tamí-Maury
All ETDs from UAB
The true nature of the association of oral lesions (OL) and gold standards of HIV progression, CD4+ T cell counts (CD4) and HIV-1 RNA viral load (VL), is not completely clear, especially when patients are on antiretroviral therapy (ART). Our aim was to assess the association between OL and virologic failure among HIV/AIDS patients on ART. We conducted a retrospective study of 744 HIV patients who entered care between 2000 and 2006 at the UAB 1917 Clinic. Data was collected for 2 years after enrollment. Prevalence of OL was 35.8%. Oropharyngeal candidiasis (OPC) was the most prevalent OL (74.9%). Among …
Examining The Association Between Body Mass Index And Weight Related Quality Of Life In Black And White Women, Tiffany Lashaun Cox
Examining The Association Between Body Mass Index And Weight Related Quality Of Life In Black And White Women, Tiffany Lashaun Cox
All ETDs from UAB
Obesity not only increases risk for morbidity/mortality, but also impacts the quality of life of obese individuals. In the United States, black women have the highest prevalence of obesity of any other group with approximately 80% of black women over age 20 having a body mass index (BMI) ≥ 25 kg/m2. We aimed to examine the association between weight and quality of life in this high risk population and compare it to weight-related quality of life in white women using the Impact of Weight on Quality of Life (IWQOL)-Lite questionnaire. Data for 343 women were analyzed (172 black, 171 white). …
Intimate Partner Violence Among Latinas In Central Alabama: Sociodemographic Characteristics, Perceptions Of Abuse, And Help-Seeking Behaviors, Angela Boy
All ETDs from UAB
This study utilized a cross-sectional design to survey 272 Latinas in the Birmingham metropolitan area and interview 29 Latinas who were known victims of IPV in the community. Prevalence, socio-demographic characteristics, perceptions of abuse, and help-seeking behaviors were examined, and the psychometric properties of the Woman Abuse Screening Tool (WAST) were assessed. Survey findings indicated current and lifetime IPV prevalence rates of 39.4% and 44.9%, respectively, among women aged 19-55. Victims were 1.9 times more likely to have been born in Central/South America than non-victims. Survey respondents had an average score of 32.5 (range 11-44) on the Perceptions of Abuse …
Sense Of Community Among Adolescents Participating In The Mobile Youth Survey: A Measurement Study, Randolph Stacer Devereaux
Sense Of Community Among Adolescents Participating In The Mobile Youth Survey: A Measurement Study, Randolph Stacer Devereaux
All ETDs from UAB
A measurement study was conducted to evaluate 11 items representing the latent variable labeled "sense of community" (SOC) employed by investigators of the Mobile Youth Survey (MYS). In previous research the 11 items representing the concept of SOC have been combined to form a composite variable, assuming that the concept was best represented by a single factor (e.g., Bolland, Bryant, Lian, McCallum, Vazsonyi & Barth, 2007). However, no systematic analysis has been conducted to determine the psychometric properties of the 11-item composite variable. The objects of the present study are a) to determine the component structure of the items used …
Host Preference Profile In An Area Of Eastern Equine Encephalitis (Eee) Virus Transmission In Alabama, Ana Lucia Oliveira
Host Preference Profile In An Area Of Eastern Equine Encephalitis (Eee) Virus Transmission In Alabama, Ana Lucia Oliveira
All ETDs from UAB
Eastern Equine Encephalitis virus (EEEV) circulates in a mosquito-avian cycle (enzootic) within well-characterized environments. However, outbreaks in birds, horses and humans can occur (epizootic/epidemic transmission). EEEV is present throughout the Americas and the Caribbean, although some geographical differences in the ecology and epidemiology of the virus exist. The North American type of EEEV is associated with severe disease in both humans and horses, and is transmitted by the enzootic vector Culiseta melanura among birds in northern North America. The South American EEEV strain in horses can present similarly to the North American type, however, in humans, infection is rare and …
Fertility Enhancing Drugs, Assisted Reproductive Technologies And Effects On Maternal And Infant Outcomes Among Live Births In Texas, Suzanne Jay Roseman
Fertility Enhancing Drugs, Assisted Reproductive Technologies And Effects On Maternal And Infant Outcomes Among Live Births In Texas, Suzanne Jay Roseman
All ETDs from UAB
Most studies evaluating outcomes among infertility treatment users use a spontaneously conceived (SC) group for comparative purposes, despite obvious limitations to this approach. Further, lack of comprehensive U.S. data-sources recording infertility treatments, especially non-assisted reproductive technology (non-ART) infertility treatments, has hampered the ability of U.S. researchers to explore the effects of a particular infertility treatment modality (for example ART) on maternal and infant outcomes while controlling for the effects of infertility itself. The present study makes use of the new data item: "Pregnancy resulted from infertility treatment," further categorized into ART and non-ART infertility treatments--from the 2003 revision of birth …
Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib
Association Between Birth Outcomes And Aflatoxin B1-Biomarker Levels Among Pregnant Women In Kumasi, Ghana, Faisal Mohammed Barbas Shuaib
All ETDs from UAB
Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Although studies have linked these toxins to adverse health outcomes, few studies have investigated the association between birth outcomes and aflatoxin B1-lysine adduct levels among pregnant women. The objective of this dissertation was to investigate the association between birth outcomes and aflatoxin B1- lysine adduct levels among pregnant women in Kumasi, Ghana. In a cross-sectional study of 755 pregnant women, Aflatoxin B1-lysine adduct (AF-ALB) levels were determined by High Performance Liquid Chromatography. AF-ALB associations were assessed as both continuous and categorical values. Analysis of variance (ANOVA) was …
Methods For Estimating Mediation Effect In Survival Analysis: Does Weight Loss Mediate The Undernutrition-Mortality Relationship In The Older Adults?, Yanhui Sun
All ETDs from UAB
The influence of undernutrition on mortality and other adverse outcomes through the mechanism of unintentional weight loss in older adults is often assumed, but the analytic methods to test these mediation mechanisms are not well-developed, and the need for methodological advances in this area motivated this program of research. We first examined the test-retest reliability and predictive validity of self-reported caloric intake as a measure of undernutrition. Acceptable reliability was observed, consistent with previous reports, but the evidence for predictive validity was inconsistent and self-reported caloric intake deficiency was not found to be related to observed weight loss. We then …
Investigation Of The Cese Framework For Viscous Flows, Balaji Shankar Venkatachari
Investigation Of The Cese Framework For Viscous Flows, Balaji Shankar Venkatachari
All ETDs from UAB
A transient viscous solver has been developed based on the novel space-time conser-vation element solution element (CESE) framework. Till date, the numerical accuracy of the CESE framework in modeling inviscid flow problems has been well documented, while very little work has been done in regards to modeling transient viscous flows. In this work, an attempt to fill that gap in literature was carried out by rigorously investigat-ing the numerical accuracy and computational performance of the CESE framework in simulating such flows. The study aims at gaining a deeper understanding on the numeri-cal accuracy and dissipation characteristics of the CESE framework, …
Chronic Alcohol Consumption Promotes Opening Of The Mitochondrial Permeability Transition Pore And Increases Mitochondrial Injury In Liver, Adrienne Lester King
Chronic Alcohol Consumption Promotes Opening Of The Mitochondrial Permeability Transition Pore And Increases Mitochondrial Injury In Liver, Adrienne Lester King
All ETDs from UAB
Alcoholic liver disease is a serious public health concern. In particular, the mitochondrion is a specific target of ethanol toxicity and much of the damage can be related to unregulated Ca2+ homeostasis and oxidative stress which are key players in the induction of the mitochondrial permeability transition pore (MPTP) within the organelle. The mechanism behind the induction of the MPTP remains elusive. Therefore, this body of work will provide insight on what effects chronic alcohol consumption has on mitochondrial dysfunction with an emphasis on the MPTP. Chapter 2: Assessment of mitochondrial dysfunction arising from treatment with hepatotoxicants provides a description …
A Pilot Study For A Computer-Tailored Program To Increase Calcium And Vitamin D Consumption In Young Women: Does Adding Quantitative Ultrasound Change Outcomes?, Donald Henry Lein Jr
A Pilot Study For A Computer-Tailored Program To Increase Calcium And Vitamin D Consumption In Young Women: Does Adding Quantitative Ultrasound Change Outcomes?, Donald Henry Lein Jr
All ETDs from UAB
Osteoporosis and osteoporosis-related fractures are costly personal and national problems. No cure exists so experts stress early practice of bone protective behaviors, like adequate calcium and vitamin D intake, to prevent osteoporosis and osteoporosis-related fractures. However, young women in the United States do not consume adequate amounts of these two nutrients. Further evaluation to identify cost effective programs to increase calcium and vitamin D consumption in young women is needed. The purpose of this study was to evaluate whether quantitative ultrasound (QUS) with bone strength feedback to a computer-tailored feedback and counseling intervention was needed to increase calcium and vitamin …
Development And Validation Of A Scale To Measure Fear Of Physical Response To Exercise Among Overweight And Obese Adults, Brooks Cotton Wingo
