Medicine and Health Sciences Commons^™

A Review Of Mesenchymal Stem Cell Injections For Osteoarthritis, Ammar Qureshi, Jill Goodwin, Franklin D. Shuler, Timothy Wilson-Byrne, John J. Jasko, Charles Giangarra

Charles Giangarra

Mesenchymal stem cell (MSC) injections for osteoarthritis is reviewed.

Methods- PubMed search identifying articles in English from 2003-2018 that used intra- articular injection (IA), cartilage repair, cartilage regeneration, chondral injury, adipose stem cells, bone marrow stem cells, mesenchymal stem cells, or autologous stem cells.

Results – 388 patients receiving IA MSC injections are discussed with data obtained from 10 case reports or case series, 4 randomized clinical trials (RCT), 1 cohort study, and 3 case controlled therapeutic studies.

Conclusions – MSC injections may be an effective adjunct in the management of osteoarthritis and a variety of cartilage related pathologies.

A Review Of Mesenchymal Stem Cell Injections For Osteoarthritis, Charles Giangarra, Jill Goodwin, Franklin D. Shuler, Timothy Wilson-Byrne, John J. Jasko

Timothy Wilson-Byrne MD

Mesenchymal stem cell (MSC) injections for osteoarthritis is reviewed.

Methods- PubMed search identifying articles in English from 2003-2018 that used intra- articular injection (IA), cartilage repair, cartilage regeneration, chondral injury, adipose stem cells, bone marrow stem cells, mesenchymal stem cells, or autologous stem cells.

Results – 388 patients receiving IA MSC injections are discussed with data obtained from 10 case reports or case series, 4 randomized clinical trials (RCT), 1 cohort study, and 3 case controlled therapeutic studies.

Conclusions – MSC injections may be an effective adjunct in the management of osteoarthritis and a variety of cartilage related pathologies.

A Review Of Mesenchymal Stem Cell Injections For Osteoarthritis, Charles Giangarra, Jill Goodwin, Franklin D. Shuler, Timothy Wilson-Byrne, John J. Jasko

John J. Jasko

Mesenchymal stem cell (MSC) injections for osteoarthritis is reviewed. Methods- PubMed search identifying articles in English from 2003-2018 that used intra- articular injection (IA), cartilage repair, cartilage regeneration, chondral injury, adipose stem cells, bone marrow stem cells, mesenchymal stem cells, or autologous stem cells. Results – 388 patients receiving IA MSC injections are discussed with data obtained from 10 case reports or case series, 4 randomized clinical trials (RCT), 1 cohort study, and 3 case controlled therapeutic studies. Conclusions – MSC injections may be an effective adjunct in the management of osteoarthritis and a variety of cartilage related pathologies.

Faster Title And Abstract Screening? Evaluating Abstrackr, A Semi-Automated Online Screening Program For Systematic Reviewers, John Rathbone, Tammy Hoffmann, Paul Glasziou

Paul Glasziou

Background: Citation screening is time consuming and inefficient. We sought to evaluate the performance of Abstrackr, a semi-automated online tool for predictive title and abstract screening. Methods: Four systematic reviews (aHUS, dietary fibre, ECHO, rituximab) were used to evaluate Abstrackr. Citations from electronic searches of biomedical databases were imported into Abstrackr, and titles and abstracts were screened and included or excluded according to the entry criteria. This process was continued until Abstrackr predicted and classified the remaining unscreened citations as relevant or irrelevant. These classification predictions were checked for accuracy against the original review decisions. Sensitivity analyses were performed to …

A Systematic Review Of How Studies Describe Educational Interventions For Evidence-Based Practice: Stage 1 Of The Development Of A Reporting Guideline, Anna Phillips, Lucy Lewis, Maureen Mcevoy, James Galipeau, Paul Glasziou, Marilyn Hammick, David Moher, Julie Tilson, Marie Williams

Paul Glasziou

Background: The aim of this systematic review was to identify which information is included when reporting educational interventions used to facilitate foundational skills and knowledge of evidence-based practice (EBP) training for health professionals. This systematic review comprised the first stage in the three stage development process for a reporting guideline for educational interventions for EBP.

