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Full-Text Articles in Medicine and Health Sciences
Cellular Basis Of Decreased Immune Responses To Pneumococcal Vaccines In Aged Mice, Manju Garg, Wei Luo, Alan M. Kaplan, Subbarao Bondada
Cellular Basis Of Decreased Immune Responses To Pneumococcal Vaccines In Aged Mice, Manju Garg, Wei Luo, Alan M. Kaplan, Subbarao Bondada
Microbiology, Immunology, and Molecular Genetics Faculty Publications
Previously, model systems were developed in our laboratory to study murine immune responses to the 23-valent pneumococcal polysaccharide vaccine Pnu-Imune, both in vivo and in vitro (M. Garg and B. Subbarao, Infect. Immun. 60:2329-2336, 1992; M. Garg, A. M. Kaplan, and S. Bondada, J. Immunol. 152: 1589-1596, 1994). Using these systems, we found that aged mice did not respond to the vaccine in vivo or in vitro. Cell separation studies showed that the unresponsiveness of the aged spleen cells to the vaccine was not due to an intrinsic B-cell defect or to T-cell-mediated immunosuppression but resulted from an accessory cell …
Review Of: Bonnie L. Walker, Injury Prevention For The Elderly- A Research Guide (Greenwood Press 1995), David E. Belfort
Review Of: Bonnie L. Walker, Injury Prevention For The Elderly- A Research Guide (Greenwood Press 1995), David E. Belfort
RISK: Health, Safety & Environment (1990-2002)
Review of: Bonnie L. Walker, Injury Prevention for the Elderly- A Research Guide (Greenwood Press 1995). Acknowledgments, appendices, author index, bibliographical references, foreword, preface, subject index. LC 95-32989; ISSN 0743-7560 [328 pp. Cloth $75.00. 88 Post Road West, Westport, CT 06881.]
American Longevity: Past, Present, And Future, Samuel H. Preston
American Longevity: Past, Present, And Future, Samuel H. Preston
Center for Policy Research
How long we live, and how long members of our families and social groups live, is extraordinarily important to us. It's not a subject of daily discussion, but it would be if we were threatened with a return to earlier conditions. Unfortunately, the subject of longevity falls between the cracks of academe and has received far less attention than it warrants. We are all aware, at least dimly, that people are living longer than they used to. The numbers are impressive: at the turn of the century, life expectancy at birth in the United States was 48 years; it's now …