Medicine and Health Sciences Commons^™

Genetic Dissection Of Behavioral And Neurogenomic Responses To Acute Ethanol, Aaron Wolen

Theses and Dissertations

Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in humans. To elucidate key molecular networks that modulate ethanol sensitivity we performed a systems genetics analysis of ethanol-responsive gene expression in brain regions of the mesocorticolimbic reward circuit (prefrontal cortex, nucleus accumbens and ventral midbrain) across the BXD RI panel, a highly diverse family of isogenic mouse strains before and after treatment with ethanol. Acute ethanol altered the expression of ~2,750 genes in one or more regions and 400 transcripts were jointly modulated in all three. Ethanol-responsive gene networks were extracted with a …

Alveolar Ridge Dimension Analysis Following Socket Preservation Using Clinical Assessment And Cone Beam Computed Tomography (Cbct)., Sayward Duggan

Theses and Dissertations

AIM: Extraction of a tooth can lead to alveolar ridge resorption which can be minimized by socket preservation. The aim of this study is to analyze vertical and horizontal alveolar ridge dimensions clinically and by CBCT immediately following extraction and 3-4 months following socket preservation. METHODS: The preserved group (P) consisted of 20 patients with1-2 non-molar teeth requiring extraction with socket preservation, while the control group (C) consisted of 5 patients requiring extraction alone. An acrylic stent was fabricated presurgically in order to measure vertical and horizontal ridge dimensions clinically and radiographically immediately following extraction and 3-4 months following socket …

Factors Considered By New Faculty In Their Decision To Choose Careers In Academic Dentistry, Harvey A. Schenkein, Al M. Best

Periodontics Publications

To determine the characteristics of new dental faculty and what factors influenced them to choose academic careers, a survey was sent to deans at all U.S. dental schools to be distributed to faculty with length of service of four years or less. Responses were received from 240 individuals. About half of the respondents had been in private practice for an average of eight years, and 20 percent had military experience averaging almost sixteen years. A majority had postgraduate training and 60 percent had specialty training. Nearly 32 percent of new faculty were female and 80 percent were U.S. citizens. Analyses …

Lack Of Effect Of Induction Of Hypothermia After Acute Brain Injury, Guy L. Clifton, Emmy R. Miller, Sung C. Choi, Harvey S. Levin, Stephen Mccauley, Kenneth R. Smith, J. Paul Muizerlaar, Franklin C. Wagner, Donald W. Marion, Thomas G. Luerssen, Randall M. Chesnut, Michael Schwartz

Biostatistics Publications

Background

Induction of hypothermia in patients with brain injury was shown to improve outcomes in small clinical studies, but the results were not definitive. To study this issue, we conducted a multicenter trial comparing the effects of hypothermia with those of normothermia in patients with acute brain injury.

Methods

The study subjects were 392 patients 16 to 65 years of age with coma after sustaining closed head injuries who were randomly assigned to be treated with hypothermia (body temperature, 33°C), which was initiated within 6 hours after injury and maintained for 48 hours by means of surface cooling, or normothermia. …

Control Of Vancomycin-Resistant Enterococcus In Health Care Facilities In A Region, Belinda E. Ostrowsky , M.D., M.P.H., William E. Trick, Annette H. Sohn, Stephen B. Quirk, Stacey Holt , B.S., Loretta A. Carson , M.S., Bertha C. Hill, Mathew J. Arduino, Mathew J. Kuehnert, William R. Jarvis

VCU Health Publications

Background

In late 1996, vancomycin-resistant enterococci were first detected in the Siouxland region of Iowa, Nebraska, and South Dakota. A task force was created, and in 1997 the assistance of the Centers for Disease Control and Prevention was sought in assessing the prevalence of vancomycin-resistant enterococci in the region’s facilities and implementing recommendations for screening, infection control, and education at all 32 health care facilities in the region.

