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Full-Text Articles in Medicine and Health Sciences
Selective Repression Of Retinoic Acid Target Genes By Rip140 During Induced Tumor Cell Differentiation Of Pluripotent Human Embryonal Carcinoma Cells, Kelly C. Heim, Kristina A. White, Dexin Deng, Craig R. Tomlinson, Jason Moore, Sarah Freemantle, Michael Spinella
Selective Repression Of Retinoic Acid Target Genes By Rip140 During Induced Tumor Cell Differentiation Of Pluripotent Human Embryonal Carcinoma Cells, Kelly C. Heim, Kristina A. White, Dexin Deng, Craig R. Tomlinson, Jason Moore, Sarah Freemantle, Michael Spinella
Dartmouth Scholarship
The use of retinoids as anti-cancer agents has been limited due to resistance and low efficacy. The dynamics of nuclear receptor coregulation are incompletely understood. Cell-and context-specific activities of nuclear receptors may be in part due to distinct coregulator complexes recruited to distinct subsets of target genes. RIP140 (also called NRIP1) is a ligand-dependent corepressor that is inducible with retinoic acid (RA). We had previously shown that RIP140 limits RA induced tumor cell differentiation of embryonal carcinoma; the pluriopotent stem cells of testicular germ cell tumors. This implies that RIP140 represses key genes required for RA-mediated tumor cell differentiation. Identification …
Uwomj Volume 76, No. 1, Western University
Uwomj Volume 76, No. 1, Western University
University of Western Ontario Medical Journal
Schulich School of Medicine & Dentistry
Effects Of The New Histone Deacetylase Inhibitor Pxd101 In Bladder Cancer, Hristos Zacharias Kaimakliotis
Effects Of The New Histone Deacetylase Inhibitor Pxd101 In Bladder Cancer, Hristos Zacharias Kaimakliotis
Yale Medicine Thesis Digital Library
Histone deacetylase inhibitors (HDACIs) mediate gene expression and chromatin assembly, and induce growth arrest and apoptosis of tumor cells, thus representing a new strategy for human cancer therapy. Changes in apoptosis signaling pathways and the effect on cell growth and cell-cycle arrest of a new HDACI, PXD101, on T-24 bladder cancer cells form the basis of this study. T-24 cells were incubated with PXD101 at varying concentrations and times, and viable cell count and proliferation curves were constructed. Cell cycle analysis was conducted with Fluorescent Activated Cell Sorting and changes in apoptosis signaling proteins that were previously found to be …