Development And Validation Of A Scale To Measure Fear Of Physical Response To Exercise Among Overweight And Obese Adults, Brooks Cotton Wingo
All ETDs from UAB
Fear-avoidance beliefs have been correlated with disability and physical function in populations with pain, but research has primarily focused on the impact of these beliefs on daily functioning, not leisure time physical activity. Current screening tools focus on a specific type or source of pain, making them inadequate for assessing fear of exercise-induced pain. The purpose of this study was to develop and establish preliminary validity of a scale to measure fear of physical response to exercise among overweight and obese adults. Additionally, the study sought to assess the relationships between scale responses and body mass index, physical activity level …
Therapeutic Interventions For Chlorine Gas Induced Lung Injury, Amit Kumar Yadav
Therapeutic Interventions For Chlorine Gas Induced Lung Injury, Amit Kumar Yadav
All ETDs from UAB
Rationale: Nitrite (NO2-) has been shown to limit injury to the heart, liver and kidneys in various models of ischemia-reperfusion injury. Currently, potential protective effects of systemic NO2- in limiting lung injury or enhancing repair have not been documented. Objectives: To assess the efficacy and mechanisms by which post-exposure intra-peritoneal injections of NO2- mitigate Cl2 induced lung injury in rats. Methods: Rats were exposed to Cl2 (400 ppm) for 30 minutes and returned to room air. Nitrite (1mg/Kg) or saline were administered intraperitoneally at 10 min, 2, 4 and 6 hrs post exposure. Rats were sacrificed at 6 hrs or …
Hypothesis Testing Based On Pool Screening With Unequal Pool Sizes, Hongjiang Gao
Hypothesis Testing Based On Pool Screening With Unequal Pool Sizes, Hongjiang Gao
All ETDs from UAB
Pool screening is a widely applied technique to estimate the prevalence of a rare event. This focus of this research is on developing statistical test of hypothesis procedures under the assumption that pool sizes are unequal but known. One of the proposed test procedures is , an exact test based on the number of positive pools (denoted by T). Another set of proposed test procedures is a modification of the likelihood ratio, Wald's and Score tests which are commonly-used likelihood-based tests. In paper 1, we derive the distribution of T which will be the basis of the exact test. Other …
Evaluations Of Clinical Signs Currently And Not Currently Used In Syndromic Case Management (Scm) Of Reproductive Tract Infections (Rtis) Among Pregnant Women In Jamaica, Gelen Receno Del Rosario
Evaluations Of Clinical Signs Currently And Not Currently Used In Syndromic Case Management (Scm) Of Reproductive Tract Infections (Rtis) Among Pregnant Women In Jamaica, Gelen Receno Del Rosario
All ETDs from UAB
Reproductive tract infections include sexually transmitted infections, endogenous infections caused by overgrowth of organisms that can be present in the genital tract of a healthy woman, and iatrogenic infections. In Jamaica, women in the reproductive age group of 15-44 years old accounts for 95% of all RTIs. RTIs among Jamaican women of reproductive age can seriously impact the health of the women and their children. The advent of HIV/AIDS has had a significant impact on increasing awareness of the effect of STIs. Health care organizations have reacted with great commit-ment to STI prevention and treatment as a significant factor in …
The Effects Of Paternal Absence On The Sexual Behaviors Of African-American Adolescents Living In Impoverished Neighborhoods, Cheri Nicolette Langley
The Effects Of Paternal Absence On The Sexual Behaviors Of African-American Adolescents Living In Impoverished Neighborhoods, Cheri Nicolette Langley
All ETDs from UAB
According to the 2005 Youth Risk Behavior Survey (YRBS), 47% of the surveyed high school students reported ever having sexual intercourse, with 6% reporting having initiated their first sexual intercourse before the age of 13 (Eaton et al., 2006). Using the Mobile Youth Survey (1998-2008), the purpose of this study is four-fold: (a) to describe the MYS sample (1998-2008) in terms of its primary independent variable (the absence of a father figure) and its primary outcomes (sexual debut, sexual frequency, number of sex partners, condom use, pregnancy in the last year, and pregnancy intention); (b) to determine the impact of …
Radiographic Damage And Functional Disability In African American Patients With Recent-Onset Rheumatoid Arthritis, Jie Zhang
All ETDs from UAB
African Americans are under-represented in rheumatoid arthritis (RA) research and factors associated with the two main RA disease outcomes, radiographic damage and functional disability, have been insufficiently studied. The objective of this project was to examine such factors using data from the Consortium for the Longitudinal Evaluation of African Americans with rheumatoid arthritis (CLEAR), a longitudinal cohort of African American patients with recent onset RA. The association between baseline generalized bone mineral density and radiographic damage at 3 years disease duration was examined among 141 subjects. The total radiographic damage score at 3-years of disease duration in subjects with reduced …