Is There Sufficient Evidence For Tuning Fork Tests In Diagnosing Fractures?, Kayalvili Mungunthan, Jenny Doust, Bodo Kurz, Paul Glasziou

Jenny Doust

Objective: To determine the diagnostic accuracy of tuning fork tests for detecting fractures. Design: Systematic review of primary studies evaluating the diagnostic accuracy of tuning fork tests for the presence of fracture. Data source: We searched MEDLINE, CINAHL, AMED, EMBASE, Sports Discus, CAB Abstracts and Web of Science from commencement to November 2012. We manually searched the reference lists of any review papers and any identified relevant studies. Study selection and data extraction: Two reviewers independently reviewed the list of potentially eligible studies and rated the studies for quality using the QUADAS-2 tool. Data were extracted to form 2x2 contingency …

Understanding The Importance, Dimensions And Settings For Developing Children’S Physical Activity Behaviour, Brendon P. Hyndman

Dr Brendon P Hyndman

Promotion of regular physical activity during childhood within schools, home and community settings is important as childhood forms the foundation for physical activity habits that can track into adulthood. Despite childhood being a crucial period for developing physical activity behaviour, there is a limited understanding of the physical activity behaviours of school-aged children. The aim of this research report is to facilitate understanding of children’s physical activity behaviours by outlining a range of measurement methods, behaviour models and correlates of children’s physical activity. The home, community and school settings in which children engage in physical activity are also discussed. Outlining …

Review Of Anatomy Education In Australian And New Zealand Medical Schools, Steven J. Craig, Noel Tait, David Boers, Darryl J. Mcandrew

Darryl J McAndrew

Anatomy instruction at Australian and New Zealand medical schools has been the subject of considerable debate recently. Many commentators have lamented the gradual devaluation of anatomy as core knowledge in medical courses. To date, much of this debate has been speculative or anecdotal and lacking reliable supporting data. To provide a basis for better understanding and more informed discussion, this study analyses how anatomy is currently taught and assessed in Australian and New Zealand medical schools. A mailed questionnaire survey was sent to each of the 19 Australian and 2 New Zealand medical schools, examining the time allocation, content, delivery …

A Review Of Anatomy Education In Australasian Medical Schools, Noel Tait, Steven J. Craig, Darryl J. Mcandrew, Christos Georgiou

Darryl J McAndrew

Changes to medical education in Australia include a proliferation of medical schools, shorter courses, shifts toward problem-based learning, and large-scale medical knowledge expansion. Students also spend less time on university campuses and more time at clinical teaching sites which are often non-specialised, regional and remote from the parent university. These changes leave little room for teaching anatomy as a pure discipline.

Moving Beyond The Therapeutic Relationship: A Selective Review Of Intimacy In The Sexual Health Encounter In Nursing Practice, Leigh East, Marie Hutchinson

Associate Professor Marie Hutchinson

Aims and objectives For the purposes of this study, a selective review of the literature was undertaken with the aim of examining nurses' preparedness to engage in intimate interactions within the context of sexual health care. Kirk's (2007) model of interactional intimacy is used as a lens to examine the literature. Background The provision of sexual health care is often a neglected area of nursing care despite being recognised as a component of holistic nursing practice. Despite theoretical discussion about various forms of intimacy and intimate care, there has been little examination of the interface between intimacy and sexual health …

Sharing Quality Resources For Teaching And Learning: A Peer Review Model For The Altc Exchange In Australia, Geraldine Lefoe, Robyn Philip, Meg O'Reilly, Dominique Parrish

Geraldine Lefoe

The ALTC Exchange (formerly the Carrick Exchange), is a national repository and networking service for Australian higher education. The Exchange was designed to provide access to a repository of shared learning and teaching resources, work spaces for team members engaged in collaborative projects, and communication and networking services. The Australian Learning and Teaching Council (ALTC) established the Exchange for those who teach, manage and lead learning and teaching in higher education. As part of the research conducted to inform the development of the Exchange, models for peer review of educational resources were evaluated. For this, a design based research approach …

