Medicine and Health Sciences Commons^™

Nutrition And Prevention Of Alzheimer's Dementia, Arun Swaminathan, Gregory A. Jicha

Neurology Faculty Publications

A nutritional approach to prevent, slow, or halt the progression of disease is a promising strategy that has been widely investigated. Much epidemiologic data suggests that nutritional intake may influence the development and progression of Alzheimer’s dementia (AD). Modifiable, environmental causes of AD include potential metabolic derangements caused by dietary insufficiency and or excess that may be corrected by nutritional supplementation and or dietary modification. Many nutritional supplements contain a myriad of health promoting constituents (anti-oxidants, vitamins, trace minerals, flavonoids, lipids, …etc.) that may have novel mechanisms of action affecting cellular health and regeneration, the aging process itself, or may …

Tendinopathy: Setting The Record Straight, Craig Nuttall, Ryan Rasmussen

Faculty Publications

Tendinopathy is a commonly diagnosed injury. Traditionally, tendinopathy was considered to be caused by an inflammatory process. It is now known that a majority of tendinopathies are caused by tendinosis, a failed healing response resulting in a degenerated tendon. The recurrent nature of tendinopathies can present a challenge for the health care provider and be very frustrating for the patient. There are several principles that should be followed when treating tendinopathies. These principles include rest, ice, eccentric exercises, and avoidance of corticosteroid injections. Proper treatment of tendinopathies can lead to optimal healing and decrease the risk of recurrence.

Method For Treating Hair Growth Disorders, Such As Female Pattern Alopecia, And Compositions Useful Therefore, Elaine L. Jacobson, Myron K. Jacobson, Hyuntae Kim, Donna L. Coyle, William R. Coyle

Pharmacology and Nutritional Sciences Faculty Patents

The invention relates to formulations useful in treating hair disorders, improving the health of hair, increasing hair growth, and in increasing the niacin content of hair follicles. Nicotinic acid alkyl esters having a straight chain alkyl group of from 1 to 22 methylene units, preferably from 6 to 16 methylene units, and most preferably from 8 to 14 methyl units, may be used, alone or in combinations for treating these conditions.

Attention Deficit Hyperactivity Disorder: Comparison Of Medication Efficacy And Cost, Robert M. David, Karlen E. Luthy, Janelle L. B. Macintosh, Lacey M. Eden

Student Works

Although a common psychological disorder, pharmacological treatment of Attention Deficit Hyperactivity Disorder can be a costly endeavor. Among 4-5 year olds, methylphenidate is a safe, efficacious, and cost-effective option for short-, intermediate-, and long-acting medication options. Short-acting methylphenidate, intermediate-acting methylphenidate ER and SR, and long-acting methylphenidate LA are the most efficacious and cost-effective medications. Selection of non-stimulant medications should be based upon recommended guidelines rather than primarily on cost. For children incapable of swallowing pills, the most efficacious and cost-effective treatments are short-acting dextroamphetamine liquid and long-acting methylphenidate LA capsules that can be opened and sprinkled over food.

Obesity Hypoventilation Syndrome: Understanding, Diagnosing, And Treating, Chad W. Padovich

Student Works

The effects of obesity are multifaceted and lead to poor quality of life, increased risk of cardiovascular disease, stroke, and death. Obesity hypoventilation syndrome (OHS) is a widely misunderstood and under diagnosed disease process, which carries specific diagnostic criteria. The purpose of this work is to: (1) provide practitioners with a better understanding of OHS and how it differs from other obesity related breathing disorders (such as Obstructive Sleep Apnea, OSA), (2) provide diagnostic criteria of OHS, (3) provide work up recommendations, and (4) provide current recommended treatment. Data Sources: An electronic search of the literature was conducted to identify …

Stilbene Analogs And Methods Of Treating Cancer, David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang

Molecular and Cellular Biochemistry Faculty Patents

Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed.

For the complete abstract, please download this patent.

Clinical Trials And Late-Stage Drug Development In Alzheimer’S Disease: An Appraisal From 1984 To 2014, L. S. Schneider, F. Mangialasche, S. Andreasen, H. Feldman, E. Giacobini, R. Jones, V. Mantua, P. Mecocci, L. Pani, B. Winblad, M. Kivipelto

Human Clinical Trials Collection

The modern era of drug development for Alzheimer's disease began with the proposal of the cholinergic hypothesis of memory impairment and the 1984 research criteria for Alzheimer's disease. Since then, despite the evaluation of numerous potential treatments in clinical trials, only four cholinesterase inhibitors and memantine have shown sufficient safety and efficacy to allow marketing approval at an international level. Although this is probably because the other drugs tested were ineffective, inadequate clinical development methods have also been blamed for the failures. Here, we review the development of treatments for Alzheimer's disease during the past 30 years, considering the drugs, …