Methods

The infection-control intervention was evaluated in October 1998 and October 1999. We performed point-prevalence surveys, conducted a case– control study of gastrointestinal colonization with vancomycin-resistant enterococci, and compared infection-control practices and …

Avoiding Medication Pitfalls, Jeffrey Delafuente

Case Studies from Age in Action

Educational Objectives

1. Discuss the prevalence and risk factors for adverse drug events in older people.

2. Identify selected medications that often should be avoided in older people.

3. Discuss methods to ensure safe medication use.

Enhancing The Quality Of Life Of Nursing Home Residents With Late Stage Alzheimer's Disease And Related Disorders, Felicity Sluga

Case Studies from Age in Action

Educational Objectives

1. Discuss the growing need for special programming and activities to improve the quality of life of nursing home residents with dementing illnesses.

2. Discuss program and activity options that have a positive impact on quality of life as measured by the resident's mood, behavioral symptoms, cognitive skills, physical condition and medication use.

3. Review the responses of a resident to our unit’s therapeutic interventions.

Bridging Aging And Domestic Violence Services In Our Communities, Janett Forte, Paula Knapp Kupstas, Stephanie White

Case Studies from Age in Action

Educational Objectives

1. To describe the problem of domestic violence in later life.

2. To show how the operating principles and service approaches of aging (APS and aging network) and domestic violence service providers differ and may cause them to interpret the same situation differently.

3. To encourage aging and domestic violence service providers to share information, expertise, resources, and philosophical perspectives with one another in order to improve the community response to older battered women.

Vision And Hearing Loss In The Older Adult - “Double Trouble”, Paige Berry

Case Studies from Age in Action

Educational Objectives

1. How to recognize age related vision and hearing loss.

2. How the loss of both vision and hearing affect the individual's day to day functioning.

3. Services and technology available to assist the professional in better meeting the needs of the individual who is experiencing a vision and hearing loss.

Virginia Dental Journal (Vol. 78, No. 3, 2001)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 78, No. 4, 2001)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 78, No. 1, 2001)

Virginia Dental Journal

No abstract provided.

Virginia Dental Journal (Vol. 78, No. 2, 2001)

Virginia Dental Journal

No abstract provided.

A Comparative Study Of Murine Mast Cell Progenitors, Shirley K. Desimone

Theses and Dissertations

This thesis is a comparative study of variables affecting differentiation and proliferation of progenitor cells from various embryonic and fetal tissue sites as they differentiate into mast cells. Embryonic stem cells from gestation day 4.5 (d4.5) differentiated exclusively into mast cells when cultured in semi-solid media with stem cell factor (SCF) and Interleukin-3 (IL-3). The same was true of d8-1 1 yolk sac cells and d8-1 1 cells from the embryo itself. However, culture with SCF and IL-3 of cells from dl4 fetal livers differentiated into mast cells, cells of the erythrocyte lineage and a few "macrophages" which may have …

The Pineal Gland, Via Melatonin, Protects Dna, Coordinates The Endocrine System With The Immune System And Controls The Timing Of Reproduction, Craig L. Anthony

Theses and Dissertations

The pineal gland secretes the hormone melatonin (n-acetyl-5-methoxytryptamine) with a circadian rhythm. This secretion's rhythm becomes disrupted with age. When melatonin secretion is decreased with advanced age, the immune, endocrine and reproductive systems fail to function optimally. Melatonin possesses lipophilic and anti-oxidant properties, providing it with access to nuclei. Melatonin protects the DNA, preventing cancerous mutation. Hippocampal degeneration and age increase and prolong the adrenocortical responses to stress. Melatonin supplementation reduces the prolonged exposure to harmful hormones.

Titrating And Evaluating Multiple Drug Regimens Within Subjects, Margaret Shih

Theses and Dissertations

The dosing of combination therapies is commonly undertaken empirically by practicing physicians, and there is a lack of a coherent algorithm to approach the problem of combination dosing. Current methods of evaluating multiple drug combinations in clinical trials generally do not provide information regarding the location of more effective dosages when the combination is not found to differ from the standard, even though the absence of a difference does not necessarily mean the new combination is ineffective. Additionally, if a new combination is found to be more effective, often a large proportion of the subjects has not benefited from the …