Earthly Indifference And Human Difference - Book Review, Lesley Head

Lesley Head

Inspired by, but also in reaction to the flattened topologies of Latourian relationality, Clark puts forward the notion of radical asymmetry. 'This is the bottom line of human being: we are utterly dependent on an earth and a cosmos that is, to a large degree, indifferent to us' (p. 50). With their disciplinary connection to the physical and natural sciences, geographers arguably need this lesson less than other social scientists. We should have learned it well from geologists who, spending their working lives in deepest time, tend to have a less anthropocentric perspective than others (perhaps accounting for their disproportionate …

A Review Of Consumer Involvement In Evaluations Of Case Management: Consistency With A Recovery Paradigm, Sarah L. Marshall, Trevor P. Crowe, Lindsay G. Oades, Frank F. Deane, David J. Kavanagh

Lindsay G Oades

This Open Forum examines research on case management that draws on consumer perspectives. It clarifies the extent of consumer involvement and whether evaluations were informed by recovery perspectives. Searches of three databases revealed 13 studies that sought to investigate consumer perspectives. Only one study asked consumers about experiences of recovery. Most evaluations did not adequately assess consumers' views, and active consumer participation in research was rare. Supporting an individual's recovery requires commitment to a recovery paradigm that incorporates traditional symptom reduction and improved functioning, with broader recovery principles, and a shift in focus from illness to well-being. It also requires …

Glycemic Index And Pregnancy: A Systematic Literature Review, Jimmy Chun Yu Louie, Jennie C. Brand-Miller, Tania P. Markovic, Glynis P. Ross, Robert G. Moses

Jimmy Chun Yu Louie

Background/Aim. Dietary glycemic index (GI) has received considerable research interest over the past 25 years although its application to pregnancy outcomes is more recent. This paper critically evaluates the current evidence regarding the effect of dietary GI on maternal and fetal nutrition. Methods. A systematic literature search using MEDLINE, EMBASE, CINAHL, Cochrane Library, SCOPUS, and ISI Web of Science, from 1980 through September 2010, was conducted. Results. Eight studies were included in the systematic review. Two interventional studies suggest that a low-GI diet can reduce the risk of large-for-gestational-age (LGA) infants in healthy pregnancies, but one epidemiological study reported an …

Asthma And Depression: A Pragmatic Review Of The Literature And Recommendations For Future Research, Melissa Opolski, Ian Wilson

Ian G Wilson

Background: Although the association between asthma and psychosocial factors has long been recognised, it is only in the last decade that the impact of coexisting asthma and depression has become the focus of considerable research interest. However, the findings so far have been confusing and often contradictory. This paper sets out a methodical review and appraisal of the literature to date, including suggestions for future research. Method: PubMed and PsycINFO databases were used to search for English-language articles relating to asthma and depression research. The resulting articles were then reviewed and summarised, creating a report that was used to develop …

Antidepressants And Inflammatory Bowel Disease: A Systematic Review, Antonina A. Mikocka-Walus, Deborah Turnbull, Nicole T. Moulding, Ian G. Wilson, Jane M. Andrews, Gerald J. Holtmann

Ian G Wilson

Background: A number of studies have suggested a link between the patient's psyche and the course of inflammatory bowel disease (IBD). Although pharmacotherapy with antidepressants has not been widely explored, some investigators have proposed that treating psychological comorbidities with antidepressants may help to control disease activity. To date a systematic analysis of the available studies assessing the efficacy of antidepressants for the control of somatic symptoms in IBD patients has not been performed. Methods: We searched electronic databases, without any language restriction. All relevant papers issued after 1990 were examined. Results: 12 relevant publications were identified. All of them referred …

General Practice Training And Virtual Communities Of Practice - A Review Of The Literature, Stephen Barnett, Sandra C. Jones, Sue Bennett, Donald C. Iverson, Andrew D. Bonney