A Comparative Study Of Radiological Threat Environments And Radiation Control, Lisa C. Mccormick
A Comparative Study Of Radiological Threat Environments And Radiation Control, Lisa C. Mccormick
All ETDs from UAB
Radiation Control Programs (RCPs) differ from state to state as does their integration with public health agencies. The purpose of this study was threefold: to describe and compare across states the environmental radiological attributes of RCPs, to describe how these programs are organized structurally within state government, and to identify if RCPs differ structurally in environments of differing radiological attributes. Publicly available information from the Nuclear Regulatory Commission and state agency websites was used to determine both the environmental attributes and the different approaches states use to organize RCPs. States were grouped based on environmental attributes by employing a principle …
Prevalence And Susceptibility Of Cryptococcus Neoformans To Fluconazole In Hiv Patients In Kenya, Rennatus Magina Mdodo
Prevalence And Susceptibility Of Cryptococcus Neoformans To Fluconazole In Hiv Patients In Kenya, Rennatus Magina Mdodo
All ETDs from UAB
Cryptococcal meningitis (CM) is a significant public health burden, and a leading cause of death among human immunodeficiency virus (HIV) positive patients in Kenya. The emergence of Cryptococcus neoformans resistance to fluconazole (FLC) was recently reported in Kenya but it is not known if this resistance is widespread. The objective of this dissertation was to determine the prevalence, risk factors and mortality associated with CM and antifungal drug susceptibilities of incident C. neoformans isolates from HIV positive patients presenting at two referral hospitals in Nairobi, Kenya. A cross-sectional study of confirmed HIV patients at Kenyatta National Hospital (KNH) and Mbagathi …
Sexual Risk Behavior Among African-American Adolescents: Trajectories And Their Predictors, Maureen Muchimba
Sexual Risk Behavior Among African-American Adolescents: Trajectories And Their Predictors, Maureen Muchimba
All ETDs from UAB
Although adolescents in the United States are at high risk of sexually transmitted infections and HIV, research indicates that many do not use condoms consistently and have high numbers of lifetime multiple sexual partners. Among adolescents, different subgroups exhibit distinct patterns of sexual behavior over time. The purpose of this dissertation was to identify trajectories of sexual risk behavior among adolescents and to determine individual, family and community factors that are predictive of membership to trajectory groups. Data were collected on sexual risk behavior among low-income African-American adolescents in Mobile County, Alabama. Gender-balanced subsamples of risky sex (N = 1294) …
The Role Of Socioeconomic Factors In Racial And Ethnic Disparities Among Child And Adult Tuberculosis Cases, Spatial And Non-Spatial Analysis: Alabama 1993-2007, Sharada Adolph
All ETDs from UAB
This study aimed to evaluate the role of individual and community/population level socioeconomic factors on racial/ethnic disparities among children and adults with TB, and used area-based socioeconomic measures (ABSMs) for the identification of high-risk geographic areas for populations-at-risk. Joinpoint, multivariable and Poisson regression, and spatial methods were used to determine the trends and risks of disease in a low TB incidence state. General disease trends declined significantly by factors of -0.044838 from 1993-1998, and -0.061821 from 2001-2007; but, were disparate and increased for the foreign-born, African Americans (AA) and Latinos, and in long-term care settings. The average annual percentage change …
Determinants Of Self-Efficacy To Seek Care For Tuberculosis And Complete Tuberculosis Treatment Among Hiv-Positive Patients Attending Government Hiv/Aids Clincis In Honduras, Mayra Silvana Arias
Determinants Of Self-Efficacy To Seek Care For Tuberculosis And Complete Tuberculosis Treatment Among Hiv-Positive Patients Attending Government Hiv/Aids Clincis In Honduras, Mayra Silvana Arias
All ETDs from UAB
HIV-positive persons bear an elevated risk of developing, relapsing, and dying from tuberculosis (TB), and have greater risk of TB treatment default. Yet little is known about the factors that influence TB care-seeking among this population. This study evaluated sociodemographic, cognitive, and psychosocial characteristics of PLHA without a history of TB receiving care in specialized HIV/AIDS clinics in Honduras, and the influence of several variables on self-efficacy to seek care, including: (1) seeking care for prolonged cough despite external constraints and potential HIV stigmatization, and (2) completing TB treatment once diagnosed. The majority of participants were women (55%). Seventy-two percent …