An Exploration Of The Relationship Between Religiousness And Treatment Seeking Trends Among College Students, Jessica M. Sturgeon

Honors Program Projects

The purpose of this study was to determine if there is a relationship between levels of religiousness and students’ openness to seeking treatment for mental health disorders in college‐aged students at a small private university. A total of 141 complete surveys were collected from students. Each participant completed the Fetzer Multidimensional Measurement of Religiousness/Spirituality for Use in Health Research along with an eight‐question survey assessing willingness to seek treatment for mental disorders. The results were analyzed to find the Spearman’s Rank Correlation Coefficient to determine correlation. Results show a significant correlation between levels of religiousness and willingness to seek treatment …

Integrated Guidance On The Care Of Familial Hypercholesterolaemia From The International Fh Foundation., Gerald F Watts, Samuel Gidding, Anthony S Wierzbicki, Peter P Toth, Rodrigo Alonso, W Virgil Brown, Eric Bruckert, Joep Defesche, Khoo Kah Lin, Michael Livingston, Pedro Mata, Klaus G Parhofer, Frederick J Raal, Raul D Santos, Eric J G Sijbrands, William G Simpson, David R Sullivan, Andrey V Susekov, Brian Tomlinson, Albert Wiegman, Shizuya Yamashita, John J P Kastelein

Division of Cardiology Faculty Papers

Familial hypercholesterolaemia (FH) is a dominantly inherited disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) cholesterol and causes premature coronary heart disease. There are at least 20million people with FH worldwide, but the majority remain undetected and current treatment is often suboptimal. To address this major gap in coronary prevention we present, from an international perspective, consensus-based guidance on the care of FH. The guidance was generated from seminars and workshops held at an international symposium. The recommendations focus on the detection, diagnosis, assessment and management of FH in adults and children, and set guidelines for clinical …

The Underutilization Of Primary Care Providers In Treating Opiate Addiction, Jennifer Jenkinson

Student Works

Opioid abuse is a worldwide problem and there are not enough care providers or treatment programs available to treat the opioid abuse epidemic. Many primary-care nurse practitioners care for patients who are dependant and/or abuse opioids. Under current legislation, nurse practitioners are not allowed to prescribe the schedule III medications necessary to treat them, even though they have been made available to primary-care physicians with some additional training. This paper discusses the effectiveness of opioid substitution therapy in a primary care setting, the patient population best suited for this therapy, patient satisfaction with primary care service, and the barriers preventing …

Mobile Delivery Of Treatment For Alcohol Use Disorders: A Review Of The Literature, Andrew Quanbeck, Ming-Yuan Chih, Andrew Isham, David H. Gustafson

Health and Clinical Sciences Faculty Publications

Several systems for treating alcohol-use disorders (AUDs) exist that operate on mobile phones. These systems are categorized into four groups: text-messaging monitoring and reminder systems, text-messaging intervention systems, comprehensive recovery management systems, and game-based systems. Text-messaging monitoring and reminder systems deliver reminders and prompt reporting of alcohol consumption, enabling continuous monitoring of alcohol use. Text-messaging intervention systems additionally deliver text messages designed to promote abstinence and recovery. Comprehensive recovery management systems use the capabilities of smart-phones to provide a variety of tools and services that can be tailored to individuals, including in-the-moment assessments and access to peer discussion groups. Game-based …

Treatment Of Chronic Hepatitis D Patients With Pegylated Interferon: A Real-World Experience, Zaigham Abbas, Mohammad S. Memon, Hammad Mithani, Wasim Jafri, Saeed Hamid

Section of Gastroenterology

Background: Published experience of treating chronic hepatitis D patients with pegylated interferon (PEG-IFN)-alpha is limited. The aim of this study was to determine the efficacy of 48 weeks of treatment with PEG-IFN in naive patients outside the clinical trial setting, in the real world.

Methods: Patients with chronic hepatitis D were treated with PEG-IFN. The primary end points were sustained clearance of HDV RNA and normal alanine aminotransferase (ALT) at 24 weeks post-treatment.

Results: The total number of patients treated with PEG-IFN was 104; 91 males, mean age ±SD 30.1 ±10.0 years (range 15-55). Cirrhosis was present in …

Osteoarthritis And Articular Cartilage: Biomechanics And Novel Treatment Paradigms, Ray Marks

Publications and Research

Background: Osteoarthritis is a widespread highly painful disabling age-related disease with no known cure. Although novel strategies for ameliorating osteoarthritic damage abound, it is likely that none will be successful over time if the entire spectrum of the disease and the effects of joint biomechanics on joint tissues are not carefully considered.

Objectives: 1) To detail the structure of healthy articular cartilage, the key tissue affected by osteoarthritis. 2) To detail what aspects of cartilage damage best characterize osteoarthritis. 3) To consider the role of biomechanical factors in developing solutions to treat osteoarthritic joint damage. Methods: Literature sources from 1980 …