Don C. Iverson

Background: Good General Practice is essential for an effective health system. Good General Practice training is essential to sustain the workforce, however training for General Practice can be hampered by a number of pressures, including professional, structural and social isolation. General Practice trainees may be under more pressure than fully registered General Practitioners, and yet isolation can lead doctors to reduce hours and move away from rural practice. Virtual communities of practice (VCoPs) in business have been shown to be effective in improving knowledge sharing, thus reducing professional and structural isolation. This literature review will critically examine the current evidence …

Effects Of Benzodiazepines, Antidepressants And Opioids On Driving: A Systematic Review And Meta-Analysis Of Epidemiological And Experimental Evidence, Tharaka L. Dassanayake, Patricia Michie, Gregory Carter, Alison L. Jones

Alison L Jones

Background: Many individuals in the community are prescribed psychoactive drugs with sedative effects. These drugs may affect their daily functions, of which automobile driving is a major component. Objective: To examine the association of three classes of commonly used psychoactive drugs (viz. benzodiazepines and newer non-benzodiazepine hypnotics, antidepressants and opioids) with (i) the risk of traffic accidents (as indexed by epidemiological indicators of risk); and (ii) driving performance (as indexed by experimental measures of driving performance). Methods: A literature search for material published in the English language between January 1966 and January 2010 in PubMed and EMBASE databases was combined …

A Review Of The Empirical Literature On The Design Of Physical Environments For People With Dementia, Richard Fleming, Patrick A. Crookes, Shima Sum

Professor Patrick Crookes

No abstract provided.

The Relationship Between Driving Anxiety And Driving Skill: A Review Of Human Factors And Anxiety-Performance Theories To Clarify Future Research Needs, Joanne Taylor, Frank P. Deane, John Podd

Frank Deane

This article examines theory and identifies gaps in research related to the role of driving skills in driving anxiety. Increasingly, investigators have examined the clinical features of driving anxiety and the more severe situation of driving fear and phobia, but the possible involvement of driving skills has been neglected. This is surprising given the potential implications for skills training and remediation in the assessment and treatment of some of those who experience driving anxiety, fear, and phobia. The largest body of relevant research comes from the driving and human factors literature on the relationship between anxiety and driving performance. The …

Gatekeeper Training As A Preventative Intervention For Suicide: A Systematic Review, Michael Isaac, Brenda Elias, Laurence Y. Katz, Shay-Lee Belik, Frank P. Deane, Murray W. Enns, Jitender Sareen

Frank Deane

Gatekeeper training is successful at imparting knowledge, building skills, and molding the attitudes of trainees; however, more work needs to be done on longevity of these traits and referral patterns of gatekeepers. There is a need for randomized controlled trials. In addition, the unique effect of gatekeeper training on suicide rates needs to be fully elucidated.

Clopidogrel Hypersensitivity: Clinical Challenges And Options For Management., Kimberly L Campbell, John R Cohn, Michael P Savage

Michael P Savage M.D.

Over 90 million patients have been prescribed clopidogrel since its US FDA approval in 1997. Clopidogrel hypersensitivity affects up to 6% of patients, most commonly in the form of a pruritic rash. Symptoms are severe enough to result in drug discontinuation in 1.5% of patients. Premature discontinuation of clopidogrel is problematic following percutaneous coronary intervention because of the risk of stent thrombosis leading to myocardial infarction and death. Accordingly, the management of patients with clopidogrel hypersensitivity is of significant clinical importance. Conventional clopidogrel desensitization protocols, while successful in most patients, employ a washout period off medication to enable accurate detection …

The Dual Diagnosis Capability Of Residential Addiction Treatment Centres: Priorities And Confidence To Improve Capability Following A Review Process, Harold Matthews, Peter Kelly, Frank P. Deane

Peter Kelly

Abstract Introduction and Aims. The Dual Diagnosis Capability of Addiction Treatment (DDCAT) index is used to assess the capacity of substance abuse services to work with individuals with co-occurring mental health problems. The current study aimed to: (i) examine the dual diagnosis capability of residential substance abuse programs in Australia; (ii) identify managers’ perceptions regarding both priorities and confidence for change following the completion of the DDCAT; and (iii) to examine the usefulness of the DDCAT to residential substance abuse programs. Design and Methods. The DDCAT was completed across 16 residential substance abuse units.An external researcher administered and scored the …

Book Review: The Nation's Diet: The Social Science Of Food Choice, Linda C. Tapsell

L. C. Tapsell

No abstract provided.

Jane (Journal/Author Name Estimator), Sharon L. Leslie

Sharon Leslie

Acceptance of a manuscript is a relief but often depends on submission to the appropriate journal. Jane is a Web-based resource to assess novelty or repetition of subject matter in MEDLINE. Researchers and scientists can use this Web site to help determine the best journal to approach for publishing a manuscript, discover who has done similar research in a specific field, and search for articles with related topics.

A Review Of Consumer Involvement In Evaluations Of Case Management: Consistency With A Recovery Paradigm, Sarah L. Marshall, Trevor P. Crowe, Lindsay G. Oades, Frank F. Deane, David J. Kavanagh

Trevor Crowe

This Open Forum examines research on case management that draws on consumer perspectives. It clarifies the extent of consumer involvement and whether evaluations were informed by recovery perspectives. Searches of three databases revealed 13 studies that sought to investigate consumer perspectives. Only one study asked consumers about experiences of recovery. Most evaluations did not adequately assess consumers' views, and active consumer participation in research was rare. Supporting an individual's recovery requires commitment to a recovery paradigm that incorporates traditional symptom reduction and improved functioning, with broader recovery principles, and a shift in focus from illness to well-being. It also requires …

A Review Of Engagement Of Indigenous Australians Within Mental Health And Substance Abuse Services., Stacey Berry, Trevor P. Crowe

Trevor Crowe

Substance misuse is a significant issue in Australia, and a large proportion of individuals with substance misuse disorders have co-existing mental health disorders. There is evidence that Indigenous Australians are more likely than non-Indigenous Australians to experience the adverse effects of alcohol consumption, and that mental health disorders are more prevalent in Indigenous communities than non-Indigenous communities. Indigenous Australians currently do not access mental health and substance abuse services at a level which is consistent with their level of need, and this is largely due to inconsistent or insufficient culturally respectful mental health services. This paper provides a review of …

Review Of 'Handbook Of Face Recognition', Harold C. Hill

Harold Hill

The Handbook of Face Recognition is a collection of chapters designed as an introduction to the state-of-the-art in automatic face recognition. Recognition of identity is the primary focus, but face detection and expression categorisation are also covered in some detail. While this book is largely written by and aimed at engineers, the study of face recognition has always been a multidisciplinary exercise and this volume provides a valuable summary of one discipline's contribution.

Gender Differences In Smoking Behaviour And Cessation, Chizimuzo T.C. Okoli, Iris Torchalla, Natalie Hemsing, Lorraine Greaves

Chizimuzo T.C. Okoli

This article reviews the literature to compare differential outcomes among men and women after smoking cessation, assess barriers they may face during cessation and provide recommendation to address gender-specific challenges in smoking cessation interventions. There is some evidence that women achieve lower abstinence rates than men after a quit attempt with nicotine replacement therapy, as well as without pharmacotherapy, and several underlying mechanisms were discussed to account for these findings. These include: (a) women have specific genetic variants that affect pharmacokinetics and pharmacodynamics of the medication, (b) hormonal influences increase nicotine metabolism and withdrawal symptoms, (c) women are more responsive …

Men's Smoking Cessation Interventions: A Brief Review, Chizimuzo T.C. Okoli, Iris Torchalla, John L. Oliffe, Joan L. Bottorff

Chizimuzo T.C. Okoli

Background: Smoking is associated with adverse health effects and significant disease burden among men, making it an important men's health issue. Conversely, smoking cessation is associated with significant reductions in smoking-attributable risk. However, few studies have examined men-specific smoking cessation programs. The aim of our study was to conduct a comprehensive review of the literature to identify men-specific smoking cessation programs to make recommendations about future efforts to develop, implement and evaluate men-centered smoking cessation interventions.

Methods: A comprehensive search of the COCHRANE Library, MEDLINE, and PsycINFO and SIGLE databases was performed. Out of 873 studies that we retrieved from …